List of Figures |
List of Tables |
Preface |
From Nanoparticles to Nanocomposites: A Brief Overview / 1: |
Nanoscience and Nanotechnology: An introduction / 1.1: |
Nanoparticles' Diversity / 1.2: |
Quantum dots / 1.2.1: |
Iron oxides / 1.2.2: |
Metal nanoparticles / 1.2.3: |
Surface Modification of Nanoparticles / 1.3: |
Ligand exchange reactions / 1.3.1: |
Inorganic nanocoating / 1.3.2: |
Encapsulation in polymers / 1.3.3: |
Designing Biointerfaces over Nanoparticles / 1.4: |
Challenges for the Future... Nanosafety for Today / 1.5: |
Polymers for Biomedical Applications: Chemical Modification and Biofunctionalization / 2: |
Drug Delivery Systems / 2.1: |
Hydrogels / 2.2: |
Application of hydrogels / 2.2.1: |
Types of hydrogels / 2.2.2: |
Bioadhesives / 2.3: |
Surface Modification / 2.4: |
Surface modification by ultra-violet radiation / 2.4.1: |
Plasma treatment / 2.4.2: |
Plasma generation / 2.4.2.1: |
Plasma polymerization and surface modification of polymers / 2.4.2.2: |
Concluding Remarks / 2.5: |
Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules / 3: |
Introduction / 3.1: |
Polymeric Nanocapsules: Production and Characterization / 3.2: |
Nanocapsules made of synthetic polymers / 3.2.1: |
Polyacrylate nanocapsules / 3.2.1.1: |
Polyester nanocapsules / 3.2.1.2: |
Nanocapsules made of natural polymers / 3.2.2: |
Lipid nanocapsules / 3.2.3: |
Therapeutical Applications of Nanocapsules / 3.3: |
Nanocapsules for oral drug delivery / 3.3.1: |
Nanocapsules for oral peptide delivery / 3.3.1.1: |
Nanocapsules for oral delivery of lipophilic low molecular weight drugs / 3.3.1.2: |
Nanocapsules as nasal drug carriers / 3.3.2: |
Nanocapsules as ocular drug carriers / 3.3.3: |
Nanocapsules in cancer therapy / 3.3.4: |
Nanocapsules as carriers for gene therapy / 3.3.5: |
Conclusions / 3.4: |
Inorganic Nanoparticles Biofunctionalization / 4: |
Bioeonjugation of Nanoparticles / 4.1: |
Nanoparticles and Their Surface Properties / 4.2: |
Surface capping of nanoparticles / 4.2.1: |
Semiconductor quantum dots and metallic nanoparticles / 4.2.2: |
Silica nanoparticles and silica encapsulation / 4.2.3: |
Attachment Schemes / 4.3: |
Covalent attachment / 4.3.1: |
Non-covalent attachment / 4.3.2: |
Affinity binding / 4.3.3: |
Specific Cases / 4.4: |
Proteins / 4.4.1: |
DNA / 4.4.2: |
Avidin / 4.4.3: |
Phospholipid encapsulation and functionalization / 4.4.4: |
Applications / 4.5: |
Cellular imaging / 4.5.1: |
Drug delivery / 4.5.2: |
Bioluminescence resonance energy transfer / 4.5.3: |
Hyperthermia / 4.5.4: |
Conclusion / 4.6: |
Silica-Based Materials: Bioprocesses and Nanocomposites / 5: |
Natural Silica Nanocomposites / 5.1: |
Diatom biosilica / 5.1.1: |
Sponge biosilica / 5.1.3: |
(Bio)-technological applications of biosilica / 5.1.4: |
Biomimetic Silica Nanocomposites / 5.2: |
Silica nanocomposites based on natural templates / 5.2.1: |
Silica nanocomposites based on model templates / 5.2.3: |
Synthetic peptides / 5.2.3.1: |
Synthetic polyamines / 5.2.3.2: |
Biological templates / 5.2.3.3: |
Biomimetism: How far can we go? / 5.2.4: |
Bio-Inspired Silica Nanocomposites / 5.3: |
Biotechnological and medical applications / 5.3.1: |
Perspectives / 5.3.3: |
Synthetic Strategies for Polymer-Based Nanocomposite Particles / 6: |
Surfaces and Interfaces: Chemical Modification of Nanoparticles / 6.1: |
In situ Synthetic Strategies for Polymer-Based Colloidal Nanocomposites / 6.3: |
In situ preparation of the fillers / 6.3.1: |
Sol-gel methods / 6.3.1.1: |
In situ polymerization of the matrix / 6.3.2: |
Organic solvent-based methods: Dispersion polymerization / 6.3.2.1: |
Water-based methods: Emulsion and miniemulsion polymerization / 6.3.2.2: |
Controlled polymerization: Surface initiated polymerization(SIP) / 6.3.3: |
Atom Transfer Radical Polymerization Atrp / 6.3.3.1: |
Reversible Addition Fragmentation chain transfer (Raft) polymerization / 6.3.3.2: |
Combined controlled polymerization mechanisms / 6.3.3.3: |
Functionalization of Polymer-Based Nanocomposites for Bio-Applications / 6.4: |
Final Remarks / 6.5: |
Synthesis of Nanocomposite Particles Using Supercritical Fluids: A Bridge with Bio-applications / 7: |
Supercritical Fluids: Definition and Current use in, Bio-Applications / 7.1: |
