| Perspectives |
| Pulling the Cart and Enjoying the Ride / Carlton C. Hunt |
| Gastrointestinal Physiology |
| Cellular and Molecular Basis for Electrical Rhythmicity in Gastrointestinal Muscles / Burton Horowitz ; Sean M. Ward ; Kenton M. Sanders |
| Ionic Conductances in Gastrointestinal Smooth Muscles and Interstitial Cells of Cajal / G. Farrugia |
| Excitation-Contraction Coupling in Gastrointestinal and Other Smooth Muscles / T. B. Bolton ; S. A. Prestwich ; A. V. Zholos ; D. V. Gordienko |
| The Enteric Nervous System and Regulation of Intestinal Motility / W. A. A. Kunze ; J. B. Furness |
| Cardiovascular Physiology |
| Mechanisms of Cardiac Pain / R. D. Foreman |
| Desensitization of G Protein-Coupled Receptors in the Cardiovascular System / M. Bunemann ; K. B. Lee ; R. Pals-Rylaarsdam ; A. G. Roseberry ; M. M. Hosey |
| Regulation of Natriuretic Peptide Secretion by the Heart / G. Thibault ; F. Amiri ; R. Garcia |
| Myoblast Cell Grafting into Heart Muscle: Cellular Biology and Potential Applications / P. D. Kessler ; B. J. Byrne |
| Comparative Physiology |
| Heat-Shock Proteins, Molecular Chaperones, and the Stress Response: Evolutionary and Ecological Physiology / Martin E. Feder ; Gretchen E. Hofmann |
| Cell Physiology |
| Genetic Diseases and Gene Knockouts Reveal Diverse Connexin Functions / Thomas W. White ; David L. Paul |
| Localized Intracellular Calcium Signaling in Muscle: Calcium Sparks and Calcium Quarks / Ernst Niggli |
| ATP-Sensitive Potassium Channels: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies / Susumu Seino |
| Endocrinology |
| Adrenomedullin and the Control of Fluid and Electrolyte Homeostasis / Willis K. Samson |
| Pathophysiology of Endothelin in the Cardiovascular System / Takashi Miyauchi ; Tomoh Masaki |
| Gene Interactions in Gonadal Development / Keith L. Parker ; Andreas Schedl ; Bernard P. Schimmer |
| Neurophysiology |
| Synchronous Activity in the Visual System / W. Martin Usrey ; R. Clay Reid |
| Timing in the Auditory System of the Bat / Ellen Covey ; John H. Casseday |
| Synaptic Mechanisms for Coding Timing in Auditory Neurons / Laurence O. Trussell |
| The Role of Timing in the Brainstem Auditory Nuclei of Vertebrates / D. Oertel |
| Timing of Synaptic Transmission / B. L. Sabatini ; W. G. Regehr |
| Respiratory Physiology |
| Structure, Strength, Failure, and Remodeling of the Pulmonary Blood-Gas Barrier / J. B. West ; O. Mathieu-Costello |
| Evolution of Vertebrate Cardio-Pulmonary System / C. G. Farmer |
| Mouse Models of Airway Responsiveness: Physiological Basis of Observed Outcomes and Analysis of Selected Examples Using These Outcome Indicators / J. M. Drazen ; P. W. Finn ; G. T. De Sanctis |
| Sodium Channels in Alveolar Epithelial Cells: Molecular Characterization, Biophysical Properties, and Physiological Significance / Sadis Matalon ; Hugh O'Brodovich |
| Renal and Electrolyte Physiology |
| Sodium-Coupled Transporters for Krebs Cycle Intermediates / Ana M. Pajor |
| Modulation of Vasopressin-Elicited Water Transport by Trafficking of Aquaporin2-Containing Vesicles / Donald T. Ward ; Timothy G. Hammond ; H. William Harris |
| Electrogenic Na[superscript +]/HCO[superscript -][subscript 3] Cotransporters: Cloning and Physiology / Michael F. Romero ; Walter F. Boron |
| Special Topic: Membrane Fusion |
| Electrophysiology of Synaptic Vesicle Cycling / Henrique von Gersdorff ; Gary Matthews |
| Genetics of Synaptic Vesicle Function: Toward the Complete Functional Anatomy of an Organelle / Rafael Fernandez-Chacon ; Thomas C. Sudhof |
| Reconstitution of Regulated Exocytosis in Cell-Free Systems: A Critical Appraisal / Julia Avery ; Reinhard Jahn ; J. Michael Edwardson |
| Special Topic: Sensory Transduction |
