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図書
edited by Sabine Szunerits, Rabah Boukherroub
出版情報: Singapore : Pan Stanford Publishing, c2015  xix, 358 p. ; 24 cm
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Foreword
Preface
Propagating Surface Plasmon Polaritons / Atef Shalabney1:
Introduction / 1.1:
Surface Plasmons on Smooth Surfaces / 1.2:
Surface Plasmon at Single Interface / 1.2.1:
Surface Plasmon in Multilayer Systems / 1.2.2:
Electromagnetic Energy Confinement and Field Enhancement / 1.2.3:
Excitation of Surface Plasmon Polaritons / 1.2.4:
Applications / 1.3:
Surface Plasmon Resonance-Based Sensors / 1.3.1:
Enhanced Spectroscopy and Emissive Processes / 1.3.2:
Concluding Remarks / 1.4:
Different Strategies for Glycan Immobilization onto Plasmonic Interfaces / Sabine Szunerits ; Rabah Boukherroub2:
Carboxymethylated Dextran Layers: The BiAcore Chip / 2.1:
Self-Assembled Monolayers Based on Thiolated Functional Groups / 2.3:
Polymer Films / 2.4:
Lamellar SPR Structures / 2.5:
Conclusion
Biophysics of DNA: DNA Melting Curve Analysis with Surface Plasmon Resonance Imaging / Arnaud Buhot ; Julia Pingel ; Jean-Bernard Fiche ; Roberto Calemczuk ; Thierry Livache3:
Temperature Regulation of SPRi for DNA Melting Curves Analysis / 3.1:
SPRi Apparatus with Temperature Regulation / 3.2.1:
Equilibrium versus Out-of-Equilibrium Melting Curves / 3.2.2:
Stability of Grafting Chemistries at High Temperatures / 3.2.3:
Electro-copolymerization of poly-pyrrole / 3.2.3.1:
Thiol self-assembling monolayer / 3.2.3.2:
Physico-Chemistry of DNA Melting at a Surface / 3.3:
Effects of Denaturant Molecules / 3.3.1:
Effects of Salt Concentration / 3.3.2:
Detection of Single Point Mutation from Melting Curve Analysis / 3.4:
Detection with Oligonucleotides Targets / 3.4.1:
Detection Limit of Somatic Mutations / 3.4.2:
Homozygous and Heterozygous Detection of PCR Products / 3.4.3:
Plasmon Waveguide Resonance Spectroscopy: Principles and Applications in Studies of Molecular Interactions within Membranes / Isabel D. Alves3.5:
Plasmon Spectroscopy / 4.1:
Description of Surface Plasmons / 4.2.1:
Types of Surface Plasmon Resonances / 4.2.2:
Conventional surface plasmon resonance / 4.2.2.1:
Plasmon-waveguide resonance / 4.2.2.2:
PWR Spectral Analysis / 4.2.3:
PWR Applications / 4.3:
Lipid Bilayers / 4.3.1:
Solid-supported lipid bilayers / 4.3.1.1:
Membranes composed of cellular membrane fragments / 4.3.1.2:
GPCR Insertion into Membranes, Activation and Signaling / 4.3.2:
Role of Lipids in GPCR Activation, Signaling, and Partition into Membrane Microdomains / 4.3.3:
Interaction of Membrane Active Peptides with Lipid Membranes / 4.3.4:
PWR Ongoing Developments / 4.4:
Surface-Wave Enhanced Biosensing / Wolfgang Knoll ; Amal Kasry ; Chun-Jen Huang ; Yi Wang ; Jakub Dostalek5:
Surface Plasmon Field-Enhanced Fluorescence Detection / 5.1:
Long-Range Surface Plasmon Fluorescence Spectroscopy / 5.3:
Optical Waveguide Fluorescence Spectroscopy / 5.4:
Conclusions / 5.5:
Infrared Surface Plasmon Resonance / Stefan Franzen ; Mark Losego ; Misun Kang ; Edward Sachet ; Jon-Paul Maria6:
The Hypothesis That Surface Plasmon Resonance Will Be Observed in Free Electron Conductors / 6.1:
Confirmation of the Hypothesis That Conducting Metal Oxides Can Support Surface Plasmon Resonance / 6.3:
The Effect of Carrier Concentration / 6.4:
The Effect of Mobility / 6.5:
Hybrid Plasmons: Understanding the Relationship between Localized LSPR and SPR / 6.6:
The Effect of Materials Properties on the Observed Surface Plasmon Polaritons / 6.7:
Detection of Mid-Infrared Surface Plasmon Polaritons / 6.8:
The Search for High Mobility Conducting Metal Oxides / 6.9:
The Unique Characteristics of Localized Surface Plasmon Resonance / Gaetan Leveque ; Abdellatif Akjouj6.10:
Localized Surface Plasmon Resonance of a Single Particle / 7.1:
Single Particle in the Quasi-Static Approximation / 7.1.1:
Case of the spherical particle / 7.1.1.1:
Case of the spheroidal particle / 7.1.1.2:
Beyond the Quasi-Static Approximation / 7.1.2:
Examples of Coupled Plasmonic Systems / 7.2:
Chain of Identical Particles / 7.2.1:
Chain of Different Particles / 7.2.2:
Localized Surface Plasmon for a Periodic Nano structure / 7.3:
Model and Simulation Method / 7.3.1:
Absorption Spectra for Au Nano structures Array / 7.3.2:
Influence of the Thickness of a Diamond Dielectric Overlayer on the LSPR / 7.3.3:
Advances in the Fabrication of Plasmonic Nanostructures: Plasmonics Going Down to the IManoscale / Thomas Maurer7.3.4:
Top-Down Techniques: A Mask-Based Process / 8.1:
Conventional Lithography Techniques: Photolithography and Particle Beam Lithography / 8.2.1:
Photolithography / 8.2.1.1:
Particle beam lithography / 8.2.1.2:
Advanced Lithography Techniques: Masks Coming from Researcher Imagination / 8.2.2:
Multilevel laser interference lithography / 8.2.2.1:
Nanostencil lithography / 8.2.2.2:
Self-assembly techniques for mask fabrication: nanosphere lithorgaphy and block copolymer lithography / 8.2.2.3:
Direct Writing / 8.2.3:
Particle beam-induced etching and particle beam-induced deposition / 8.2.3.1:
Laser ablation / 8.2.3.2:
3D laser lithography / 8.2.3.3:
Printing, Replica Molding and Embossing / 8.2.4:
Printing / 8.2.4.1:
Replica molding / 8.2.4.2:
Embossing / 8.2.4.3:
Conclusion about the Top-Down Strategy / 8.2.5:
Bottom-Up Techniques: Atom by Atom Building / 8.3:
The Bottom-Up Strategy / 8.3.1:
Physical route / 8.3.1.1:
Electrochemical route / 8.3.1.2:
Chemical route / 8.3.1.3:
Self-Organization, the Next Challenge of Plasmonics / 8.3.2:
Laboratory self-assembly techniques / 8.3.2.1:
Mass Production Using Wet Coating Processes / 8.3.3:
Mixing Top-Down and Bottom-Up Routes / 8.4:
Porous Membranes for Ordered Nanowires Growth / 8.4.1:
Copolymer Template Control of Plasmonic Nanoparticle Synthesis via Thermal Annealing / 8.4.2:
Let's Play Your Imagination / 8.4.3:
Conclusion: First, Choose Materials / 8.5:
Colorimetric Sensing Based on Metallic Nanostructures / Daniel Aili ; Borja Sepulveda9:
Introduction and Historical Perspective / 9.1:
Synthesis of Gold Nanoparticles / 9.2:
Optical Properties of Gold Nanoparticles / 9.3:
Colloidal Stability and Surface Chemistry of Gold Nanoparticles / 9.4:
Surface Functionalization / 9.4.1:
Molecular Recognition for Modulation of Nanoparticle Stability / 9.5:
Cross-Linking Assays / 9.5.1:
Redispersion Assays / 9.5.2:
Non-Cross-Linking Assays / 9.5.3:
Outlook and Challenges / 9.6:
Assays with Reversed Sensitivity and Plasmonic ELISA / 9.6.1:
Assays for the Future / 9.6.2:
Surface-Enhanced Raman Scattering: Principles and Applications for Single-Molecule Detection / Diego P. dos Santos ; Marcia I. A. Temperini ; Alexandre G. Brolo10:
Raman Scattering / 10.1:
SERS / 10.3:
SERS Substrates / 10.4:
Single-Molecule SERS / 10.5:
Graphene-Based Plasmonics / Sinan Balci ; Emre Ozan Polat ; Coskun Kocabas10.6:
Introduction: Plasmons in Reduced Dimensions / 11.1:
Optical Properties of Graphene / 11.2:
Synthesis of Graphene / 11.3:
Plasma Oscillations on Graphene-Metal Surface / 11.4:
Graphene Functionalized SPR Sensors / 11.5:
Graphene Passivation for SPR Sensors / 11.6:
Biomolecular Detection Using Graphene Functionalized SPR Sensors / 11.7:
Graphene Oxide Functionalization / 11.8:
Gate-Tunable Graphene Plasmonics / 11.9:
SPR: An Industrial Point of View / Iban Larroulet11.10:
Companies / 12.1:
Future Trends / 12.3:
Index
Foreword
Preface
Propagating Surface Plasmon Polaritons / Atef Shalabney1:
2.