Definition / 7.2.1: |
Scps in biomedical applications / 7.2.2: |
Development of drug delivery systems / 7.2.2.1: |
scC02 for purification and sterilization / 7.2.2.2: |
Can Scfs be Used to Introduce Inorganic NPs into Polymers? / 7.3: |
Formation of hybrid organic-inorganic NPs in Scps(route 1) / 7.3.1: |
Encapsulation of inorganic NPs into a polymer shell (route 2) / 7.3.2: |
Polymer swelling and in situ growth of inorganic NPs (route 3) / 7.3.3: |
Polymer swelling by scC02 / 7.3.3.1: |
Chemical transformation of impregnated metal precursor / 7.3.3.2: |
Biocomposites Containing Magnetic Nanoparticles / 7.4: |
Magnetic Properties / 8.1: |
Magnetism at nanoscale level: Concepts and main phenomena / 8.2.1: |
Basic concepts / 8.2.1.1: |
Systems with interactions between magnetic centers / 8.2.1.2: |
Superparamagnetism / 8.2.1.3: |
Magnetism concepts subjacent to bio-applicatons / 8.2.2: |
Magnetic separation and drug delivery / 8.2.2.1: |
Magnetic resonance imaging (Mri) / 8.2.2.2: |
Magnetic hyperthermia / 8.2.2.3: |
Magnetic Nanoparticles for Bio-Applications / 8.3: |
Iron oxide nanoparticles / 8.3.1: |
Metallic nanoparticles / 8.3.2: |
Metal alloy nanoparticles / 8.3.3: |
Bimagnetic nanoparticles / 8.3.4: |
Strategies of Synthesis of Magnetic Biocomposite Nanoparticles / 8.4: |
In situ formation of magnetic nanoparticles / 8.4.1: |
Other magnetic nanoparticles / 8.4.1.1: |
Encapsulation of magnetic nanoparticles within biopolymers / 8.4.2: |
Conclusions and Future Outlook / 8.5: |
Multifunctional Nanoeomposite Particles for Biomedical Applications / 9: |
Types of Multifunctional Magnetic-Fluorescent Nanocomposites / 9.1: |
Main Approaches to the Preparation of Multifunctional Magnetic-Fluorescent Nanocomposites / 9.3: |
Silica coated magnetic-fluorescent nanoparticles / 9.3.1: |
Organic polymer coated magnetic cores treated with fluorescent entities / 9.3.2: |
Ionic assemblies of magnetic cores and fluorescent entities / 9.3.3: |
Fluoreseently-labeled lipid coated magnetic nanoparticles / 9.3.4: |
Magnetic core directly linked to fluorescent entity via a molecular spacer / 9.3.5: |
Magnetic cores coated by fluorescent semiconducting shells / 9.3.6: |
Magnetically-doped Qds / 9.3.7: |
Magnetic nanoparticles and Qds embedded within a polymer or silica matrix / 9.3.8: |
Biomedical Applications / 9.4: |
Bio-imaging probes / 9.4.1: |
Cell tracking, sorting and bioseparation / 9.4.2: |
Applications in nanomedicine / 9.4.3: |
Bio-Applications of Functionalized Magnetic Nanoparticles and Their Nanocomposites / 9.5: |
Fundaments of Nanomagnetism / 10.1: |
Single-domain particles / 10.2.1: |
Magnetic anisotropy energy / 10.2.2: |
Fundaments of Colloidal Stability / 10.2.3: |
Bio-Applications of Magnetic Nanoparticles / 10.4: |
Magnetic separation / 10.4.1: |
Nuclear magnetic resonance imaging (Mri) / 10.4.2: |
Contrast agents based on superparamagnetic nanomagnets / 10.4.3.1: |
Magnetobiosensors / 10.4.4: |
Magnetobiosensors based on magnetorelaxometry / 10.4.4.1: |
Magnetobiosensors based on magnetoresistance / 10.4.4.2: |
Magnetosensors based on Hall effect / 10.4.4.3: |
Magnetoplasmonics / 10.4.4.4: |
Summary and Outlook / 10.4.5: |
Anti-Microbial Polymer Nanocomposites / 11: |
Packaging / 11.1: |
Textiles / 11.1.2: |
Coatings / 11.1.3: |
Antimicrobial coatings / 11.1.3.1: |
Medicine, pathology and surgical implants/ biomedical coatings / 11.1.3.2: |
Anti-Microbial Polymer-Based Nanocomposites / 11.2: |
Mechanisms of Antibacterial Action / 11.3: |
Detection of microbes / 11.3.1: |
Control of microbial growth / 11.3.2: |
Environmental and Health Concerns / 11.4: |
Biosensing Applications Using Nanoparticles / 12: |
Biosensors: A Definition / 12.1: |
Uses of Gold Nanoparticles / 12.2: |
Tailoring biointerfaces over gold nanoparticles / 12.2.1: |
Biosensing applications of gold nanoparticles / 12.2.2: |
Crosslinking-based biosensing / 12.2.2.1: |
Non-crosslmking-based biosensing / 12.2.2.2: |
Semiconductor Quantum Dots / 12.3: |
Properties of quantum dots / 12.3.1: |
Biosensing with quantum dots / 12.3.2: |
Immunosensing / 12.3.2.1: |
Dna assays / 12.3.2.2: |
Resonance energy transfer-based assays / 12.3.2.3: |
Outlook Remarks / 12.4: |
Index |