| Cytochrome P-450 3A4: Regulation and Role in Drug Metabolism / F. Peter Guengerich |
| Methylation Pharmacogenetics: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase / Richard M. Weinshilboum ; Diane M. Otterness ; Carol L. Szumlanski |
| The Pineal Gland and Melatonin: Molecular and Pharmacologic Regulation / Jimo Borjigin ; Xiaodong Li ; Solomon H. Snyder |
| Regulation of Gene Expression by Reactive Oxygen / Timothy P. Dalton ; Howard G. Shertzer ; Alvaro Puga |
| Induction of Cytochrome P4501A1 / James P. Whitlock, Jr. |
| Cytotoxicity of Short-Chain Alcohols / R. C. Baker ; R. E. Kramer |
| Glial Cells in Neurotoxicity Development / M. Aschner ; J. W. Allen ; H. K. Kimelberg ; R. M. LoPachin ; W. J. Streit |
| Regulation and Inhibition of Phospholipase A[subscript 2] / Jesus Balsinde ; Maria A. Balboa ; Paul A. Insel ; Edward A. Dennis |
| Inhibition of Nitric Oxide Synthase as a Potential Therapeutic Target / Adrian J. Hobbs ; Annie Higgs ; Salvador Moncada |
| Genetic Regulation of Glutamate Receptor Ion Channels / Scott J. Myers ; Raymond Dingledine ; Karin Borges |
| Redox Regulation of c-Ha-ras and Osteopontin Signaling in Vascular Smooth Muscle Cells: Implications in Chemical Atherogenesis / Kenneth S. Ramos |
| Metallothionein: An Intracellular Protein to Protect Against Cadmium Toxicity / Curtis D. Klaassen ; Jie Liu ; Supratim Choudhuri |
| Cyclins and Cell Cycle Checkpoints / D. G. Johnson ; C. L. Walker |
| New Insights into Dopaminergic Receptor Function Using Antisense and Genetically Altered Animals / David R. Sibley |
| [beta]-Adrenergic Receptors and Receptor Signaling in Heart Failure / Steven R. Post ; H. Kirk Hammond |
| Biochemical, Cellular, and Pharmacological Aspects of the Multidrug Transporter / Suresh V. Ambudkar ; Saibal Dey ; Christine A. Hrycyna ; Muralidhara Ramachandra ; Ira Pastan ; Michael M. Gottesman |
| Teratology of Retinoids / Michael D. Collins ; Gloria E. Mao |
| Excitatory Amino Acid Transporters: A Family in Flux / R. P. Seal ; S. G. Amara |
| Indexes |
| Subject Index |
| Cumulative Index of Contributing Authors, Volumes 35-39 |
| Cumulative Index of Chapter Titles, Volumes 35-39 |
| Predicting Human Drug Glucuronidation Parameters: Application of In Vitro and In Silico Modeling Approaches / John O. Miners ; Paul A. Smith ; Michael J. Sorich ; Ross A. McKinnon ; Peter I. Mackenzie |
| Oxidative Stress, Toxicology, and Pharmacology of CYP2E1 / Andres A. Caro ; Arthur I. Cederbaum |
| The Identification of Ligands at Orphan G-Protein Coupled Receptors / Alan Wise ; Steven C. Jupe ; Stephen Rees |
| Biochemical Mechanism of Nitroglycerin Action and Tolerance: Is This Old Mystery Solved? / Ho-Leung Fung |
| Developmental Neuropathology of Environmental Agents / Lucio G. Costa ; Michael Aschner ; Annabella Vitalone ; Tore Syversen ; Offie Porat Soldin |
| The Integration of Pharmacokinetics and Pharmacodynamics: Understanding Dose-Response / Susan M. Abdel-Rahman ; Ralph E. Kauffman |
| Transporters and Renal Drug Elimination / Wooin Lee ; Richard B. Kim |
| Identification of the Major Steps in Botulinum Toxin Action / Lance L. Simpson |
| ErbB Receptors: Directing Key Signaling Networks Throughout Life / Thomas Holbro ; Nancy E. Hynes |
| Novel Angiogenic Signaling Pathways and Vascular Targets / Roy Bicknell ; Adrian L. Harris |
| The Role of Oxidative Stress in Carcinogenesis / James E. Klaunig ; Lisa M. Kamendulis |
| DARPP-32: An Integrator of Neurotransmission / Per Svenningsson ; Akinori Nishi ; Gilberto Fisone ; Jean-Antoine Girault ; Angus C. Nairn ; Paul Greengard |
| [beta]-Adrenergic Receptors and Regulation of Energy Expenditure: A Family Affair / Jacques Robidoux ; Tonya L. Martin ; Sheila Collins |
| Protein Sulfenic Acids in Redox Signaling / Leslie B. Poole ; P. Andrew Karplus ; Al Claiborne |
| The Role of Calpain in Oncotic Cell Death / Xiuli Liu ; Terry Van Vleet ; Rick G. Schnellmann |
| Voltage-Gated Sodium Channels and Hyperalgesia / Josephine Lai ; Frank Porreca ; John C. Hunter ; Michael S. Gold |
