Introduction - Guide to the Talks / Douglas R. O. Morrison |
Polymorphic Genotype Matching in Acquired Creutzfeldt-Jakob Disease: An Analysis of Donor/Recipient Case Pairs / Paul Brown ; Larisa Cervenakova ; Lisa McShane ; Paul Kleihues ; Jean-Francois Foncin ; George Collins ; Frank Bastian ; Lev G. Goldfarb ; D. Carleton Gajdusek |
Human Prion Protein Gene Mutation at Codon 183 Associated with an Atypical Form of Prion Disease / Ricardo Nitrini ; Sergio Rosemberg ; Maria Rita Passos-Bueno ; Luis S. Texeira da Silva ; Paula Iughetti ; Maria Papadopoulos ; P.M. Carrilho ; Paulo Caramelli ; Steffen Albrecht ; Mayana Zatz ; Andrea LeBlanc |
Fatal Familial Insomnia: A Human Model of Prion Disease / Elio Lugaresi ; Pasquale Montagna ; Pietro Cortelli ; Paolo Tinuper ; Patrizia Avoni ; Giuseppe Plazzi |
Mechanisms of Phenotypic Heterogeneity in Human Prion Diseases / Pierluigi Gambetti ; Shu G. Chen ; Piero Parchi |
Transgenic Mice with Neuron-Specific Expression of a Hamster Prion Protein Minigene Are Susceptible to Hamster Scrapie Agent / Bruce Chesebro ; Suzette A. Priola ; Richard E. Race |
The Use of Transgenic Mice in the Investigation of Transmissible Spongiform Encephalopathies / Charles Weissmann ; Marek Fischer ; Alex Raeber ; Hans Ruedi Bueler ; Andreas Sailer ; Doron Shmerling ; Thomas Rulicke ; Sebastian Brandner ; Adriano Aguzzi |
Large-Scale Sequencing of Human, Mouse, and Sheep Prion Protein Genes / Inyoul Lee ; David Westaway ; Arian Smit ; Carol Cooper ; Hong Yao ; Stanley B. Prusiner ; Leroy Hood |
Electron Microscopy in Prion Research: Tubulovesicular Structures Are Not Composed of Prion Protein (PrP) but They May Be Intimately Associated with PrP Amyloid Fibrils / P.P. Liberski ; M. Jeffrey ; C. Goodsir |
Familial Prion Diseases Modeled in Cell Culture / David A. Harris ; Sylvain Lehmann ; Nathalie Daude |
Yeast Approach to Protein "Prionization": SUP35-[PSI] System / S. G. Inge-Vechtomov ; E. A. Ilmov ; L. N. Mironova ; V. L. Tikchomirova ; K. V. Volkov ; S.P. Zadorsky |
Prions of Yeast: Genetic Evidence that the Non-Mendelian Elements, [PSI] and [URE3] Are Altered Self-Replicating Forms of Sup35p and Ure2p, Respectively / Reed B. Wickner ; Daniel C. Masison ; Herman Edskes ; Marie-Lise Maddelein |
Early Clinical Detection of Brain Diseases in Animals / B.F. Semenov ; S.V. Ozherelkov ; V.V. Vargin |
Prion Biology and Diseases - Fatal Conformations of Proteins during a Journey from Heresy to Orthodoxy |
New Variant Creutzfeldt-Jakob Disease / Robert Will |
The Molecular Basis of Cellular Dysfunction in Prion Diseases / Randal R. Nixon ; Yin Qiu ; William Hyun ; William C. Mobley ; Stephen J. DeArmond |
Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer's Disease: [beta]-Amyloid Production and Parallels to Prion Diseases / G.A. Carlson ; C. Bergeron ; G. Levesque ; R. Sherrington ; H. Yao ; R. Strome ; B. Perry ; A. Davies ; S. Gandy ; C. Weaver ; P. Davies ; D. Shenk ; J. Rommens ; J. Roder ; P.E. Fraser ; P. St. George-Hyslop |
Polyene Antibiotics in Experimental Transmissible Subacute Spongiform Encephalopathies / Vincent Beringue ; Remi Demaimay ; Karim T. Adjou ; Severine Demart ; Francois Lamoury ; Michel Seman ; Corinne I. Lasmezas ; Jean-Philippe Deslys ; Dominique Dormont |
Scrapie Pathogenesis in Brain Grafts |
Structural Properties of Recombinant Human Prion Protein / Graham Jackson ; Andrew Hill ; Catherine Joseph ; Anthony Clarke ; John Collinge |
