| Engineered Tropoelastin and Elastin-Based Biomaterials / Steven G. Wise ; Suzanne M. Mithieux ; Anthony S. Weiss |
| Introduction / I： |
| Hydrogels / II： |
| Electrospun Materials / III： |
| Material Coating / IV： |
| References |
| The Architecture of the Cornea and Structural Basis of Its Transparency / Carlo Knupp ; Christian Pinali ; Philip N. Lewis ; Geraint J. Parfitt ; Robert D. Young ; Keith M. Meek ; Andrew J. Quantock |
| The Cornea-a Macroscopic Overview |
| Collagen |
| Glycosaminoglycans and Proteoglycans |
| The Structure of the Corneal Stroma / V： |
| Corneal Transparency / VI： |
| Summary / VII： |
| Structural Biology of Periplasmic Chaperones / William J. Allen ; Gilles Phan ; Gabriel Waksman |
| Chaperones Involved in Folding and Stabilization of Proteins in the Periplasm |
| Carrier Chaperones |
| Conclusion |
| Separate Roles of Structured and Unstructured Regions of Y-Family DNA Polymerases / Haruo Ohmori ; Tomo Hanafusa ; Eiji Ohashi ; Cyrus Vaziri |
| Historical Background |
| Flexible Structures of Y-Family DNA Polymerases |
| Functional Significance of Protein-Protein Interactions Involving TLS DNA Polymerases |
| Author Index |
| Subject Index |
| Genomic Studies and Computational Predictions of Nucleosome Positions and Formation Energies / Denis Tolkunov ; Alexandre V. Morozov |
| Experimental Studies of Chromatin Structure |
| Computational Studies of Chromatin Structure |
| Summary and Conclusions |
| Protein Homorepeats: Sequences, Structures, Evolution, and Functions / Julien Jorda ; Andrey V. Kajava |
| Distribution of Homorepeats in Proteomes |
| Structural Properties of Homorepeat Regions |
| Evolutionary Dynamics of Homorepeats |
| Functional Associations of Homorepeat Regions |
| Protein Aggregation: From Inclusion Bodies to Amyloid and Biomaterials / Anna Mitraki |
| Historical Perspective: "Unboiling the Egg" |
| Protein Aggregation In Vitro |
| Inclusion Bodies: Mechanisms of Formation and Structural Features |
| Protein Aggregation and Disease: Amyloids |
| Fusion Proteins in the Study of Inclusion Bodies and Amyloids |
| Short Sequences may Suffice to Drive Aggregation |
| Amyloid Character of Inclusion Bodies |
| Natural Amyloids / VIII： |
| Protein Biomaterials: Amyloids as Bio-Nanomaterials / IX： |
| Summary and Outlook / X： |
| Taking Charge of Proteins: From Neurodegeneration to Industrial Biotechnology / Bryan F. Shaw ; Demetri T. Moustakas ; Julian P. Whitelegge ; Kym F. Faull |
| One of the Great Challenges for Biochemists in the 21st Century: Protein Aggregation |
| Almost All Proteins are Charged at Physiological pH |
| The Net Charge of a Protein Affects Its Rate of Aggregation |
| Misfolded or Mischarged? |
| The Case of Cu, Zn Superoxide Dismutase-1 and Amyotrophic Lateral Sclerosis |
| How Significant are Reductions in the Net Charge of ALS-SODI Variants? |
| Cryptic Amino Acid Substitutions That Cause Other Familial Aggregation Diseases Reduce Net Charge |
| Measuring the Net Charge of Proteins with Capillary Electrophoresis |
| Increasing the Durability of Enzymes with Organic Chemistry |
| The Effects of Acetylation on the Activity, Secondary Structure, and Thermostability of BLA |
| The Highly Charged BLA Protein Resists Thermal Precipitation / XI： |
| Industrial Applications for Highly Charged Enzymes / XII： |
| Acetylation Increases the Half-Life of BLA in Hot Solutions of Sodium Dodecyl Sulfate / XIII： |
| Why Does the Acetylation of Lysine Residues Increase the Half-Life of ?-Amylase in Solutions of Surfactant? / XIV： |
| Identifying the Unmodified Lysine Residues in BLA-Ac(?17) / XV： |
| Conclusion and Outlook: Charge Boosting Drugs / XVI： |
