Amsterdam ; New York : Elsevier/North Holland Biomedical Press , New York : sole distributors for the U.S.A. and Canada, Elsevier/North-Holland, 1979 xii, 233 p. ; 24 cm
Determination of Glucose in Blood--Amperometric Biosensor / 8.1:
Survey of Biosensor Methods for the Determination of Glucose / 8.1.1:
Aim / 8.1.2:
Determination of Nanogram Levels of Copper(I) in Water Using Anodic Stripping Voltammetry, Employing an Electrode Modified with a Complexing Agent / 8.2:
Background to Stripping Voltammetry--Anodic and Cathodic / 8.2.1:
Determination of Several Ions Simultaneously--'The Laboratory on a Chip' / 8.2.2:
Sensor Arrays and 'Smart' Sensors / 8.3.1:
Background to Ion-Selective Field-Effect Transistors / 8.3.3:
Determination of Attomole Levels of a Trinitrotoluene--Antibody Complex with a Luminescent Transducer / 8.3.4:
Discovery of the Aquaporins and Their Impact on Basic and Clinical Physiology / Peter Agre ; Mario J. Borgnia ; Masato Yasui ; John D. Neely ; Jennifer Carbrey ; David Kozono ; Eric Beitz ; Jason Hoffer ; Virginia Leitch ; Landon S. KingChapter 1:
Pre-Aquaporin Era / I.:
The First Recognized Water Channel Protein / II.:
Other Mammalian Aquaporins / III.:
Nonmammalian Homologs / IV.:
Perspective / V.:
References
The Aquaporin Superfamily: Structure and Function / Henning Stahlberg ; Bernard Heymann ; Kaoru Mitsuoka ; Yoshinori Fuyijoshi ; Andreas EngelChapter 2:
Introduction
Two-Dimensional Crystallization of Membrane Proteins
Electron Crystallography
Atomic Force Microscopy
AQP1, The Erythrocyte Water Channel
AQP0: The Major Intrinsic Protein of Lens Fiber Cells / VI.:
Water Channel of Escherichia coli: AqpZ / VII.:
Glycerol Channel of Escherichia coli: GlpF / VIII.:
Comparison of the High-Resolution Projection Structures of GlpF and AQP1 / IX.:
Conclusion and Perspectives / X.:
Physiological Roles of Aquaporins in the Kidney / Mark A. Knepper ; Soren Nielsen ; Chung-Lin ChouChapter 3:
Water Transport along the Renal Tubule
Water Permeability along the Renal Tubule
Aquaporin-1 Facilitates Isoosmotic Fluid Transport in Proximal Tubule
Aquaporin-1 Allows Osmotic Equilibration in the Thin Descending Limb of Henle Despite Rapid Flow of Tubule Fluid
Aquaporin-1 Allows Osmotic Equilibration in the Descending Vasa Recta
Aquaporins Provide Molecular Targets for Regulation of Water Transport in the Renal Collecting Duct
Pathophysiology of Renal Aquaporins / Tae-Hwan Kwon ; Henrik Hager ; David Marples ; Jorgen FrokiaerChapter 4:
Inherited NDI and CDI
Acquired NDI
Urinary Concentrating Defects
States of Water Retention
Conclusions
Genetic and Biophysical Approaches to Study Water Channel Biology / A. S. Verkman ; Baoxue Yang ; William R. Skach ; Alok Mitra ; Yuanlin Song ; Geoffrey T. Manley ; Tonghui MaChapter 5:
Lessons from Aquaporin Knockout Mice
Biophysical Analysis of Aquaporin Function
Aquaporin Structure and Function
New Directions in Aquaporin Physiology and Biophysics
Trafficking of Native and Mutant Mammalian MIP Proteins / Peter M. T. Deen ; Dennis BrownChapter 6:
Normal Routing of MIP Proteins
Disturbed Trafficking of MIP Proteins
Aquaporins of Plants: Structure, Function, Regulation, and Role in Plant Water Relations / Maarten J. Chrispeels ; Raphael Morillon ; Christophe Maurel ; Patricia Gerbeau ; Per Kjellbom ; Ingela JohanssonChapter 7:
The Transpiration Stream
Water Movement in and between Living Tissues
Molecular Characteristics and Transport Properties of Plant Aquaporins
Subcellular Location of Plant Aquaporins
What Do the Water and Solute Transport Properties of Membranes Tell Us about the Aquaporins in Those Membranes?
