Introduction to in Vivo EPR / Harold M. Swartz ; Lawrence J. BerlinerChapter 1: |
Aim and Scope of the Book / 1.: |
Rationale for in Vivo EPR / 2.: |
Challenges of in Vivo EPR / 3.: |
Types of Paramagnetic Species Observable with in Vivo EPR / 4.: |
Types of Instrumental Approaches Used for in Vivo EPR / 5.: |
Experiments with Animals / 6.: |
Conclusions and a Look to the Future / 7.: |
The Nomenclature of Biomedical EPR--Reducing the Confusion / 8.: |
References / 9.: |
Theory and Instrumentation / Section I.: |
Principles of in Vivo EPR / Sankaran Subramanian ; James B. Mitchell ; Murali C. KrishnaChapter 2: |
Introduction |
Time-Domain EPR |
CW versus Time Domain EPR |
Summary and Conclusions |
Frequency and Power Considerations for in Vivo EPR and Related Techniques / James M. S. HutchisonChapter 3: |
RF Absorption in Ideal Sample Shapes |
Resonators and RF Absorption |
B[subscript 1] and Power |
Localised EPR and Surface Coils |
CW EPR Signal Detection Bridges / Janusz KoscielniakChapter 4: |
Principles of CW Mode Signal Detection |
Bridge Devices |
Detectors |
Automatic Frequency Control Circuits |
The Complete CW EPR System |
Conclusions |
Acknowledgments |
Resonators for Low-Field in Vivo EPR / Kenneth A. RubinsonChapter 5: |
Origin of Radiofrequency Resonance |
Transmission Lines |
Matching Impedances |
Resonant Structures Used in Vivo |
Principles of Imaging / Periannan Kuppusamy ; Michael Chzhan ; Jay L. ZweierChapter 6: |
Fundamentals of Imaging |
Definition of Projection |
Field Gradient Techniques |
Projection Data Acquisition |
Data Processing and Image Reconstruction |
Software |
Instrumentation |
Magnet and Gradient Coil Design |
Special Imaging Techniques/Applications / 10.: |
Scope and Limitations / 11.: |
Time-Domain Radio Frequency EPR Imaging / 12.: |
Challenges in Time Domain EPR Spectroscopy and Imaging at RF |
Data Collection and Image Reconstruction |
Spin Probes |
Examples of Time-Domain Imaging Experiments at 300 MHz |
Conclusion and Future Directions |
Acknowledgements |
Biochemical Applications: Biochemistry and Biophysics / Section II.: |
Stable Soluble Paramagnetic Compounds / Howard J. HalpernChapter 8: |
What's in a Spectrum? |
Nitroxyls |
Trityls |
Overview of Application of Infusible Paramagnetic Compounds |
Stable Particulate Paramagnetic Materials as Oxygen Sensors in EPR Oximetry: Coals, Lithium Phthalocyanine, and Carbon Chars / R. B. Clarkson ; Paul Ceroke ; Shong-Wan Norby ; B. M. OdintsovChapter 9: |
Oxygen and EPR Line Width |
Carbon Char Synthesis |
Sensor Morphology |
Chars as Oxygen Sensors |
Dynamic Nuclear Polarization |
DNP Imaging and Oximetry |
Packaging of Paramagnetic Materials in Oximetry and Other Applications / Bernard GallezChapter 10: |
Applications |
Conclusions and Perspectives |
Spin Trapping in Vivo: Facts and Artifacts / Graham S. Timmins ; Ke Jian LiuChapter 11: |
Classes of Spin Traps |
Considerations for in Vivo Spin Trapping Experiments |
Potential Problems, Artifacts and General Recommendations for in Vivo Spin Trapping |
Future Prospects for in Vivo Spin Trapping |
Ex Vivo Detection of Free Radical Metabolites of Toxic Chemicals and Drugs by Spin Trapping / Ronald P. Mason ; Maria B. KadiiskaChapter 12: |
Spin Traps |
Sensitivity Advance |
Applications of Spin Trapping |
