Genome Chaos : Rethinking Genetics, Evolution, and Molecular Medicine

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Genome Chaos : Rethinking Genetics, Evolution, and Molecular Medicine / Henry H. Heng

資料種別:: 電子ブック
出版情報:: Elsevier ScienceDirect Books Complete
Academic Press, 2019
著者名:: Heng, Henry H.
ISBN:: 9780128136355 [0128136359]
9780128136362 [0128136367]
書誌ID:: OB00519444

子書誌情報

フルテキスト

所蔵情報

書誌詳細

言語:

英語

目次情報:

Preface

Acknowledgments

From Mendelian Genetics to 4D Genomics / 1：

Summary / 1.1：

The Emergence of Genomics / 1.2：

Diminishing Power of Gene-Based Genomics / 1.3：

New Genomic Science on the Horizon / 1.4：

Genes and Genomes Represent Different Biological Entities / 2：

The Definition of the Genome / 2.1：

"Parts Versus the Whole": The Emergent Relationship (Which Challenges Reductionism) / 2.3：

ReExamining Gene Theory Predictions / 2.4：

The Conflicting Relationship Between the Gene and the Genome / 2.5：

Genome Context Determines Gene Function / 2.6：

Action Needed / 2.7：

Genome Chaos and Macrocellular Evolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer / 3：

SOS: We Need a New Conceptual Framework for Cancer Research / 3.1：

Genome Chaos: Rediscovery of the Importance of the Karyotype in Cancer / 3.3：

A New Genomic Model for Cancer Evolution / 3.4：

Chromosomal Coding and Fuzzy Inheritance: The Genomic Basis of Bio-information and Heterogeneity / 4：

Chromosomal or Karyotype Coding / 4.1：

Fuzzy Inheritance / 4.3：

Overlooked Genome Variations / 4.4：

Why Sex? Genome Reinterpretation Dethrones the Queen / 5：

What Is the Purpose of Sex? The Answer Is Not Obvious / 5.1：

Surprise! Asexual Reproduction Does Not Generate Clonal Progenitors! / 5.3：

The Search for the Main Function and Common Mechanism of Sex / 5.4：

The Battle Is On: Changing Concepts / 5.5：

Simulation: Ask the Simplest Question About the Function of Sex / 5.6：

Case Studies: Reinterpretation Using New Framework / 5.7：

Lessons Learned / 5.8：

Breaking the Genome Constraint: The Mechanism of Macroevolution / 6：

Pattern of Cellular Evolution Challenges Current Evolutionary Theory / 6.1：

Artificial Selection and Natural Selection Are Fundamentally Different / 6.3：

Both Isolated Cases and Isolated Natural Environments Represent Exceptions That Fail to Demonstrate the Relationship Between Micro- and Macroevolution / 6.4：

Maintaining Genome Integrity: The Major Evolutionary Constraint / 6.5：

Implications of Genome Theory to Evolutionary Concepts / 6.6：

Evolution Is True but Its Mechanism Must Be Reexamined / 6.7：

Implications: Creating Artificial Species by Shattering the Genome Followed by Artificial Mating/Genome Selection / 6.8：

The Genome Theory: A New Framework / 7：

The Rationale for Establishing a Genome-Based Genomic Theory / 7.1：

Unique Considerations for Genome Theory / 7.3：

Outline of the Genome Theory / 7.4：

The Predictions, Implications, Limitations, and Falsifiability of the Genome Theory / 7.5：

Challenges Ahead / 7.6：

The Rationale and Challenges of Molecular Medicine / 8：

A Brief History: The Promises of Molecular Medicine / 8.1：

The Challenges and Opportunities for Precision Medicine / 8.3：

Future Direction / 8.4：

Epilogue (or Why We Did What We Did)

Bibliography

Index

Preface

Acknowledgments

From Mendelian Genetics to 4D Genomics / 1：

Summary / 1.1：

The Emergence of Genomics / 1.2：

Diminishing Power of Gene-Based Genomics / 1.3：

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