| Redox Glycosidation: A Stereoselective Synthesis of Sucrose / A.G.M. Barrett |
| Solution of Complex Stereochemical Problems with the Aid of Molecular Mechanics-Based Modeling: An Application to the Total Synthesis of (+)-Pleuromutilin / R.K. Boeckman, Jr |
| Total Synthesis of (+)-Ginkgolide B / M.C. Desai ; A.K. Ghosh ; M. Kang ; I.N. Houpis |
| Synthetic Studies on Pentacyclic Quassinoids / B. Ganem |
| Total Synthesis of Taxusin: An Initial Step toward Taxol Synthesis / R.A. Holton |
| Three and One-Half Approaches to the Synthesis of Pederin / P. Kocie*aanski ; K. Jarowicki ; S. Marczak ; T.M. Willson |
| The Champagne Route to Avermectins and Milbemycins / S.V. Ley ; A. Armstrong |
| The Total Synthesis of (+)-Neolemnane and (+)-14-Deoxyisoamijiol: "The Rest of the Story." / G. Majetich |
| Synthesis of Cembranoid Natural Products by Intramolecular SE' Additions of Allylic Stannanes to Ynals / J.A. Marshall |
| Synthesis of Cancer Growth-Inhibiting Diterpene: Spatol / R.G. Salomon |
| Total Synthesis of the FK506/FKBP Complex / J.A. Ragan, R.F. Standaert ; S.L. Schreiber |
| Total Synthesis of (-)FK506 / R.P. Volante |
| An Industrial Perspective on Total Synthesis; Penem Antibacterial CP-70,429 / R.A. Volkmann ; B.T. O'Neill |
| Chapter References |
| Index |
| Methodology Validation and Structure Correction by Total Synthesis: the Case of the Clerodane Diterpenoid, Sacacarin / 1： |
| Total Synthesis of ( )-Cylindrospermopsin / 2： |
| The Total Synthesis of (-)-Arisugacin A / 3： |
| Total Synthesis of Kainoids by Dearomatizing Anionic Cyclization / 4： |
| Total Synthesis of Jatrophatrione, an Unprecedented [5.9.5] Tricyclic Antileukemic Diterpene / 5： |
| Alkynyliodonium Salts in Organic Synthesis / 6： |
| How to Thread a String Through the Eye of a Molecular Needle: Template Synthesis of Interlocked Molecules / M. Kogej7： |
| Total Synthesis of Spongistatin 1 (Altohyrtin A): a Tale of Ten Aldols / 8： |
| The Ring-Closing Metathesis Approach to Fumagillol / 9： |
| Devising an Especially Efficient Route to the 'Miracle' Nutrient Coenzyme Q10 / 10： |
| Total Synthesis of Lipid I and Lipid II: Late Stage Intermediates Utilized in Bacterial Cell Wall Biosynthesis / 11： |
| Ring Rearrangement Metathesis (RRM) - A New Concept in Piperidine and Pyrrolidine Synthesis / 12： |
| Catalytic Asymmetric Total Synthesis of (-) -Strychnine and Fostriecin / 13： |
| The Synthesis of () úStrychnine via a Cobalt Mediated [2 + 2 + 2] Cycloaddition / 14： |
| Total Synthesis of RK-397 / chapter 1： |
| A Formal Total Synthesis of The Marine Diterpenoid, Diisocyanoadociane / chapter 2： |
| Total Syntheses of Zoapatanol / chapter 3： |
| Synthesis of Molecular Tweezers and Clips by The use of a Molecular Lego set and Their Supramolecular Functions / chapter 4： |
| Application of C-Glycosides in The Total Synthesis of (-)-Gambierol / chapter 5： |
| A Biomimetic Approach to the Ocaglamides Employing Photogeneration of Oxidopyryliums Derived From 3-Hydroxyflavones / chapter 6： |
| Synthesis Studies of Dolabellanes and Transannular Processes Leading to Related Diterpenes / chapter 7： |
| Diphenyloxazinones: Versatile Templates for the Asymmetric Synthesis of -Amino acids, Peptide Isosteres, and Natural Products / chapter 8： |
| Rhodium-Catalyzed Cycloisomerization Reactions of Allenes in Diversity-Oriented Synthesis / chapter 9： |
| Hydrogen-Bond-Mediated Organic Synthesis in the Solid State / chapter 10： |
| Total Syntheses of Natural Products Using the Combined Ch Activation/Cope Rearrangement as The Key Step / chapter 11： |
| The Total Synthesis of Amphibian Alkaloids Using the Intramolecular Schmidt Reaction / chapter 12： |
| Seduced by a Sirens Call: Expanding Applications for Aromatic Compounds and the Synthesis of (+)-Rishirilide B / chapter 13： |
| Contributors |
| Foreword |
| Preface |
| Total Syntheses of Solandelactones E and F / Anna Robinson ; Catherine J. Fletcher ; Varinder K. Aggarwal |
| Introductions and Background |
| Retrosynthetic Analysis |
| Synthesis of Solandelactone E |
| Synthesis of Solandelactone F |
| Conclusions |
| References |
| The Marine Alkaloid Halichlorine: Its Defenses and Its Defeat / Derrick L. J. Clive |
| Introduction |
| The First Approach |
| The First Surprise |
| The Second Approach |
| Saved by Selenium |
| A Stereochemical Disaster-But a Blessing in Disguise |
| The Ring A Problem and the Development of a General Annulation Method |
| The Continuing Saga of Ring A |
| Formation of the Macrolactone |
| The Optical Purity Problem |
