| Protection Reactions |
| General Considerations |
| Alpha-Amino Protection (Nalpha-Protection) |
| Carboxy Protection |
| Side Chain Protection |
| Photocleavable Protections |
| Conclusion |
| Experimental Section |
| The Huisgen Cycloaddition in Peptidomimetic Chemistry |
| Introduction |
| The Huisgen [2+3] Cycloaddition Between Azides and Acetylenes |
| Mechanistic Consideration for the Cu-Huisgen and Ru-Huisgen Cycloaddition |
| Building Blocks for the Synthesis of Triazole Modified Peptidomimetics |
| Cyclic Triazole Peptidomimetics |
| Acylic Triazole Peptidomimetics |
| Useful Experimental Procedures |
| Recent Advances in Beta-Strand Mimetics |
| Macrocyclic Peptidomimetics |
| Acyclic Compounds |
| Aliphatic and Aromatic Carbocycles |
| Ligands Containing One Ring or Multiple Rings with One Heteroatom (O, S) |
| Ligands Containing One Ring with Two Heteroatoms (N,N) |
| Ligands Containing One Ring with Two Heteroatoms (N,S) or Three Heteroatoms (N,N,S or N,N,N) |
| Ligands Containing Two Rings with One Heteroatom (N or O) |
| Ligands Containing Two Rings with Two or Three Heteroatoms (N,N or N,S or N,N,N) |
| Concluding Remarks |
| Medicinal Chemistry of Alpha-Amino Acids |
| Glutamic Acid |
| Conformational Restriction |
| Bioisosterism |
| Structure-Activity-Studies |
| Medicinal Chemistry of Alicyclic Beta-Amino Acids |
| Five-Membered Alicyclic Beta-Amino Acids |
| Six-Membered Alicyclic Beta-Amino Acids |
| medicinal Chemistry of Alpha-Hydroxy-Beta-Amino Acids |
| Alpha-Hydroxy-Beta-Amino Acids |
| Antibacterial Agents |
| Inhibitors of Aminopeptidases |
| Aspartyl Proteases Inhibitors |
| Paclitaxel and its Derivatives |
| Peptide Drugs |
| Lights and Shades of Peptide and Protein Drugs |
| Peptide Drugs Available on the Market |
| Approved Peptides in Oncology |
| Antimicrobial Peptides |
| Perspectives |
| Oral Bioavailability of Peptide and Peptidomimetic Drugs |
| Fundamental Considerations of Intestinal Absorption |
| Barriers Limiting Oral Peptide/Peptidomimetic Drugs Bioavailability |
| Strategies to Improve Peptide-Based Drugs Oral Bioavailability |
| Conclusions |
| Asymmetric Synthesis of Beta-Lactams Via the Staudinger Reaction |
| The Staudinger Reaction |
| Influence of the Geometry of the Imine on Stereoselectivity in the Reaction |
| Influence of the Polarity of the Solvent on Stereoselectivity of the Reaction |
| Influence of the Isomerization of the Imine Prior to its Nucleophilic Attack onto the Ketene Stereoselectivity in the Reaction |
| Influence of the Order of Addition of the Reactants to the Reaction |
| Influence of Chiral Substituents on the Stereoselectivity of the Reaction |
| Asymmetric Induction from the Imine Component |
| Asymmetric Induction from the Ketene Component |
| Double Asymmetric Cycloinduction |
| Influence of Catalysts on the Stereoselectivity of the Reaction |
| Advances in N- and O-Glycopeptide Synthesis - A Tool to Study Clycosylation and Develop New Therapeutics |
| O-Glycopeptide Synthesis |
| Synthesis of Mucin Type Glycopeptides |
| Synthesis of Tumor-Associated Glycopeptides and Glycopeptide Vaccines |
| Synthesis of Tn, T, sialyl Tn, sialyl T Glycosylated Amino Acid Building Blocks |
| Synthesis of Tn, T, sialyl Tn, sialyl T Glycopeptides and Vaccines |
| Synthesis of Glycopeptide Recognition Domain of P-Selectin Glycoprotein Ligand 1 (PSGL-1) |
| Synthesis of a Core 2 sLe AMino Acid Building Block Including a sLe Mimic |
| Synthesis of Unsulfated and Sulfated Core 2 sLe and Core 2 sLe Mimic PSGL-1 Glycopeptides |
| Chemoenzymatic Synthesis of Unsulphated and Sulphated Sialyl Lewis PSGL-1 Glycopeptide |
| Synthesis of Other Types of O-Glycopeptides |
| Synthesis of Fmoc-GlcNAc-Ser/Thr Amino Acids |
| Synthesis of Estrogene Receptor Peptides for Conformational Analysis |
| Synthesis of N-Glycopeptides |
| Synthesis of Ribonuclease C (RNase C) Glycoprotein |
| Synthesis of Erythropoietin N-Glycopeptide Fragment 1-28 |
| Synthesis of Biantennary Dodecasaccharide |
| Synthesis of N-Glycopeptide Fragment 1-28 |
| Chemoenzymatic Synthesis of a HIV GP120 V3 Domain N-Glycopeptide |
| Synthesis of the Oxazoline Tetrasaccharide Donor |
| Synthesis of Fmoc-GlcNAc-Asn Amino Acid Building Block |
| Synthesis of V3 Cyclic GlcNAc Peptide and Endo A Coupling with Man3GlcNAc Oxazoline Donor |
| Recent Developments in Neoglycopeptide Synthesis |
| Neoglycoside and Neoglycopeptide Synthesis |
| Protein Side-Chain Modifications |
| Cu-Catalyzed Azide-Alkyne "Click" Cycloaddition |
| Cross Metathesis |
| Application of Neoglycopeptides as Synthetic Vaccines |
| Enzymatic, Molecular and Cell Biological Techniques |
| Combinatorial/Library Peptide Synthesis |
| High Throughput Synthesis of Peptides |
| Peptide Libraries |
| Future of Peptide Libraries |
| Synthetic Protocols |
| Protection Reactions |
| General Considerations |
| Alpha-Amino Protection (Nalpha-Protection) |
| Carboxy Protection |
| Side Chain Protection |
| Photocleavable Protections |
電子ブック
Amino Acids, Peptides and Proteins in Organic Chemistry: Origins and Synthesis of Amino Acids
