In vivo carbon-13 NMR

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In vivo carbon-13 NMR / edited by Lawrence J. Berliner and Pierre-Marie Robitaille

資料種別:

図書

出版情報:

New York ; London : Kluwer Academic, Plenum Publishers, c1998

形態:

xv, 255 p. ; 24 cm

シリーズ名:

Biological magnetic resonance / edited by Lawrence J. Berliner and Jacques Reuben ; v. 15 <BA00368883>

著者名:

ISBN:

9780306458866 [0306458861]

書誌ID:

BA41334714

子書誌情報

フルテキスト

所蔵情報

他の版・巻

書誌詳細

注記:

Includes bibliographical references and index

主題:

異性体．立体化学．共鳴

言語:

英語

目次情報:

Tracer Theory and [superscript 13]C NMR / Maren R. Laughlin ; Joanne K. KelleherChapter 1：

Introduction / 1.：

Overview / 1.1.：

Definitions / 1.2.：

Characteristics of a Perfect Tracer / 2.：

Compartmental Models / 3.：

Objectives and Identifiability / 3.1.：

Parameter Estimation and Goodness of Fit / 3.3.：

Linearity and Tracer Models / 3.4.：

The Basic Tracer Experiment / 4.：

General Considerations / 4.1.：

Single Pool Model / 4.2.：

Multicompartmental Catenary Model / 4.3.：

Saturable Kinetic Processes / 5.：

Condensation Reactions / 6.：

Tissue Heterogeneity / 7.：

Metabolic and Isotopic Steady State, Time-Dependent Experiment / 7.1.：

Tissue Heterogeneity Measured in Pre-Isotopic Steady State / 7.2.：

Fractional Enrichment in the Metabolic and Isotopic Steady-State Experiment / 7.3.：

The [superscript 13]C NMR Experiment / 8.：

Chemical Shift and Spectral Resolution / 8.1.：

Metabolic Perturbation / 8.2.：

Detection Limits / 8.3.：

Correction for Natural Abundance Fractional Enrichment / 8.4.：

Subtraction of Natural Abundance Spectra in in Vivo Experiments / 8.5.：

Sites of Label Entry and Sampling, and Substrate Enrichment / 8.6.：

Fractional Enrichment / 8.7.：

Sensitivity and Time / 8.8.：

Use of Reporter Molecules / 8.9.：

Conclusions / 9.：

References

[superscript 13]C Isotopomer Analysis of Glutamate: A NMR Method to Probe Metabolic Pathways Intersecting in the Citric Acid Cycle / A. Dean Sherry ; Craig R. MalloyChapter 2：

The Role of the Citric Acid Cycle in Substrate Oxidation

Anaplerotic Functions of the Citric Acid Cycle

Quantitation of Glutamate Isotopomers by [superscript 13]C NMR

Relation of Glutamate Isotopomers to Multiplets in the [superscript 13]C NMR Spectrum / 2.1.：

Acquisition of the [superscript 13]C NMR Spectrum / 2.2.：

Quantitation of [superscript 13]C Fractional Enrichment by [superscript 1]H NMR / 2.3.：

Influence of Natural Abundance [superscript 13]C on an Isotopomer Analysis / 2.4.：

Mathematical and Computer Models: Applications for Isotopomer Analysis

The Value of Mathematical Models

Historical Background of Current Modeling Techniques

The Evolution of [superscript 13]C Isotopomers in the Citric Acid Cycle

The Steady-State [superscript 13]C Isotopomer Analysis

The Nonsteady-State Analysis

The Direct C4 Analysis: A Readout of Relative Substrate Utilization

Steady-State Analysis under Nosteady-State Conditions

Absolute Metabolic Fluxes from [superscript 13]C Isotopomer Data

Other Considerations / 10.：

Determination of Metabolic Fluxes by Mathematical Analysis of [superscript 13]C-Labeling Kinetics / John C. Chatham ; Edwin M. ChanceChapter 3：

Approach to Analyzing Labeling Kinetics

Formulation of Model

Numerical Methods

Results and Discussion

Metabolic Flux and Subcellular Transport of Metabolites / E. Douglas LewandowskiChapter 4：

The General Utility of Dynamic-Mode [superscript 13]C NMR: Lessons from the Heart

