Contributors |
Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila / Pierre Hutter1: |
Introduction / I: |
Experimental Approaches / II: |
Influences of Rab9D on Viability of Hybrids Between D. melanogaster and Its Sibling Species / III: |
Predictions of Functions for 6paRAB9 Proteins / IV: |
General Considerations / V: |
References |
The Neurospora crassa Circadian Clock / Christian Heintzen ; Yi Liu2: |
Neurospora as a Circadian Model System |
The Molecular Machinery of the Neurospora Circadian Oscillator |
Temporal Input from the Environment |
Temporal Output from the Oscillator |
FRQ-Less Oscillators / VI: |
Conclusions / VII: |
Involvement of Homologous Recombination in Carcinogenesis / Ramune Reliene ; Alexander J. R. Bishop ; Robert H. Schiestl3: |
HR Involvement in DNA Repair |
HR and Carcinogenesis |
Other Diseases Attributable to HR |
Carcinogen-Induced HR in Experimental Systems |
Summary |
Mutational Analysis of the Ribosome / Kathleen L. Triman4: |
Mutational Analysis of 16S rRNA Structure and Function |
Mutational Analysis of 23S rRNA Structure and Function |
Mutational Analysis of Ribosomal Protein Structure and Function |
Mutational Analysis of Ribosomal Factor Structure and Function |
Concluding Remarks |
Application of Genomics to Molecular Breeding of Wheat and Barley / Rajeev K. Varshney ; Peter Langridge ; Andreas Graner5: |
Molecular Markers and Marker-Assisted Breeding |
Genomic Resources and Approaches |
Comparative Genomics |
Exploitation of Natural Variation and Allelic Diversity |
Index |
Volumes 20-39 |
Subject Index |
Contributor Index |
Genetics and Molecular Biology of Rhythms in Drosophila and Other Insects / Jeffrey C. Hall |
Mutants Used to Identify Cells and Tissues that Mediate Inputs to Circadian Pacemakers in Drosophila / I.: |
Mutants Apparently Defective in Central-Pacemaking Functions Underlying Drosophila's Circadian Rhythmicity / III.: |
Additional Mutants with Defects in Daily Cycles and Other Time-Based Phenotypes / IV.: |
Molecular Genetics of Central-Pacemaking Functions / V.: |
Places and Times of Clock-Gene Expressions / VI.: |
Natural Variants of Clock Genes, Including Interspecific Studies / VII.: |
Temperature Changes and How Clock-Gene Products are Involved in Compensating for Them / VIII.: |
Molecular Genetics of Clock Resetting by Environmental Stimuli / IX.: |
Gene-Defined Functions Connecting Central Pacemaking to Circadian Chronobiology / X.: |
Conclusion / XI.: |
Glossary |
The Inspection Paradox and Whole-Genome Analysis / Marc Jeanpierre |
Inspection Paradox |
Homozygosity Mapping |
X-Linked Mutations |
Discussion |
Gene Expression Studies in Mosquitoes / Xiao-Guang Chen ; Geetika Mathur ; Anthony A. James |
Study of Gene Expression in Mosquitoes |
Phylogeny of Tec Family Kinases: Identification of a Premetazoan Origin of Btk, Bmx, Itk, Tec, Txk, and the Btk Regulator SH3BP5 / Csaba Ortutay ; Beston F. Nore ; Mauno Vihinen ; C.I. Edvard Smith |
Tyrosine kinases and the Tec Family |
Aim of this Review |
The function of individual domains in TFKs |
The ancestry of TFKs |
SH3BP5-A conserved negative regulator of TFKs |
The origin of phosphotyrosine signaling and the role of cytoplasmic tyrosine Kinases |
Therapeutic Approaches to Ion Channel Diseases / Diana Conte Camerino ; Jean-Francois Desaphy ; Domenico Tricarico ; Sabata Pierno ; Antonella Liantonio |
Pharmacotherapy of Ion Channelopathies |
Molecular Pharmacology of Ion Channels |
Common Genetic Variation and Human Disease / Nick Orr ; Stephen Chanock |
Variation in the Human Genome |
Utilization of Genetic Variation in Gene Mapping Studies |
Mapping Complex Disease Genes Using Association |
Genome-wide Association Studies |
Study Design and Data Analysis |
