Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury

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Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury / edited by Kenneth V. Honn ... [et al.]

資料種別:

図書

出版情報:

New York : Plenum Press, c1997-

形態:

v. ; 26 cm

シリーズ名:

Advances in experimental medicine and biology ; v. 400A, 400B, 407, 469, 507 <BA00008720>

著者名:

ISBN:

9780306453601 [0306453606] (2, pt. A)
9780306453601 [0306453606] (2, pt. B)
9780306454875 [0306454874] (3)
9780306461385 [0306461382] (4)
9780306472831 [030647283X] (5)

書誌ID:

BA32665404

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書誌詳細

注記:

2: "Proceedings of the Third International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, held October 13-16, 1993, in Washington, D.C." --T.p. verso. -- 3: "Proceedings of the Fourth International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, held October 4-7, 1995, in Hong Kong" --T.p. verso. -- 4: "This volume constitutes the proceedings of the 5th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer Inflammation and related diseases, which was held at the Sheraton Grand Torrey Pines in La Jolla, California, in September 1997" --Pref. -- 5: "This volume represents a collection of contributions from the 6th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases held in Boston from September 12-15, 1999" --Pref
Includes bibliographical references and index
4- published by: New York : Kluwer Academic/Plenum Publishers

主題:

Carcinogenesis--Congresses; Eicosanoic acid--Derivatives--Metabolism--Congresses; Eicosanoic acid--Derivatives--Pathophysiology--Congresses; Eicosanoic acid--Derivatives--Physiological effect--Congresses; Inflammation--Mediators--Congresses; Lipids--Peroxidation--Congresses

言語:

英語

目次情報:

Phospholipases / Part A：

Regulation of Phosphoinsitide Phospholipases by G-Proteins / J. Exton1：

The Effects of Group II Phospholipase A[subscript 2] in Ras-Induced Metastasis / T. Davis2：

Activation of Ca[superscript 2+]-Sensitive Cytosolic Phospholipase A[subscript 2] (cPLA[subscript 2]) in Human Platelets / R. Kramer3：

Involvement of Reactive Oxygen Species in Phospholipase A[subscript 2] Activation: Inhibition of Protein Tyrosine Phosphatases and Activation of Protein Kinases / U. Zor ; R. Goldman4：

High Molecular Weight Phospholipase A[subscript 2]: Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa / I.A. Tavares5：

Biosynthetic Enzymes

(S)-Type Lipoxygenase and Cyclooxygenase Reaction Box Models Characterizing the Stereochemistry of the Dioxygenation Reaction / W. Lehman6：

Activation of 5-Lipoxygenase in Whole Polymorphonuclear Leukocytes by Arachidonic Acid: Evidence of Cytosolic Active Enzyme / L. Vila7：

Intracellular Distribution, Activity, and Ca[superscript 2+]-Dependent Translocation of 12-Lipoxygenase in Lewis Lung Tumor Cells / W. Hagmann8：

Cloning and Sequencing of Prostaglandin H Synthetase from Rat Tracheal Epithelial Cells: Structural Evidence that a TPA Regulated mRNA Codes for the Rat Ortholog of Murine PHS-1 / J. Kitzler9：

Non-enzymatic Rearrangement of Leukotriene A[subscript 4] to 5-Keto-(7E, 9E, 11Z, 14Z)-eicosatetraenoic Acid in Aqueous Media / D. Reindeau10：

Bromoacetamido-Analogs of Indomethacin and Mefenamic Acid Affinity-Label Prostaglandin H[subscript 2] Synthase at Two Sites / M. Tang11：

Regulation of Eicosanoid Synthesis in Liver Macrophages / P. Dieter12：

Comparison of Arachidonic Acid Metabolism by Normal Pre-Cancerous and Neoplastic Epithelial Cell Lines of the Upper Aerodigestive Tract / C. Snyderman13：

Induction of Prostaglandin Endoperoxide Synthase-1 (cox-1) in a Human Promonocytic Cell Line by Treatment with the Differentiating Agent TPA / C. Smith14：

X-ray Crystallographic Study of the Structure of Prostaglandin H Synthase / M. Garavito15：

Properties of Prostacyclin Synthase / V. Ullrich16：

Regulation of Prostaglandin H Synthase-1 Gene Expression / K. Wu17：

Mammalian Arachidonate 12-Lipoxygenases / S. Yamamoto18：

The Three-Dimensional Structure of Soybean Lipoxygenase-1: An Arachidonic Acid 15-Lipoxygenase / M. Amzel19：

Purification and Characterization of the Epidermal 8(S)-Lipoxygenase / M. Loschke20：

The Effect of 5-Lipoxygenase-Activating Protein (FLAP) on Substrate Utilization by 5-Lipoxygenase / P. Vickers21：

Leukotriene A[subscript 4] Hydrolase: Differential Inhibition of the Catalytic Activities by Divalent Cations / J. Haeggstrom22：

Regulation of 12(S)-HETE Production in Tumor Cells / Y.Q. Chen23：

Distribution of COX 1 and COX 2 in Normal and Inflamed Tissues / K. Seibert24：

Examination of Prostaglandin H Synthase-1 Topology in the Endoplasmic Reticulum Membrane / R. Kulmacz25：

Coordinate Regulation of the Inducible Forms of Prostaglandin Synthase and Nitric Oxide Synthase in Fibroblasts and Macrophages / H. Herschmann26：