| Neurogenesis in the Adult Brain: New Strategies for Central Nervous System Diseases / D. Chichung Lie ; Hongjun Song ; Sophia A. Colamarino ; Guo-li Ming ; Fred H. Gage |
| Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes and Clinical Implications / Jurgen Wess |
| Mixed-Lineage Kinases: A Target for the Prevention of Neurodegeneration / Leo H. Wang ; Cagri G. Besirli ; Eugene M. Johnson, Jr. |
| Analysis of GABA[subscript A] Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics / Uwe Rudolph ; Hanns Mohler |
| Sex Differences in Pharmacokinetics and Pharmacodynamics / Monica Gandhi ; Francesca Aweeka ; Ruth M. Greenblatt ; Terrence F. Blaschke |
| CRF and CRF Receptors: Role in Stress Responsivity and Other Behaviors / Tracy L. Bale ; Wylie W. Vale |
| Membrane Trafficking of G Protein-Coupled Receptors / Christopher M. Tan ; Ashley E. Brady ; Hilary Highfield Nickols ; Qin Wang ; Lee E. Limbird |
| Cumulative Index of Contributing Authors, Volumes 40-44 |
| Cumulative Index of Chapter Titles, Volumes 40-44 |
| Regulation of CYP3A Gene Transcription by the Pregnane X Receptor / Bryan Goodwin ; Matthew R. Redinbo ; Steven A. Kliewer |
| Inhibition of Carcinogenesis by Tea / Chung S. Yang ; Pius Maliakal ; Xiaofeng Meng |
| COX-2: A Target for Colon Cancer Prevention / Lawrence J. Marnett ; Raymond N. DuBois |
| Cytokine Modulators as Novel Therapies for Asthma / Peter J. Barnes |
| Protein Allergenicity Assessment of Foods Produced Through Agricultural Biotechnology / Steve L. Taylor |
| Challenges for Biomedical Informatics and Pharmacogenomics / Russ B. Altman ; Teri E. Klein |
| Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory / J. Paige Adams ; J. David Sweatt |
| Glutamatergic Mechanisms in Schizophrenia / Guochuan Tsai ; Joseph T. Coyle |
| Molecular Basis of Environmentally Induced Birth Defects / Richard H. Finnell ; Janee Gelineau-van Waes ; James D. Eudy ; Thomas H. Rosenquist |
| Protein Tyrosine Phosphatases: Structure and Function, Substrate Specificity, and Inhibitor Development / Zhong-Yin Zhang |
| AKAP-Mediated Signal Transduction / Jennifer J. Carlisle Michel ; John D. Scott |
| Cellular Mechanisms for the Repression of Apoptosis / Carl D. Bortner ; John A. Cidlowski |
| Signal Transduction by Cell Adhesion Receptors and the Cytoskeleton: Functions of Integrins, Cadherins, Selectins, and Immunoglobulin-Superfamily Members / R. L. Juliano |
| Designing Inhibitors of Cyclin-Dependent Kinases / Ian R. Hardcastle ; Bernard T. Golding ; Roger J. Griffin |
| Drug Efficacy at G Protein-Coupled Receptors / Terry Kenakin |
| Glycoperptide Antibiotic Resistance / Jeff Pootoolal ; John Neu ; Gerard D. Wright |
| Dimerization: An Emerging Concept for G Protein-Coupled Receptor Ontogeny and Function / Stephane Angers ; Ali Salahpour ; Michel Bouvier |
| The Binding Site of Aminergic G Protein-Coupled Receptors: The Transmembrane Segments and Second Extracellular Loop / Lei Shi ; Jonathan A. Javitch |
| Structure, Function, and Inhibition of Chemokines / Elias J. Fernandez ; Elias Lolis |
| Altered DNA Methylation: A Secondary Mechanism Involved in Carcinogenesis / Jay I. Goodman ; Rebecca E. Watson |
| The Changing Face of the Na[superscript +]/H[superscript +] Exchanger, NHE1: Structure, Regulation, and Cellular Actions / L. K. Putney ; S. P. Denker ; D. L. Barber |
| The Spinal Phospholipase-Cyclooxygenase-Prostanoid Cascade in Nociceptive Processing / Camilla I. Svensson ; Tony L. Yaksh |
| The Biochemistry and Physiology of S-Nitrosothiols / Neil Hogg |
| Cumulative Index of Contributing Authors, Volumes 38-42 |
| Cumulative Index of Chapter Titles, Volumes 38-42 |
| Frontispiece / John Doull |
| Toxicology Comes of Age |
| Anesthetics and Ion Channels: Molecular Models and Sites of Action / Tomohiro Yamakura ; Edward Bertaccini ; James R. Trudell ; R. Adron Harris |
| Tumor Cell Death Induced by Topoisomerase-Targeting Drugs / Tsai-Kun Li ; Leroy F. Liu |
| The Clinical Pharmacology of L-Arginine / Rainer H. Boger ; Stefanie M. Bode-Boger |
