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1.

電子ブック

EB
Ludwig Brand, Michael L. Johnson
出版情報: Elsevier ScienceDirect Books , 2009
所蔵情報: loading…
目次情報: 続きを見る
Contributors
Preface
Volumes in Series
Phase Response Curves: Elucidating the Dynamics of Coupled Oscillators / A. Granada ; R. M. Hennig ; B. Ronacher ; A. Kramer ; H. Herzel1:
Introduction
Estimation of Phase Response Curves / 2:
Specific Applications / 3:
Discussion / 4:
Acknowledgments / Appendix I:
References
Multiple Ion Binding Equilibria, Reaction Kinetics, and Thermodynamics in Dynamic Models of Biochemical Pathways / Kalyan C. Vinnakota ; Fan Wu ; Martin J. Kushmerick ; Daniel A. Beard
Biochemical Conventions and Calculations
Application to Physiological Systems
Acknowledgment
Analytical Methods for the Retrieval and Interpretation of Continuous Glucose Monitoring Data in Diabetes / Boris Kovatchev ; Marc Breton ; William Clarke
Decomposition of Sensor Errors
Measures of Average Glycemia and Deviation from Target
Risk and Variability Assessment
Measures and Plots of System Stability / 5:
Time-Series-Based Prediction of Future BG Values / 6:
Conclusions / 7:
Analysis of Heterogeneity in Molecular Weight and Shape by Analytical Ultracentrifugation Using Parallel Distributed Computing / Borries Demeler ; Emre Brookes ; Luitgard Nagel-Steger
Methodology
Job Submission
Results
Discrete Stochastic Simulation Methods for Chemically Reacting Systems / Yang Cao ; David C. Samuels
The Chemical Master Equation
The Stochastic Simulation Algorithm
The Tau-Leaping Method
Measurement of Simulation Error
Software and Two Numerical Experiments
Conclusion
Analyses for Physiological and Behavioral Rhythmicity / Harold B. Dowse
Types of Biological Data and Their Acquisition
Analysis in the Time Domain
Analysis in the Frequency Domain
Time/Frequency Analysis and the Wavelet Transform
Signal Conditioning
Strength and Regularity of a Signal
A Computational Approach for the Rational Design of Stable Proteins and Enzymes: Optimization of Surface Charge-Charge Interactions / Katrina L. Schweiker ; George I. Makhatadze8:
Computational Design of Surface Charge-Charge Interactions
Experimental Verification of Computational Predictions
Closing Remarks
Efficient Computation of Confidence Intervals for Bayesian Model Predictions Based on Multidimensional Parameter Space / Amber D. Smith ; Alan Genz ; David M. Freiberger ; Gregory Belenky ; Hans P. A. Van Dongen
Height of the Probability Density Function at the Boundary of the Smallest Multidimensional Confidence Region
Approximating a One-Dimensional Slice of the Probability Density Function by Means of Normal Curve Spline Pieces
Locating the Boundary of the Smallest Multidimensional Confidence Region
Finding the Minimum and Maximum of the Prediction Model over the Confidence Region
An Application: Bayesian Forecasting of Cognitive Performance Impairment during Sleep Deprivation
95% Confidence Intervals for Bayesian Predictions of Cognitive Performance Impairment during Sleep Deprivation
Appendix
Analyzing Enzymatic pH Activity Profiles and Protein Titration Curves Using Structure-Based pK<a/ Calculations and Titration Curve Fitting / Jens Erik Nielsen9:
Calculating the pH Dependence of Protein Characteristics
Setting up and Running a pKa/ Calculation
Analyzing the Results of a pKa/ Calculation
How Reliable Are Calculated pKa/ Values?
