| Contributors |
| Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila / Pierre Hutter1： |
| Introduction / I： |
| Experimental Approaches / II： |
| Influences of Rab9D on Viability of Hybrids Between D. melanogaster and Its Sibling Species / III： |
| Predictions of Functions for 6paRAB9 Proteins / IV： |
| General Considerations / V： |
| References |
| The Neurospora crassa Circadian Clock / Christian Heintzen ; Yi Liu2： |
| Neurospora as a Circadian Model System |
| The Molecular Machinery of the Neurospora Circadian Oscillator |
| Temporal Input from the Environment |
| Temporal Output from the Oscillator |
| FRQ-Less Oscillators / VI： |
| Conclusions / VII： |
| Involvement of Homologous Recombination in Carcinogenesis / Ramune Reliene ; Alexander J. R. Bishop ; Robert H. Schiestl3： |
| HR Involvement in DNA Repair |
| HR and Carcinogenesis |
| Other Diseases Attributable to HR |
| Carcinogen-Induced HR in Experimental Systems |
| Summary |
| Mutational Analysis of the Ribosome / Kathleen L. Triman4： |
| Mutational Analysis of 16S rRNA Structure and Function |
| Mutational Analysis of 23S rRNA Structure and Function |
| Mutational Analysis of Ribosomal Protein Structure and Function |
| Mutational Analysis of Ribosomal Factor Structure and Function |
| Concluding Remarks |
| Application of Genomics to Molecular Breeding of Wheat and Barley / Rajeev K. Varshney ; Peter Langridge ; Andreas Graner5： |
| Molecular Markers and Marker-Assisted Breeding |
| Genomic Resources and Approaches |
| Comparative Genomics |
| Exploitation of Natural Variation and Allelic Diversity |
| Index |
| Volumes 20-39 |
| Subject Index |
| Contributor Index |
| Genetics and Molecular Biology of Rhythms in Drosophila and Other Insects / Jeffrey C. Hall |
| Mutants Used to Identify Cells and Tissues that Mediate Inputs to Circadian Pacemakers in Drosophila / I.： |
| Mutants Apparently Defective in Central-Pacemaking Functions Underlying Drosophila's Circadian Rhythmicity / III.： |
| Additional Mutants with Defects in Daily Cycles and Other Time-Based Phenotypes / IV.： |
| Molecular Genetics of Central-Pacemaking Functions / V.： |
| Places and Times of Clock-Gene Expressions / VI.： |
| Natural Variants of Clock Genes, Including Interspecific Studies / VII.： |
| Temperature Changes and How Clock-Gene Products are Involved in Compensating for Them / VIII.： |
| Molecular Genetics of Clock Resetting by Environmental Stimuli / IX.： |
| Gene-Defined Functions Connecting Central Pacemaking to Circadian Chronobiology / X.： |
| Conclusion / XI.： |
| Glossary |
| The Inspection Paradox and Whole-Genome Analysis / Marc Jeanpierre |
| Inspection Paradox |
| Homozygosity Mapping |
| X-Linked Mutations |
| Discussion |
| Gene Expression Studies in Mosquitoes / Xiao-Guang Chen ; Geetika Mathur ; Anthony A. James |
| Study of Gene Expression in Mosquitoes |
| Phylogeny of Tec Family Kinases: Identification of a Premetazoan Origin of Btk, Bmx, Itk, Tec, Txk, and the Btk Regulator SH3BP5 / Csaba Ortutay ; Beston F. Nore ; Mauno Vihinen ; C.I. Edvard Smith |
| Tyrosine kinases and the Tec Family |
| Aim of this Review |
| The function of individual domains in TFKs |
| The ancestry of TFKs |
| SH3BP5-A conserved negative regulator of TFKs |
| The origin of phosphotyrosine signaling and the role of cytoplasmic tyrosine Kinases |
| Therapeutic Approaches to Ion Channel Diseases / Diana Conte Camerino ; Jean-Francois Desaphy ; Domenico Tricarico ; Sabata Pierno ; Antonella Liantonio |
| Pharmacotherapy of Ion Channelopathies |
| Molecular Pharmacology of Ion Channels |
| Common Genetic Variation and Human Disease / Nick Orr ; Stephen Chanock |
| Variation in the Human Genome |
| Utilization of Genetic Variation in Gene Mapping Studies |
| Mapping Complex Disease Genes Using Association |
| Genome-wide Association Studies |
| Study Design and Data Analysis |
