Phage nanobiotechnology

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Phage nanobiotechnology / edited by Valery A. Petrenko, George P. Smith

資料種別:

図書

出版情報:

Cambridge, UK : RSC Publishing, c2011

形態:

xiv, 273 p. ; 24 cm

シリーズ名:

RSC nanoscience & nanotechnology ; no. 17 <BA76171059>

著者名:

ISBN:

9780854041848 [0854041842] (: hbk.)

書誌ID:

BB09437632

子書誌情報

フルテキスト

所蔵情報

他の版・巻

書誌詳細

ISSN:

17577136

注記:

Includes bibliographical references and index

主題:

Bacteriophages; Biotechnology; Nanotechnology

言語:

英語

目次情報:

The Phage Nanoparticle Toolkit / George P. SmithChapter 1：

Introduction / 1.1：

Virion Structure and Purification / 1.2：

Intrusion / 1.3：

DNA Replication Cycle and Gene Expression / 1.4：

Extrusion of Progeny Virions / 1.5：

Display of Guest Peptides / 1.6：

The Engineer's Toolkit / 1.7：

Acknowledgements

References

The Roles of Structure, Dynamics and Assembly in the Display of Peptides on Filamentous Bacteriophage / Stanley J. OpellaChapter 2：

Molecular and Structural Biology of Filamentous Bacteriophage / 2.1：

Packaging of the Genome into Filamentous Bacteriophage / 2.2：

Structural Form of the Major Coat Protein / 2.3：

Membrane-bound Form of Filamentous Bacteriophage Coat Proteins / 2.4：

Assembly / 2.5：

Phage Display / 2.6：

Conclusion / 2.7：

Quantitative Analysis of Peptide Libraries / Lee MakowskiChapter 3：

Assessing the Quality of a Phage-displayed Library / 3.1：

Peptide Sequence Censorship / 3.2.1：

Experimental Measures / 3.2.2：

Conceptual Measures / 3.2.3：

Quantitative Measures / 3.2.4：

Assessing the Quality of an Affinity Screen Experiment / 3.3：

Change in Diversity / 3.3.1：

Change in Information / 3.3.2：

Identification of Motifs in a Peptide Population / 3.4：

Similarity Matrices / 3.5：

Identification of Binding Sites in Proteins / 3.6：

Identification of Binding Proteins in a Proteome / 3.7：

Relic / 3.8：

Discussion

Phage-mediated Drug Delivery / Valery A. Petrenko ; Prashanth K. JayannaChapter 4：

Targeting of Drugs/Drug Carrier Systems / 4.1：

Targeting Ligands / 4.3：

Phage-displayed Libraries as a Source of Peptide Targeting Ligands / 4.4：

Bacteriophage Capsid-mediated Drug Delivery / 4.5：

Drug-bearing Filamentous Phage as Targeted Chemotherapeutics / 4.6：

Phage Fusion Proteins as Targeting Ligands for Nanomedicines / 4.7：

Imaging with Bacteriophage-derived Probes / Susan L. Deutscher ; Kimberly A. Kelly4.8：

Selection of Bacteriophage as Imaging Probes / 5.1：

Imaging Agents / 5.1.1：

Phage Nanoparticles / 5.1.2：

Phage Display for Imaging Probe Discovery / 5.1.3：

Radiolabled Phage as Imaging Agents / 5.2：

Optical Molecular Imaging with Phage / 5.3：

Phage-based Pathogen Biosensors / Suiqiong Li ; Ramji S. Lakshmanan ; Bryan A. Chin5.4：