Predicting pH Activity Profiles
Decomposition Analysis
Predicting Protein Stability Profiles
Fitting pH Titration Curves, pH Activity Profiles, and pH Stability Profiles
Least Squares in Calibration: Weights, Nonlinearity, and Other Nuisances / Joel Tellinghuisen10:
Review of Least Squares
Experiment Design Using Vprior/-Numerical Illustrations
Evaluation and Comparison of Computational Models / Jay I. Myung ; Yun Tang ; Mark A. Pitt11:
Conceptual Overview of Model Evaluation and Comparison
Model Comparison Methods
Model Comparison at Work: Choosing between Protein Folding Models
Desegregating Undergraduate Mathematics and Biology - Interdisciplinary Instruction with Emphasis on Ongoing Biomedical Research / Raina Robeva12:
Course Description
Mathematical Algorithms for High-Resolution DNA Melting Analysis / Robert Palais ; Carl T. Wittwer13:
Extracting Melting Curves from Raw Fluorescence
Methods Used for Clustering and Classifying Melting Curves by Genotype
Methods Used for Modeling Melting Curves
Biomathematical Modeling of Pulsatile Hormone Secretion: A Historical Perspective / William S. Evans ; Leon S. Farhy ; Michael L. Johnson14:
Early Attempts to Identify and Characterize Pulsatile Hormone Release
Impact of Sampling Protocol and Pulse Detection Algorithm on Hormone Pulse Detection
Application of Deconvolution Procedures for the Identification and Characterization of Hormone Secretory Bursts
Limitations and Subsequent Improvements in Deconvolution Procedures
Evaluation of Pulsatile and Basal Hormone Secretion Using a Stochastic Differential Equations Model
Characterization of Regulation of Signal and Response Elements: Estimation of Approximate Entropy
Evaluation of Coupled Systems
Evaluation of Hormonal Networks with Feedback Interactions
Future Directions
AutoDecon: A Robust Numerical Method for the Quantification of Pulsatile Events / Lenore Pipes ; Paula P. Veldhuis ; Ralf Nass ; Michael O. Thorner15:
Methods
Modeling Fatigue over Sleep Deprivation, Circadian Rhythm, and Caffeine with a Minimal Performance Inhibitor Model / Patrick L. Benitez ; Gary H. Kamimori ; Thomas J. Balkin ; Alexander Greene16:
Author Index
Subject Index
Contributors
Preface
Volumes in Series
2.

電子ブック

EB
Michael L. John, Ludwig Brand, Michael L. Johnson
出版情報: Elsevier ScienceDirect Books , Elsevier Science & Technology, 2009
所蔵情報: loading…
目次情報: 続きを見る
Contributors
Preface
Volumes in Series
Correlation Analysis: A Tool for Comparing Relaxation-Type Models to Experimental Data / Maurizio Tomaiuolo ; Joel Tabak ; Richard Bertram1:
Introduction
Scatter Plots and Correlation Analysis / 2:
Example 1: Relaxation Oscillations / 3:
Example 2: Square Wave Bursting / 4:
Example 3: Elliptic Bursting / 5:
Example 4: Using Correlation Analysis on Experimental Data / 6:
Summary / 7:
Acknowledgments
References
Trait Variability of Cancer Cells Quantified by High-Content Automated Microscopy of Single Cells / Vito Quaranta ; Darren R. Tyson ; Shawn P. Garbett ; Brandy Weidow ; Mark P. Harris ; Walter Georgescu
Background
Experimental and Computational Workflow
Application to Traits Relevant to Cancer Progression
Conclusions
Matrix Factorization for Recovery of Biological Processes from Microarray Data / Andrew V. Kossenkov ; Michael F. Ochs
Overview of Methods
Application to the Rosetta Compendium
Results of Analyses
Discussion
Modeling and Simulation of the Immune System as a Self-Regulating Network / Peter S. Kim ; Doron Levy ; Peter P. Lee
Mathematical Modeling of the Immune Network
Two Examples of Models to Understand T Cell Regulation
How to Implement Mathematical Models in Computer Simulations
Concluding Remarks
Acknowledgmentss
Entropy Demystified: The ôThermoö-dynamics of Stochastically Fluctuating Systems / Hong Qian
Energy
Entropy and ôThermoö-dynamics of Markov Processes
A Three-State Two-Cycle Motor Protein
Phosphorylation-Dephosphorylation Cycle1 Kinetics
Summary and Challenges
Effect of Kinetics on Sedimentation Velocity Profiles and the Role of Intermediates / John J. Correia ; P. Holland Alday ; Peter Sherwood ; Walter F. Stafford
Methods
ABCD Systems
Monomer-Tetramer Model
Algebraic Models of Biochemical Networks / Reinhard Laubenbacher ; Abdul Salam Jarrah
Computational Systems Biology
Network Inference
Reverse-Engineering of Discrete Models: An Example
High-Through put Computing in the Sciences / Mark Morgan ; Andrew Grimshaw8:
What is an HTC Application?