Molecular Cloning of Prostacyclin Synthase from Bovine Endothelial Cells / T. Tanabe27：

Interaction of PGH Synthase Isozymes-1 and -2 with Nonsteroidal Anti-Inflammatory Drugs / W. Smith28：

Receptors

Dual Effect of Propanonol on the Human Platelet Activation by Thrombin: Potentiation of Free Intracellular Ca[superscript 2+] Mobilization and Inhibition of Phospholipase D Activity / S. Svetlov29：

Molecular Diversity of Prostanoid Receptors; Subtypes and Isoforms of Prostaglandin E Receptor / S. Narumiya30：

Molecular Characterization and Physiological Functions of PAF Receptors / H. Bito31：

Identification of the FP-Receptor as a Discrete Entity by Radioligand Binding in Biosystems that Exhibit Different Functional Rank Orders of Potency in Response to Prostanoids / D. Woodward32：

Cellular Activation by Thromboxane A2 and 8-EPi-PGF2[alpha] / G. Fitzgerald33：

Modification on Ligand Binding to TX[subscript A2]/PGH[subscript 2] Receptors by Diethylpyrocarbonate / K. Schror34：

Prostaglandin Receptors Involved in Inflammatory Events / R.L. Jones35：

LTB[subscript 4] Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs / P. Wong36：

Isolation and Cloning of Human Peroxisome Proliferator Activated Receptor Gamma CDNA / M. Greene37：

Structure and Localization of the Rabbit Prostaglandin EP3 Receptor / R. Breyer38：

Prostaglandin Regulation of Gene Expression and Growth in Normal and Malignant Tissues / M. Hughes-Fulford39：

Distinct Signaling Pathways Mediate Induction of c-fos by PGE[subscript 2] in Glomerular Mesangial Cells / M. Dunn40：

Cytosolic 12(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid Binding Sites in Carcinoma Cells / S. Hammarstrom41：

Protein Kinases/Phosphatases

Diacylglycerol Second Messengers: Molecular Switches in Growth Control / R. Bell42：

Sphingolipid Second Messengers: Tumor Suppressor Lipids / Y. Hannun43：

The Role of Protein Kinase C in Signal Transduction, Growth Control and Lipid Metabolism / B. Weinstein44：

Tumor Responsiveness to the Metastasis-Stimulatory Effects of Prostaglandin E[subscript 2] Is Restricted by Protein Phosphatases / R. Young45：

Interactions between Specific Phosphorproteins During Modulation of Prostacyclin Secretion in Cultured Bovine Aortic Endothelial Cells / J. Grose46：

The Role of Lipid Peroxidation Products in the Regulation of Protein Kinase C Activity in Vitro / E. Mal'tseva47：

Role of Protein Kinase C and Phosphatases in 12(S)-HETE-Induced Tumor Cell Cytoskeletal Reorganization / D. Tang48：

Inhibitors of Bioactive Lipids and Signal Transduction

PX-52, a Novel Inhibitor of 14 kDa Cytosolic Phospholipases A[subscript 2] / R. Franson49：

Hepoxilin A[subscript 3] Inhibits Agonist-Evoked Rise in Free Intracellular Calcium in Human Neutrophils / C. Pace-Asciak50：

The Discovery of LY293111, A Novel, Potent and Orally Active Leukotriene B[subscript 4] Receptor Antagonist of the Biphenylphenol Class / M. Sofia51：

Inhibition of Leukotriene B[subscript 4] (LTB[subscript 4]) in Human Neutorphils by L-Threo-Dihydrosphingosine / J. Darges52：

Carcinogenesis

Aspirin and Gastrointestinal Cancer / M. Thun53：

Monohydroxylated Fatty Acids in Mouse Epidermis Papilloma Quantification and Stereochemical Characterization / W. Lehmann54：

Negative Growth Regulation of Oncogene-Transformed Mammary Epithelial Cells by Tumor Inhibitors / N. Telang55：

Different Expression of Prostaglandin-H Synthase Isozymes and Lipoxygenase during Multistage Carcinogenesis in Mouse Skin / G. Furstenberger56：

Expression of Two cPLA[subscript 2] Isoforms in Mouse Epidermis in Vivo / 57：

Regulation of Arachidonic Acid Release by Metabolism by Tumor Promoters / S. Fischer58：

Effect of the Peroxisome Proliferators Ciprofibrate and Perfluorodecanoic Acid on Eicosanoid Concentrations in Rat Liver / H. Glauert59：

Cell Growth I

A Mitogenic and Hormonal Signalling Network Regulate Mammalian Cell Division Commitment Time / L. Jimenez de Asua60：

Growth Inhibitory Effects of Thromboxane Antagonists on Breast Cancer Cell Lines: A Preliminary Study / K. Marshall ; K. Lane61：

The Rise and Fall of Ceramide and 1,2-Diacylglycerol (DAG): Modulation by Transforming Growth Factor-[beta]1 (TGF[beta]1) and by Epidermal Growth Factor (EGF) / T. Goldkorn62：

Antioxidant Defence Mechanisms and PGE Secretion by Different Types of Transformed and Tumor Cells: in Vivo Selective Advantages / G. Deichmann63：

The Relationship between Farnesylation and Carcinogenesis: The Effect of Lovastatin on Fibroblast Proliferation / M.P. Braquet64：

