Antiparasitic and antibacterial drug discovery : from molecular targets to drug candidates

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Antiparasitic and antibacterial drug discovery : from molecular targets to drug candidates / edited by Paul M. Selzer

資料種別:: 図書
出版情報:: [Hoboken, N.J.] : Wiley-Blackwell
Weinheim : Wiley-VCH, c2009
形態:: xx, 489 p. ; 25 cm
シリーズ名:: Drug discovery in infectious diseases / edited by Paul M. Selzer <BB1188044X>
著者名:: Selzer, P. M. (Paul M.)
ISBN:: 9783527323272 [3527323279] (: hardback)
書誌ID:: BB11880461

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注記:

Includes bibliographical references and index

主題:

Communicable diseases--Chemotherapy

言語:

英語

目次情報:

Foreword

Preface

List of Contributors

Drug Discovery Approaches / Part 1：

Target Identification and Mechanism-Based Screening for Anthelmintics: Application of Veterinary Antiparasitic Research Programs to Search for New Antiparasitic Drugs for Human Indications / Timothy G. Geary ; Debra J. Woods ; Tracey Williams ; Solomon Nwaka1：

Anthelmintic Resistance as a Guide to the Discovery of New Drugs? / Georg v. Samson-Himmelstjerna ; Roger K. Prichard ; Adrian J. Wolstenholme2：

Drug Discovery for Neglected Diseases: View of A Public-Private Partnership / Rob Don ; Eric Chatelain3：

Bioinformatics and Chemoinformatics: Key Technologies in the Drug Discovery Process / Andreas Krasky ; Andreas Rohwer ; Richard J. MarhÃ¶fer ; Paul M. Selzer4：

Target Identification and Validation in Antiparasitic Drug Discovery / Christian Wolf ; Nikolas Gunkel5：

Selective Drug Targets in Parasites / Peter KÃ¶hler6：

Lessons Learned from Target-Based Lead Discovery / Michael Gassel ; JÃ¶rg Cramer ; Christopher Kern ; Sandra Noack ; Wolfgang Streber7：

Approaches Towards Antiparasitic Drug Candidates for Veterinary Use / Christophe Chassaing ; Harald Sekljic8：

Learning to Relate Structural Space to Property Space / Michael Berger ; Michael Hinz ; Christina Mertens ; Christian Miculka ; Trevor Newton ; JÃ¶rg SchrÃ¶der9：

Recruiting the Host Defense Mechanisms: Roles for Vaccines and Chemotherapeutics / Theo P.M. Schetters10：

Protozoan Parasites / Part 2：

Proteases of Parasitic Protozoa - Current Status and Validation / Mohammed Sajid ; Michael J. Blackman ; Patricia Doyle ; Chen He ; Kirkwood M. Land ; Cheryl Lobo ; Zachary Mackey ; Momar Ndao ; Sharon L. Reed ; Brian Shiels ; Ryan Swenerton ; William Weir11：

In Search of Trypanocidal Drugs / Leopold FlohÃ©12：

Trypanosomatid Protein Kinases As Potential Drug Targets / Martin Wiese ; Andrew Morris ; Karen M. Grant13：

Targeting the Malaria Kinome: Discovering Kinase Inhibitors as Novel Antimalarial Agents / Dayadevi Jirage ; Susan M. Keenan ; Norman C. Waters14：

Malaria and Antimalarials - a Focused View / Frank Seeber15：

Multicellular Parasites / Part 3：

Chemotherapeutic Development Strategies for Schistosomiasis / Conor R. Caffrey ; David L. Williams ; Matthew H. Todd ; David L. Nelson ; Jennifer Keiser ; JÃ¼rg Utzinger16：

Searching New Antiparasitics in Virtual Space / Frank Oellien ; Kristin Engels17：

Cyclooctadepsipeptides - an Anthelmintically Active Class of Compounds Exhibiting a Novel Mode of Action / Achim Harder ; Kathryn Bull ; Marcus Guest ; Lindy Holden-Dye ; Robert Walker18：

Chemical Optimization of Anthelmintic Compounds - A Case Study / Thorsten Meyer ; Manfred Uphoff ; Anja R. Heckeroth ; Petra Rohrwild ; Thomas Ilg19：

Bacteria / Part 4：

Pathogenomics: Identification of Novel Drug Targets and Vaccine Candidates in Bacteria / Knut Ohlsen ; Martin Eckart ; Ulrich Dobrindt ; Heike Bruhn ; JÃ¶rg Hacker20：

Decreasing the Number of Gaps in the Draft Assembly of the Mannheimia haemolytica M7/2 Genome Sequence / Hon Q. Tran ; Mathias Beig ; Volker Spehr ; Gottfried Unden22：

Total Synthesis and Configurational Assignment of Pasteurestin A and B, a Natural Product with Antimicrobial Activity on Pasteurellaceae / Marion KÃ¶gl ; Lothar Brecker ; Ralf Warrass ; Johann Mulzer23：

Index

Foreword

Preface

List of Contributors

Drug Discovery Approaches / Part 1：

Anthelmintic Resistance as a Guide to the Discovery of New Drugs? / Georg v. Samson-Himmelstjerna ; Roger K. Prichard ; Adrian J. Wolstenholme2：

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