HTC Technologies
High-Throughput Computing Examples
Advanced Topics
Large Scale Transcriptome Data Integration Across Multiple Tissues to Decipher Stem Cell Signatures / Ghislain Bidaut ; Christian J. Stoeckert9:
Systems and Data Sources
Data Integration
Artificial Neural Network Training and Validation
Future Development and Enhancement Plans
DynaFit-A Software Package for Enzymology / Petr Kuzmiĉ10:
Equilibrium Binding Studies
Initial Rates of Enzyme Reactions
Time Course of Enzyme Reactions
General Methods and Algorithms
Discrete Dynamic Modeling of Cellular Signaling Networks / Réka Albert ; Rui-Sheng Wang11:
Cellular Signaling Networks
Boolean Dynamic Modeling
Variants of Boolean Network Models
Application Examples
Conclusion and Discussion
The Basic Concepts of Molecular Modeling / Akansha Saxena ; Diana Wong ; Karthikeyan Diraviyam ; David Sept12:
Homology Modeling
Molecular Dynamics
Molecular Docking
Deterministic and Stochastic Models of Genetic Regulatory Networks / Ilya Shmulevich ; John D. Aitchison13:
Boolean Networks
Differential Equation Models
Probabilistic Boolean Networks
Stochastic Differential Equation Models
Bayesian Probability Approach to ADHD Appraisal / Raina Robeva ; Jennifer Kim Penberthy14:
Bayesian Probability Algorithm
The Value of Bayesian Probability Approach as a Meta-Analysis Tool
Discussion and Future Directions
Simple Stochastic Simulation / Maria J. Schilstra ; Stephen R. Martin15:
Understanding Reaction Dynamics
Graphical Notation
Reactions
Reaction Kinetics
Transition Firing Rules
Notes
Monte Carlo Simulation in Establishing Analytical Quality Requirements for Clinical Laboratory Tests: Meeting Clinical Needs / James C. Boyd ; David E. Bruns16:
Modeling Approach
Methods for Simulation Study
Results
Nonlinear Dynamical Analysis and Optimization for Biological/Biomedical Systems / Amos Ben-Zvi ; Jong Mm Lee17:
Hypothalamic-Pituitary-Adrenal Axis System
Development of a Clinically Relevant Performance-Assessment Tools
Dynamic Programming
Computation of Optimal Treatments for HPA Axis System
Modeling of Growth Factor-Receptor Systems: From Molecular-Level Protein Interaction Networks to Whole-Body Compartment Models / Florence T. H. Wu ; Marianne O. Stefanini ; Feilim Mac Gabhann ; Aleksander S. Popel18:
Molecular-Level Kinetics Models: Simulation of In Vitro Experiments
Mesoscale Single-Tissue 3D Models: Simulation of In Vivo Tissue Regions
Single-Tissue Compartmental Models: Simulation at In Vivo Tissue
Multitissue Compartmental Models: Simulation of Whole Body
The Least-Squares Analysis of Data from Binding and Enzyme Kinetics Studies: Weights, Bias, and Confidence Intervals in Usual and Unusual Situations / Joel Tellinghuisen19:
Least Squares Review
Statistics of Reciprocals
Weights When y is a True Dependent Variable
Unusual Weighting: When x is the Dependent Variable
Assessing Data Uncertainty: Variance Function Estimation
Conclusion
Nonparametric Entropy Estimation Using Kernel Densities / Douglas E. Lake20:
Motivating Application: Classifying Cardiac Rhythms
Renyi Entropy and the Friedman-Tukey Index
Kernel Density Estimation
Mean-Integrated Square Error
Estimating the FT Index
Connection Between Template Matches and Kernel Densities
Summary and Future Work
Pancreatic Network Control of Glucagon Secretion and Counterregulation / Leon S. Farhy ; Anthony L. McCall21:
Mechanisms of Glucagon Counterregulation (GCR) Dysregulation in Diabetes
Interdisciplinary Approach to Investigating the Defects in the GCR
Initial Qualitative Analysis of the GCR Control Axis
Mathematical Models of the GCR Control Mechanisms in STZ-Treated Rats
Approximation of the Normal Endocrine Pancreas by a Minimal Control Network (MCN) and Analysis of the GCR Abnormalities in the Insulin Deficient Pancreas
Advantages and Limitations of the Interdisciplinary Approach
Enzyme Kinetics and Computational Modeling for Systems Biology / Pedro Mendes ; Hanan Messiha ; Naglis Malys ; Stefan Hoops22:
Computational Modeling and Enzyme Kinetics
Yeast Triosephosphate Isomerase (EC 5.3.1.1)
Initial Rate Analysis
Progress Curve Analysis
Fitting Enzyme Kinetic Data with KinTek Global Kinetic Explorer / Kenneth A. Johnson23:
Challenges of Fitting by Simulation
Progress Curve Kinetics
Fitting Full Progress Curves
Slow Onset Inhibition Kinetics
Author Index
Subject Index
Contributors
Preface
Volumes in Series
3.

電子ブック

EB
Ludwig; Johnson, Michael L.; Brand, Ludwig Brand, Ludwig Brand, Michael L. Johnson
出版情報: Elsevier ScienceDirect Books Complete , Academic Press, 2009
所蔵情報: loading…
目次情報: 続きを見る
Contributors
Preface
Volumes in Series
Phase Response Curves: Elucidating the Dynamics of Coupled Oscillators / A. Granada ; R. M. Hennig ; B. Ronacher ; A. Kramer ; H. Herzel1:
Introduction
Estimation of Phase Response Curves / 2:
Specific Applications / 3:
Discussion / 4:
Acknowledgments / Appendix I:
References
Multiple Ion Binding Equilibria, Reaction Kinetics, and Thermodynamics in Dynamic Models of Biochemical Pathways / Kalyan C. Vinnakota ; Fan Wu ; Martin J. Kushmerick ; Daniel A. Beard
Biochemical Conventions and Calculations
Application to Physiological Systems
Acknowledgment
Analytical Methods for the Retrieval and Interpretation of Continuous Glucose Monitoring Data in Diabetes / Boris Kovatchev ; Marc Breton ; William Clarke
Decomposition of Sensor Errors
Measures of Average Glycemia and Deviation from Target
Risk and Variability Assessment
Measures and Plots of System Stability / 5:
Time-Series-Based Prediction of Future BG Values / 6:
Conclusions / 7:
Analysis of Heterogeneity in Molecular Weight and Shape by Analytical Ultracentrifugation Using Parallel Distributed Computing / Borries Demeler ; Emre Brookes ; Luitgard Nagel-Steger
Methodology
Job Submission
Results
Discrete Stochastic Simulation Methods for Chemically Reacting Systems / Yang Cao ; David C. Samuels
The Chemical Master Equation
The Stochastic Simulation Algorithm
The Tau-Leaping Method
Measurement of Simulation Error
Software and Two Numerical Experiments
Conclusion
Analyses for Physiological and Behavioral Rhythmicity / Harold B. Dowse
Types of Biological Data and Their Acquisition
Analysis in the Time Domain
Analysis in the Frequency Domain
Time/Frequency Analysis and the Wavelet Transform
Signal Conditioning
Strength and Regularity of a Signal
A Computational Approach for the Rational Design of Stable Proteins and Enzymes: Optimization of Surface Charge-Charge Interactions / Katrina L. Schweiker ; George I. Makhatadze8:
Computational Design of Surface Charge-Charge Interactions
Experimental Verification of Computational Predictions
Closing Remarks