Eicosanoid Production and Growth Regulation in Rat Intestinal Epithelial Cells / R. DuBois65：

Role of Arachidonic Acid and Linoleic Acid Metbolism in Epidermal Growth Factor Initiated Proliferation of Syrian Hamster Embryo Fibroblasts / T. Eling66：

Phenylacetate and Phenylbutyrate as Novel, Nontoxic Differentiation Inducers / D. Samid67：

Structural Requirements for Enhancement of EGF-Dependent DNA Synthesis by Oxygenated Metabolites of Linoleic Acid / W. Glasgow68：

Decreased DNA Synthesis in SCC-25 Cells with ETYA and SC41661 / F. Ondrey69：

Liver Fatty Acid Binding Protein and Mitogenesis in Transfected Hepatoma Cells / S. Sorof70：

Induction of 12-Lipoxygenase Expression by Epidermal Growth Factor Is Mediated by Protein Kinase C in A431 Cells / W.C. Chang71：

Prostaglandin F[subscript 2[alpha]] (PGF[subscript 2[alpha]]) Triggers Protein Kinase C (PKC) and Tyrosine Kinase Activity in Cultured Mammalian Cells / J. Jimenez de Asua72：

Mechanisms of the Selective Cytotoxic Actions of Certain Essential Fatty Acids / R. Cantrill73：

Eicosanoids, Cancer Metastasis, and Gene Regulation: An Overview / X. Gao74：

Apoptosis and Differentiation / Part B：

Radiation-Induced Apoptosis in Tumors: Effects of Radiation Modulating Agents / L. Milas75：

Prostaglandin E[subscript 2] Mediated Apoptosis in Subsets of Malignant B Lymphoma Cells / R. Phipps76：

13-HODE Dehydrogenase Activity as a Modulator of Intestinal Cell Differentiation / A. Bull77：

Cytokines and Bioactive Lipids in Inflammation

Effect of GM-CSF on Leukotriene B[subscript 4] Synthesis in Human Neutrophils: Facilitation of the Priming Effect by Autologous Plasma / E. Krump78：

Docosahexaenoic and Eicosapentaenoic Acids Inhibit in Vitro Human Endothelial Cell Production of Interleukin-6 / B. Khalfoun79：

Regulation of 15-Lipoxygenase Expression by Cytokines / H. Kuhn80：

Modulating Effect of [omega]-3 Fatty Acids on the Proliferative Pattern of Human Colorectal Mucosa / M. Anti81：

Agonist-Induced Lipoxin A[subscript 4] Generation in Vitro and in Aspirin-Sensitive Asthmatics: Detection by a Novel Lipoxin A[subscript 4]-ELISA / B. Levy82：

Regulation of Inducible Prostaglandin G/H Synthase by Interleukin-1, Transforming Growth Factors-[alpha] and -[beta], and Prostaglandins in Bone Cells / C. Pilbeam83：

Potential Role of Heat Shock Transcription Factor in the Expression of Inflammatory Cytokines / C. Cahill84：

Transcellular Pathways and Cell Adhesion as Potential Contributors to Leukotriene and Lipoxin Biosynthesis in Acute Glomerulonephritis / H. Brady85：

Lipoxin Metabolism by Human Promyelocytic Leukemia (HL-60) Cells / C. Serhan86：

IL-1 Increases the Ability of Human Endothelial Cells to Transform Linoleic Acid into Monohydroxy-Isomers and their Incorporation into Cell Lipids / M. Camacho87：

Cell Motility and Cytoskeletal Alterations

Apoptosis in Tumor Biology and Therapy / R. Meyn88：

Integrin Functions and Signal Transduction / K. Yamada89：

Regulation of Tumor Cell Motility by 12(S)-HETE / A. Raz90：

Inhibition of Mouse B16 Melanoma Cell Motility by Sphingosine-1-Phosphate / Y. Igarishi91：

Effects of Leukotrienes B[subscript 4] (LTB[subscript 4]) and D[subscript 4] (LTD[subscript 4]) on Motility of Isolated Normodense Human Eosinophils and Neutrophils / C. Spada92：

12(S)-HETE Increases the Motility of Prostate Tumor Cells through Selective Activation of PKC[alpha] / B. Liu93：

Adhesions Mechanisms in Inflammation and Metastasis

Role of Complex Gangliosides in the Integrin-Dependent Adhesion of Cells in Culture / G. Mugnai94：

Enhancement of Metastatic Potential in a Murine Fibrosarcoma Line by Exposure to Corynebacterium Parvum-Elicited Macrophages; Effect of Eicosanoid Biosynthesis Inhibition / S. Ruggieri95：

A Regulatory Role of Prostaglandin E2-Activated Adhesion Molecules in Myelopoiesis / Y. Shibata96：

Efficacy of Cicaprost on Metastasis in Advanced Tumor Disease / M. Schirner97：

Post-Translational Regulation of Surface Integrin Expression in Tumor Cells by 12(S)-HETE / J. Timar98：

Eicosanoid 12(S)-HETE Upregulates Endothelial Cell [alpha][nu][beta]3 Integrin Expression and Promotes Tumor Cell Adhesion to Vascular Endothelium / K.V. Honn99：

Dietary Fatty Acids Alter the Adhesion Properties of Lymphocytes to Extracellular Matrix Proteins / F. Stephen100：

