List Of Contributors |
Nomenclature |
Introduction And Overview / 1: |
The Biological Importance of DNA / 1.1: |
The Origins of Nucleic Acids Research / 1.2: |
Early Structural Studies on Nucleic Acids / 1.3: |
The Discovery of the Structure of DNA / 1.4: |
The Advent of Molecular Biology / 1.5: |
The Partnership of Chemistry and Biology / 1.6: |
Frontiers in Nucleic Acids Research / 1.7: |
DNA and RNA Structure / 2: |
Structures of Components / 2.1: |
Standard DNA Structures / 2.2: |
Real DNA Structures / 2.3: |
Structures of RNA Species / 2.4: |
Dynamics of Nucleic Acid Structures / 2.5: |
Higher-order DNA Structures / 2.6: |
Nucleosides And Nucleotides / 3: |
Chemical Synthesis of Nucleosides / 3.1: |
Chemistry of Esters and Anhydrides of Phosphorus Oxyacids / 3.2: |
Nucleoside Esters of Polyphosphates / 3.3: |
Biosynthesis of Nucleotides / 3.4: |
Catabolism of Nucleotides / 3.5: |
Polymerisation of Nucleotides / 3.6: |
Therapeutic Applications of Nucleoside Analogues / 3.7: |
Synthesis Of Oligonucleotides / 4: |
Synthesis of Oligodeoxyribonucleotides / 4.1: |
Synthesis of Oligoribonucleotides / 4.2: |
Enzymatic Synthesis of Oligonucleotides / 4.3: |
Synthesis of Modified Oligonucleotides / 4.4: |
Nucleic Acids In Biotechnology / 5: |
DNA Sequence Determination / 5.1: |
Gene Cloning / 5.2: |
Enzymes Useful in Gene Manipulation / 5.3: |
Gene Synthesis / 5.4: |
The Detection of Nucleic Acids Sequences by Hybridization / 5.5: |
Gene Mutagenesis / 5.6: |
Oligonucleotides as Reagents and Therapeutics / 5.7: |
Footprinting / 5.8: |
Genes And Genomes / 6: |
Gene Structure / 6.1: |
Gene Families / 6.2: |
Intergenic DNA / 6.3: |
Chromosomes / 6.4: |
DNA Sequence and Bioinformatics / 6.5: |
Copying DNA / 6.6: |
DNA Mutation and Genome Repair / 6.7: |
DNA Recombination / 6.8: |
RNA Structure And Function / 7: |
Overview of RNA Structural Motifs / 7.1: |
RNA Processing and Modification / 7.2: |
RNAs in the Protein Factory: Translation / 7.3: |
RNAs Involved in Export and Transport / 7.4: |
RNAs and Epigenetic Phenomena / 7.5: |
RNA Structure and Function in Viral Systems / 7.6: |
Covalent Interactions Of Nucleic Acids With Small Molecules And Their Repair / 8: |
Hydrolysis of Nucleosides, Nucleotides, and Nucleic Acids / 8.1: |
Reduction of Nucleosides / 8.2: |
Oxidation of Nucleosides, Nucleotides, and Nucleic Acids / 8.3: |
Reactions with Nucleophiles / 8.4: |
Reactions with Electrophiles / 8.5: |
Reactions with Metabolically Activated Carcinogens / 8.6: |
Reactions with Anti-cancer Drugs / 8.7: |
Photochemical Modification of Nucleic Acids / 8.8: |
Effects of Ionising Radiation on Nucleic Acids / 8.9: |
Biological Consequences of DNA Alkylation / 8.10: |
DNA Repair / 8.11: |
Reversible Small Molecule-nucleic Acid Interactions / 9: |
Introduction / 9.1: |
Binding Modes and Sites of Interaction / 9.2: |
Counter-ion Condensation and Polyelectrolyte Theory / 9.3: |
Non-specific Outside-edge Interactions / 9.4: |
Hydration Effects and Water-DNA Interactions / 9.5: |
DNA Intercalation / 9.6: |
Interactions in the Minor Groove / 9.7: |
Intercalation versus Minor Groove Binding / 9.8: |
Co-operativity in Ligand-DNA Interactions / 9.9: |
Small Molecule Interactions with Higher-order DNA / 9.10: |
Protein-Nucleic Acid Interactions / 10: |
Structural Features of DNA Important in Protein Recognition / 10.1: |
The Physical Chemistry of Protein-Nucleic Acid Interactions / 10.2: |
Representative DNA Recognition Motifs / 10.3: |
Kinetic and Thermodynamic Aspects of Protein-Nucleic Acid Interactions / 10.4: |
The Specificity of DNA Enzymes / 10.5: |
DNA Packaging / 10.6: |
Polymerases / 10.7: |
Machines that Manipulate Duplex DNA / 10.8: |
RNA-Protein Interactions and RNA-mediated Assemblies / 10.9: |
Physical And Structural Techniques Applied To Nucleic Acids / 11: |
Spectroscopic Techniques / 11.1: |
Nuclear Magnetic Resonance / 11.2: |
X-ray Crystallography / 11.3: |
Hydrodynamic and Separation Methods / 11.4: |
Microscopy / 11.5: |
Mass Spectrometry / 11.6: |
Molecular Modelling and Dynamics / 11.7: |
Introduction and overview |
DNA and RNA structure |
Chemical synthesis |
Biosynthesis of nucleotides |
DNA sequence information, replication, and rearrangement |
RNA sequence information and transmission |
Covalent interactions of nucleic acids with small molecules |
Reversible interactions of nucleic acids with small molecules |
Interaction of proteins with nucleic acids |
Techniques applied to nucleic acids |
Glossary |
List Of Contributors |
Nomenclature |
Introduction And Overview / 1: |
The Biological Importance of DNA / 1.1: |
The Origins of Nucleic Acids Research / 1.2: |
Early Structural Studies on Nucleic Acids / 1.3: |