| Conclusion |
| Acknowledgments |
| An Adventure in Synthesis Inspired by the Pseudolaric Acids / Pauline Chiu |
| How this Chemist Came to Be |
| Pseudolaric Acids |
| The First Strategy |
| Development of the Copper Hydride-Induced Reductive Aldol Cyclization |
| The Second Strategy to Pseudolaric Acid A |
| Case 1: When Model Reactions Fail |
| Case 2: When Model Reactions Fail |
| Too Happy too Quickly, and the Importance of IR Spectroscopy |
| But it was not Time to Give Up |
| Other Natural Products |
| Epilogue |
| Total Synthesis of Papulacandin D / Tetsuya Kobayashi ; Christopher S. Regens ; Scott E. Denmark |
| Introduction and Background |
| Preparation of the Spirocyclic Aryl Glycoside |
| Synthesis of Fatty Acid Side Chain 26 and Acylation |
| Studies on the Global Deprotection to Synthesize Papulacandin D |
| New Protecting Group Strategy |
| Global Deprotection |
| Asymmetric Total Synthesis of the Antitumor Sesquiterpenoid (+)-Eremantholide A / Karl J. Hale ; Yi Li |
| Prologue (Karl J. Hale) |
| Introduction: Background and Previous Total Syntheses of (+)-Eremantholide A |
| The Hale-Li Retrosynthetic Analysis of (+)-Eremantholide A |
| The Hale-Li Total Synthesis of (+)-Eremantholide A (17) |
| Acknowledgment |
| A Chemo- and Diastereoselective Ring Closing Metathesis Macrocyclization Approach to the Total Syntheses of Aigialomycin C and D / Naval Bajwa ; Michael P. Jennings |
| Initial Retrosynthetic Analysis of Aigialomycin D |
| Second Generation Retrosynthetic Analysis of Aigialomycin D |
| Third Retrosynthetic Analysis of Aigialomycin D |
| Regio- and Stereoselective Metal-Catalyzed Reactions and Their Application to a Total Synthesis of (-)-Dactylolide / Daesung Lee ; Ivan Volchkov |
| Review of Previous Total Syntheses |
| New Synthetic Methods Development and Application |
| Completion of Dactylolide Synthesis |
| Summary |
| Development of a General Approach to the Leucetta-Derived Alkaloids / Carl J. Lovely |
| Strategic Considerations |
| C4-Substituted Derivatives |
| C4,C5-Substituted Derivatives |
| Naphthimidazole Derivatives |
| Oxidized Derivatives |
| The Adventure of Abudinol and the Misadventure of Muzitone / Frank E. McDonald ; Rongbiao Tong ; Matthew A. Boone ; Jason C. Valentine |
| Introduction: Identification of Marine Polyether Terpenes as a Synthetic Target |
| First-Generation Synthesis of Abudinol B |
| Second-Generation Synthesis of Abudinol B |
| Synthesis of the Purported Structure of Muzitone |
| Conclusion: Biosynthetic Considerations in the Proposal of Other Structures for Muzitone |
| In Pursuit of an Elusive Target: Our Kendomycin Story / Harry J. Martin ; Thomas Magauer ; Johann Mulzer |
| Synthetic Approaches to Kendomycin |
| Synthesis of the Lycopodium Alkaloid Lyconadin A: Discovery of a Unique C-N Bond Forming Reaction / Richmond Sarpong |
| The Lycopodium Alkaloids |
| The Selection of Lyconadin A |
| Initial Thoughts on Strategy |
| Successful Execution of a Strategy to Lyconadin A |
| Studies of the Oxidative C-N Bond Formation |
| Selective Alkane C-H Bond Substitutions: Strategies for the Preparation of Functionalized Diamondoids (Nanodiamonds) / Andrey A. Fokin ; Peter R. Schreiner |
| Diamondoid C-H Bond Substitutions: An Exercise in Preparative Alkane Functionalization |
| Selectivities and Mechanisms |
| Concluding Remarks |
| A Dipolar Cycloaddition Strategy for the Synthesis of 3,8-DiazabicycIo[3.2.1]Octane Tetrahydroisoquinoline Antitumor Antibiotics: The Total Synthesis of (-)-Lemonomycin / Eric Ashley ; Brian Stoltz |
| Lemonomycin and the Tetrahydroisoquinoline Antitumor Antibiotics |
| Strategic Considerations for the Synthesis of (-)-Lemonomycin |
| Retrosynthetic Analysis of Lemonomycin |
| The Total Synthesis of (-)-Lemonomycin |
| Studies on the Synthesis of the Apoptolidins / Stephen T. Chau ; Gary A. Sulikowski ; Bin Wu |
| Biosynthesis |
| Total Syntheses of Apoptolidin A |
| Total Syntheses of Apoptolidinone A and D |
| Precursor-Directed Glycosylation |
| Conclusion and Epilogue |
| The Story Behind the Total Synthesis of Vibsanin E and 5-ep/-Vibsanin E / Craig M. Williams15： |
| Redox Glycosidation: A Stereoselective Synthesis of Sucrose / A.G.M. Barrett |
| Solution of Complex Stereochemical Problems with the Aid of Molecular Mechanics-Based Modeling: An Application to the Total Synthesis of (+)-Pleuromutilin / R.K. Boeckman, Jr |
| Total Synthesis of (+)-Ginkgolide B / M.C. Desai ; A.K. Ghosh ; M. Kang ; I.N. Houpis |
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