Radioprotection and Radiosensitization

Radioprotection by Misoprostol (PGE[subscript 1] Methyl Analog) in Combination with Vitamin E, Selenomethionine and WR-3689 794 / V. Srinivasan101：

Behavioral and Radioprotective Effects of Misoprostol in Adrenalectomized Mice / M.R. Landauer102：

Effects of Eicosanoid Radioprotectors on Rat Motor Performance / V. Bogo103：

Protection from Radiation-Induced Oral Mucositis by a Mouth Rinse Containing the Prostaglandin E[subscript 1] Analog, Misoprostol: A Placebo Controlled Double Blind Clinical Trial / W.R. Hanson104：

Interleukin, Radiation and Thermoregulation / S.B. Kandasamy105：

Tumor Radiosensitization Based on the Use of Inhibitors of the Mevalonate Pathway of Cholesterol Synthesis / A.C. Miller106：

Synergistic Protection of Irradiated Mice by a Combination of Iloprost and Misoprostol / K. Kumar Sree107：

Regulation of the Biosynthesis of the Sulphido-Leukotrienes / A.W. Ford-Hutchinson108：

The Role of Lipid Peroxidation in Growth Suppression of Human Breast Carcinoma by Dietary Fish Oil / C. Welsch109：

Misoprostol: A Potent Cytotoxic and Oncogenic Radioprotector / R. Miller110：

Modification and Radiation-Induced Gastrointestinal and Hematopoietic Injury in Mice by Combinations of Agents: Effects of Indomethacin and Caffeine / J. Weiss111：

Anti-Inflammatory Drug Treatment of Radiation Injuries / A.S. Michalowski112：

Low Dose Radiation Induces Endothelial Cell Eicosanoid Metabolism and Cytoskeletal Rearrangement / J.M. Onoda113：

Nonlethal [gamma]Radiation Displays Similar Cytoplasmic Rearrangements as 12(S)-HETE / J.D. Taylor114：

Dietary Modulation and Prevention

Dietary Arachidonic Acid Increases Eicosanoid Production in the Presence of Equal Amounts of Dietary Eicosapentaenoic Acid / J. Whelan115：

Impairment in the Fatty Acid Composition of Keloids / L. Louw116：

Linoleic Acid Levels in Cutaneous Tumors with Different Growth Patterns as an Additional Sensitive Diagnostic Feature / 117：

The Importance of Linoleic Acid in the Total Fatty Acid Compositions of Benign and Malignant Neuroglial Tumors / 118：

Dietary Fat and Energy Modulation of Biochemical Events in Tumor Promotion / D. Birt119：

Chemoprevention of Colon Cancer by Dietary Administration of Naturally Occurring and Related Synthetic Agents / B. Reddy120：

Diradyglycerol Formation is Altered by n-3 Highly Unsaturated Fatty Acids, with Differences between Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) Acids / R. Sebaldt121：

Clinical Studies

Arachidonic Acid Metabolites in Saliva of Patients with Squamous Cell Carcinoma of the Head and Neck / 122：

Preparation of Two Dosage Forms Containing Antitumor Prostaglandin and their Antitumor Effect in Vitro and in Vivo: Lipiodol Solution for I.A. Administration and Lipid Microspheres for I.P. or I.V. Administration / S. Fukushima123：

Urinary Excretion of Prostanoid in Children with Chronic Pyelonephritis / A. Kucherenko124：

Interaction of Phospholipase C-g with Activated Growth Factor Receptor Tyrosine Kinases / G. Carpenter125：

Prostanoid and Anti-Thrombin III Levels in Premature Infants / V. Suchkova126：

Molecular Biology of Prostanoid Biosynthetic Enzymes and Receptors / 127：

Tumor Infiltrating Lymphocytes in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Enhancement Using Prostaglandin Synthetase Inhibitors / D. Cross128：

Contributors

Index

Lipoxygenase: Studies on the Active Site of Leuktriene A4 Hydrolase / A. Wetterholm, et al.

PGH Synthase: Disruption of the Mouse Cyclooxygenase I Gene: Characteristics of the Mutant and Areas of Future Study / R. Langenbach, et al.

Alteration of Gene Expression: Characterization of Prostaglandin H Synthase-2 Deficient Mice and Implications for Mechanisms of NSAID Action / S.G. Morham, et al.

Receptors: Structure and Regulation of Platelet Activating Factor Receptor Gene / T. Shimizu ; H. Mutoh

Inflammation: PGE2 Regulation of B Lymphocytes and T Helper 1 and T Helper 2 Cells: Induction of Inflammatory Versus Allergic Response / E.R. Fedyk, et al.

Signal Transduction: Plasma Membrane Guanylate Cyclase: A Multimodule Transduction System / R.K. Sharma ; T. Duda

Anandamide: Anandamide Amidohydrolase from Porcine Brain: Partial Purification and Characterization / N. Ueda, et al.

PAF: Cloning and Characterization of a Murine Platelet-Activating Factor Receptor Gene / S. Ishii, et al.