| Mechanisms of Hair Cell Tuning / R. Fettiplace ; P. A. Fuchs |
| Ion Channels of Nociception / Edwin W. McCleskey ; Michael S. Gold |
| Controversial Issues in Vertebrate Olfactory Transduction / Geoffrey H. Gold |
| Cellular Mechanisms of Taste Transduction / M. Scott Herness ; Timothy A. Gilbertson |
| Indexes |
| Subject Index |
| Cumulative Index of Contributing Authors, Volumes 57-61 |
| Cumulative Index of Chapter Titles, Volumes 57-61 |
| In Vivo Veritas: Probing Brain Function Through the Use of Quantitative In Vivo Biochemical Techniques / Louis Sokoloff |
| Ventricular Fibrillation: Mechanisms of Initiation and Maintenance / Jose Jalife |
| Basic Mechanisms of Atrial Fibrillation--Very New Insights into Very Old Ideas / S. Nattel ; D. Li ; L. Yue |
| Ischemic Preconditioning: From Adenosine Receptor to K[subscript ATP] Channel / Michael V. Cohen ; Christopher P. Baines ; James M. Downey |
| Sodium-Calcium Exchange: A Molecular Perspective / Kenneth D. Philipson ; Debora A. Nicoll |
| The Evolutionary Physiology of Animal Flight: Paleobiological and Present Perspectives / Robert Dudley |
| Variability in the Size, Composition, and Function of Insect Flight Muscles / James H. Marden |
| Flight Respiration and Energetics / Jon F. Harrison ; Stephen P. Roberts |
| Mechanisms Underlying the Cost of Living in Animals / A. J. Hulbert ; Paul Lewis Else |
| Special Topic: Transgenic Models |
| Functional Consequences of Altering Myocardial Adrenergic Receptor Signaling / W. J. Koch ; R. J. Lefkowitz ; H. A. Rockman |
| Remodeling the Cardiac Sarcomere Using Transgenesis / Jeffrey Robbins |
| Genetic Dissection of Cardiac Growth Control Pathways / W. Robb MacLellan ; Michael D. Schneider |
| Genetically Engineered Models with Alterations in Cardiac Membrane Calcium Handling Proteins / Helen Kiriazis ; Evangelia G. Kranias |
| Diapause / M. B. Renfree ; G. Shaw |
| Multiple Endocrine Neoplasias / A. O. Hoff ; G. J. Cote ; R. F. Gagel |
| Leptin, Rexford / S. Ahima ; Jeffrey S. Flier |
| The Mechanism of Action of Thyroid Hormones / Jinsong Zhang ; Mitchell A. Lazar |
| Role of CFTR in the Colon / R. Greger |
| Intracellular Ca[superscript 2+] and Cl[superscript -] Channel Activation in Secretory Cells / J. F. Kidd ; P. Thorn |
| The Na-K-Cl Cotransporter of Secretory Epithelia / Mark Haas ; Bliss Forbush, III |
| Chloride Secretion by the Intestinal Epithelium: Molecular Basis and Regulatory Aspects / Kim E. Barrett ; Stephen J. Keely |
| Structure and Regulation of Amiloride-Sensitive Sodium Channels / Diego Alvarez de la Rosa ; Cecilia M. Canessa ; Gregor K. Fyfe ; Ping Zhang |
| Branching Morphogenesis During Kidney Development / M. Pohl ; R. O. Stuart ; H. Sakurai ; K. Nigam |
| Intrarenal Dopamine: A Key Signal in the Interactive Regulation of Sodium Metabolism / Anita C. Aperia |
| Endothelial Signal Integration in Vascular Assembly / Thomas O. Daniel ; Dale Abrahamson |
| Mechanisms of Guanylin Action Via Cyclic GMP in the Kidney / Leonard R. Forte ; Roslyn M. London ; William J. Krause ; Ronald H. Freeman |
| Special Topic: Language Faculty As an Organ |
| The Human Language Faculty As an Organ / Stephen R. Anderson ; David W. Lightfoot |
| Neural Adaptation in the Generation of Rhythmic Behavior / K. G. Pearson |
| Ligand-Gated Ion Channel Interactions with Cytoskeletal and Signaling Proteins / Morgan Sheng ; Daniel T. S. Pak |
| Insignts from Mouse Models into the Molecular Basis of Neurodegeneration / N. Heintz ; H. Y. Zoghbi |
| Spatial Considerations for Stimulus-Dependent Transcription in Neurons / Sohyun Ahn ; Antonelle Riccio ; David D. Ginty |
| Lung Development and Function in Preterm Infants in the Surfactant Treatment Era / Alan H. Jobe ; Machiko Ikegami |