Autonomous Folding and Three-Dimensional Structure of the Carboxy-Terminal Domain of the Mouse Prion Protein, PrP (121-231) / Rudi Glockshuber ; Simone Hornemann ; Roland Riek ; Gerhard Wider ; Martin Billeter ; Kurt Wuthrich |
Protease-Resistant Prion Protein Formation / Byron Caughey ; Gregory J. Raymond |
Biophysical Studies on Structure Structural Transitions and Infectivity of the Prion Protein / Detlev Riesner ; Klaus Kellings ; Karin Post ; Martin Pitschke ; Holger Wille ; Hana Serban ; Darlene Groth ; Michael A. Baldwin |
Amyloidogenesis in Transmissible Spongiform Encephalopathies / Franco Cardone ; Maurizio Pocchiari |
Neuronal Degeneration and Cell Death in Prion Disease / Hans A. Kretzschmar ; Armin Giese ; Jochen W. Herms ; David R. Brown |
Clinical, Pathological, and Molecular Characterization of Gerstmann-Straussler-Scheinker Disease in the Indiana Kindred (PRNP F198S) / B. Ghetti ; F. Tagliavini ; S.R. Dlouhy ; P. Piccardo ; K. Young ; R.D. Yee ; G.D. Hutchins ; G. Giaccone ; F. Prelli ; B. Frangione ; F. Unverzagt ; O. Bugiani ; M.R. Farlow |
Studies on the Pathogenesis of Scrapie and the Purification of Scrapie Agent in the Hamster Model / Heino Diringer ; Elizabeth Baldauf ; Michael Beekes ; Muhsin Ozel |
PrP Petides as a Tool to Investigate the Pathogenesis of Prion Protein Amyloidoses / Fabrizio Tagliavini ; Giorgio Giaccone ; Frances Prelli ; Blas Frangione ; Mario Salmona ; Gianluigi Forloni ; Bernardino Ghetti ; Orso Bugiani |
Properties of the Prion Proteins in Creutzfeldt Jakob Disease Patients Heterozygous for the E200K Mutation / Ruth Gabizon ; Glenn Telling ; Zeev Meiner ; Michele Halimi ; Irit Kahana |
Strain Variation in Scrapie and BSE / Moira E. Bruce |
Transmission Studies of Fatal Familial Insomnia / Katie Sidle ; Bob Will ; Peter Lantos |
Molecular, Genetic, and Transgenetic Studies of Human Prion Disease / J. Collinge ; J. Beck ; T.A. Campbell ; M. Desbuslais ; I. Gowland ; A. Hill ; S. Mahal ; J. Meads ; K.C.L. Sidle ; J.G.R. Jefferys |
Molecular Biology of Prion Propagation / Kiyotoshi Kaneko ; Martin Vey ; Michael Scott ; Albert Taraboulos ; Stephen J. De Armond ; Fred E. Cohen |
Ultrastructural and Immunocytochemical Studies on Prion Pathogenesis / Lajos Laszlo |
Overview of the BSE Epidemic / John Wilesmith |
Assessing Risks of BSE Transmission to Humans |
Human Activities Are Causing Selection of Pathogenic Agents / Luc Montagnier |
Pathogenic Similarity of Slow Infections, Induced by Prions and Virions / V. A. Zouev |
Protein Folding and Misfolding / A. R. Clarke |
CJD Risk Factors: Analysis of 104 Patients / Eva Mitrova |
Concluding Talk: Prions from a Physicist's Viewpoint - Is the 'Protein Only' Hypothesis Correct? |
List of Speakers |
Names and Addresses of Participants |
Index |
Introduction - Guide to the Talks / Douglas R. O. Morrison |
Polymorphic Genotype Matching in Acquired Creutzfeldt-Jakob Disease: An Analysis of Donor/Recipient Case Pairs / Paul Brown ; Larisa Cervenakova ; Lisa McShane ; Paul Kleihues ; Jean-Francois Foncin ; George Collins ; Frank Bastian ; Lev G. Goldfarb ; D. Carleton Gajdusek |
Human Prion Protein Gene Mutation at Codon 183 Associated with an Atypical Form of Prion Disease / Ricardo Nitrini ; Sergio Rosemberg ; Maria Rita Passos-Bueno ; Luis S. Texeira da Silva ; Paula Iughetti ; Maria Papadopoulos ; P.M. Carrilho ; Paulo Caramelli ; Steffen Albrecht ; Mayana Zatz ; Andrea LeBlanc |