Cell Growth and Apoptosis

Poster Sessions

76 Additional Articles

Phospholipase A2 Modification of Lipoproteins: Potential Effects on Atherogenesis / Peter Satirpy ; German Camejo ; Lennart Svensson ; Eva Hurt-Camejo1.：

Type IIA Secretory PLA2-Mediated Delayed PGE2 Biosynthesis is Regulated by the Products of the Cytosolic PLA2 / Hiroshi Kuwata ; Shinji Yamamoto ; Yoshihito Nakatani ; Makoto Murakami ; Ichiro Kudo2.：

Functional Coupling Between Phospholipase A2S and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways / Terumi Kambe-Ohkura3.：

Cytosolic Phospholipase A2(Interacts with Microtubules / Sachiyo Sunaga4.：

Group IV Cytosolic Phospholipase A2 (PLA2) Function: Insights from the Knockout Mouse / Joseph V. Bonventre ; Adam Sapirstein5.：

Investigation into the Involvement of Phospholipases A2 and MAP kinases in Modulation of AA Release and Cell Growth in A549 Cells / Quamrul G. Choudhury ; Diane T. Mckay ; Roderick J. Flower ; Jamie D. Croxtall6.：

Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mast Cells / Bruno L. Diaz ; Hiroshi Fujishima ; Jonathan P. Arm7.：

Lipoxygenases and Cyclooxygenases

Analysis of Cyclooxygenase-Substrate Interactions Using Stereospecifically-Labeled Arachidonic Acids / Claus Schneider ; William E. Boeglin ; Alan R. Brash8.：

Sequence Determinants for the Positional Specificity of Lipoxygenases / Kristin Schwarz ; Monika Anton ; Hartmut Kuhn9.：

Regulation of Leukotriene C4 Synthase Gene Expression by SP1 and SP3 in Mononuclear Phagocytes / Kenneth J. Serio ; Craig R. Hodulik ; Timothy D. Bigby10.：

PGG2, 11R-HPETE and 15R/S-HPETE are Formed from Different Conformers of Arachidonic Acid in the Prostaglandin Endoperoxide H Synthase-1 Cyclooxygenase Site / Elizabeth D. Thuresson ; Karen M. Lakkides ; William L. Smith11.：

Supression of Cyclooxygenase-2 Gene Transcription by Humulon / Kei Yamamoto ; Jining Wang ; Shozo Yamamoto ; Hiroyasu Tobe12.：

Ishibition of 5-LO Activating Protein (FLAP) Activity Decreases Proteinuria in Streptozotocin (STZ)-Induced Diabetic Rats / Jose M. Valdivielso ; Angel Montero ; Karen A. Munger ; Kamal F. Badr13.：

Inhibition of Ultraviolet Light B-Induced Cutaneous Inflammation by a Specific Cyclooxygenase-2-Inhibitor / T.A. Wilgus ; M.L. Parrett ; M.S. Ross ; K.L. Tober ; F.M. Robertson ; T.M. Oberyszyn14.：

Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells / MacKenzie Hilfers Bilunas ; Steven A. Moore15.：

Down-Regulation of 5-Lipoxygenase Activity and Leukotriene Production by Prolonged Exposure to Lipopolysaccharide / Thomas G. Brock16.：

Endothelial COX-2 Induction by Hypoxia Liberates 6-Keto-PGF1(,a Potent Epithelial Secretagogue / Sean P. Colgan ; Cormac T. Taylor ; Sailaja Narravula ; Kristin Synnestvedt ; Elizabeth D. Blume17.：

Substrate Down Regulation of 12-Lipoxygenase in Human Platelets / Maria Dadaian ; Par Westlund18.：

Calcium Binding to 5-Lipoxygenase / Tove Hammarberg ; Konda Veera Reddy ; Bengt Persson ; Olof Radmark19.：

Expression of Cyclooxygenase-2 in Human Bladder and Renal Cell Carcinoma / Shuntaro Hara ; Yukihiro Kondo ; Ichiro Matsuzawa ; Yoshitaka Hashimoto ; Go Kimura ; Masao Akimoto ; Nobumasa Imura20.：

Modulation of Cyclooxygenase-2 Expression by APC in HT-29 Human Colorectal Carcinoma Cells / Linda C. Hsi ; Julie Angerman-Stewart ; Thomas E. Eling21.：

15-Lipoxygenase-1 Overexpression in Prostate Adenocarcinoma / Uddhav Kelavkar ; Cynthia Cohen ; Thomas Eling ; Kamal Dadr22.：

Characterization of Epidermal 12(S) and 12(R) Lipoxygenases / Maeve McDonnell ; Hongwei Li ; Colin D. Funk23.：

Selective Inhibition of Cyclooxygenase-2 Attenuates Expression of Inflammation-Related Genes in CNS Injury / M. Kerry OiBanion ; Stephanos Kyrkanides ; John A. Olschowka24.：

Intracellular Activation and Induction of 12-Lipoxygenase in Mouse Peritoneal Macrophages / Hiroo Kawajiri ; Isamu Makino ; Tanihiro Yoshimoto25.：

Epidermis-Type Lipoxygenases / Peter Krieg ; Markus Heidt ; Malte Siebert ; Andreas Kinzig ; Friedrich Marks ; Gerhard Furstenberger26.：

Manganese Lipoxygenase has a Mononuclear Redox Center / Chao Su ; Margareta Sahlin ; Ernst H. Oliw27.：

Cyclooxygenase-2 in Human Pathological Disease / Alane Koki ; Nasir K. Khan ; B. Mark Woerner ; A.J. Dannenberg ; Lisa Olson ; Karen Seibert ; Dorothy Edwards ; Madorra Hardy ; Peter Isakson ; Jaime L. Masferrer28.：