図書

図書
edited by Zhongwei Gu
出版情報: Weinheim : Wiley-VCH, c2015  xxi, 337 p. ; 25 cm
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List of Contributors
Preface
Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics / Jiyuan Yang ; Jindrich Kopecek1:
Introduction / 1.1:
Water-Soluble Polymers as Carriers of Anticancer Drugs / 1.2:
First Generation Conjugates - Design, Synthesis, and Activity / 1.2.1:
Analysis of Design Factors That Need Attention / 1.2.2:
Design of Conjugates for the Treatment of Noncancerous Diseases / 1.2.2.1:
Combination Therapy Using Polymer-Bound Therapeutics / 1.2.2.2:
New Targeting Strategies / 1.2.2.3:
Relationship Between Detailed Structure of the Conjugates and Their Properties / 1.2.2.4:
Impact of Binding a Drug to a Polymer on the Mechanism of Action / 1.2.2.5:
Mechanism of Internalization and Subcellular Trafficking / 1.2.2.6:
Relationship Between the Molecular Weight of the Carrier and the Efficacy of the Conjugate / 1.2.2.7:
Design of Second Generation Conjugates - Long-Circulating and Backbone Degradable / 1.2.3:
RAFT Copolymerization for the Synthesis of Conjugates / 1.2.3.1:
Click Reactions for Chain Extension into Multiblock Copolymers / 1.2.3.2:
Biological Properties of Long-Circulating Macromolecular Therapeutics / 1.2.3.3:
Summary of Part 2 and Future Prospects / 1.2.4:
Drug-Free Macromolecular Therapeutics - A New Paradigm in Drug Delivery / 1.3:
Biorecognition in Hybrid Polymer Systems / 1.3.1:
Coiled-Coils in Biomedical Systems / 1.3.2:
Coiled-Coil Based Drug-Free Macromolecular Therapeutics: Design, In Vitro, and In Vivo Activity / 1.3.3:
Potential, Limitations, and Future Prospect of Drug-Free Macromolecular Therapeutics / 1.3.4:
General Summary and Outlook / 1.4:
Acknowledgments
References
Dendritic Polymers as Targeting Nanoscale Drug Delivery Systems for Cancer Therapy / Kui Luo ; Zhongwei Gu2:
Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect / 2.1:
Functional Dendritic Polymers for Encapsulation of Anticancer Drugs / 2.2.1:
Chemical Conjugation Functional Dendritic Polymers as Drug Delivery Systems / 2.2.2:
Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy / 2.3:
Conclusion / 2.4:
Composite Colloidal Nanosystems for Targeted Delivery and Sensing / Pilar Rivera Gil ; Moritz Nazarenus ; Wolfgang J. Parak3:
Working Toolkit / 3.1:
Engineering a Multifunctional Carrier / 3.1.2:
Objective / 3.2:
Cellular Behavior of the Carrier / 3.3:
Intracellular Fate / 3.3.1:
Biocompatibility / 3.3.2:
Applications / 3.4:
Delivery with Multifunctional PEM Capsules / 3.4.1:
Magnetic Targeting and Magnetofection / 3.4.1.1:
Strategies for Controlled Opening / 3.4.1.2:
Intracellular Ion Sensing / 3.4.2:
Conclusions / 3.5:
Abbreviations
Polymeric Micelles for Cancer-Targeted Drug Delivery / Huabing Chen ; Zhishen Ge ; Kazunori Kataoka4:
Micelle Formulations in Clinical Development / 4.1:
Particle Size of Micelles / 4.3:
Morphology of Micelles / 4.4:
Targeting Design of Micelles for Enhanced Accumulation and Cell Internalization / 4.5:
Functional Designs of Micelles / 4.6:
Design of Micelles for Gene Delivery / 4.7:
Challenge and Future Perspective 103 / 4.8:
Biomimetic Polymers for in Vivo Drug Delivery / Wenping Wang ; Kinam Park5:
Commonly Used Biomimetic Polymers and Their Applications in DDS / 5.1:
Polylactones and Their Modifications / 5.2.1:
Poly(lactic acid) (PLA) / 5.2.1.1:
Poly(lactic-co-glycolic acid) (PLGA) / 5.2.1.2:
Poly(ε-caprolactone) (PCL) / 5.2.1.3:
Dendrimer / 5.2.2:
Structure and Properties of Dendrimers / 5.2.2.1:
Types of Dendrimers / 5.2.2.2:
Applications of Dendrimers as Carriers in Drug Delivery Systems / 5.2.2.3:
Synthetic Polypeptides / 5.2.3:
Challenges and Perspectives / 5.3:
Drug Delivery from Protein-Based Nanoparticles / Dan Ding ; Xiqun Jiang6:
Preparation of Protein-Based Nanoparticles / 6.1:
Desolvation / 6.2.1:
Emulsification / 6.2.2:
Coacervation / 6.2.3:
Polymer-Monomer Pair Reaction System / 6.2.4:
Drug Delivery from Albumin-Based Nanoparticles / 6.3:
Albumin-Based Nanoparticles as Drug Carriers / 6.3.1:
Targeting Ligand-Functionalized Albumin-Based Nanoparticles / 6.3.2:
Nanoparticle Albumin-Bound (nab) Technology / 6.3.3:
Drug Delivery from Gelatin-Based Nanoparticles / 6.4:
Gelatin-Based Nanoparticles as Drug Carriers / 6.4.1:
Targeting Ligand-Functionalized Gelatin-Based Nanoparticles / 6.4.2:
Site-Specific Drug Delivery System / 6.4.3:
Drug Delivery from Other Protein-Based Nanoparticles / 6.5:
Polymeic Gene Carriers / Xuesi Chen ; Huayu Tian ; Xiuwen Guan7:
Gene Therapy and Gene Carriers / 7.1:
Gene Therapy / 7.1.1:
The Concept of Gene Therapy / 7.1.1.1:
Development and the Present Situation of Gene Therapy / 7.1.1.2:
Methods and Strategies of Gene Therapy / 7.1.1.3:
Research Contents and Challenges of Gene Therapy / 7.1.1.4:
Gene Carriers / 7.1.2:
The Concept of Gene Carrier / 7.1.2.1:
The Necessity of the Gene Carrier / 7.1.2.2:
Requirements of Gene Carrier / 7.1.2.3:
Classification of Gene Carrier / 7.1.2.4:
Polymeric Gene Carriers / 7.2:
Cationic Polymer Gene Carriers / 7.2.1:
Process of the Polycation Vector Mediated Gene Delivery / 7.2.1.1:
Categories and Research Situation of the Cationic Polymer Gene Vector / 7.2.1.2:
PEI Grafting Modification Polymeric Gene Carriers / 7.3:
Amino Acid Derivatives Modified Polymeric Gene Carriers / 7.3.1:
Poly(glutamic acid) Derivatives Modified PEI / 7.3.1.1:
Polyphenyialanine Derivatives Modified PEI / 7.3.1.2:
PEG Modified Hyperbranched PEI / 7.3.2:
Low Molecular Weight (LWM) PEI Base Polymeric Gene Carriers / 7.4:
Crosslinked Polycations / 7.4.1:
Crosslinlced Polycation OEI-CBA / 7.4.1.1:
Crosslinked Polycation OEI-PBLG-PEGDA / 7.4.1.2:
Hexachlorotriphosphazene Crosslinked Polycation / 7.4.1.3:
Grafted Polycations / 7.4.2:
Grafted Cationic Polymer MP-g-OEI / 7.4.2.1:
Graft Cationic Polymer N-PAE-g-OEI / 7.4.2.2:
Graft Cationic Polymer mPEGT-PMCC-g-OEI / 7.4.2.3:
Targeted Shielding System for Polymeric Gene Carriers / 7.5:
Static Shielding System / 7.5.1:
Poly(glutamine acid) Shielding System and PEGylations / 7.5.1.1:
