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1.

図書

図書
edited by Lawrence J. Berliner
出版情報: New York ; London : Plenum Press, c1998  xvii , 423 p. ; 24 cm
シリーズ名: Biological magnetic resonance / edited by Lawrence J. Berliner and Jacques Reuben ; v. 14
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目次情報: 続きを見る
Analysis of Spin Label Lineshapes with Novel Inhomogenous Broadening from Different Component Widths
Application to Spatially Disconnected Domains in Membranes / M.B. Sankarum ; D. Marsh
Progressive Saturation and Saturation transferred EPR for Measuring Exchange Processes and Proximity Relations in Membranes / D. Marsh, et al.
Comparative Spin Label Spectra at X-band (9.5GHz) and W-band (95GHz) / A.I. Smirnov, et al.
Use of Imidazoline Nitroxides in Studies of Chemical Reactions
ESR Measurements of the Concentration and Reactivity of Protons, Thiols, and Nitric Oxide / V. Khramtsov ; L. Volodarsky
ENDOR of Spin-Labels for Structure Determination: From Small Molecules to Enzyme Reaction Intermediates / M.W. Makinen, et al.
Spin-Labeled Nucleic Acids / R.S. Keyes ; A.M. Bobst
Spin Label Applications to Food Science / M.A. Hemminga ; I.J. van den Dries
EPR Studies of Living Animals and Related Model Systems (in Vivo EPR) / H.M. Swartz ; H. Halpern
Index
Analysis of Spin Label Lineshapes with Novel Inhomogenous Broadening from Different Component Widths
Application to Spatially Disconnected Domains in Membranes / M.B. Sankarum ; D. Marsh
Progressive Saturation and Saturation transferred EPR for Measuring Exchange Processes and Proximity Relations in Membranes / D. Marsh, et al.
2.