Significance for Public Health |
Genetics of the Framingham Heart Study Population / Diddahally R. Govindaraju ; L. Adrienne Cupples ; William B. Kannel ; Christopher J. O'Donnell ; Larry D. Atwood ; Ralph B. D'Agostino, Sr. ; Caroline S. Fox ; Marty Larson ; Daniel Levy ; Joanne Murabito|cRamachandran S. Vasan ; Greta Lee Splansky ; Philip A. Wolf ; Emelia J. BenjaminVIII: |
The Study Population |
Phenotypic and Genetic Architecture of Complex Traits |
Linkage and Association Studies |
Genotype-Environment Interactions |
Ethical Issues |
Prospects and Conclusions |
Neurogenetics of Courtship and Mating in Drosophila / Adriana Villella |
Mutations and Genes Affecting Sensory Functions That Control Courtship |
Neurogenetics of the CNS's Control of Sex-Specific Behaviors |
Genetic Manipulations of Experience-Dependent Reproductive Behavior |
Fruitless: A Crucial Single-Gene Regulator of Male-Specific Behavior and Sexual Differentiation of the Nervous System |
Neurogenetic Relationships Between the Regulation of Reproduction and Rhythms |
Conclusions and Prospects |
NMD: Multitasking Between mRNA Surveillance and Modulation of Gene Expression / Gabriele Neu-Yilik ; Andreas E. Kulozik |
Mechanism and Actors |
Targets of NMD |
Disobedient NMD Targets |
Good Cop, Bad Cop: Medical Importance of NMD |
Moonlighting NMD Proteins: Moonlighting Pathway? |
The Molecular Links Between TDP-43 Dysfunction and Neurodegeneration / Emanuele Buratti ; Francisco E. Baralle |
Main Text |
Early Lessons From Animal Models |
Gain- Versus Loss-of-Function Scenarios |
Resources and Strategies to Integrate the Study of Ethical, Legal, and Social Implications of Genetics into the Undergraduate Curriculum / Jinnie M. Garrett |
Resources |
Strategies |
Synthetic Genetic Interactions: Allele Dependence, Uses, and Conservation / Joseph V. Gray ; Sue A. Krause |
Genetic Enhancement |
Expected Underlying Functional Relationships |
Systematic Discovery of Genetic Enhancements |
Network Characteristics |
Extracting Functional Relationships from Global Networks |
Conservation |
Drosophila Models of Parkinson's Disease / Alex Whitworth |
Cell Cycle Regulated Gene Expression In Yeasts / Christopher J. McInerny |
RNA editing by mammalian ADARs / Mary A. O'Connell ; Marion Hogg ; Simona Paro ; Liam P. Keegan |
Cell entry of enveloped viruses / Dimitri Lavillette ; François-Loic COSSET |
Molecular Signalling: how do axons die? / Michael Coleman |
Restless Genomes: humans as a model organism for understanding host-retrotransposable element dynamics / Victoria P. Belancio ; Dale J. Hedges |
Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC) / Yehuda Ben-Shahar |
Chemosensation |
Mechanosensation |
Peripheral Pain |
Genetic and Phenotypic Consequences of Introgression Between Humans and Neanderthals / Christopher Wills |
The First Genetic Evidence for Introgression in Our Species |
Evidence for Introgression Obtained from Present-Day Human Genomes |
History of Hominans in Europe |
Comparison of Middle European Neanderthal Nuclear DNA with Modern Human Nuclear DNA |
The ABBA-BAB A Test for Introgression |
Different Regions of the Neanderthal Genome are Found in Different Modern Humans |
The Genetic Contribution of the Denisovans to Our Species |
Possible Range of Phenotypic Impacts of Neanderthal and Denisovan Introgressions into Modern Humans / IX: |
Acknowledgments |
Genomic Approaches to Understanding Hox Gene Function / Siew Woh Choo ; Steven Russell |
Introduction: Historical Perspective |
The Molecular Genetics of Hox Complexes: Conservation and Colinearity |
Hox Target Genes and Functions |
Early Experiments to Identify Hox Target Genes |
Genomic Approaches to Identifying Hox Target Genes |
Microarray Expression Profiling |
ChIP Approaches |