Threat of Pathogenic Microorganisms / 6.1：

Pathogen Detection Techniques / 6.1.2：

Current Trends and Existing Methodologies for Pathogen Detection / 6.2：

Conventional Pathogen Detection Techniques / 6.2.1：

Polymerase Chain Reaction (PCR) / 6.2.2：

Enzyme-linked Immunosorbent Assay (ELISA) / 6.2.3：

Biosensor Techniques / 6.2.4：

Biomolecular Recognition Element / 6.2.5：

Whole Filamentous Bacteriophage Particles as a Biorecognition Probe / 6.3：

Phage Immobilization on Biosensor Platforms / 6.3.1：

Current Trends in Development of Phage-based Biosensors / 6.3.2：

Phage-based Magnetoelastic Particle Resonator Biosensors / 6.4：

Magnetoelastic (ME) Particle Resonator Sensor Platform / 6.4.1：

Fabrication of the Sensor Platform / 6.4.2：

ME Biosensor Assembly / 6.4.3：

Performance of Phage-based ME Biosensors / 6.4.4：

Phage-mediated Detection of Biological Threats / Steven Ripp6.5：

Phage Typing Schemes / 7.1：

Exploiting Phage Specificity for Bacterial Detection / 7.3：

Labeled Phage / 7.3.1：

Reprter Phage / 7.3.2：

Phage Amplification / 7.3.3：

Electrochemical-based Sensing Assays / 7.3.4：

Surface Plasmon Resonance-based Sensing Assays / 7.3.5：

The Phage-mediated Adenylate Kinase Assay / 7.3.6：

Genetically Engineered Virulent Phage Banks for the Detection and Control of Bacterial Biosecurity Threats / Francois Iris ; Flqvie Pouillot ; Helene Blois ; Manuel Geo ; Paul-Henri Lampe7.4：

Host Range engineering / 8.1：

Production of a Genetically Engineered T4 Phage Bank with Vastly Increased Host Range / 8.3：

Reversible Inhibition of the T4 Lytic Cycle Within the Bacterial Host / 8.4：

Large-scale Recombinations into the Genomes of an Infective Wild-type T4 Population / 8.5：

Construction of a T4 Bank of Host Range Variants / 8.6：

Conclusion and Perspectives / 8.7：

Methods / 8.9：

High-fidelity PCR / 8.9.1：

Error-prone PCR / 8.9.2：

Selective High-fidelity Amplification of Desired Fragments / 8.9.3：

Reconstruction of Sequence Through PCR / 8.9.4：

DNA Sequencing and Analysis / 8.9.5：

Production and Expression of Non-functional E. coli Rho Genes / 8.9.6：

Construction and Expression of the Heat-inducible Red-Recombinase System / 8.9.7：

Site-directed Chemical Modification of Phage Particles / Lana Saleh ; Christopher J. NorenChapter 9：

Unique Chemical Properties of Selenocysteine Compared with Cysteine / 9.1：

In vivo Incorporation of Sec by E. coli / 9.3：

Construction of Selenopeptide-displayed Phage Libraries / 9.4：

Applications Using Selenopeptide Phage Display / 9.5：

Screening for Sec Insertion in vivo: Investigating the Stringency of E. coli SECIS Requirements Using Phage Display / 9.5.1：

Catalysis-based Selection of Novel Enzyme Activities from Substrate-appended Phage Libraries / 9.5.2：

Mechanical Manipulation of M13 Phage / 9.5.3：

Filamentous Fhage-templated Synthesis and Assembly of Inorganic Nanomaterials / Binrui Cao ; Chuanbin Mao9.6：

Virion Structure and Phage Display / 10.1：

Biology / 10.2.1：

Chemistry / 10.2.2：

Site-specific Engineering of the Virion Surface / 10.2.3：

Liquid Crystalline Behavior / 10.2.4：

Exploiting Phage Display to Alter Surface Chemistry by Selection Rather Than Rational Design225 / 10.3：

Random Peptide Libraries225 / 10.3.1：

Affinity Selection ('Biopanning')226 / 10.3.2：

Synthesis and Assembly of Inorganic Materials on Individual Virions / 10.4：

Synthesis and Assembly of Inorganic Materials on a Self-assembled Phage Scaffold / 10.5：

Applications of Phage-templated Nanomaterials / 10.6：

Summary and Outlook / 10.7：

Phage Vaccines and Phage Therapy / Karen ManoutcharianChapter 11：

Introduction to Phage / 11.1：

Phage Immunogens / 11.2：

Epitope Discovery with Phage Libraries and Phage Vaccines / 11.3：

Autoimmune Disorders / 11.4：

Cancer / 11.5：

Neurological Disorders / 11.6：

Other Diseases / 11.7：

Antibacterial Therapy / 11.8：

Subject Index

The Phage Nanoparticle Toolkit / George P. SmithChapter 1：

Introduction / 1.1：

Virion Structure and Purification / 1.2：

Intrusion / 1.3：

DNA Replication Cycle and Gene Expression / 1.4：

Extrusion of Progeny Virions / 1.5：

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