Complete Table of All Free Radical Metabolites Detected by ex Vivo ESR |
Chemistry and Biology of Nitric Oxide / Andrei M. KomarovChapter 13: |
Nitric Oxide Molecule: Redox Forms of NO |
NO as an EPR Probe for Metalloproteins |
Discovery of Endothelium Derived Relaxation Factor (EDRF) and EPR Studies of EDRF |
Biosynthesis of Nitric Oxide: Three Isoforms of Nitric Oxide Synthase |
Biological Functions and Molecular Targets of Nitric Oxide |
Nitric Oxide in Disease |
Global Importance of Nitric Oxide |
In Vivo and in Vitro Detection of NO by EPR / Hirotada FujiiChapter 14: |
Physico-Chemical Methods of Detecting NO |
Detection of NO by EPR |
Detection and Quantitation of NO in Biological Specimens |
In Vivo Detection of NO Generated in Biological Systems |
Visualization of NO Generation in Biological Systems |
The Measurement of Oxygen in Vivo Using EPR Techniques / Chapter 15: |
Methods and Materials Available for EPR Oximetry |
Interactions and Use of Oxygen-Sensitive Paramagnetic Materials in Biological Systems |
Physical Basis for EPR Oximetry |
Overview of Results of EPR Oximetry |
Cardiac Applications of in Vivo EPR Spectroscopy and Imaging / Alexandre SamouilovChapter 16: |
Why Image Free Radicals in the Heart? |
Instrumentation for EPR Spectroscopy and Imaging of the Heart |
Measurement of Nitroxide Radicals in the Normally Perfused and Ischemic Heart |
EPR Oximetry in the Perfused Heart |
Three-Dimensional Spectral-Spatial EPR Imaging of the Heart |
Four-Dimensional Spectral-Spatial EPR Imaging of the Heart |
Three-Dimensional Spatial Imaging of the Heart |
Gated EPR Imaging of the Beating Heart |
Imaging of Nitric Oxide in the Heart |
Applications of in Vivo EPR Spectroscopy and Imaging in Cancer Research / Chapter 17: |
Problems in Cancer Research |
Applications of in Vivo EPR Spectroscopy and Imaging to Skin / Jurgen Fuchs ; Norbert Groth ; Thomas HerrlingChapter 18: |
Skin Morphology and Practical Implications for EPR Studies |
Diseases of the Skin and Cutaneous Manifestations of Systemic Diseases |
Instrumental Aspects of Human Skin in Vivo EPR |
Pharmaceutical Applications of in Vivo EPR / Karsten MaderChapter 19: |
Pharmaceutical Technology and Drug Delivery Systems |
Metabolism of Xenobiotics and Drugs |
Pharmacokinetics of Paramagnetic Compounds |
Pharmacodynamics Characterisation of Drugs |
Proton-Electron Double-Resonance Imaging (PEDRI) / David J. LurieChapter 20: |
PEDRI Techniques and Pulse Sequences |
Hardware for PEDRI and Related Techniques |
Sensitivity Considerations |
Biological Applications of PEDRI, FC-PEDRI, and FC-DNP |
Combining NMR and EPR/ESR for in Vivo Experiments / Jeff F. DunnChapter 21: |
Illustrative Combined Uses of NMR and EPR |
Potential Medical (Clinical) Applications of EPR: Overview and Perspectives / Chapter 22: |
Rationale for Development of Clinical Applications of in Vivo EPR |
Current Status of Clinical Uses of in Vivo EPR |
Challenges and Feasible Solutions for the Implementation of in Vivo EPR in the Clinical Setting |
Suggested Strategy for the Initial Clinical Applications of in Vivo EPR |
Glossary |
Contents of Previous Volumes |
Index |
Introduction to in Vivo EPR / Harold M. Swartz ; Lawrence J. BerlinerChapter 1: |
Aim and Scope of the Book / 1.: |
Rationale for in Vivo EPR / 2.: |