Leukotrienes and Lipoxins

Leukotriene D4-Induced Calcium Signaling in Human Intestinal Epithelial Cells / Charles Kumar Thodeti ; Anita Sjolander29.：

Do Leukotrienes Increase Cell Viability in Human Intestinal Epithelial Cells? / John F. Ohd ; Katarina Wikstrom30.：

Aspirin-Triggered 15-EPI-Lipoxin A4 Biosynthesis in Rat Liver Cells / Esther Titos ; Nan Chiang ; Charles N. Serhan ; Mario Romano ; Joan Gaya ; Gloria Pueyo ; Joan Claria31.：

Inhibiton of Allergen-Induced Eosinophil Migration by Lipoxin (LX)A4 and Aspirin-Triggered 15-EPI-LXA4 / Christianne Bandeira-Melo ; Renato S.B. Cordeiro ; Peter J. Jose ; Marco A. Martins ; Patricia T. Bozza32.：

Anti-Leukotrienes as Novel Anti-Inflammatory Treatments in Asthma / Jeffrey M. Drazen, M.D.33.：

Lipoxin A4 and Aspirin-Triggered 15-EPI_Lipoxin A4 Modulate Adhesion Molecule Expression on Human Leukocytes in Whole Blood and Inhibit Neutrophil-Endothelial Cell Adhesion / Janos G. Filep ; Christine Zouki ; Nicos A. Petasis ; Mohamed Hachicha34.：

Mechanisms of Active Intestinal Inflammation and Potential Down-Regulation via Lipoxins / Andrew T. Gewirtz ; Andrew S. Neish ; James L. Madara35.：

Interactions Between 5-Oxo-ETE and Chemokines in Stimulating Eosinophils / William S. Powell ; Sylvie Gravel ; Joshua Rokach36.：

Enzymes in Eicosanoid Biosynthesis and Metabolism

Structure and Function of Human NAD+-Linked 15-Hydroxyprostaglandin Dehydrogenase / Hsin-Hsiung Tai ; Charles Mark Ensor ; Huiping Zhou ; Fengxiang Yan37.：

Catalytic Properties of Purified Recombinant Anandamide Amidohydrolase / Natsuo Ueda ; Kazuhisa Katayama ; Sravan Kumar Goparaju ; Yuko Kurahashi ; Kenji Yamanaka ; Hiroshi Suzuki38.：

Purification and Characterization of Membrane-Bound Prostaglandin E Synthase from Bovine Hearts / Kikuko Watanabe ; Kayoko Kurihara ; Toshiko Suzuki39.：

cDNA Cloning and Mutagenesis Study of Liver-Type Prostaglandin F Synthase, and Identification of the Prostaglandin F Producing Cells in the Liver / Toshiko Suzuki-Yamamoto ; Yutaka Fujii ; Masashi Miyano ; Lan-Ying Chen ; Tomohiro Takahashi ; Hiromichi Yokoi ; Yoshihiro Tsuruo ; Kazunori Ishimura40.：

Determination of Cyclooxygenase and Arachidonic Acid Metabolites in Invasive Human Prostate Cancer Cells / Kasem Nithipatikom ; Christine L. Borscheid ; Andre Kajdacsy-Balla ; Sushma kaul ; Paul F. Lindholm ; Kristen B. Pytynia ; William B. Campbell41.：

Effects of Overexpression of Prostacyclin Synthase in Vascular Smooth Muscle Cells / Chieko Yokoyama ; Tatemi Todaka ; Hiroji Yanamoto ; Toshihisa Hatae ; Manabu Shimonishi ; Susumu Ohkawara ; Masayuki Wada ; Tadashi Tanabe42.：

Analysis of the Transcriptional Regulation of Mouse Prostacyclin Synthase Gene / 43.：

Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase / Per-Johan Jakobsson ; Staffan Thoren ; Ralf Morgenstern ; Bengt Samuelsson44.：

Receptors, Agonists and Antagonists

Activation-Dependent Internalization of the Human Prostacyclin Receptor / Emer M. Smyth ; Sandra C. Austin ; Garret A. FitzGerald45.：

The Design and Synthesis of Selective Prostaglandin Analogs as Bone Anabolic Agents for the Potential Treatment of Osteoporosis / David Lindsey Soper ; Yili Wang ; Biswanath De ; Mitchell Anthony deLong ; Michelle Jeanine Dirr ; Michelle Elaine Soehner ; Mark Walden Lundy ; Glen Edward Mieling ; John August Wos46.：

Leukotrienes and the Pulmonary Vascular Bed / Laurence Walch ; Xavier Norel ; Jean-Pierre Gascard ; Charles Brink47.：

The Contraction of the Human Pulmonary Artery by LTC4 is Resistant to CysLT1 Antagonists and Counteracted by Prostacyclin Release / Magnus Back ; Sven-Erik Dahlen48.：

Targeted Gene Disruption of the Prostaglandin E2 EP2 Receptor / Richard M. Breyer ; Cristopher R. J. Kennedy ; Yahua Zhang ; Youfei Guan ; Matthew D. Breyer49.：

Ocular Hypotensive Activity of Prostaglandin F2(PGF20 Analogs with Neutral Substituents at Position 1 is Predicted by the Isolated Cat Iris Sphincter Smooth Muscle Prepararion but not Ca+ Signaling in Swiss 3T3 Cells / Robert M. Burk ; David F. Woodward ; Achim H.P. Krauss ; June Chen ; Charles E. Protzmann ; Linda S. Williams ; Ming F. Chan50.：

