Real-time in vitro measurement of Intrinsic and Ras GAP-mediated GTP hydrolysis |
Schwann cell preparation from single mouse embryos: Analyses of neurofibromin function in Schwann cells |
Regulation of the nucleotide state of oncogenic Ras proteins by nucleoside diphosphate kinase |
Measurements of TSC2 GAP activity toward Rheb |
Characterization of AND-34 function and signalling |
Studying the spatial and temporal regulation of Ras GTPase-activating proteins |
Activation of Ras Proteins by Ras Guanine Nucleotide Releasing Protein Family Members |
Ras and Rap1 Activation of PLC? lipase activity |
Specificity and expression of RalGPS as RalGEFs |
Biochemical and biological analyses of Rgr RalGEF oncogene |
Analysis of Ras Activation in Living Cells with GFP-RBD |
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function |
Characterization of the activation of the Rap specific exchange factor epac by cyclic nucleotides |
Biochemistry of the Rap-specific guanine nucleotide exchange factors PDZ-GEF1 and 2 |
Characterization of interactions between Ras family GTPases and their effectors |
Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis |
Sequencing analysis of BRAF mutations in human cancers |
KSR regulation of the Raf-MEK-ERK cascade |
Ras-sensitive IMP modulation of the Raf/MEK/ERK cascade through KSR1 |
Raf Kinase Inhibitor Protein (RKIP) regulation of Raf and MAPK signalling |
Harnessing RNAi for Analyses of Ras Signaling and Transformation |
The Rac Activator Tiam1and Ras induced Oncogenesis |
Phospholipase Ce C+ guanine nucleotide exchange factor activity and activation of Rap1 |
Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases |
RASSF family proteins and Ras transformation |
Ras and the Rain/RasBP1 effector |
The RIN family of Ras effectors |
RAP1 regulation of RIAM and cell adhesion |
Regulation of cell-cell adhesion by Rap1 |
Effects of Ras signaling on gene expression analyzed by customized microrays |
Protein-fragment complementation assays (PCA) in small GTPase research and drug discovery |
Ras Up-regulation of Cycloxygenase-2 |
Regulation of the expression of tropomyosins and actin cytoskeleton by ras-transformation |
Regulation of Par-4 by Oncogenic Ras |
Using Drosophila and yeast genetics to investigate a role for the RhebGTPase in cell growth |
Biochemistry and Biology of ARHI (DIRAS3), An Imprinted Tumor Suppressor Gene Whose Expression Is Lost In Ovarian and Breast Cancer |
Gem protein signaling and regulation |
Analysis of Rem/RGK Signaling and Biological Activity |
Analysis of Rit Signaling and Biological Activity |
Characterization of RERG: An estrogen-regulated tumor suppressor gene |
Inhibition of transcription factor NF-?B activation by ?B-Ras |
Analysis of Rhes activation state and effector function |
Rheb activation of mTOR and S6K1 signaling |
Use of Retrovirus Expression of Interfering RNA to Determine the Contribution of Activated K-Ras and Ras Effector Expression to Human Tumor Cell Growth |
Using inhibitors of prenylation to block localization and transforming activity |
Sorafenib (BAY 43-9006), a dual action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature |
Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction |
A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins |
A genetically defined normal human somatic cell system to study Ras oncogenesis in vivo and in vitro |
Analyses of Ras transformation of human thyroid epithelial cells |
Use of Ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer |
Physiological analysis of oncogenesic Kras |
Use of conditionally active Ras Fusion Proteins to study Epidermal Growth, Differentiation and Neoplasia |
Pancreatic duct epithelial cell isolation and cultivation in two dimensional and three dimensiona |
Real-time in vitro measurement of Intrinsic and Ras GAP-mediated GTP hydrolysis |
Schwann cell preparation from single mouse embryos: Analyses of neurofibromin function in Schwann cells |
Regulation of the nucleotide state of oncogenic Ras proteins by nucleoside diphosphate kinase |
Measurements of TSC2 GAP activity toward Rheb |
Characterization of AND-34 function and signalling |
Studying the spatial and temporal regulation of Ras GTPase-activating proteins |