| Significance for Public Health |
| Genetics of the Framingham Heart Study Population / Diddahally R. Govindaraju ; L. Adrienne Cupples ; William B. Kannel ; Christopher J. O'Donnell ; Larry D. Atwood ; Ralph B. D'Agostino, Sr. ; Caroline S. Fox ; Marty Larson ; Daniel Levy ; Joanne Murabito|cRamachandran S. Vasan ; Greta Lee Splansky ; Philip A. Wolf ; Emelia J. BenjaminVIII： |
| The Study Population |
| Phenotypic and Genetic Architecture of Complex Traits |
| Linkage and Association Studies |
| Genotype-Environment Interactions |
| Ethical Issues |
| Prospects and Conclusions |
| Neurogenetics of Courtship and Mating in Drosophila / Adriana Villella |
| Mutations and Genes Affecting Sensory Functions That Control Courtship |
| Neurogenetics of the CNS's Control of Sex-Specific Behaviors |
| Genetic Manipulations of Experience-Dependent Reproductive Behavior |
| Fruitless: A Crucial Single-Gene Regulator of Male-Specific Behavior and Sexual Differentiation of the Nervous System |
| Neurogenetic Relationships Between the Regulation of Reproduction and Rhythms |
| Conclusions and Prospects |
| NMD: Multitasking Between mRNA Surveillance and Modulation of Gene Expression / Gabriele Neu-Yilik ; Andreas E. Kulozik |
| Mechanism and Actors |
| Targets of NMD |
| Disobedient NMD Targets |
| Good Cop, Bad Cop: Medical Importance of NMD |
| Moonlighting NMD Proteins: Moonlighting Pathway? |
| The Molecular Links Between TDP-43 Dysfunction and Neurodegeneration / Emanuele Buratti ; Francisco E. Baralle |
| Main Text |
| Early Lessons From Animal Models |
| Gain- Versus Loss-of-Function Scenarios |
| Resources and Strategies to Integrate the Study of Ethical, Legal, and Social Implications of Genetics into the Undergraduate Curriculum / Jinnie M. Garrett |
| Resources |
| Strategies |
| Synthetic Genetic Interactions: Allele Dependence, Uses, and Conservation / Joseph V. Gray ; Sue A. Krause |
| Genetic Enhancement |
| Expected Underlying Functional Relationships |
| Systematic Discovery of Genetic Enhancements |
| Network Characteristics |
| Extracting Functional Relationships from Global Networks |
| Conservation |
| Drosophila Models of Parkinson's Disease / Alex Whitworth |
| Cell Cycle Regulated Gene Expression In Yeasts / Christopher J. McInerny |
| RNA editing by mammalian ADARs / Mary A. O'Connell ; Marion Hogg ; Simona Paro ; Liam P. Keegan |
| Cell entry of enveloped viruses / Dimitri Lavillette ; François-Loic COSSET |
| Molecular Signalling: how do axons die? / Michael Coleman |
| Restless Genomes: humans as a model organism for understanding host-retrotransposable element dynamics / Victoria P. Belancio ; Dale J. Hedges |
| Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC) / Yehuda Ben-Shahar |
| Chemosensation |
| Mechanosensation |
| Peripheral Pain |
| Genetic and Phenotypic Consequences of Introgression Between Humans and Neanderthals / Christopher Wills |
| The First Genetic Evidence for Introgression in Our Species |
| Evidence for Introgression Obtained from Present-Day Human Genomes |
| History of Hominans in Europe |
| Comparison of Middle European Neanderthal Nuclear DNA with Modern Human Nuclear DNA |
| The ABBA-BAB A Test for Introgression |
| Different Regions of the Neanderthal Genome are Found in Different Modern Humans |
| The Genetic Contribution of the Denisovans to Our Species |
| Possible Range of Phenotypic Impacts of Neanderthal and Denisovan Introgressions into Modern Humans / IX： |
| Acknowledgments |
| Genomic Approaches to Understanding Hox Gene Function / Siew Woh Choo ; Steven Russell |
| Introduction: Historical Perspective |
| The Molecular Genetics of Hox Complexes: Conservation and Colinearity |
| Hox Target Genes and Functions |
| Early Experiments to Identify Hox Target Genes |
| Genomic Approaches to Identifying Hox Target Genes |
| Microarray Expression Profiling |
| ChIP Approaches |
