DNA microarray technology and data analysis in cancer research

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DNA microarray technology and data analysis in cancer research / Shaoguang Li, Dongguang Li

資料種別:

図書

出版情報:

Hackensack, N.J. : World Scientific, c2008

形態:

xi, 118 p. ; 24 cm

著者名:

ISBN:

9789812790453 [9812790454]

書誌ID:

BB15460559

子書誌情報

フルテキスト

所蔵情報

他の版・巻

書誌詳細

注記:

Includes bibliographical references (p. 105-115) and index

主題:

Cancer cells--Growth--Regulation; DNA microarrays

言語:

英語

目次情報:

Preface

Introduction of Authors

DNA Microarray Technology / Chapter 1：

Experimental Procedure / 1.1：

Experimental Design / 1.2：

Quality Control / 1.3：

Interpretation of DNA Microarray Data / 1.4：

Advantages and Disadvantages / 1.5：

Applications of DNA Microarray Technology in Cancer Research / Chapter 2：

Solid Tumors / 2.1：

Blood Cancers / 2.2：

Our DNA Microarray Study Using Mouse Model of BCR-ABL-Induced Leukemia / 2.3：

Leukemia mouse model study / 2.3.1：

Cell line study / 2.3.2：

Current Analytical Methods of DNA Microarray Data / Chapter 3：

Method / 3.1：

Robust multi-chip averaging (RMA) / 3.2.1：

iterPLIER / 3.2.2：

Quality Control Diagnostics / 3.3：

Saturation / 3.3.1：

Transformed intensities across arrays / 3.3.2：

Normalized intensities across arrays / 3.3.3：

Scatterplot of normalized intensities / 3.3.4：

Average MA plot of normalized intensities / 3.3.5：

Statistical Analysis / 3.4：

Analysis of variance (ANOVA) model / 3.4.1：

Contrasts / 3.4.2：

Coefficient of Variation Analysis / 3.5：

A Novel Method for DNA Microarray Data Analysis: SDL Global Optimization Method / Chapter 4：

Research Subjects / 4.1：

Rationale / 4.2：

Fold Change Analysis / 4.3：

More Information on SDL Global Optimization / 4.4：

Genetic algorithms (GAs) / 4.4.1：

SDL global optimization algorithms / 4.4.2：

Applications of the SDL Global Optimization Method in DNA Microarray Data Analysis / Chapter 5：

Leukemia Cell Line Study / 5.1：

Introduction / 5.1.1：

Datasets / 5.1.2：

Analysis strategies / 5.1.3：

Discussion and conclusion / 5.1.4：

Analyses of Publicly Available Human Microarray Data / 5.2：

Overall Methodology / 5.2.1：

Orthogonal arrays (OAs) and sampling procedure / 5.3.1：

Objective function / 5.3.2：

Search space reduction for global search / 5.3.3：

Mathematical form of SDL optimization / 5.3.4：

Multi-subset class predictor / 5.3.5：

Validation (predicting through a voting mechanism) / 5.3.6：

Experimental Results / 5.4：

Discussion / 5.5：

Conclusion / 5.6：

General Discussion and Future Directions / Chapter 6：

References

Index

Preface

Introduction of Authors

DNA Microarray Technology / Chapter 1：

Experimental Procedure / 1.1：

Experimental Design / 1.2：

Quality Control / 1.3：

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