| Ventilatory Responses to Changes in Temperature in Mammals and Other Vertebrates / Jacopo P. Mortola ; Peter B. Frappell |
| Role of Transcription Factors in Fetal Lung Development and Surfactant Protein Gene Expression / Carole R. Mendelson |
| Views and Overviews of the 20th Century |
| A Century of Thinking About Cell Membranes / Paul De Weer |
| Unity in Diversity: A Perspective on the Methods, Contributions, and Future of Comparative Physiology / George N. Somero |
| One-Hundred Years of Inquiry: The Mechanism of Glucose Absorption in the Intestine / Luis Reuss |
| Endocrinology: Survial as a Discipline in the 21st Century? / Jean D. Wilson |
| The 20th Century in Respiratory Physiology: One View / Donald Massaro |
| Toward the New Millennium |
| Commentary on the Special Topic Section on the Use of Transgenic Models |
| Cumulative Index of Contributing Authors, Volumes 58-62 |
| Cumulative Index of Chapter Titles, Volumes 58-62 |
| Medicine or Physiology: My Personal Mix / Alexander Leaf |
| Special Topic: Intermediary Metabolism |
| [superscript 13]C NMR of Intermediary Metabolism: Implications for Systemic Physiology / Robert G Shulman ; Douglas L Rothman |
| Gastrin, CCK, Signaling, and Cancer / Enrique Rozengurt ; John H Walsh |
| Intracellular Signaling Mechanisms Activated by Cholecystokinin-Regulating Synthesis and Secretion of Digestive Enzymes in Pancreatic Acinar Cells / John A Williams |
| Specific Ca[superscript 2+] Signaling Evoked by Cholecystokinin and Acetylcholine: The Roles of NAADP, cADPR, and IP[subscript 3] / Jose Manuel Cancela |
| The Gastrins: Their Production and Biological Activities / GJ Dockray ; A Varro ; R Dimaline ; T Wang |
| Control of Growth by the Somatropic Axis: Growth Hormone and the Insulin-Like Growth Factors Have Related and Independent Roles / Andrew A Butler ; Derek Le Roith |
| Role of Estrogen Receptor Beta in Estrogen Action / Katarina Pettersson ; Jan-Ake Gustafsson |
| StAR Protein and the Regulation of Steroid Hormone Biosynthesis / Douglas M Stocco |
| The Guanylyl Cyclase Family at Y2K / BJ Wedel ; DL Garbers |
| Molecular Diversity of Pacemaker Ion Channels / U Benjamin Kaupp ; Reinhard Seifert |
| Cellular Mechanisms of Oxygen Sensing / Jose Lopez-Barneo ; Ricardo Pardal ; Patricia Ortega-Saenz |
| Evolution and Physiological Roles of Phosphagen Systems / W Ross Ellington |
| Antifreeze and Ice Nucleator Proteins in Terrestrial Arthropods / John G Duman |
| Antifreeze Proteins of Teleost Fishes / Garth L Fletcher ; Choy L Hew ; Peter L Davies |
| Cytoplasmic Signaling Pathways that Regulate Cardiac Hypertrophy / Jeffery D Molkentin ; Gerald W Dorn, II |
| Somatic Gene Therapy in the Cardiovascular System / I Baumgartner ; JM Isner |
| Genetic Assembly of the Heart: Implications for Congenital Heart Disease / Deepak Srivastava |
| Molecular Regulation of Lung Development / Wellington V Cardoso |
| The Pulmonary Collectins and Surfactant Metabolism / Samuel Hawgood ; Francis R Poulain |
| Surfactant Proteins A and D and Pulmonary Host Defense / Erika Crouch ; Jo Rae Wright |
| Function of Surfactant Proteins B and C / Timothy E Weaver ; Juliana Johnson Conkright |
| G Protein-Coupled Prostanoid Receptors and the Kidney / Matthew D Breyer ; Richard M Breyer |
| Nephrogenic Diabetes Insipidus / Jean-Pierre Morello ; Daniel G Bichet |
| Chloride Channels in the Loop of Henle / W Brian Reeves ; Christopher J Winters ; Thomas E Andreoli |
| Special Topic: Circadian Rhythms |
| Molecular Analysis of Mammalian Circadian Rhythms / Steven M Reppert ; David R Weaver |
| Circadian Photoperception / Paul F Devlin ; Steve A Kay |
| Endogenous Timekeepers in Photosynthetic Organisms / Carl Hirschie Johnson |
| Molecular Components of the Circadian System in Drosophila / Julie A Williams ; Amita Sehgal |