Computational Approaches |
Prospects |
GATA Transcription Factors in the Developing Reproductive System / Tamara Zaytouni ; Evgeni E. Efimenko ; Sergei G. Tevosian |
Molecular Control of Gonadal Development |
Canonical WNT Signaling Control of Gonadal Development |
The GATA-FOG Transcriptional Partnership |
GATA4-FOG2 Control of Gonadal Development |
Acknowledgment |
Biotechnologies for the Management of Genetic Resources for Food and Agriculture / Preetmoninder Lidder ; Andrea Sonnino |
Biotechnologies Applied to the Characterization, Conservation, and Utilization of Genetic Resources for Food and Agriculture |
Current Status of Biotechnologies for the Management of Crop Genetic Resources |
Current Status of Biotechnologies for the Management of Forest Genetic Resources |
Current Status of Biotechnologies for the Management of Animal Genetic Resources |
Current Status of Biotechnologies for the Management of Aquatic Genetic Resources |
Current Status of Biotechnologies for the Management of Microbial Genetic Resources |
Conclusions and Outlook |
Transposable Elements and Insecticide Resistance / Wayne G. Rostant ; Nina Wedell ; David J. Hosken |
Transposable Elements |
Effects of TEs on Host Fitness and Evolution |
Insecticide Resistance |
TEs Conferring Insecticide Resistance |
Sex-Specific Effects of TEs Independent of DDT Resistance |
Ongoing and Future Research Acknowledgments |
From Pluripotency to Islets: miRNAs as Critical Regulators of Human Cellular Differentiation / Andrew Hinton ; Shaun Hunter ; Gloria Reyes ; Gary B. Fogel ; Charles C. King |
miRNAs and ESCs |
miRNAs and ESC Pluripotency |
miRNAs that Regulate Early Cell Fate Decisions in hESC |
miRNAs that Regulate Endoderm and Pancreatic Precursor Formation |
miRNAs that Regulate Pancreatic Endocrine Cell Function |
Conclusions and Future Directions |
The Genetics of Dystonias / Mark S. LeDoux |
Clinical Features |
Primary Dystonia |
Dystonia Plus |
Heredodegenerative Dystonia |
Dystonia in Association with other Neurogenetic Disorders |
Exome Sequencing and Advances in Crop Improvements / Devi Singh ; Pankaj K. Singh ; Sarika Chaudhary ; Kamiya Mehla ; Shashi Kumar |
Sequencing: Tools and Techniques |
Exome Sequencing for Crop Improvement |
Crop Improvement Beyond Exome Sequencing |
Competing Interests |
Abbreviations |
Applications of Functional Protein Microarrays in Basic and Clinical Research / Heng Zhu ; Jiang Qian |
Fabrication of Functional Protein Microarrays |
Signal Detection |
Applications of Functional Protein Microarrays |
Outlook |
Acknowledgements |
miRNA, Development and Disease / Jeanne Amiel ; Loïc de Pontual ; Alexandra Henrion-Caude |
Biogenesis and Development |
Conservation, Hox Genes, and miRNA Regulation |
Expression, Developmental Switches and Phenotypic Modulators |
miRNAs and Brain |
miRNAs and Skeletal Development / 6: |
miRNAs and Myogenesis / 7: |
miRNAs and Target Mutations in Human Disease / 8: |
Perspectives / 9: |
Precision Editing of Large Animal Genomes / Wenfang (Spring) Tan ; Daniel F. Carlson ; Mark W. Walton ; Scott C. Fahrenkrug ; Perry B. Hackett |
Precision Genetic Engineering |
Future Directions-Applications of Precision Genetics in Animals |
The Genetic Analysis of Functional Connectomics in Drosophila / Ian A. Meinertzhagen ; Chi-Hon Lee |
Revealing the Structural Connectome |
Assigning Functions to Structural Networks |
Bridging Synaptophysiology to Structural Connectomics |
Contributors |
Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila / Pierre Hutter1: |
Introduction / I: |
Experimental Approaches / II: |
Influences of Rab9D on Viability of Hybrids Between D. melanogaster and Its Sibling Species / III: |
Predictions of Functions for 6paRAB9 Proteins / IV: |