Mass spectral and GC data of drugs, poisons, pesticides, pollutants, and their metabolites

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Mass spectral and GC data of drugs, poisons, pesticides, pollutants, and their metabolites / Karl Pfleger, Hans H. Maurer, Armin Weber

版:

3rd rev. and enl. ed

資料種別:

図書

出版情報:

Weinheim : Wiley-VCH, c2007

形態:

2 v. ; 29 cm

著者名:

ISBN:

9783527315383 [3527315381] (: set (1-2))

書誌ID:

BA83323190

子書誌情報

フルテキスト

所蔵情報

他の版・巻

書誌詳細

その他の標題:

Mass spectral and GC data

注記:

Includes bibliographical references and indexes

主題:

Drugs--Analysis--Tables; Gas chromatography--Tables; Mass spectrometry--Tables; Poisons--Analysis--Tables

言語:

英語

目次情報:

(Methods, Tables) / Volume 1：

Methods

Introduction / 1：

Experimental Section / 2：

Origin and choice of samples / 2.1：

Sample preparation / 2.2：

Standard extraction procedures / 2.2.1：

Standard liquid-liquid extraction (LLE) for plasma, urine or gastric contents (P, U, G) / 2.2.1.1：

STA procedure (hydrolysis, extraction and microwave-assisted acetylation) for urine (U+UHYAC) / 2.2.1.2：

Extraction of urine after cleavage of conjugates by glucuronidase and arylsulfatase (UGLUC) / 2.2.1.3：

Extractive methylation procedure for urine or plasma (UME, PME) / 2.2.1.4：

Solid-phase extraction for plasma or urine (PSPE, USPE) / 2.2.1.5：

LLE of plasma for determination of drugs for brain death diagnosis / 2.2.1.6：

Extraction of ethylene glycol and other glycols from plasma or urine followed by microwave-assisted pivalylation (PEGPIV or UEGPIV) / 2.2.1.7：

Derivatization procedures / 2.2.2：

Acetylation (AC) / 2.2.2.1：

Methylation (ME) / 2.2.2.2：

Ethylation (ET) / 2.2.2.3：

tert.-Butyldimethylsilylation (TBDMS) / 2.2.2.4：

Trimethylsilylation (TMS) / 2.2.2.5：

Trimethylsilylation followed by trifluoroacetylation (TMSTFA) / 2.2.2.6：

Trifluoroacetylation (TFA) / 2.2.2.7：

Pentafluoropropionylation (PFP) / 2.2.2.8：

Pentafluoropropylation (PFPOL) / 2.2.2.9：

Heptafluorobutyrylation (HFB) / 2.2.2.10：

Pivalylation (PIV) / 2.2.2.11：

Heptafluorobutyrylprolylation (HFBP) / 2.2.2.12：

GC-MS Apparatus / 2.3：

Apparatus and operation conditions / 2.3.1：

Quality assurance of the apparatus performance / 2.3.2：

Determination of retention indices / 2.4：

Systematic toxicological analysis (STA) of several classes of drugs and their metabolites by GC-MS / 2.5：

Screening for 200 drugs in blood plasma after LLE / 2.5.1：

Screening for most of the basic and neutral drugs in urine after acid hydrolysis, LLE and acetylation / 2.5.2：

Systematic toxicological analysis procedures for the detection of acidic drugs and/or their metabolites / 2.5.3：

General screening procedure for zwitterionic compounds after SPE and silylation / 2.5.4：

Application of the electronic version of this handbook / 2.6：

Quantitative determination / 2.7：

Correlation between Structure and Fragmentation / 3：

Principle of electron-ionization mass spectrometry (EI-MS) / 3.1：

Correlation between fundamental structures or side chains and fragment ions / 3.2：

Formation of Artifacts / 4：

Artifacts formed by oxidation during extraction with diethyl ether / 4.1：

N-Oxidation of tertiary amines / 4.1.1：

S-Oxidation of phenothiazines / 4.1.2：

Artifacts formed by thermolysis during GC (GC artifact) / 4.2：

Decarboxylation of carboxylic acids / 4.2.1：

Cope elimination of N-oxides (-(CH3)2NOH, -(C2H5)2NOH, -C6H14N2O2) / 4.2.2：

Rearrangement of bis-deethyl flurazepam (-H2O) / 4.2.3：

Elimination of various residues / 4.2.4：

Methylation of carboxylic acids in methanol ((ME), ME in methanol) / 4.2.5：

Formation of formaldehyde adducts using methanol as solvent (GC artifact in methanol) / 4.2.6：

Artifacts formed by thermolysis during GC and during acid hydrolysis (GC artifact, HY artifact) / 4.3：

Dehydration of alcohols (-H2O) / 4.3.1：

Decarbamoylation of carbamates / 4.3.2：

Cleavage of morazone to phenmetrazine / 4.3.3：

Artifacts formed during acid hydrolysis / 4.4：

Cleavage of the ether bridge in beta-blockers and alkanolamine antihistamines (HY) / 4.4.1：

Cleavage of 1,4-benzodiazepines to aminobenzoyl derivatives (HY) / 4.4.2：

Cleavage and rearrangement of N-demethyl metabolites of clobazam to benzimidazole derivatives (HY) / 4.4.3：

Cleavage and rearrangement of bis-deethyl flurazepam (HY -H2O) / 4.4.4：

Cleavage and rearrangement of tetrazepam / 4.4.5：

(Methods, Tables) / Volume 1：

Methods

Introduction / 1：

Experimental Section / 2：

Origin and choice of samples / 2.1：

Sample preparation / 2.2：

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