The Multiple Roles of Aquaporins: How to Link Water Transport Properties to Functions at the Cellular and Tissue Level
Regulation of Aquaporin Expression and Water Transport Activity
Microbial Water Channels and Glycerol Facilitators / Gerald Kayingo ; Roslyn M. Bill ; Guiseppe Calamita ; Stefan Hohmann ; Bernard A. PriorChapter 8:
Microbial Aquaporins and Glycerol Facilitators
Transport Properties and Channel Selectivity of Microbial MIP Channels
From Primary to Quaternary Structure in Microbial MIPs
Physiological Roles
Microbial MIP Channels in Osmoregulation
Control of the Function of Microbial MIP Channels
Conclusions and Future Perspectives
Future Directions of Aquaporin Research / Chapter 9:
Identification and Characterization of New MIP Channels
Why Have So Many MIP Channels?
Analysis of the Physiological Roles of Aquaporins
Structure and Function
Aquaporins as Targets for Treatment of Human Disease
Aquaporins as Possible Targets for Genetic Engineering and Crop Improvement
Cyclodextrin Complexes of Lanthanide Ions for Homogeneous Hydrolysis of Amides
Relevance of the Lanthanide-Mediated Amide Hydrolysis to DNA Hydrolysis
Conclusion
Acknowledgment
Abbreviations
Co(III)-Promoted Hydrolysis of Amides and Small Peptides / David A. Buckingham ; Charles R. ClarkChapter 3:
Early Studies and Scope
Co(III) Linkage Isomers and Isomerization
Hydrolysis by Direct Polarization
Bimolecular Reactions of Co-OH[subscript 2]/OH
Intramolecular Reactions of CoOH[subscript 2]/OH
Kinetic Parameters and Reaction Mechanism
Related Nonmetal Hydrolysis Reactions / 8.:
Synthetic Cu(II) and Ni(II) Peptidases / Gregory M. Polzin ; Judith N. BurstynChapter 4:
Hydrolysis of Simple Peptides by Cu(II) and Ni(II) Ions in Solution
Cleavage of Substrates Containing a Metal Binding Site by Cu(II) and Ni(II) Ions
Cleavage of Amides, Peptides, and Proteins by Defined Metal Complexes
Conclusions
Palladium(II) and Platinum(II) Complexes as Synthetic Peptidases / Nebojsa M. Milovic ; Nenad M. KosticChapter 5:
Selective Binding of Metal Complexes to Peptides and Peptide Cleavage
Cleavage of Proteins
Prospects
Acknowledgments
Abbreviations and Symbols
Protease Activity of 1,10-Phenanthroline-Copper Systems / Makoto Kito ; Reiko UradeChapter 6:
Can Free Copper(II) Ions Degrade Proteins?
Protein Degradation by the 1,10-Phenanthroline-Copper(II) Complex
Protease Activity of the Chemically Modified 1,10-Phenanthroline-Copper(II) Complex
Specific Protein Degradation by Copper(II) Ions / Geoffrey AllenChapter 7:
Peptide Sequence Specificity for Cleavage by Copper(II) Ions
Conditions Affecting the Rate of Cleavage of Peptides by Copper(II) Ions
Possible Mechanisms of Copper(II)-Mediated Hydrolysis of Peptide Bonds
Physiological Relevance of the Degradation of Proteins by Copper(II) Ions
Artificial Iron-Dependent Proteases / Saul A. Datwyler ; Claude F. MearesChapter 8:
Introduction: Historical Background and Concepts
Principles and Practical Aspects
Methodology
Transcription Complexes in Escherichia coli
Hydroxyl Radical Footprinting of Proteins Using Metal Ion Complexes / Tomasz Heyduk ; Noel Baichoo ; Ewa HeydukChapter 9:
Experimental Methodology of Protein Footprinting
Applications of Protein Footprinting Methodology
Future Directions
Abbreviations and Definitions
Nickel- and Cobalt-Dependent Oxidation and Cross-Linking of Proteins / Steven E. Rokita ; Cynthia J. BurrowsChapter 10:
Determinants of Nickel- and Cobalt-Dependent Oxidation
Intrinsic Sensitivity of Native Proteins
Mapping Tertiary and Quaternary Structure of Proteins
Effects of Metal Ions on the Oxidation and Nitrosation of Cysteine Residues in Proteins and Enzymes / Ann M. English ; Dean E. WilcoxChapter 11:
Background: Properties and Biological Roles of Cysteine Residues
Oxidation of Cysteines
Nitrosation of Cysteines
Protein Cross-Linking Mediated by Metal Ion Complexes / Kathlynn C. Brown ; Thomas KodadekChapter 12:
Small-Molecule Cross-Linking Reagents Used Free in Solution
Development of Affinity Cross-Linking Reagents: Use of Peptides or Proteins to Deliver a Cross-Linking Reagent Site-Specifically
Ferrocenoyl Amino Acids and Peptides: Probing Peptide Structure / Heinz-Bernhard Kraatz ; Marek GalkaChapter 13:
Introduction: Organometallic Probes in Biological Systems
Synthetic Studies of Ferrocenoyl Amino Acids and Peptides
Structural and Theoretical Studies
Electrochemistry of Ferrocenoyl Amino Acids and Peptides
Summary
Synthetic Analogs of Zinc Enzymes / Gerard ParkinChapter 14:
Structural and Functional Models of Zinc Enzymes as Classified by Active Site Composition
Use of Metal Ion Substitution to Provide Insight into the Structures and Mechanisms of Action of Zinc Enzymes
Perspectives
Mimicking Biological Electron Transfer and Oxygen Activation Involving Iron and Copper Proteins: A Bio(in)organic Supramolecular Approach / Martinus C. FeitersChapter 15:
Mimics for Iron-Sulfur Proteins
Mimics for Blue Copper Proteins
Cytochrome P450 Mimics
Mimics for Oxygen Binding and Activation by Copper Proteins
Chemistry and Biology -- Historial and Philosophical Aspects / Gerhard Quinkert
Using Small Molecules To Explore Biology / Part II:
Using Small Molecules to Unravel Biological Mechanisms / Tarun Kapoor
Using Natural Products to Unravel Cell Biology / Craig Crews
Engineering Control Over Protein Function Using Chemistry / Kevan Shokat
Controlling Protein Function by Caged Compounds / Carsten Schultz
Transcription Control by Small-Molecules / John Koh
Controlling Protein-Protein Interactions / Virginia Cornish ; Columbia University) Controlling Protein-Protein Interactions Using Chemical Inducers and Disrupters of Dimerization ; Tim Clackson
Protein Secondary Structure Mimetics as Modulators of Protein-Protein and Protein-Ligand Interactions / Andrew Hamilton
Expanding the Genetic Code / Masahiko Sisido
Discovering Small Molecule Probes For Biological Mechanisms / Part III:
Forward Chemical Genetics / Stuart Schreiber ; Steve Haggarty
Reverse Chemical Genetics -- An Important Strategy for the Study of Protein Function in Chemical and Drug Discovery / Herbert Waldmann
Chemical Biology and Enzymology: Protein Phosphorylation as a Case Study / Phil Cole
Chemical Strategies for Activity-based Proteomics / Ben Cravatt
The Biarsenical Tetracysteine Protein Tag: Chemistry and Biological Applications / Steve Adams
Chemical Approaches to Exploit Fusion Proteins for Functional Studies / Kai Johnsson
Expanding The Scope Of Chemical Synthesis / Part IV:
Diversity-oriented Synthesis / Derek Tan
Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides / Chaitan Khosla
Expressed Protein Ligation / Tom Muir
Chemical Synthesis of Proteins and Large Bioconjugates / Phil Dawson
New Methods for Protein Bioconjugation / Matt Francis
The Search for Chemical Probes to Illuminate Carbohydrate Function / Laura Kiessling
Chemical Clydomics as Basis for Drug Discovery / Peter Seeberger
The Bicyclid Depsipeptide Family of Histone Deacetylase / A. Ganesan
Chemical Informatics / Part V:
Wombat and Wombat-Pk / Paul Clemons
Bioactivity Databases for Lead and Drug Discovery / Tudor Oprea
Drug discovery / Part VI:
Managerial Challenges in Implementing Chemical Biology Platforms / Frank Douglas
The Molecular Basis of Predicting Druggability / Andrew Hopkins ; Pfizer)
The Target Family Approach / Peter Nestler ; Sanofi-Aventis)