| Histone Acetylation, Acetyltransferases, and Ataxia-Alteration of Histone Acetylation and Chromatin Dynamics is Implicated in the Pathogenesis of Polyglutamine-Expansion Disorders / Shaun D. McCullough ; Patrick A. Grant |
| Packaging and Accessibility of DNA in the Context of Chromatin |
| Gcn5 is a Histone Acetyltransferase that Functions in the Context of SAGA and its Related Complexes in Eukaryotes |
| Substrate Targeting of Gcn5 Histone Acetyltransferase Activity is Regulated by Interactions with Adaptor Proteins |
| SAGA and Related Complexes Possess Histone Deubiquitination Activity |
| Gcn5 and PCAF Acetyltransferases Exhibit Distinct, Yet Partially Overlapping, Functions |
| Polyglutamine Stretches are Common Attributes of Transcription Factors |
| Polyglutamine-Expansion Disorders |
| Spinocerebellar Ataxia Type 7 |
| Transgenic Mouse Models of SCA7 |
| Proteolytic Processing of ataxin-7 |
| Ataxin-7 is a Subunit in SAGA and SAGA-Related Histone Acetyltransferase Complexes |
| Chemotherapeutic Options for the Treatment of Polyglutamine-Expansion Disorders |
| Proteomics technologies for the global identification and quantification of proteins / Ian A. Brewis ; P. Brennan |
| Targeted metabolomics and mass spectrometry / E. Dudley ; M. Yousef ; Y. Wang ; W.J. Griffiths |
| Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling / Tatyana Karabencheva ; Christo Christov |
| Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling / Jonathan G. L. Mullins ; Seo-Kyung Chung ; Mark I. Rees |
| Positive and Negative Modulation of Nicotinic Receptors / Hugo R. Arias |
| Sonochemically Born Proteinaceous Micro- and Nanocapsules / Elena D. Vassileva ; Neli S. Koseva |
| Nucleic Acid-Mediated Protein Aggregation and Assembly / Changlin Liu ; Yong Zhang |
| Nucleic Acid-Mediated Aggregation of Amyloid Proteins |
| Nucleic Acid Sequestration to Pathological Tissues |
| Self-Assembly of Protein Nanostructures in the Presence of Nucleic Acids |
| Aggregation, Stability, and Formulation of Human Antibody Therapeutics / D. Lowe ; K. Dudgeon ; R. Rouet ; P. Schofield ; L. Jermutus ; D. Christ |
| Expression of Human Monoclonal Antibodies and Antibody Fragments |
| Methods for Analyzing Solubility, Aggregation and Stability of Monoclonal Antibodies |
| Addressing Aggregation and Increasing Stability of Monoclonal Antibodies |
| Lysozyme: A Model Protein for Amyloid Research / Rajaram Swaminathan ; Vijay Kumar Ravi ; Satish Kumar ; Mattaparthi Venkata Satish Kumar ; Nividh Chandra |
| Amyloid and Amyloidosis |
| Human Lysozyme |
| Aggregation of Hen Lysozyme In Vitro |
| Recovery and Purification of Lysozyme from Inclusion Bodies |
| Inhibition of Lysozyme Aggregation |
| Future Perspectives |
| Protein Aggregation in a Membrane Environment / Galyna Gorbenko ; Valeriya Trusova |
| The Role of Electrostatics in Membrane-Mediated Protein Aggregation |
| Hydrophobic Effect as Driving Force for Protein Aggregation |
| Hydrogen-Bonding as Determinant of Protein Aggregation Propensity |
| Experimental Techniques Used to Study Protein Aggregation |
| Concluding Remarks |
| Contactins: Structural Aspects in Relation to Developmental Functionsin Brain Disease / Amila Zuko ; Samuel Bouyain ; Bert Van Der Zwaag ; J. Peter H. Burbach |
| Genetic Implication of Cntn4, Cntn5, and Cntn6 in Neurodevelopment |
| Expression of Contactins During Brain Development |
| Phenotypes in Contactin Null-Mutants |
| Structural Architecture of Contactins |
| Protein-Protein Interactions Mediated by Contactins |
| Final Remarks |
| Engineered Tropoelastin and Elastin-Based Biomaterials / Steven G. Wise ; Suzanne M. Mithieux ; Anthony S. Weiss |
| Introduction / I： |
| Hydrogels / II： |
| Electrospun Materials / III： |
| Material Coating / IV： |
| References |
