Contributors |
Preface |
Force in Biology / 1: |
What Are We Made Of? / 1.1: |
Human Body and Force / 1.2: |
Gravity and hydrodynamic force / 1.2.1: |
Frictional coefficients / 1.2.2: |
Biomechanics as the Big Brother / 1.3: |
Molecular Basis for Structural Design / 1.4: |
Soft versus Hard Materials / 1.5: |
Biological and Biomimetic Structural Materials / 1.6: |
Wear and Tear of Biological Structures / 1.7: |
Thermodynamics and Mechanics in Nanometer Scale Biology / 1.8: |
Bibliography |
Introduction to Basic Mechanics / 2: |
Elastic and Plastic Deformation of Materials / 2.1: |
Stress and Strain Relationship / 2.2: |
Mechanical Breakdown of Materials / 2.3: |
Viscoelasticity / 2.4: |
Mechanical Moduli of Biological Materials / 2.5: |
Mechanical deformations / 2.5.1: |
Shear deformation and rigidity modulus / 2.5.2: |
Triaxial deformation and bulk compressibility / 2.5.3: |
Y, G, and K are all related through Poisson's ratio / 2.5.4: |
What is Poisson's ratio? / 2.5.5: |
Fluid and Viscosity / 2.6: |
Adhesion and Friction / 2.7: |
Mechanically Controlled Systems / 2.8: |
Force and Force Measurement Apparatuses / 3: |
Mechanical, Thermal, and Chemical Forces / 3.1: |
Laser Trap / 3.2: |
Atomic Force Microscope / 3.3: |
History and principle / 3.3.1: |
How to use AFM for force measurement / 3.3.2: |
Biomembrane Force Probe / 3.4: |
Equation of force transduction / 3.4.1: |
Magnetic Beads / 3.5: |
Gel Columns / 3.6: |
Cantilever Force Sensors / 3.7: |
Loading-rate Dependence / 3.8: |
Derivation of the loading-rate dependence of the mean rupture force / 3.8.1: |
Force Clamp Method / 3.9: |
Specific versus Nonspecific Forces / 3.10: |
Polymer Chain Mechanics / 4: |
Polymers in Biological World / 4.1: |
Polymer Chains / 4.2: |
End-to-End Distance / 4.3: |
Definition / 4.3.1: |
Randomly coiled polymer / 4.3.2: |
The FJC (Freely Jointed Chain) / 4.3.3: |
Persistence Length / 4.4: |
Effect of cross-links / 4.4.1: |
Polymers in Solution / 4.5: |
General cases / 4.5.1: |
Denatured proteins and DNA / 4.5.2: |
Polymers on the Surface / 4.6: |
Polymer as Biomimetic Materials / 4.7: |
Polymer Pull-out / 4.8: |
Interaction Forces / 5: |
Covalent versus Noncovalent Force / 5.1: |
Basics of Electrostatic Interaction Force / 5.2: |
Various Types of Noncovalent Forces / 5.3: |
Charge-charge interaction / 5.3.1: |
Charge-dipole interaction / 5.3.2: |
Dipole-dipole interaction / 5.3.3: |
Dipole-induced dipole interaction / 5.3.4: |
Dispersion interaction / 5.3.5: |
Hydrogen-bonding interaction / 5.3.6: |
Hydrophobic interaction / 5.3.7: |
Application of External Force / 5.4: |
Interaction Force Between Macromolecules / 5.5: |
Exclusion effect / 5.5.1: |
Depletion effect / 5.5.2: |
Water at the Interface / 5.6: |
Single-Molecular Interaction Forces / 6: |
Ligand-receptor Interactions / 6.1: |
Biotin-avidin interaction / 6.1.1: |
Interaction of synaptic-vesicle fusion proteins / 6.1.2: |
Interaction between transferrin and its membrane receptor / 6.1.3: |
Sugar-lectin Interactions / 6.2: |
Antigen-antibody Interactions / 6.3: |
GroEL and Unfolded-protein Interactions / 6.4: |
Lipid-protein Interactions / 6.5: |