Chemical Biology of Kinases Studied by NMR Spectroscopy / Harald Schwalbe
The Nuclear Receptor Superfamily and Drug Discovery / Kenneth Pearce
The GPCR-7TM Receptor Target Family / Edgar Jacoby
Drugs Targeting Protein-Protein Interactions / Patrick Chene ; Novartis)
Systems Biology / Part VII:
Prediction of ADMET properties / Ulf Norinder ; AstraZeneca)
Systems Biology of the JAK-STAT Signaling Pathway / Jens Timmer
Modeling Intracellular Signal Transduction Processes / Jason Haugh
Genome-wide Gene Expression and Application to the Analysis of T-Cell Subsets in Inflammatory Diseases / Lars Rogge
Scanning the Proteome for Targets of Organic Small Molecules Using Bifunctional Receptor Ligands / Nikolai Kley
Outlook / Part VIII:
Introduction / Part I:
Chemistry and Biology -- Historial and Philosophical Aspects / Gerhard Quinkert
Using Small Molecules To Explore Biology / Part II:
Activator Proteins for Lysosomal Glycolipid Hydrolases / E. Conzelmann ; K. Sandhoff
Isolation and Analysis of Cell Walls from Plant Material / R. R. Selvendran ; M. A Neill
Electro-Optical Reflection Methods for Studying Bioactive Substances at Electrode-Solution Interfaces-An Approach to Biosurface Behavior / K. Takamura ; F. Kusu
Isoelectric Focusing in Immobilized pH Gradients: Theory and Newer Technology / P. G. Righetti ; E. Gianazza
Assays for Superoxide Dismutase / J. V. Bannister ; L. Calabrese
The Radiation Inactivation Method as a Tool to Study Structure-Function Relationships in Proteins / G. Beauregard ; A. Maret ; R. Salvayre ; M. Potier
Immunoassay with Electrochemical Detection / W. R. Heineman et al.
Index
Activator Proteins for Lysosomal Glycolipid Hydrolases / E. Conzelmann ; K. Sandhoff
Isolation and Analysis of Cell Walls from Plant Material / R. R. Selvendran ; M. A Neill
Electro-Optical Reflection Methods for Studying Bioactive Substances at Electrode-Solution Interfaces-An Approach to Biosurface Behavior / K. Takamura ; F. Kusu
Nick Cozzarelli: A personal remembrance / Stephen D. Levene ; Lynn Zechiedrich
Mathematical methods in DNA topology: Applications to chromosome organization and site-specific recombination / Javier Arsuaga ; Yuanan Diao ; Mariel Vazquez
Conformational statistics of DNA and diffusion equations on the Euclidean group / Gregory S. Chirikjian
Perspectives on DNA looping / Laura Finzi
Differences between positively and negatively supercoiled DNA that topoisomerases may distinguish / Jonathan M. Fogg ; Daniel J. Catanese, Jr. ; Graham L. Randall ; Michelle C. Swick
Calibration of tethered particle motion experiments / Lin Han ; Bertrand H. Lui ; Seth Blumberg ; John F. Beausang ; Philip C. Nelson ; Rob Phillips
Useful intrusions of DNA topology into experiments on protein-DNA geometry / Jason D. Kahn ; James R. Jenssen ; Vasavi Vittal
Topological analysis of DNA-protein complexes / Soojeong Kim ; Isabel K. Darcy
Closing the loop on protein-DNA interactions: Interplay between shape and flexibility in nucleoprotein assemblies having implications for biological regulation / Yongli Zhang
Four-way helical junctions in DNA molecules / David M.J. Lilley
Micromechanics of single supercoiled DNA molecules / John F. Marko
Flexibility of nucleosomes on topologically constrained DNA / Andrei Sivolob ; Christophe Lavelle ; Ariel Prunell
The mathematics of DNA structure, mechanics, and dynamics / David Swigon
Paradox regained: a topological coupling of nucleosomal DNA wrapping and chromatin fibre coiling / Andrew Travers
Statistical-mechanical analysis of enzymatic topological transformations in DNA molecules / Alexander Vologodskii
List of workshop participants
Foreword
Preface