図書

図書
edited by Lawrence J. Berliner and Pierre-Marie Robitaille
出版情報: New York ; London : Kluwer Academic, Plenum Publishers, c1998  xv, 255 p. ; 24 cm
シリーズ名: Biological magnetic resonance / edited by Lawrence J. Berliner and Jacques Reuben ; v. 15
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Tracer Theory and [superscript 13]C NMR / Maren R. Laughlin ; Joanne K. KelleherChapter 1:
Introduction / 1.:
Overview / 1.1.:
Definitions / 1.2.:
Characteristics of a Perfect Tracer / 2.:
Compartmental Models / 3.:
Objectives and Identifiability / 3.1.:
Parameter Estimation and Goodness of Fit / 3.3.:
Linearity and Tracer Models / 3.4.:
The Basic Tracer Experiment / 4.:
General Considerations / 4.1.:
Single Pool Model / 4.2.:
Multicompartmental Catenary Model / 4.3.:
Saturable Kinetic Processes / 5.:
Condensation Reactions / 6.:
Tissue Heterogeneity / 7.:
Metabolic and Isotopic Steady State, Time-Dependent Experiment / 7.1.:
Tissue Heterogeneity Measured in Pre-Isotopic Steady State / 7.2.:
Fractional Enrichment in the Metabolic and Isotopic Steady-State Experiment / 7.3.:
The [superscript 13]C NMR Experiment / 8.:
Chemical Shift and Spectral Resolution / 8.1.:
Metabolic Perturbation / 8.2.:
Detection Limits / 8.3.:
Correction for Natural Abundance Fractional Enrichment / 8.4.:
Subtraction of Natural Abundance Spectra in in Vivo Experiments / 8.5.:
Sites of Label Entry and Sampling, and Substrate Enrichment / 8.6.:
Fractional Enrichment / 8.7.:
Sensitivity and Time / 8.8.:
Use of Reporter Molecules / 8.9.:
Conclusions / 9.:
References
[superscript 13]C Isotopomer Analysis of Glutamate: A NMR Method to Probe Metabolic Pathways Intersecting in the Citric Acid Cycle / A. Dean Sherry ; Craig R. MalloyChapter 2:
The Role of the Citric Acid Cycle in Substrate Oxidation
Anaplerotic Functions of the Citric Acid Cycle
Quantitation of Glutamate Isotopomers by [superscript 13]C NMR
Relation of Glutamate Isotopomers to Multiplets in the [superscript 13]C NMR Spectrum / 2.1.:
Acquisition of the [superscript 13]C NMR Spectrum / 2.2.:
Quantitation of [superscript 13]C Fractional Enrichment by [superscript 1]H NMR / 2.3.:
Influence of Natural Abundance [superscript 13]C on an Isotopomer Analysis / 2.4.:
Mathematical and Computer Models: Applications for Isotopomer Analysis
The Value of Mathematical Models
Historical Background of Current Modeling Techniques
The Evolution of [superscript 13]C Isotopomers in the Citric Acid Cycle
The Steady-State [superscript 13]C Isotopomer Analysis
The Nonsteady-State Analysis
The Direct C4 Analysis: A Readout of Relative Substrate Utilization
Steady-State Analysis under Nosteady-State Conditions
Absolute Metabolic Fluxes from [superscript 13]C Isotopomer Data
Other Considerations / 10.:
Determination of Metabolic Fluxes by Mathematical Analysis of [superscript 13]C-Labeling Kinetics / John C. Chatham ; Edwin M. ChanceChapter 3:
Approach to Analyzing Labeling Kinetics
Formulation of Model
Numerical Methods
Results and Discussion
Metabolic Flux and Subcellular Transport of Metabolites / E. Douglas LewandowskiChapter 4:
The General Utility of Dynamic-Mode [superscript 13]C NMR: Lessons from the Heart
[superscript 13]C NMR and Metabolic Activity
[superscript 13]C-Enrichment Patterns and Oxidative Metabolism
Fractional Enrichment and [superscript 13]C NMR of Metabolic Flux
Models and Parameters of Glutamate Enrichment
Direct Kinetic Analysis of Dynamic [superscript 13]C NMR Spectra
Metabolic Flux and Regulation from Dynamic [superscript 13]C NMR Spectroscopy
Metabolite Compartmentation Effects on [superscript 13]C Kinetics
[superscript 13]C NMR of Subcellular Transport Rates
Summary / 11.:
Assessing Cardiac Metabolic Rates during Pathologic Conditions with Dynamic [superscript 13]C NMR Spectra / Robert G. Weiss ; Gary GerstenblithChapter 5:
Dynamic [superscript 13]C NMR Spectroscopy in Paradigms of Myocardial Dysfunction: "Stunned" and "Hibernating" Myocardium
"Stunned" Myocardium
"Hibernating" Myocardium
Implications for Distinguishing Types of Dysfunctional Myocardium in the Clinical Setting: In Vivo [superscript 13]C NMR
A Strategy for Measuring TCA Cycle Flux with [superscript 13]C NMR
Dynamic [superscript 13]C NMR Spectroscopy of Glycolysis in Ischemic Preconditioning
Metabolic Changes in Ischemic Preconditioned Hearts
Attenuated Ischemic Acidosis in Preconditioned Hearts
Applications of [superscript 13]C Labeling to Studies of Human Brain Metabolism in Vivo / Graeme F. MasonChapter 6:
Measurement of the TCA Cycle Rate in the Brain
A General Description
Theoretical Basis of the Kinetic Modeling: Mass and Isotope Balance
Overview of Interpretation of the Data by Mathematical Modeling
Methods of Detection Currently in Use for Metabolic Studies of Brain in Vivo
Mathematical Modeling: A Detailed Discussion
Description of Metabolic Flow
Equations and Procedures Used to Determine Model Parameters
Measurement of Glutamate Turnover Rate (V[superscript gt])
Determination of V[superscript x]/V[superscript tca] and V[superscript tca] and C4/C3 Labeling Time Courses
Determination of Glutamate/Glutamine Carbon Flow (V[superscript gln]) / 3.5.:
Derivation of Secondary Parameters
Estimation of Carbon Sources for the TCA Cycle
Determination of CMR[subscript gl]
Brain Oxygen Consumption
Quantitative Analyses of Sensitivities
Glucose Turnover Time / 5.1.:
Exchange of Lactate and Pyruvate / 5.2.:
Effects of Metabolic Intermediates and Aspartate / 5.3.:
Rates of Influx and Efflux of Lactate and Pyruvate / 5.4.:
Exchange Between [alpha]-Ketoglutarate and Glutamate / 5.5.:
Pyruvate Carboxylase / 5.6.:
Pentose Phosphate Shunt / 5.7.:
Glucose Label Scrambling / 5.8.:
Glutamate/Glutamine Carbon Flow / 5.9.:
Summary of Sensitivity Analysis / 5.10.:
Metabolic Compartmentation
Neuronal Activity and Compartmentation / 6.1.:
Effects of Glutamate/Glutamine Compartmentation on Measured V[subscript tca] / 6.2.:
Future of [superscript 13]C-Labeling Studies of the Brain in Vivo
In Vivo [superscript 13]C NMR Spectroscopy: A Unique Approach in the Dynamic Analysis of Tricarboxylic Acid Cycle Flux and Substrate Selection / Pierre-Marie Luc RobitailleChapter 7:
The Interaction between Major Biochemical Pathways and Reactions
The Myoglobin System
The Lactate and Alanine Systems
The Creatine Kinase System
The History of Cellular [superscript 13]C NMR
Post-Steady-State Analysis
The Theory of Post-Steady-State Analysis
In Vivo [superscript 13]C NMR Analysis of Substrate Selection
Contents of Previous Volumes
Index
Tracer Theory and [superscript 13]C NMR / Maren R. Laughlin ; Joanne K. KelleherChapter 1:
Introduction / 1.:
Overview / 1.1.:
3.

図書

図書
edited by N. Rama Krishna and Lawrence J. Berliner
出版情報: New York ; London : Kluwer Academic/Plenum, c1998  xvi,387p ; 24cm
シリーズ名: Biological magnetic resonance / edited by Lawrence J. Berliner and Jacques Reuben ; v. 16
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