Prostanoid FP Receptor-Mediated, Endothelium Dependent Vasodilatation and the Ocular Surface Hyperemic Response to PGF2( and Related Compounds / 51.：

Regulation of the CD36 Expression in Human Melanoma Cells / Min Chen ; Erica Pych ; Cyndy Corpron ; Carroll M. Harmon52.：

Novel Eicosanoid Activators of PPAR( Formed by Raw 264.7 Macrophage Cultures / Sven Hammarstrom ; Cecilia Trinks ; Jane Wigren ; Sailesh Surapureddi ; Mats Soderstrom ; Christopher K. Glass53.：

Isoprostane Activation of the Nuclear Hormone Receptor PPAR / Peter McNamara ; John A. Lawson54.：

In Vivo Chemotaxis using CHO Cells Expressing Human Leukotriene B4 Receptor / Takehiko Yokomizo ; Eisei Noiri ; Takashi Isumi ; Takao Shimizu55.：

Cancer and Inhibitors of Eicosanoid Biosynthesis

Mechanism of Inhibition of Novel COX-2 Inhibitors / James Gierse ; Ravi Kurumbail ; Mark Walker ; Bill Hood ; Joe Monahan ; Jennifer Pawlitz ; Rick Stegeman ; Anna Stevens ; Jim Kiefer ; Carol Koboldt ; Kirby Moreland ; Scott Rowlinson ; Larry Marnett ; Jennifer Pierce ; Jeff Carter ; John Talley56.：

Chemopreventive Effects of Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, Against PHIP-Induced Mammary Carcinogenesis / Toshihiko Kawamori ; Seiichi Nakatsugi ; Toshihisa Ohta ; Takashi Sugimura ; Keiji Wakabayashi57.：

Antitumor Effects of Piroxicam in Spontaneous Canine Invasive Urinary Bladder Cancer, a Relevant Model of Human Invasive Bladder Cancer / Deborah W. Knapp. Nita W. Glickman ; Sulma I. Mohammed ; Dennis B. DeNicola ; William R. Widmer ; Patty L. Bonney ; Amalia E. DeGortari58.：

Cannabimimetic Eicosanoids in Cancer and Inflammation: an Update / Dominique Melck ; Tiziana Bisogno ; Luciano De Petrocellis ; Pierre Beaulieu ; Andrew S.C. Rice ; Vincenzo Di Marzo59.：

Acetyl-11-Keto-(-Boswellic Acid (AKBA) is Cytotoxic for Meningioma Cells and Inhibits Phosphorilation of the Extracellular-Signal Regulated Kinase 1 and 2 / Yong Seok Park ; Joung H. Lee ; Jyoti A. Harwalkar ; Judy Bondar ; Hasan Safayhi ; Mladen Golubic60.：

Nitric Oxide, Cox-2 and Apostosis

Cyclooxygenase-2 Induction in Rat Spinal Cord Injury Mediated by Proinflammatory Tumor Necrosis Factor-( and Interleukin-1 / Takeharu Tonai ; Yutaka Taketani ; Yasukazu Ohmoto ; Takehiko Nishisho61.：

Growth Stimulation and Epidermal Growth factor Receptor Induction in Cyclooxygenase-Overexpressing Human Colon Carcinoma Cells / Yoshitaka Takahashi ; Takahiro Kinoshita ; Toshiki Sakashita ; Hiroyasu Inoue62.：

Relationship Between Apoptosis, Angiogenesis and Colon-26 Tumor Growth after Oral NSAID-Treatment / Joanne R. Brown ; Mike P. Seed ; Derek A. Willoughby63.：

Molecular Mechanisms of Prostate cancer Cell Death Triggered by Inhibition of Arachidonate 5-Lipoxygenase: Involvement of FAS Death Receptor-Mediate Signals / Jagadananda Ghosh ; Charles E. Myers64.：

Induction of Apoptosis in Mouse T Cells upon Peroxisome Proliferator-Activated Receptor Gamma (PPAR0 Binding / Sarah G. Harris ; Richard P. Phipps65.：

Nitration of Cytochrome C by Peroxynitrite: a Putative Antiapoptotic Pathway Mediated by Prostaglandin H2 Synthase (PGHS) and Nitric Oxide (NO) Synthase / Elizabeth S. Roberts-Kirchhoff ; Cheryl K. Kim ; Hyesook Kim66.：

Apoptosis in Vascular Smooth Muscle Accompanied by Increases in Arachidonic Acid / Edward F. LaBelle ; Ken Wilson ; Cyril Pilane67.：

Sphingolipids in Vascular Biology / Kelley M. Argraves ; Lina M. Obeid ; Yusuf A. Hannun68.：

Cyclooxygenase-2: A Molecular Target for Chemoprevention of Epithelial Tumors of Skin and Colon / K. Muller-Decker ; S. Charyalertsak ; C. Albert ; G. Reinerth ; F. Marks69.：

Signaling Pathways

MK 886 Functions as a Radiomimetic Agent: Genomic Responses Related to Oxidative Stress, the Cell Cycle, Proliferation and Programmed Cell Death in PANC-1 Cells / Ken M. Anderson ; Waddah Alrefai ; Colin Anderson ; Philip Bonomi ; Jules Harris70.：