Sulfonamides Related Shielding System / 7.5.1.2:
Other Design Strategies of Cationic Gene Carrier / 7.5.2:
pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging / Yi Li ; Guang Hui Gao ; Ick Chan Kwon ; Doo Sung Lee7.6:
pH-Sensitive Polymers / 8.1:
pH-Sensitive Anionic Polymers / 8.2.1:
pH-Sensitive Cationic Polymers / 8.2.2:
pH-Sensitive Neutral Polymers / 8.2.3:
pH-Sensitive Polymers as Drug Carriers / 8.3:
pH-Sensitive Polymer-Drug Conjugates / 8.3.1:
pH-Sensitive Polymeric Micelles / 8.3.2:
pH-Sensitive Polymersomes / 8.3.3:
pH-Sensitive Polymer-Inorganic Hybrid Nanoparticles / 8.3.4:
pH-Sensitive Dendrimers / 8.3.5:
pH-Sensitive Polymers for Bioimaging / 8.4:
Charge-Reversal Polymers for Biodelivery / Bo Zhan ; Kai Wang ; Jingxing Si ; Meihua Sui ; Youqing Shen8.5:
Applications of Cationic Polymers in Biodelivery / 9.1:
Barriers for Cationic Polymers in In vitro and In vivo Applications / 9.2:
Characteristic pH Gradients in Tumor Interstitium and Endo/Lyso somes / 9.3:
Chemistry of Charge-Reversal Polymers Based on Acid-Labile Amides / 9.4:
pHe-Triggered Charge-Reversal / 9.4.1:
pHL-Triggered Charge-Reversal / 9.4.2:
Applications of Charge-Reversal Polymers in Biodelivery Systems / 9.5:
Charge-Reversal in Cancer Drug Delivery / 9.5.1:
Charge-Reversal in Gene Delivery / 9.5.2:
Charge-Reversal in Protein Delivery / 9.5.3:
Charge-Reversal Incorporated with Inorganic Materials / 9.5.4:
Perspectives / 9.6:
Phenylbaronic Acid-Containing Glucose-Responsive Polymer Materials: Synthesis and Applications in Drug Delivery / Rujiang Ma ; Linqi Shi10:
PBA-Containing Polymers Operating Under Physiological Conditions / 10.1:
Chemically Crosslinked PBA-Based Gels / 10.3:
Self-Assembled PBA-Based Polymer Micelles / 10.4:
Self-Assembled PBA-Based Polymersomes / 10.5:
Extracellular pH-Activated Nanocarriers for Enhanced Drug Delivery to Tumors / You-Yong Yuan ; Cheng-Qiong Mao ; Jin-Zhi Du ; Xian-Zhu Yang ; Jun Wang10.6:
Passive and Active Tumor Targeting / 11.1:
Targeting the Extracellular pH (pHe) in Tumors / 11.3:
Extracellular pH-Induced Drug Delivery to Tumors / 11.4:
Ligand Exposure by a Shielding/Deshielding Method / 11.5:
Surface Charge Reversing Nanoparticles / 11.6:
Enhanced Cellular Uptake by Surface Charge Reversing Nanoparticles / 11.6.1:
Overcoming MDR by Surface Charge Reversing Nanoparticles / 11.6.2:
Enhanced Delivery of siRNA by Surface-Charge Reversing Nanoparticles / 11.6.3:
Stimulation-Sensitive Drug Delivery Systems / Xintao Shuai ; Du Cheng11.7:
pH-Sensitive Delivery Systems / 12.1:
pH-Sensitive Micellar Delivery Systems / 12.2.1:
pH-Sensitive Liposomes / 12.2.2:
Thermo-Sensitive Delivery Systems / 12.3:
Biomolecule-Sensitive Delivery Systems / 12.4:
Enzyme-Sensitive Nanocarriers / 12.4.1:
Reduction-Responsive Conjugates / 12.4.2:
Other Environmentally Sensitive Nanocarriers / 12.5:
Outlook / 12.6:
Index
List of Contributors
Preface
Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics / Jiyuan Yang ; Jindrich Kopecek1:
3.