| Computational Approaches |
| Prospects |
| GATA Transcription Factors in the Developing Reproductive System / Tamara Zaytouni ; Evgeni E. Efimenko ; Sergei G. Tevosian |
| Molecular Control of Gonadal Development |
| Canonical WNT Signaling Control of Gonadal Development |
| The GATA-FOG Transcriptional Partnership |
| GATA4-FOG2 Control of Gonadal Development |
| Acknowledgment |
| Biotechnologies for the Management of Genetic Resources for Food and Agriculture / Preetmoninder Lidder ; Andrea Sonnino |
| Biotechnologies Applied to the Characterization, Conservation, and Utilization of Genetic Resources for Food and Agriculture |
| Current Status of Biotechnologies for the Management of Crop Genetic Resources |
| Current Status of Biotechnologies for the Management of Forest Genetic Resources |
| Current Status of Biotechnologies for the Management of Animal Genetic Resources |
| Current Status of Biotechnologies for the Management of Aquatic Genetic Resources |
| Current Status of Biotechnologies for the Management of Microbial Genetic Resources |
| Conclusions and Outlook |
| Transposable Elements and Insecticide Resistance / Wayne G. Rostant ; Nina Wedell ; David J. Hosken |
| Transposable Elements |
| Effects of TEs on Host Fitness and Evolution |
| Insecticide Resistance |
| TEs Conferring Insecticide Resistance |
| Sex-Specific Effects of TEs Independent of DDT Resistance |
| Ongoing and Future Research Acknowledgments |
| From Pluripotency to Islets: miRNAs as Critical Regulators of Human Cellular Differentiation / Andrew Hinton ; Shaun Hunter ; Gloria Reyes ; Gary B. Fogel ; Charles C. King |
| miRNAs and ESCs |
| miRNAs and ESC Pluripotency |
| miRNAs that Regulate Early Cell Fate Decisions in hESC |
| miRNAs that Regulate Endoderm and Pancreatic Precursor Formation |
| miRNAs that Regulate Pancreatic Endocrine Cell Function |
| Conclusions and Future Directions |
| The Genetics of Dystonias / Mark S. LeDoux |
| Clinical Features |
| Primary Dystonia |
| Dystonia Plus |
| Heredodegenerative Dystonia |
| Dystonia in Association with other Neurogenetic Disorders |
| Exome Sequencing and Advances in Crop Improvements / Devi Singh ; Pankaj K. Singh ; Sarika Chaudhary ; Kamiya Mehla ; Shashi Kumar |
| Sequencing: Tools and Techniques |
| Exome Sequencing for Crop Improvement |
| Crop Improvement Beyond Exome Sequencing |
| Competing Interests |
| Abbreviations |
| Applications of Functional Protein Microarrays in Basic and Clinical Research / Heng Zhu ; Jiang Qian |
| Fabrication of Functional Protein Microarrays |
| Signal Detection |
| Applications of Functional Protein Microarrays |
| Outlook |
| Acknowledgements |
| miRNA, Development and Disease / Jeanne Amiel ; Loïc de Pontual ; Alexandra Henrion-Caude |
| Biogenesis and Development |
| Conservation, Hox Genes, and miRNA Regulation |
| Expression, Developmental Switches and Phenotypic Modulators |
| miRNAs and Brain |
| miRNAs and Skeletal Development / 6： |
| miRNAs and Myogenesis / 7： |
| miRNAs and Target Mutations in Human Disease / 8： |
| Perspectives / 9： |
| Precision Editing of Large Animal Genomes / Wenfang (Spring) Tan ; Daniel F. Carlson ; Mark W. Walton ; Scott C. Fahrenkrug ; Perry B. Hackett |
| Precision Genetic Engineering |
| Future Directions-Applications of Precision Genetics in Animals |
| The Genetic Analysis of Functional Connectomics in Drosophila / Ian A. Meinertzhagen ; Chi-Hon Lee |
| Revealing the Structural Connectome |
| Assigning Functions to Structural Networks |
| Bridging Synaptophysiology to Structural Connectomics |
| Contributors |
| Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila / Pierre Hutter1： |
| Introduction / I： |
| Experimental Approaches / II： |
| Influences of Rab9D on Viability of Hybrids Between D. melanogaster and Its Sibling Species / III： |
| Predictions of Functions for 6paRAB9 Proteins / IV： |