| Genetic and Molecular Analysis of Circadian Rhythms in Neurospora / Jennifer J Loros ; Jay C Dunlap |
| Dynamic Signaling Between Astrocytes and Neurons / Alfonso Araque ; Giorgio Carmignoto ; Philip G Haydon |
| On the Cellular and Network Bases of Epileptic Seizures / David A McCormick ; Diego Contreras |
| Maintaining the Stability of Neural Function: A Homeostatic Hypothesis / Graeme W Davis ; Ilya Bezprozvanny |
| Resurgence of Sodium Channel Research / Alan L Goldin |
| Cumulative Index of Contributing Authors, Volumes 59-63 |
| Cumulative Index of Chapter Titles, Volumes 59-63 |
| Frontispiece / S. Jonathan Singer |
| Some Early History of Membrane Molecular Biology |
| Myocardial Aging and Senescence: Where Have the Stem Cells Gone? / Mark A. Sussman ; Piero Anversa |
| Viral-Based Myocardial Gene Therapy Approaches to Alter Cardiac Function / Matthew L. Williams ; Walter J. Koch |
| Developmental Regulation of Lung Liquid Transport / Richard E. Olver ; Dafydd V. Walters ; Stuart M. Wilson |
| Mechanism of Rectification in Inward-Rectifier K[superscript +] Channels / Zhe Lu |
| Metabolic Regulation of Potassium Channels / Xiang Dong Tang ; Lindsey Ciali Santarelli ; Stefan H. Heinemann ; Toshinori Hoshi |
| Structure and Function of Glutamate Receptor Ion Channels / Mark L. Mayer ; Neali Armstrong |
| Biochemical Indicators of Stress and Metabolism: Applications for Marine Ecological Studies / Elizabeth P. Dahlhoff |
| Field Physiology: Physiological Insights from Animals in Nature / Daniel P. Costa ; Barry Sinervo |
| Metabolic Rate and Body Temperature Reduction During Hibernation and Daily Torpor / Fritz Geiser |
| Sleep and Circadian Rhythms in Mammalian Torpor / H. Craig Heller ; Norman F. Ruby |
| Estrogens in the Nervous System: Mechanisms and Nonreproductive Functions / Adriana Maggi ; Paolo Ciana ; Silvia Belcredito ; Elisabetta Vegeto |
| The Role of Corepressors in Transcriptional Regulation by Nuclear Hormone Receptors / Martin L. Privalsky |
| Molecular and Integrative Physiology of Intestinal Peptide Transport / Hannelore Daniel |
| Oral Rehydration Therapy: New Explanations for an Old Remedy / Mrinalini C. Rao |
| Recent Advances in Carrier-Mediated Intestinal Absorption of Water-Soluble Vitamins / Hamid M. Said |
| Learning Mechanisms in Addiction: Synaptic Plasticity in the Ventral Tegmental Area as a Result of Exposure to Drugs of Abuse / Julie A. Kauer |
| Localization of Voltage-Gated Ion Channels in Mammalian Brain / James S. Trimmer ; Kenneth J. Rhodes |
| Myosin-1c, the Hair Cell's Adaptation Motor / Peter G. Gillespie ; Janet L. Cyr |
| Regulation of Renal K Transport by Dietary K Intake / WenHui Wang |
| The Extracellular Cyclic AMP-Adenosine Pathway in Renal Physiology / Edwin K. Jackson ; Dubey K. Raghvendra |
| Alterations in SP-B and SP-C Expression in Neonatal Lung Disease / Lawrence M. Nogee |
| Epithelial-Mesenchymal Interactions in the Developing Lung / John M. Shannon ; Brian A. Hyatt |
| Genetically Engineered Mouse Models for Lung Cancer / I. Kwak ; S.Y. Tsai ; F.J. DeMayo |
| Special Topic: Proton and Electron Transporters |
| Bacteriorhodopsin / Janos K. Lanyi |
| The Cytochrome bc[subscript 1] Complex: Function in the Context of Structure / Antony R. Crofts |
| Special Topic: Functional Imaging in Physiology |
| Interpreting the BOLD Signal / Nikos K. Logothetis ; Brian A. Wandell |
| Live Optical Imaging of Nervous System Development / Cristopher M. Niell ; Stephen J Smith |
| Special Chapter: Muscle Physiology |
| Control of the Size of the Human Muscle Mass / Michael J. Rennie ; Henning Wackerhage ; Espen E. Spangenburg ; Frank W. Booth |
| Cumulative Index of Contributing Authors, Volumes 62-66 |
| Cumulative Index of Chapter Titles, Volumes 62-66 |