| Pharmacogenomics: Unlocking the Human Genome for Better Drug Therapy / Howard L. McLeod ; William E. Evans |
| Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors / T. Sueyoshi ; M. Negishi |
| Regulation and Role of Adenylyl Cyclase Isoforms / Jacques Hanoune ; Nicole Defer |
| The Basic and Clinical Pharmacology of Nonpeptide Vasopressin Receptor Antagonists / M. Thibonnier ; P. Coles ; A. Thibonnier ; M. Shoham |
| Novel Effects of Nitric Oxide / Karen L. Davis ; Emil Martin ; Illarion V. Turko ; Ferid Murad |
| Interactions Between Monoamines, Glutamate, and GABA in Schizophrenia: New Evidence / Arvid Carlsson ; Nicholas Waters ; Susanna Holm-Waters ; Joakim Tedroff ; Marie Nilsson ; Maria L. Carlsson |
| Properties and Biological Activities of Thioredoxins / Garth Powis ; William R. Montfort |
| Regulation, Function, and Tissue-Specific Expression of Cytochrome P450 CYP1B1 / Graeme I. Murray ; William T. Melvin ; William F. Greenlee ; M. Danny Burke |
| Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium Messengers / Hon Cheung Lee |
| Use of Biomarkers and Surrogate Endpoints in Drug Development and Regulatory Decision Making: Criteria, Validation, Strategies / LJ Lesko ; AJ Atkinson, Jr. |
| Cellular Responses to DNA Damage / Chris J. Norbury ; Ian D. Hickson |
| Antisense Oligonucleotides: Promise and Reality / Irina Lebedeva ; C. A. Stein |
| Cancer Chemoprevention Using Natural Vitamin D and Synthetic Analogs / Kathryn Z. Guyton ; Thomas W. Kensler ; Gary H. Posner |
| Metabolism of Fluorine-Containing Drugs / B. Kevin Park ; Neil R. Kitteringham ; Paul M. O'Neill |
| Ca[superscript 2+]/CaM-Dependent Kinases: From Activation to Function / Sara S. Hook ; Anthony R. Means |
| Lysophospholipid Receptors / Nobuyuki Fukushima ; Isao Ishii ; James J. A. Contos ; Joshua A. Weiner ; Jerold Chun |
| Interindividual Variability in Inhibition and Induction of Cytochrome P450 Enzymes / Jiunn H. Lin ; Anthony Y. H. Lu |
| Neurotrophic and Neuroprotective Actions of Estrogens and Their Therapeutic Implications / Susan J. Lee ; Bruce S. McEwen |
| Genetic Variations and Polymorphisms of G Protein-Coupled Receptors: Functional and Therapeutic Implications / Brinda K. Rana ; Tetsuo Shiina |
| Drug Treatment Effects on Disease Progression / P. L. S. Chan ; N. H. G. Holford |
| Prostanoid Receptors: Subtypes and Signaling / Richard M. Breyer ; Carey K. Bagdassarian ; Scott A. Myers ; Matthew D. Breyer |
| Pharmacology of the Lower Urinary Tract / William C. de Groat ; Naoki Yoshimura |
| Role of Osteopontin in Cellular Signaling and Toxicant Injury / David T. Denhardt ; Cecilia M. Giachelli ; Susan R. Rittling |
| Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes / Susan F. Steinberg ; Laurence L. Brunton |
| Molecular Approach to Adenosine Receptors: Receptor-Mediated Mechanisms of Tissue Protection / J. Linden |
| Molecular Targets of Lithium Action / Christopher J. Phiel ; Peter S. Klein |
| Molecular Basis of Ethnic Differences in Drug Disposition and Response / Hong-Guang Xie ; Alastair J. J. Wood ; C. Michael Stein |
| Endothelin System: The Double-Edged Sword in Health and Disease / Rafal M. Kedzierski ; Masashi Yanagisawa |
| Neurokinin[subscript 1] Receptor Antagonists as Potential Antidepressants / Steven C. Stout ; Michael J. Owens ; Charles B. Nemeroff |
| Cumulative Index of Contributing Authors, Volumes 37-41 |
| Cumulative Index of Chapter Titles, Volumes 37-41 |
| Cytochrome P-450 3A4: Regulation and Role in Drug Metabolism / F. Peter Guengerich |
| Methylation Pharmacogenetics: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase / Richard M. Weinshilboum ; Diane M. Otterness ; Carol L. Szumlanski |
| The Pineal Gland and Melatonin: Molecular and Pharmacologic Regulation / Jimo Borjigin ; Xiaodong Li ; Solomon H. Snyder |
| Regulation of Gene Expression by Reactive Oxygen / Timothy P. Dalton ; Howard G. Shertzer ; Alvaro Puga |
| Induction of Cytochrome P4501A1 / James P. Whitlock, Jr. |
| Cytotoxicity of Short-Chain Alcohols / R. C. Baker ; R. E. Kramer |
