| Contributors |
| Preface |
| Discovery of New Macrolides / Kazuro Shiomi ; Satoshi Omura1.： |
| Introduction / I.： |
| Macrolides from Actinomycetes / II.： |
| Macrolides from Bacteria Including Myxobacteria / III.： |
| Macrolides from Fungi / IV.： |
| Macrolides from Plants and Lichens / V.： |
| Macrolides from Insects / VI.： |
| Other Macrolides / VII.： |
| Concluding Remarks / VIII.： |
| References |
| Discovery of New Macrolides from Marine Organisms / Masami Ishibashi2.： |
| Macrocyclic Lactones of Marine Organism Origin |
| Chemical Modification of Macrolides / Toshiaki Sunazuka ; Sadafumi Omura ; Shigeo Iwasaki3.： |
| Fourteen-Membered Macrolides |
| Sixteen-Membered Macrolide Antibiotics and the Avermectin Family |
| Total Synthesis of Macrolides / Tadashi Nakata4.： |
| Synthetic Strategy for Macrolide Synthesis |
| Total Synthesis of Selected Macrolides |
| Biosynthesis, Regulation, and Genetics of Macrolide Production / Haruo Ikeda5.： |
| Reaction Mechanism of Polyketide Biosynthesis |
| Polyketide Synthase |
| Genes Encoding Modular Polyketide Synthase |
| Sugar Biosynthesis |
| Genetic Manipulation of PKS Genes |
| Pharmacokinetics and Metabolism of Macrolides / Yoshiro Kohno6.： |
| Pharmacokinetics and Metabolism |
| Drug Interaction |
| Antimicrobial Macrolides in Clinical Practice / Salvador Alvarez-Elcoro ; Joseph D. C. Yao7.： |
| Fourteen- and Fifteen-Membered Macrolides |
| Sixteen-Membered Macrolides |
| Ivermectin in Clinical Practice / Osamu Zaha ; Tetsuo Hirata ; Fukunori Kinjo ; Atsushi Saito8.： |
| Novel Activity of Ivermectin in Clinical Practice |
| Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice / Tadahiro Amaya ; Jun Hiroi ; Ira D. Lawrence9.： |
| Tacrolimus, a Brief Developmental History |
| Novel Activity of Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice |
| Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides / Yoshinori Nakajima10.： |
| Mode of Action of Macrolide Antibiotics |
| Mechanisms of Resistance to Antimicrobial Macrolides |
| Important Developments in Macrolide Antibiotics |
| Addendum |
| Mode of Action of Macrolides with Motilin Agonistic Activity--Motilides / Nobuhiro Inatomi ; Fumihiko Sato ; Zen Itoh11.： |
| Mode of Action of Motilin |
| Invention of Motilides |
| Biological Activity of Motilides |
| Clinical Trials of Motilides |
| Novel Activity of Erythromycin and Its Derivatives / Shoji Kudoh ; Arata Azuma ; Jyun Tamaoki ; Hajime Takizawa ; Koh Nakata ; Hajime Goto12.： |
| Erythromycin Treatment in Diffuse Panbronchiolitis |
| Inhibition of Chloride Channel |
| Effects of Macrolides on Cytokine/Chemokine Expression |
| Modulation of Bacterial Function |
| New Challenge for Novel Action |
| Mode of Action of Avermectin / 13.： |
| Target of Avermectin Action |
| Cloning and Structure of Avermectin Binding Protein |
| Mode of Action of FK506 and Rapamycin / Nobuhiro Takahashi14.： |
| Initial Cellular Target for FK506 and Rapamycin; Peptidyl Prolyl cis-trans Isomerases (Rotamases, Immunophilins) |
| Target of FK506-FKBP12 Complex: Calcineurin |
| Target of Rapamycin-FKBP12 Complex: mTOR/FRAP/RFAT |
| Intervention of Intracellular Signaling Pathways by FK506 and Rapamycin |
| Index |
| Contributors |
| Preface |
| Discovery of New Macrolides / Kazuro Shiomi ; Satoshi Omura1.： |
| Introduction / I.： |
| Macrolides from Actinomycetes / II.： |
| Macrolides from Bacteria Including Myxobacteria / III.： |