LPS-Induced Synthesis and Release of PGE2 in Liver Macrophages: Regulation by cPLA2, COX-1, COX-2, and PGE2 synthase / Peter Dieter ; Roland Scheibe ; Sabine Kamionka ; Angelika Kolada71.：

13(S)-HpODE Modulates Mitogenic Signal Transduction Through Enhancing the Phosphorylation and Association of the EGF Receptor with the Tyrosine Phosphatase SHP-2 / Wayne C. Glasgow ; Rutai Hui ; Hideto Kameda72.：

KU 70/80 Lupus Autoantigen is the Transcription Factor Induced by Interleukins (IL)-13 and -4 Leading to Induction of 15-Lipoxygenase (15-LO) in Human Cells / Susheng Wang73.：

Divergence in Intracellular Signaling Between Interleukin-4 (IL-4) and IL-13 in Human Cells Localizes to Monomeric/Dimeric Expression of a Transcription Factor, The Lupus Autoantigen 70/80, Induced by Both Cytokins / 74.：

Role of Phosphatidylethanolamine in G Protein Coupled Receptor-Associated Signal Transduction / Klara Kitajka ; Esther Martinez ; Antonio Miralles ; Pablo V. Escriba75.：

The p21-Activated Protein Kinases (PAKs) Receive and Integrate Messages from a Variety of Signaling Pathways / Jian P. Lian ; Lisa Crossley ; Qian Zhan ; RiYun Huang ; Dwight Robinson ; John A. Badwey76.：

Signaling Pathways for TNF(-Induced COX-2 Expression: Mediation Through Map Kinases and NFkB, and Inhibition by Certain Nonsteroidal Anti-Inflammatory Drugs / Jihye Paik ; Joo Y. Lee ; Daniel Hwang77.：

12(S)-HETE, Pleiotropic Functions, Multiple Signaling Pathways / Charles K. Szekeres ; Mohit Trikha ; Kenneth V. Honn78.：

Hydroxy Fatty Acids, Lipids and Isoeicosanoids

Formation of Novel D-Ring and E-Ring Isoprostane-Like Compounds (D4 /E4-Neuroprostanes) in vivo from Docosahexaenoic Acid / Erin E. Reich ; Thomas J. Montine ; Jason D. Morrow79.：

Regulation of Cell-Substrate Adhesion by the Lypoxygenase and Cyclooxygenase Branches of Arachidonic Acid Metabolism / Louis A. Roberts ; Honor L. Glenn ; Rebecca A. Whitfield ; Bruce S. Jacobson80.：

Development of Enzyme Immunoassays for 5,6-, 8,9-, 11,12- and 14,15-EETS and the Corresponding DHETS / Diane M. Sasaki ; Ying Yuan ; Katherine Gikas ; Malla Reddy ; John R. Falck ; Denis M. Callewaert81.：

Enzyme Immunoassays for 15-F2t Isoprostane-M, an Urinary Biomarker for Oxidant Stress / Kazuo Kanai ; Douglass Taber ; L. Jackson Roberts II82.：

Biphasic Regulation of Leukocyte Trafficking by Lipoxins / Catherine Stenson ; Siobhan Mitchell ; David Lappin ; Hugh R. Brady ; Catherine Godson83.：

Pantothenic Acid: An Organ-Specific Pro-Oxidant Vitamin-Brain and Liver Neuroprostane Levels in Rats Fed a Pantothenic Acid-Deficient Diet / Jihan Youssef ; Alan Davis ; L. Jackson Roberts ; Larry L. Swift ; Mostafa Badr84.：

Linoleate Diol Synthase and PHG Synthase n A New Gene Family of Fatty Acid Heme Dioxygenases? / Lena Hornsten85.：

Eicosanoids Regulation of Transcription Factors in PC-3 Prostate Cancer Cells / Mustapha Kandouz86.：

Knock-Out Animal Models

Non-Prostaglandin Effects of Aspirin III and Salicylate: Inhibition of Integrin-Dependent Human Neutrophil Aggregation and Inflammation in COX-2 and NFKB (P105)-Knockout Mice / Gerald Weissmann ; M. Carmen Montesinos ; Michael Pillinger ; Bruce N. Cronstein87.：

Dietary EPA Reduces Tumor Load in Apc Min/+ Mice by Altering Arachidonic Acid Metabolism, But Conjugated Linoleic Acid, Gamma- and Alpha-Linoleic Acids Have No Effect / Jay Whelan ; Melissa B. Hansen Petrik ; Michael F. McEntee ; Mark G. Obukowicz88.：

The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Mice / Leslie R. Ballou89.：

Prostanoids in Health and Disease; Lessons from Receptor-Knockout Mice / Takuya Kobayashi ; Shuh Narumiya90.：

Phospholipases / Part A：

Regulation of Phosphoinsitide Phospholipases by G-Proteins / J. Exton1：

The Effects of Group II Phospholipase A[subscript 2] in Ras-Induced Metastasis / T. Davis2：

Activation of Ca[superscript 2+]-Sensitive Cytosolic Phospholipase A[subscript 2] (cPLA[subscript 2]) in Human Platelets / R. Kramer3：

Involvement of Reactive Oxygen Species in Phospholipase A[subscript 2] Activation: Inhibition of Protein Tyrosine Phosphatases and Activation of Protein Kinases / U. Zor ; R. Goldman4：

High Molecular Weight Phospholipase A[subscript 2]: Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa / I.A. Tavares5：

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