Efficient Computation of Confidence Intervals for Bayesian Model Predictions Based on Multidimensional Parameter Space / Amber D. Smith ; Alan Genz ; David M. Freiberger ; Gregory Belenky ; Hans P. A. Van Dongen
Height of the Probability Density Function at the Boundary of the Smallest Multidimensional Confidence Region
Approximating a One-Dimensional Slice of the Probability Density Function by Means of Normal Curve Spline Pieces
Locating the Boundary of the Smallest Multidimensional Confidence Region
Finding the Minimum and Maximum of the Prediction Model over the Confidence Region
An Application: Bayesian Forecasting of Cognitive Performance Impairment during Sleep Deprivation
95% Confidence Intervals for Bayesian Predictions of Cognitive Performance Impairment during Sleep Deprivation
Appendix
Analyzing Enzymatic pH Activity Profiles and Protein Titration Curves Using Structure-Based pK<a/ Calculations and Titration Curve Fitting / Jens Erik Nielsen9:
Calculating the pH Dependence of Protein Characteristics
Setting up and Running a pKa/ Calculation
Analyzing the Results of a pKa/ Calculation
How Reliable Are Calculated pKa/ Values?
Predicting pH Activity Profiles
Decomposition Analysis
Predicting Protein Stability Profiles
Fitting pH Titration Curves, pH Activity Profiles, and pH Stability Profiles
Least Squares in Calibration: Weights, Nonlinearity, and Other Nuisances / Joel Tellinghuisen10:
Review of Least Squares
Experiment Design Using Vprior/-Numerical Illustrations
Evaluation and Comparison of Computational Models / Jay I. Myung ; Yun Tang ; Mark A. Pitt11:
Conceptual Overview of Model Evaluation and Comparison
Model Comparison Methods
Model Comparison at Work: Choosing between Protein Folding Models
Desegregating Undergraduate Mathematics and Biology - Interdisciplinary Instruction with Emphasis on Ongoing Biomedical Research / Raina Robeva12:
Course Description
Mathematical Algorithms for High-Resolution DNA Melting Analysis / Robert Palais ; Carl T. Wittwer13:
Extracting Melting Curves from Raw Fluorescence
Methods Used for Clustering and Classifying Melting Curves by Genotype
Methods Used for Modeling Melting Curves
Biomathematical Modeling of Pulsatile Hormone Secretion: A Historical Perspective / William S. Evans ; Leon S. Farhy ; Michael L. Johnson14:
Early Attempts to Identify and Characterize Pulsatile Hormone Release
Impact of Sampling Protocol and Pulse Detection Algorithm on Hormone Pulse Detection
Application of Deconvolution Procedures for the Identification and Characterization of Hormone Secretory Bursts
Limitations and Subsequent Improvements in Deconvolution Procedures
Evaluation of Pulsatile and Basal Hormone Secretion Using a Stochastic Differential Equations Model
Characterization of Regulation of Signal and Response Elements: Estimation of Approximate Entropy
Evaluation of Coupled Systems
Evaluation of Hormonal Networks with Feedback Interactions
Future Directions
AutoDecon: A Robust Numerical Method for the Quantification of Pulsatile Events / Lenore Pipes ; Paula P. Veldhuis ; Ralf Nass ; Michael O. Thorner15:
Methods
Modeling Fatigue over Sleep Deprivation, Circadian Rhythm, and Caffeine with a Minimal Performance Inhibitor Model / Patrick L. Benitez ; Gary H. Kamimori ; Thomas J. Balkin ; Alexander Greene16:
Author Index
Subject Index
Contributors
Preface
Volumes in Series
4.

