| Foreword |
| Why Stem Cell Research? |
| A New Path ? |
| Induced Pluripotent Stem Cells |
| Embryonic Stem Cells |
| Versus Adult Stem Cells |
| 'Stemness': Definitions, Criteria and Standards |
| Introduction to Stem Cells / Part 1： |
| Present Perspective and Future Challenges / 1： |
| Embryonic Stem Cells in Perspective / 2： |
| The Development of Epithelial Stem Cell Concepts / 3： |
| The Advent of Direct Reprogramming / 4： |
| Clinical Translation of Stem Cells / 5： |
| Basic Biology Mechanisms / Part 2： |
| Molecular Basis of Pluripotency / 6： |
| Stem Cell Niches / 7： |
| Mechanisms of Stem Cell Self-Renewal / 8： |
| Cell Cycle Regulators in Stem Cells / 9： |
| Epigenetic Mechanisms of Cellular Memory / 10： |
| Cell Fusion and the Differentiated State / 11： |
| How Cells Change Their Phenotype / 12： |
| Tissue and Organ Development / Part 3： |
| Differentiation in Early Development / 13： |
| Primordial Germ Cells in Mouse and Human / 14： |
| Stem Cells in Extraembryonic Lineages / 15： |
| Amniotic Fluid Derived Pluripotent Cells / 16： |
| Cord Blood Stem Cells / 17： |
| Neurogenesis in the Vertebrate Embryo / 18： |
| The Nervous System / 19： |
| Neuronal Progenitors in the Adult Brain / 20： |
| Sensory Epithelium of the Eye and Ear / 21： |
| Epithelial Skin Stem Cells / 22： |
| The Ontogeny of the Hematopoietic System / 23： |
| Hematopoietic Stem Cells / 24： |
| Red Blood Cells / 25： |
| Cell Differentiation in the Skeleton / 26： |
| Vascular Progenitor Cells / 27： |
| Multipotent Adult Progenitor Cells / 28： |
| Mesenchymal Stem Cells / 29： |
| Skeletal Muscle Stem Cells / 30： |
| Stem Cells and the Regenerating Heart / 31： |
| Potential of ES Cell Differentiation Culture for Vascular Biology / 32： |
| Cell Lineages and Stem Cells in the Kidney / 33： |
| Adult Liver Stem Cells / 34： |
| Pancreatic Stem Cells / 35： |
| Stem Cells in the Gastrointestinal Tract / 36： |
| Stem Cells in the Lung / 37： |
| Methods / Part 4： |
| Generation of Induced Pluripotent Stem Cells / 38： |
| Characteristics and Characterization of Pluripotent Stem Cells / 39： |
| Isolation and Maintenance of Murine Embryonic Stem Cells / 40： |
| Isolation, Characterization, and Maintenance of Primate ES Cells / 41： |
| Approaches for Derivation and Maintenance of Human ES cells: Detailed Procedures and Alternatives / 42： |
| Derivation and Differentiation of Human EG Cells / 43： |
| Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells / 44： |
| Feeder-Free Culture / 45： |
| Genetic Manipulation of Human Embryonic Stem Cells / 46： |
| Homologous Recombination in Human Embryonic Stem Cells / 47： |
| Surface Antigen Markers / 48： |
| Lineage Marking / 49： |
| Genomic Reprogramming / 50： |
| Isolation and Characterization of Hematopoietic Stem Cells / 51： |
| Microarray Analysis of Stem Cells and Differentiation / 52： |
| Zebrafish and Stem Cell Research / 53： |
| Applications / Part 5： |
| Cancer Stem Cells / 54： |
| Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases / 55： |
| Spinal Cord Injury / 56： |
| Use of Embryonic Stem Cells to Treat Heart Disease / 57： |
| Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes / 58： |
| Burns and Skin Ulcers 978-0-12-370465-8 / 59： |
| Stem Cells and Heart Disease / 60： |
| Stem Cells for the Treatment of Muscular Dystropy / 61： |
| Skin Regeneration / 62： |
| Orthopaedic Applications of Stem Cells / 63： |
| Embryonic Stem Cells in Tissue Engineering / 64： |
| Adult Stem Cells in Tissue Engineering / 65： |
| Stem Cell Gene Therapy / 66： |
| Regulation and Ethics / Part 6： |
| Ethical Considerations / 67： |
| Religious Considerations / 68： |
| Regulatory Considerations / 69： |
| Ití s Not About Curiosity, Ití s About Cures / 70： |
| Epilogue: Concluding Statement |
| Foreword |
| Why Stem Cell Research? |
| A New Path ? |
| Induced Pluripotent Stem Cells |
| Embryonic Stem Cells |
| Versus Adult Stem Cells |
