| Arsenite Resistance in Leishmania and Possible Drug Targets / Gaganmeet Singh ; K.G. Jayanarayan ; Chinmoy S. Dey1： |
| Abstract |
| Introduction |
| Arsenite Resistance in Leishmania |
| Potential Drug Targets |
| Conclusion |
| Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets in Trypanosomatids / Dotan Sela ; Neta Milman ; Irit Kapeller ; Aviad Zick ; Rachel Bezalel ; Nurit Yaffe ; Joseph Shlomai2： |
| Reevaluating the Kinetoplast as a Potential Target for Anti-Trypanosomal Drugs |
| The kDNA Network and Its Monomeric Components |
| Unique Characteristics of the kDNA Replication System |
| Replication of Free kDNA Minicircles and Catenated Maxicircles |
| Regulation of kDNA Replication |
| Concluding Remarks |
| Drugs and Transporters in Kinetoplastid Protozoa / Scott M. Landfear3： |
| Roles of Membrane Transport Proteins among the Kinetoplastida |
| Leishmania Glucose Transporters |
| Leishmania Purine Transporters |
| Selective Lead Compounds Against Kinetoplastid Tubulin / R.E. Morgan ; K.A. Werbovetz4： |
| Oryzalin as a Lead Compound against Kinetoplastid Tubulin |
| Aromatic Thiocyanates as Lead Compounds |
| Generating New Leads |
| Fishing for Anti-Leishmania Drugs: Principles and Problems / Emanuela Handman ; Lukasz Kedzierski ; Alessandro D. Uboldi ; James W. Goding5： |
| The Disease Burden of Leishmaniasis |
| Transmission and Epidemiology |
| Disease Manifestations |
| Management and Control of Leishmaniasis |
| The Impact of New Technologies on Drug Discovery |
| High Throughput Screening |
| Structure-Based Drug Discovery |
| Proteomics |
| Monoclonal Antibodies |
| Natural Products |
| Target Selection and Validation |
| Proteins and Metabolic Pathways Unique to the Parasite |
| Proteins Essential for Parasite Survival and Virulence Factors |
| Target Validation |
| Sterol 14-Demethylase Inhibitors for Trypanosoma Cruzi Infections / Frederick S. Buckner6： |
| Chagas Disease |
| Drug Development for Changes Disease |
| Sterol Biosynthesis-Overview |
| Sterol 14-Demethylase (CYP51) and Azole Inhibitors |
| Sterols of T. cruzi |
| Activity of Azole Compounds against T. cruzi |
| The Development Status of Sterol 14-Demethylase Inhibitors |
| Can a Better Sterol 14-Demethylase Inhibitor Be Developed against T. cruzi? |
| Summary |
| Histone Deacetylases / David Horn7： |
| The Deacetylases |
| The Inhibitors |
| Current Research |
| Targeting Glycoproteins or Glycolipids and their Metabolic Pathways for Antiparasite Therapy / Sumi Mukhopadhyay nee Bandyopadhyay ; Chitra Mandal8： |
| An Introduction to the Kinetoplastid Parasites |
| Trypanosomiasis |
| Leishmaniasis |
| Why Target Glycoproteins and Glycolipids? |
| Glycoconjugates of Trypanosomes |
| Biological Relevance of Glycoconjugates in Trypanosomiasis |
| Targeting VSG Epitopes |
| Targeting Mucin Glycoproteins |
| Lactose Derivatives Are Inhibitors of Trans-Sialidase Present in the Mucins |
| Glycoconjugate Biosynthetic Machinery in Trypanosome |
| Targeting Enzymes of the Biosynthetic Pathway |
| Glycoconjugates of Leishmania |
| Biological Relevance |
| Development of Anti-Leishmanials by Targeting |
| gp63 Producing Enzymes |
| Galactofuranose on LPG |
| Sialoglycans |
| Other Glyoconjugates |
| PPG |
| Glycosylphosphatidylinositol (GPI) Lipids |
| Enzymes Producting Glycoproteins |
| As Drug Carrier |
| Perspective |
| DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy / Benu Brata Das ; Agneyo Ganguly ; Hemanta K. Majumder9： |
| DNA Topoisomerases: The Wonder Enzyme |
| Classification of DNA Topoisomerases |
| Topoisomerases of Kinetoplastid Parasites |
| Topoisomerases as Therapeutic Targets |
| Antiparasitic Chemotherapy: Tinkering with the Purine Salvage Pathway / Alok Kumar Datta ; Rupak Datta ; Banibrata Sen10： |
| General Strategies for Development and Characterisation of Drug Targets in Trypanosomatids |
| Acquisition and Assimilation of Purines in L. donovani Promastigotes |
| Purine Metabolism in L. donovani Amastigotes |
| Purine Salvage Enzymes as Targets for Structure-Based Inhibitor Design |
| Prospects of Adenosine Kinase (AdK) as the Drug Target |
| General Biochemical Properties of the L. donovani AdK |
| Structure of AdK from Different Sources |
| Sequence Characteristics of LdAdK Gene and Homology Model-Based Structural Analysis of the Protein |
| Identification of Potential Amino Acid Residues Involved in Catalysis |
| Mechanism of Ado Binding |
| Mechanism of Phosphate Transfer |
| Product-Mediated Enzyme Regulation |
| Conclusions and Perspectives |
| Searching The Tritryp Genomes for Drug Targets / Peter J. Myler11： |
| Tritryp Genome Content |
| Computational Approaches for Drug Target Selection |
| Databases of Tritrype Metabolism |
| Identification of Metabolic "Choke-Points" |
| Searching for Parasite Orthologues of Known Drug Targets |
| Matching Drug-Like Chemicals to Parasite Proteins |
| Purine and Pyrimidine Metabolism in Leishmania / Nicola S. Carter ; Phillip Yates ; Cassandra S. Arendt ; Jan M. Biotz ; Buddy Ullman12： |
| Nomenclature |
| Purine Metabolism |
| Purine Transport in Leishmania |
| Purine Transporters as Drug Targets in Leishmania |
| Structure-Function Studies on Purine Transporters |
| Purine Salvage Enzymes of Leishmania |
| Purine Salvage Enzymes as Drug Targets in Leishmania |
| The Compartmentalization of Purine Salvage in Leishmania |
| Pyrimidine Metabolism |
| Pyrimidine Biosynthesis in Leishmania |
| Pyrimidine Salvage and Nucleotide Synthesis in Leishmania |
| The Pyrimidine Pathway as a Drug Target in Leishmania |
| Index |
| Arsenite Resistance in Leishmania and Possible Drug Targets / Gaganmeet Singh ; K.G. Jayanarayan ; Chinmoy S. Dey1： |
| Abstract |
| Introduction |
図書