[superscript 13]C NMR and Metabolic Activity

[superscript 13]C-Enrichment Patterns and Oxidative Metabolism

Fractional Enrichment and [superscript 13]C NMR of Metabolic Flux

Models and Parameters of Glutamate Enrichment

Direct Kinetic Analysis of Dynamic [superscript 13]C NMR Spectra

Metabolic Flux and Regulation from Dynamic [superscript 13]C NMR Spectroscopy

Metabolite Compartmentation Effects on [superscript 13]C Kinetics

[superscript 13]C NMR of Subcellular Transport Rates

Summary / 11.：

Assessing Cardiac Metabolic Rates during Pathologic Conditions with Dynamic [superscript 13]C NMR Spectra / Robert G. Weiss ; Gary GerstenblithChapter 5：

Dynamic [superscript 13]C NMR Spectroscopy in Paradigms of Myocardial Dysfunction: "Stunned" and "Hibernating" Myocardium

"Stunned" Myocardium

"Hibernating" Myocardium

Implications for Distinguishing Types of Dysfunctional Myocardium in the Clinical Setting: In Vivo [superscript 13]C NMR

A Strategy for Measuring TCA Cycle Flux with [superscript 13]C NMR

Dynamic [superscript 13]C NMR Spectroscopy of Glycolysis in Ischemic Preconditioning

Metabolic Changes in Ischemic Preconditioned Hearts

Attenuated Ischemic Acidosis in Preconditioned Hearts

Applications of [superscript 13]C Labeling to Studies of Human Brain Metabolism in Vivo / Graeme F. MasonChapter 6：

Measurement of the TCA Cycle Rate in the Brain

A General Description

Theoretical Basis of the Kinetic Modeling: Mass and Isotope Balance

Overview of Interpretation of the Data by Mathematical Modeling

Methods of Detection Currently in Use for Metabolic Studies of Brain in Vivo

Mathematical Modeling: A Detailed Discussion

Description of Metabolic Flow

Equations and Procedures Used to Determine Model Parameters

Measurement of Glutamate Turnover Rate (V[superscript gt])

Determination of V[superscript x]/V[superscript tca] and V[superscript tca] and C4/C3 Labeling Time Courses

Determination of Glutamate/Glutamine Carbon Flow (V[superscript gln]) / 3.5.：

Derivation of Secondary Parameters

Estimation of Carbon Sources for the TCA Cycle

Determination of CMR[subscript gl]

Brain Oxygen Consumption

Quantitative Analyses of Sensitivities

Glucose Turnover Time / 5.1.：

Exchange of Lactate and Pyruvate / 5.2.：

Effects of Metabolic Intermediates and Aspartate / 5.3.：

Rates of Influx and Efflux of Lactate and Pyruvate / 5.4.：

Exchange Between [alpha]-Ketoglutarate and Glutamate / 5.5.：

Pyruvate Carboxylase / 5.6.：

Pentose Phosphate Shunt / 5.7.：

Glucose Label Scrambling / 5.8.：

Glutamate/Glutamine Carbon Flow / 5.9.：

Summary of Sensitivity Analysis / 5.10.：

Metabolic Compartmentation

Neuronal Activity and Compartmentation / 6.1.：

Effects of Glutamate/Glutamine Compartmentation on Measured V[subscript tca] / 6.2.：

Future of [superscript 13]C-Labeling Studies of the Brain in Vivo

In Vivo [superscript 13]C NMR Spectroscopy: A Unique Approach in the Dynamic Analysis of Tricarboxylic Acid Cycle Flux and Substrate Selection / Pierre-Marie Luc RobitailleChapter 7：

The Interaction between Major Biochemical Pathways and Reactions

The Myoglobin System

The Lactate and Alanine Systems

The Creatine Kinase System

The History of Cellular [superscript 13]C NMR

Post-Steady-State Analysis

The Theory of Post-Steady-State Analysis

In Vivo [superscript 13]C NMR Analysis of Substrate Selection

Contents of Previous Volumes

Index

Tracer Theory and [superscript 13]C NMR / Maren R. Laughlin ; Joanne K. KelleherChapter 1：

Introduction / 1.：

Overview / 1.1.：

Definitions / 1.2.：

Characteristics of a Perfect Tracer / 2.：

Compartmental Models / 3.：

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