Nick Cozzarelli: A personal remembrance / Stephen D. Levene ; Lynn Zechiedrich
organized by the Science Council of Japan ; under the auspices of the International Union Biochemistry ; secretariat Seventh International Congress of Biochemistry
出版情報:
Tokyo : The Science Council of Japan, 1967 v. ; 28 cm
The Discovery of Ionophores: An Historical Account / Berton C. PressmanChapter 1:
Abbreviations
References
Tetracyclines and Daunorubicin / R. Bruce MartinChapter 2:
Introduction / 1.:
Tetracyclines / 2.:
Daunorubicin / 3.:
Interaction of Metal Ions with Streptonigrin and Biological Properties of the Complexes / Joseph HajduChapter 3:
Structural and Chemical Properties of Streptonigrin and Its Metal Complexes
Biological Activity and Suggested Mechanistic Schemes for the Antitumor Action of Streptonigrin
Conclusions / 4.:
Bleomycin Antibiotics: Metal Complexes and Their Biological Action / Yukio Sugiura ; Tomohisa Takita ; Hamao UmezawaChapter 4:
Structural and Synthetic Aspects of Bleomycin
Characteristics of Bleomycin-Metal Complexes
Oxygen Activation and Redox Cycle of the Bleomycin-Iron Complex
Interaction of Bleomycin and Its Iron Complex with DNA / 5.:
Sequence-Specific DNA Cleavage by the Bleomycin-Iron Complex / 6.:
Metal Complexes and DNA Cleavage of Bleomycin Analogs: Peplomycin, Tallysomycin, and Phleomycin / 7.:
Metal Complexes and Oxygen Activation by Synthetic Analogs and Biosynthetic Intermediates of Bleomycin / 8.:
Molecular Mechanism of Bleomycin Action / 9.:
Interaction Between Valinomycin and Metal Ions / K. R. K. Easwaran10.:
Structure and Conformation of Free Valinomycin
Structure and Conformation of Valinomycin-Metal Ion Complexes
Valinomycin-Metal Ion Complexes in Transmembrane Ion Transport
Abbreviations and Definitions
Beauvericin and the Other Enniatins / Larry K. SteinraufChapter 6:
Ion Binding
Membrane Transport
Analogs
Complexing Properties of Gramicidins / James F. Hinton ; Roger E. Koeppe IIChapter 7:
Structural Properties
Ion-Complexing Properties
Transport Properties
Nactins: Their Complexes and Biological Properties / Yoshiharu Nawata ; Kunio Ando ; Yoichi IitakaChapter 8:
Molecular Structure of Nactins
Complexes
Biological Properties
Cation Complexes of the Monovalent and Polyvalent Carboxylic Ionophores: Lasalocid (X-537A), Monensin, A23187 (Calcimycin), and Related Antibiotics / George R. PainterChapter 9:
Structure of Ionophore-Cation Inclusion Complexes
Techniques for Measuring Equilibrium Ionophore-Ion Affinities
Carboxylic Ionophore-Mediated Ion Transport
Biological Test Systems
Conformational Aspects of Ion Capture and Membrane Transport
Biological Applications of Ionophores
Overview
Complexes of D-Cycloserine and Related Amino Acids with Antibiotic Properties / Paul O'BrienChapter 10:
Mode of Action
Uses of D-Cycloserine
Organic Chemistry of D-Cycloserine
Metal Ion Coordination by D-Cycloserine
Metal Ion Coordination by D-Cycloserine Derivatives
Iron-Containing Antibiotics / J. B. Neilands ; J. R. ValentaChapter 11:
Iron(III) Complexes
Iron(II) Complexes
Miscellaneous Compounds
General Conclusions
Cation-Ionophore Interactions: Quantification of the Factors Underlying Selective Complexation by Means of Theoretical Computations / Nohad Gresh ; Alberte PullmanChapter 12:
Outline of the Methodology
Selective Binding of Alkali Cations by Valinomycin
Selective Complexation of K[superscript +], Na[superscript +], and NH[superscript + subscript 4] by Nonactin
Selective Binding of Mg[superscript 2+] and Ca[superscript 2+] by Ionophore A23187
Structural Properties of Valinomycin and A23187
Energy Profiles for Single and Double Occupancy by Na[superscript +] of the Gramicidin A Channel