電子ブック

EB
Michael L. John, Ludwig Brand, Michael L. Johnson
出版情報: Elsevier ScienceDirect Books Complete , Academic Press, 2009
所蔵情報: loading…
目次情報: 続きを見る
Contributors
Preface
Volumes in Series
Correlation Analysis: A Tool for Comparing Relaxation-Type Models to Experimental Data / Maurizio Tomaiuolo ; Joel Tabak ; Richard Bertram1:
Introduction
Scatter Plots and Correlation Analysis / 2:
Example 1: Relaxation Oscillations / 3:
Example 2: Square Wave Bursting / 4:
Example 3: Elliptic Bursting / 5:
Example 4: Using Correlation Analysis on Experimental Data / 6:
Summary / 7:
Acknowledgments
References
Trait Variability of Cancer Cells Quantified by High-Content Automated Microscopy of Single Cells / Vito Quaranta ; Darren R. Tyson ; Shawn P. Garbett ; Brandy Weidow ; Mark P. Harris ; Walter Georgescu
Background
Experimental and Computational Workflow
Application to Traits Relevant to Cancer Progression
Conclusions
Matrix Factorization for Recovery of Biological Processes from Microarray Data / Andrew V. Kossenkov ; Michael F. Ochs
Overview of Methods
Application to the Rosetta Compendium
Results of Analyses
Discussion
Modeling and Simulation of the Immune System as a Self-Regulating Network / Peter S. Kim ; Doron Levy ; Peter P. Lee
Mathematical Modeling of the Immune Network
Two Examples of Models to Understand T Cell Regulation
How to Implement Mathematical Models in Computer Simulations
Concluding Remarks
Acknowledgmentss
Entropy Demystified: The ôThermoö-dynamics of Stochastically Fluctuating Systems / Hong Qian
Energy
Entropy and ôThermoö-dynamics of Markov Processes
A Three-State Two-Cycle Motor Protein
Phosphorylation-Dephosphorylation Cycle1 Kinetics
Summary and Challenges
Effect of Kinetics on Sedimentation Velocity Profiles and the Role of Intermediates / John J. Correia ; P. Holland Alday ; Peter Sherwood ; Walter F. Stafford
Methods
ABCD Systems
Monomer-Tetramer Model
Algebraic Models of Biochemical Networks / Reinhard Laubenbacher ; Abdul Salam Jarrah
Computational Systems Biology
Network Inference
Reverse-Engineering of Discrete Models: An Example
High-Through put Computing in the Sciences / Mark Morgan ; Andrew Grimshaw8:
What is an HTC Application?