Anchoring Force of Proteins to the Membrane / 6.6: |
Receptor Mapping / 6.7: |
Protein Unanchoring and Identification / 6.8: |
Membrane Breaking / 6.9: |
Single-molecule DNA and RNA Mechanics / 7: |
Stretching of Double-stranded DNA / 7.1: |
Hybridization and Mechanical Force / 7.2: |
Chain Dynamics and Transition of DNA and RNA / 7.3: |
DNA-protein Interaction / 7.4: |
Prospect for Sequence Analysis / 7.5: |
Single-molecule Protein Mechanics / 8: |
Protein-stretching Experiments / 8.1: |
Intramolecular Cores / 8.2: |
Stretching of Modular Proteins / 8.3: |
Dynamic Stretching / 8.4: |
Catch Bond / 8.5: |
Protein-compression Experiments / 8.6: |
Hertz model / 8.6.1: |
Tatara model / 8.6.2: |
Internal Mechanics of Protein Molecules / 8.7: |
Mechanical Control of Protein Activity / 8.8: |
Computer Simulation of Protein Deformation / 8.9: |
Case Study: Carbonic Anhydrase II / R. Afrin |
Motion in Nano-biology / 9: |
Cell Movement and Structural Proteins / 9.1: |
Muscle and Motor Proteins / 9.2: |
Single-motor Measurements / 9.3: |
Flagella for Bacterial Locomotion / 9.4: |
Mycoplasma Gliding / 9.5: |
Mechanics and Efficiency of Motor Proteins / 9.6: |
Cell Mechanics / 10: |
Changes in Shape of Red Blood Cell / 10.1: |
Membrane and Cytoskeleton / 10.2: |
Association of Membrane Proteins with Cytoskeleton / 10.3: |
Detergent treatment / 10.3.1: |
Diffusion coefficients / 10.3.2: |
Force-curve measurement / 10.3.3: |
Deformation of 2D Membrane / 10.4: |
Helfrich Theory of Membrane Mechanics / 10.5: |
Cytoplasm and Subcellular Structures / 10.6: |
Indentation Experiment and the Use of Sneddon's Formulae / 10.7: |
Sneddon's formula / 10.7.1: |
Correction for thin samples / 10.7.2: |
Deformation Mechanics of a Thin Plate / 10.8: |
Manipulation at the Molecular Level / 11: |
Prospects for Useful Applications of Nanomechanics / 11.1: |
Cell Surgery / 11.2: |
Chromosomal Surgery and Gene Manipulation / 11.3: |
Tissue Surgery / 11.4: |
Liposomal Technology / 11.5: |
Drug Delivery / 11.6: |
DNA and RNA Recovery From the Chromosome and the Cell / 11.7: |
Finite Element Analysis of Microscopic Biological Structures / S. Kasas ; T. Gmur ; G. Dietler12: |
Introduction / 12.1: |
A Brief History of the Finite Element Method / 12.2: |
The Finite Element Method / 12.3: |
Application of the Finite Element Method to Microbiological Samples / 12.4: |
Proteins / 12.4.1: |
Axonemata and cilia / 12.4.2: |
Cell nuclei / 12.4.3: |
Micro-organisms / 12.4.4: |
Single cells / 12.4.5: |
Embryology and cell division / 12.4.6: |
Conclusion / 12.5: |
Beam Bending / A.1: |
Supported beam at two ends / A.1.1: |
Cantilever bending / A.1.1.2: |
Distributed force / A.1.1.3: |
Radius of curvature / A.1.1.4: |
Buckling / A.1.2: |
Basics of Linear Mechanics According to Landau and Lifshitz / A.1.3: |
V-shaped Cantilever / A.2: |
Persistence Length and Kuhn Statistical Segment / A.2.1: |
Hertz Model / A.3.1: |
Concentrated load / A.4.1: |
Distributed load / A.4.1.2: |
Contact problem of two spheres / A.4.1.3: |
Index |
Contributors |
Preface |
Force in Biology / 1: |
What Are We Made Of? / 1.1: |
Human Body and Force / 1.2: |
Gravity and hydrodynamic force / 1.2.1: |