図書

図書
edited by Ben M. Dunn
出版情報: Hoboken, N.J. : Wiley, c2015  xvi, 318 p., [8] p. of colored plates ; 25 cm
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Preface
List of Contributors
Peptide Therapeutics / Nader Fotouhi1:
History of Peptides as Drugs / 1.1:
Factors Limiting the Use of Peptides in the Clinic / 1.2:
Advances that have Stimulated the Use of Peptides as Drugs / 1.3:
Development of Peptide Libraries / 1.4:
Modification of Peptides to Promote Stability and Cell Entry / 1.5:
Targeting Peptides to Specific Cells / 1.6:
Formulations to Improve Peoperties / 1.7:
References
Methods for the Peptide Synthesis and Analysis / Judit Tulla-Puche ; Ayman El-Faham ; Athanassios S. Galanis ; Eliandre de Oliveira ; Aikaterini A. Zompra ; Fernando Albericio2:
Introduction / 2.1:
Solid Supports / 2.2:
Linkers / 2.3:
Protecting Groups / 2.4:
The Special Case of Cysteine / 2.4.1:
Methods for Peptide Bond Formation / 2.5:
Peptide-Bond Formation from Carbodiimide-Mediated Reactions / 2.5.1:
Peptide-Bond Formation from Preformed Symmetric Anhydrides / 2.5.2:
Peptide-Bond Formation from Acid Halides / 2.5.3:
Peptide-Bond Formatiion from Phosphonium Salt-Mediated Reactions / 2.5.4:
Peptide-Bond Formation from Aminium/Uronium Salt-Mediated Reactions / 2.5.5:
Solid-Phase Stepwise Synthesis / 2.6:
Long Peptides / 2.6.1:
Synthesis in Solution / 2.7:
Nα Protection of the N-Terminal Amino Acid Derivative or Fragment / 2.7.1:
Carboxy-Group Protection of the C-terminal Amino-Acid Derivative or Fragment / 2.7.2:
Peptide Bond Formation / 2.7.3:
Hybrid Synthesis-Combination of Solid and Solution Synthesis / 2.8:
Classical Segment Condensation / 2.8.1:
Native Chemical Ligation / 2.8.2:
Cyclic Peptides / 2.9:
Depsipeptides / 2.10:
Separation and Purification of Peptides / 2.11:
Gel-Filtration Chromatography / 2.11.1:
Ion-Exchange Chromatography / 2.11.2:
Reverse-Phase High Performance Liquid Chromatography / 2.11.3:
Characterization of Peptides Through Mass Spectrometry / 2.12:
Ionization Source / 2.12.1:
Mass Analysers / 2.12.2:
Peptide Fragmentation / 2.12.3:
Quantification by MS / 2.12.4:
Conclusions / 2.13:
Acknowledgments
Abbreviations
Peptide Design Strategies for G-Protein Coupled Receptors (GPCRs) / Anamika Singh ; Carrie Haskell-Luevano3:
Classification of GPCRs / 3.1:
Catalog of Peptide-Activated G-Protein Coupled Receptors / 3.3:
Structure of GPCRs: Common Features / 3.4:
Crystal Structures / 3.4.1:
GPCR Activation / 3.5:
Ligand (Peptide) Binding and Receptor Activation / 3.5.1:
Common Structural Changes among GPCRs / 3.5.2:
G-Protein Coupled Intracellular Signaling Pathwayws / 3.5.3:
Structure and Function of Peptide Hormones / 3.6:
Design Approaches for GPCR Selective Peptide Ligands / 3.7:
Structure-Activity Relationship (SAR) Studies / 3.7.1:
Chimeric Peptide Analogs / 3.7.2:
Combinatorial Libraries / 3.7.3:
Three-Dimensional (3D) GPCR Homology Molecular Modeling / 3.7.4:
Peptide-Resed Inhibitors of Enzymes / Anna Knapinska ; Sabrina Amar ; Trista K. Robichaud ; Gregg B. Fields3.8:
Angiotensin-Converting Enzyme and Neprilysin/Neutral Endopeptidase / 4.1:
Peptide Inhibitors of the HIV-1 Viral Life Cycle / 4.3:
Matrix Metalloproteinases / 4.4:
Antrax Lethal Factor Inhibition by Defensins / 4.5:
Kinases / 4.6:
Glycosyltransferases (Oligosaccharyltransferases) / 4.7:
Telomerase Inhibitors / 4.8:
Tyrosinase / 4.9:
Peptidyl-Prolyl Isomerase / 4.10:
Histone Modifying Enzymes / 4.11:
Histone Deacetylase / 4.11.1:
Histone Methyl-Transferase / 4.11.2:
Putting it all Together: Peptide Inhibitor Applications in Skin Care / 4.12:
Strategies for the Discovery of Novel Peptide Inhibitors / 4.13:
Discovery of Peptide Drugs as Enzyme Inhibitors and Activators / Jeffrey-Tri Nguyen ; Yoshiaki Kiso5:
Peptide Residue Nomenclature / 5.1:
Common Methods of Drug Design / 5.1.2:
Phases of Drug Development / 5.1.3:
Enzyme Types That Process Peptides / 5.2:
Enzymes as Chemicals in Consumer and Medical Products / 5.2.1:
Nonspecific Enzyme Inhibitors / 5.2.2:
Amino Acid Drugs / 5.3:
Thyroid Hormones / 5.3.1:
An Ornithine Decarboxylase Inhibitor / 5.3.2:
Catecholamines / 5.3.3:
Serine Proteases and Blood Clotting / 5.4:
Blood Coagulating Agents / 5.4.1:
Enzymes as Blood Anticoagulants / 5.4.2:
Direct Thrombin Inhibitors as Blood Anticoagulants / 5.4.3:
Diabetes Mellitus / 5.5:
Peptide Hormones and Blood Glucose Regulation / 5.5.1:
Glucagon-Like Peptide-1 and Analogs / 5.5.2:
Dipeptidyl Peptidase-4 Inhibitors / 5.5.3:
Renin-Angiotensin-Aldosterone System / 5.6:
ACE Inhibitors / 5.6.1:
Renin Inhibitors / 5.6.2:
Penicillin and Cephalosporin Antibiotics / 5.7:
HIV Protease / 5.8:
HIV-Specific Protease Inhibitors / 5.8.1:
Peptide Drugs Under Development / 5.9:
Cathepsins / 5.9.1:
Cysterine Proteases / 5.9.2:
Secretases in Alzheimer's Disease / 5.9.3:
Trypsin-Like Serine Proteases / 5.9.4:
Zinc Metalloproteases / 5.9.5:
Non-Mammalian Proteases / 5.9.6:
Discussion / 5.10:
Discovery of Peptide Drugs from Natural Sources / Sónia T Henriques ; David J Craik6:
Peptides are Involved in the Host Defense Mechanism of Living Organisms / 6.1:
Cationic AMPs from Eukaryotes, Peptides that Target the Membrane / 6.2.1:
Peptides and the Host Defense in Bacteria-Bacteriocins / 6.2.2:
Cyclotides, Ultra-Stable Peptides that are Part of Plant Defense Mechanism / 6.2.3:
Animal Venoms, a Rich Source of Peptides with Therapeutic Potential / 6.3:
Conotoxins, a Naturally Occurring Combinatorial Peptide Library / 6.3.1:
Optimization of Peptides for Drug Development / 6.4:
Chemical Modifications to Improve Activity / 6.4.1:
Modification of Peptides of Limit Metabolism / Isuru R. kumarasinghe ; Victor J. Hruby6.5:
Introduction of Unnatural Amino Acids / 7.1:
Cyclization of Linear Peptides to Improve Stability Toward Blood and Brain Protease Degradation / 7.3:
Introduction of D-Amino Acids into Peptides Improves Stability Toward Blood and Brain Protease Degradation / 7.4:
Introduction of β-Amino Acids Increases the Stability Toward Blood and Brain Protease Degradation / 7.5:
INtroduction of Peptide Bond Isosteres / 7.6:
Introduction of a N-Methylation of the Amide Bond of Peptides can Improve the Stability Toward Blood and Brain Protease Degradation / 7.7:
Use of Unnatural Amino Acids-Use of Topographically Constrained Amino Acid / 7.8:
Using Glycosylated Amino Acids to Increase the Resistance of the Proteolytic Degradation / 7.9:
Creation of Peptides as Multiple Antigen Peptide (MAP) Dendrimeric Forms Increases the Stability Toward Blood and Brain Protease Degradation / 7.10:
Halogenations of Aromatic Residues in Peptides can Reduce the Enzymatic Recognition Required for Peptide Hydrolysis / 7.11:
Concluding Discussion / 7.12:
Delivery of Peptide Drugs / 8:
Lipinski's Rule of Five / 8.1:
Molecular Size / 8.2.1:
Lipophilicity / 8.2.2:
Chemical Stability / 8.2.3:
Routes of Administration / 8.2.4:
Approaches to Delivering Peptide Drugs / 8.3:
Enzyme Inhibitors / 8.3.1:
Permeation Enhancers / 8.3.2:
Delivery of Peptide Drugs across the Blood-Brain Barrier / 8.3.3:
Parenteral Peptide Drugs / 8.4:
Topical Peptide Drugs for Local Effects / 8.5:
Cosmeceutical Peptides / 8.5.1:
Intranasal Peptide Drug Delivery / 8.6:
Enteral Peptide Drugs / 8.7:
DIfferent Routes of Administration for Insulin / 8.8:
Index / 8.9:
Preface
List of Contributors
Peptide Therapeutics / Nader Fotouhi1:
4.

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Kanji Text Research Group, University of Tokyo
出版情報: Tokyo : Tuttle Publishing, 2015-  2 v. ; 26 cm
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Wolfgang Drexler, James G. Fujimoto, editors
出版情報: Cham : Springer Reference, c2015  3 v. (xxx, 2571 p.) ; 24 cm
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edited by Seth Love ... [et al.]
出版情報: Boca Raton : CRC Press, c2015  2 v. ; 29 cm
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editor, Eric E. Bouhassira ; associate editor, Krishna S. Vyas
出版情報: Los Angeles : SAGE Reference, c2015  3 v. (xli, 1471 p.) ; 29 cm
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北村薫 [著]
出版情報: 東京 : KADOKAWA, 2015.10  237p ; 15cm
シリーズ名: 角川文庫 ; 19402, [き24-9]
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目次情報: 続きを見る
マスカット・グリーン
腹中の恐怖
微塵隠れのあっこちゃん
三つ、惚れられ
よいしょ、よいしょ
元気でいてよ、R2‐D2。
さりさりさり
ざくろ
スイッチ
マスカット・グリーン
腹中の恐怖
微塵隠れのあっこちゃん
概要: 気心のしれた女同士で飲むお酒は、自分を少し素直にしてくれる...そんな中、思い出すのは、取り返しのつかない色んなこと(「元気でいてよ、R2‐D2。」)。産休中の女性編集者の下に突然舞い込んだ、ある大物作家の原稿。彼女は育児に追われながらも、 自ら本作りに乗り出すが...(「スイッチ」)。本人ですら気付かない本心がふと顔を出すとき、世界は崩れ出す。人の本質を巧みに描く、書き下ろしを含む9つの物語。 続きを見る
9.

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written by Lee Davis
出版情報: New York, N.Y. : DK Publishing, 2015  47 p. ; 23 cm
シリーズ名: Dorling Kindersley readers ; 2, Beginning to read alone
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Damian Harper ... [et al.]
出版情報: Footscray, Vic. : Lonely Planet, 2015  1053 p. ; 20 cm
シリーズ名: Lonely Planet
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