Preface to the Series |
Preface to Volume 38 |
Contributors |
Contents of Previous Volumes |
Handbook on Toxicity of Inorganic Compounds |
Handbook on Metals in Clinical and Analytical Chemistry |
Handbook on Metalloproteins |
Peptide Bond Characteristics / R. Bruce MartinChapter 1: |
Background / 1.: |
Proton Binding and Loss / 2.: |
Metal Ion Binding at the Peptide Bond / 3.: |
Free Energies of Peptide Bond Hydrolysis and Formation / 4.: |
Equilibrium Constants for Peptide Bond Formation in the Presence of Metal Ions / 5.: |
Peptide Oxygen Basicity Determined by Amide Amino Group Basicity / 6.: |
Metal Ion Effects on Rates of Peptide Bond Hydrolysis / 7.: |
References |
Lanthanide Ion-Mediated Peptide Hydrolysis / Makoto KomiyamaChapter 2: |
Introduction |
Amide Hydrolysis by Lanthanide Ions |
Mechanism of Ce(IV) Catalysis |
Cyclodextrin Complexes of Lanthanide Ions for Homogeneous Hydrolysis of Amides |
Relevance of the Lanthanide-Mediated Amide Hydrolysis to DNA Hydrolysis |
Conclusion |
Acknowledgment |
Abbreviations |
Co(III)-Promoted Hydrolysis of Amides and Small Peptides / David A. Buckingham ; Charles R. ClarkChapter 3: |
Early Studies and Scope |
Co(III) Linkage Isomers and Isomerization |
Hydrolysis by Direct Polarization |
Bimolecular Reactions of Co-OH[subscript 2]/OH |
Intramolecular Reactions of CoOH[subscript 2]/OH |
Kinetic Parameters and Reaction Mechanism |
Related Nonmetal Hydrolysis Reactions / 8.: |
Synthetic Cu(II) and Ni(II) Peptidases / Gregory M. Polzin ; Judith N. BurstynChapter 4: |
Hydrolysis of Simple Peptides by Cu(II) and Ni(II) Ions in Solution |
Cleavage of Substrates Containing a Metal Binding Site by Cu(II) and Ni(II) Ions |
Cleavage of Amides, Peptides, and Proteins by Defined Metal Complexes |
Conclusions |
Palladium(II) and Platinum(II) Complexes as Synthetic Peptidases / Nebojsa M. Milovic ; Nenad M. KosticChapter 5: |
Selective Binding of Metal Complexes to Peptides and Peptide Cleavage |
Cleavage of Proteins |
Prospects |
Acknowledgments |
Abbreviations and Symbols |
Protease Activity of 1,10-Phenanthroline-Copper Systems / Makoto Kito ; Reiko UradeChapter 6: |
Can Free Copper(II) Ions Degrade Proteins? |
Protein Degradation by the 1,10-Phenanthroline-Copper(II) Complex |
Protease Activity of the Chemically Modified 1,10-Phenanthroline-Copper(II) Complex |
Specific Protein Degradation by Copper(II) Ions / Geoffrey AllenChapter 7: |
Peptide Sequence Specificity for Cleavage by Copper(II) Ions |
Conditions Affecting the Rate of Cleavage of Peptides by Copper(II) Ions |
Possible Mechanisms of Copper(II)-Mediated Hydrolysis of Peptide Bonds |
Physiological Relevance of the Degradation of Proteins by Copper(II) Ions |
Artificial Iron-Dependent Proteases / Saul A. Datwyler ; Claude F. MearesChapter 8: |
Introduction: Historical Background and Concepts |
Principles and Practical Aspects |
Methodology |
Transcription Complexes in Escherichia coli |
Hydroxyl Radical Footprinting of Proteins Using Metal Ion Complexes / Tomasz Heyduk ; Noel Baichoo ; Ewa HeydukChapter 9: |
Experimental Methodology of Protein Footprinting |
Applications of Protein Footprinting Methodology |
Future Directions |
Abbreviations and Definitions |
Nickel- and Cobalt-Dependent Oxidation and Cross-Linking of Proteins / Steven E. Rokita ; Cynthia J. BurrowsChapter 10: |
Determinants of Nickel- and Cobalt-Dependent Oxidation |
Intrinsic Sensitivity of Native Proteins |
Mapping Tertiary and Quaternary Structure of Proteins |
Effects of Metal Ions on the Oxidation and Nitrosation of Cysteine Residues in Proteins and Enzymes / Ann M. English ; Dean E. WilcoxChapter 11: |
Background: Properties and Biological Roles of Cysteine Residues |
Oxidation of Cysteines |
Nitrosation of Cysteines |
Protein Cross-Linking Mediated by Metal Ion Complexes / Kathlynn C. Brown ; Thomas KodadekChapter 12: |
Small-Molecule Cross-Linking Reagents Used Free in Solution |
Development of Affinity Cross-Linking Reagents: Use of Peptides or Proteins to Deliver a Cross-Linking Reagent Site-Specifically |
Ferrocenoyl Amino Acids and Peptides: Probing Peptide Structure / Heinz-Bernhard Kraatz ; Marek GalkaChapter 13: |
Introduction: Organometallic Probes in Biological Systems |
Synthetic Studies of Ferrocenoyl Amino Acids and Peptides |
Structural and Theoretical Studies |
Electrochemistry of Ferrocenoyl Amino Acids and Peptides |
Summary |
Synthetic Analogs of Zinc Enzymes / Gerard ParkinChapter 14: |
Structural and Functional Models of Zinc Enzymes as Classified by Active Site Composition |
Use of Metal Ion Substitution to Provide Insight into the Structures and Mechanisms of Action of Zinc Enzymes |
Perspectives |
Mimicking Biological Electron Transfer and Oxygen Activation Involving Iron and Copper Proteins: A Bio(in)organic Supramolecular Approach / Martinus C. FeitersChapter 15: |
Mimics for Iron-Sulfur Proteins |
Mimics for Blue Copper Proteins |
Cytochrome P450 Mimics |
Mimics for Oxygen Binding and Activation by Copper Proteins |
Concluding Remarks |
Subject Index |
Preface to the Series |
Preface to Volume 38 |
Contributors |
Contents of Previous Volumes |
Handbook on Toxicity of Inorganic Compounds |
Handbook on Metals in Clinical and Analytical Chemistry |