HTC Technologies
High-Throughput Computing Examples
Advanced Topics
Large Scale Transcriptome Data Integration Across Multiple Tissues to Decipher Stem Cell Signatures / Ghislain Bidaut ; Christian J. Stoeckert9:
Systems and Data Sources
Data Integration
Artificial Neural Network Training and Validation
Future Development and Enhancement Plans
DynaFit-A Software Package for Enzymology / Petr Kuzmiĉ10:
Equilibrium Binding Studies
Initial Rates of Enzyme Reactions
Time Course of Enzyme Reactions
General Methods and Algorithms
Discrete Dynamic Modeling of Cellular Signaling Networks / Réka Albert ; Rui-Sheng Wang11:
Cellular Signaling Networks
Boolean Dynamic Modeling
Variants of Boolean Network Models
Application Examples
Conclusion and Discussion
The Basic Concepts of Molecular Modeling / Akansha Saxena ; Diana Wong ; Karthikeyan Diraviyam ; David Sept12:
Homology Modeling
Molecular Dynamics
Molecular Docking
Deterministic and Stochastic Models of Genetic Regulatory Networks / Ilya Shmulevich ; John D. Aitchison13:
Boolean Networks
Differential Equation Models
Probabilistic Boolean Networks
Stochastic Differential Equation Models
Bayesian Probability Approach to ADHD Appraisal / Raina Robeva ; Jennifer Kim Penberthy14:
Bayesian Probability Algorithm
The Value of Bayesian Probability Approach as a Meta-Analysis Tool
Discussion and Future Directions
Simple Stochastic Simulation / Maria J. Schilstra ; Stephen R. Martin15:
Understanding Reaction Dynamics
Graphical Notation
Reactions
Reaction Kinetics
Transition Firing Rules
Notes
Monte Carlo Simulation in Establishing Analytical Quality Requirements for Clinical Laboratory Tests: Meeting Clinical Needs / James C. Boyd ; David E. Bruns16:
Modeling Approach
Methods for Simulation Study
Results
Nonlinear Dynamical Analysis and Optimization for Biological/Biomedical Systems / Amos Ben-Zvi ; Jong Mm Lee17:
Hypothalamic-Pituitary-Adrenal Axis System
Development of a Clinically Relevant Performance-Assessment Tools
Dynamic Programming
Computation of Optimal Treatments for HPA Axis System
Modeling of Growth Factor-Receptor Systems: From Molecular-Level Protein Interaction Networks to Whole-Body Compartment Models / Florence T. H. Wu ; Marianne O. Stefanini ; Feilim Mac Gabhann ; Aleksander S. Popel18:
Molecular-Level Kinetics Models: Simulation of In Vitro Experiments
Mesoscale Single-Tissue 3D Models: Simulation of In Vivo Tissue Regions
Single-Tissue Compartmental Models: Simulation at In Vivo Tissue
Multitissue Compartmental Models: Simulation of Whole Body
The Least-Squares Analysis of Data from Binding and Enzyme Kinetics Studies: Weights, Bias, and Confidence Intervals in Usual and Unusual Situations / Joel Tellinghuisen19:
Least Squares Review
Statistics of Reciprocals
Weights When y is a True Dependent Variable
Unusual Weighting: When x is the Dependent Variable
Assessing Data Uncertainty: Variance Function Estimation
Conclusion
Nonparametric Entropy Estimation Using Kernel Densities / Douglas E. Lake20:
Motivating Application: Classifying Cardiac Rhythms
Renyi Entropy and the Friedman-Tukey Index
Kernel Density Estimation
Mean-Integrated Square Error
Estimating the FT Index
Connection Between Template Matches and Kernel Densities
Summary and Future Work
Pancreatic Network Control of Glucagon Secretion and Counterregulation / Leon S. Farhy ; Anthony L. McCall21:
Mechanisms of Glucagon Counterregulation (GCR) Dysregulation in Diabetes
Interdisciplinary Approach to Investigating the Defects in the GCR
Initial Qualitative Analysis of the GCR Control Axis
Mathematical Models of the GCR Control Mechanisms in STZ-Treated Rats
Approximation of the Normal Endocrine Pancreas by a Minimal Control Network (MCN) and Analysis of the GCR Abnormalities in the Insulin Deficient Pancreas
Advantages and Limitations of the Interdisciplinary Approach
Enzyme Kinetics and Computational Modeling for Systems Biology / Pedro Mendes ; Hanan Messiha ; Naglis Malys ; Stefan Hoops22:
Computational Modeling and Enzyme Kinetics
Yeast Triosephosphate Isomerase (EC 5.3.1.1)
Initial Rate Analysis
Progress Curve Analysis
Fitting Enzyme Kinetic Data with KinTek Global Kinetic Explorer / Kenneth A. Johnson23:
Challenges of Fitting by Simulation
Progress Curve Kinetics
Fitting Full Progress Curves
Slow Onset Inhibition Kinetics
Author Index
Subject Index
Contributors
Preface
Volumes in Series
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