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1.

図書

図書
G.I. Marchuk ; translated by Jiri Ružička
出版情報: New York : Springer-Verlag, 1975  viii, 316 p. ; 24 cm
シリーズ名: Applications of mathematics ; v. 2
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2.

図書

図書
edited by Joseph O. Hirschfelder
出版情報: New York ; London ; Sydney : Interscience, c1967  xi, 643 p. ; 24 cm
シリーズ名: Advances in chemical physics / edited by I. Prigogine ; vol. 12
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3.

図書

図書
edited by R.W.B. Stephens and H.G. Leventhall
出版情報: London : Chapman and Hall , New York : Wiley, 1974-  v. ; 24 cm
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4.

図書

図書
edited by K.E. Shuler
出版情報: New York ; London ; Sydney : Interscience, c1969  xiii, 391 p. ; 24 cm
シリーズ名: Advances in chemical physics / edited by I. Prigogine ; v. 15
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5.

図書

図書
edited by W.H. Taliaferro and J.H. Humphrey
出版情報: New York ; Tokyo : Academic Press, 1961-  v. ; 24 cm
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目次情報: 続きを見る
Molecular Basis of Fc Receptor Function / M.D. Hulett ; P.M. Hogarth
Fas and Fas Ligand: A Death Factor and Its Receptor / S. Nagata
Interleukin-5 and Its Receptor System: Implications in the Immune System and Inflammation / K. Takatsu ; S. Takaki ; Y. Hitoshi
Human Antibodies from Combinatorial Libraries / D.R. Burton ; C.F. Barbas, III
Immune Response against Tumors / C. Roth ; C. Rochlitz ; P. Kourilsky
Formation of the Chicken B-Cell Repertoire: Ontogenesis, Regulation of Ig Gene Rearrangement and Diversification by Gene Conversion / C.-A. Reynaud ; B. Bertocci ; A. Dahan ; J.-C. Weill
Subject Index
Contents of Volumes 66-82
Cumulative Subject Indexes for 66-82
Contributors to Volumes 66-82
Contributors
Fate Decisions Regulating Bone Marrow and Peripheral B Lymphocyte Development / John G. Monroe ; Kenneth Dorshkind1:
Introduction
B Lymphocyte Development in the Bone Marrow / 2:
Development of Immature B Cells in the Bone Marrow and Periphery / 3:
BCR-Dependent Signaling and Fate Decisions by Bone Marrow and Peripheral Immature B Lymphocytes / 4:
BCR Signaling During the Transitional to Mature B-Lymphocyte Transition / 5:
Peripheral B Lymphocyte Survival: Synergy Between BCR and BAFF-R Signaling / 6:
Development of FO and MZ Mature B Lymphocytes / 7:
Concluding Remarks / 8:
Acknowledgments
References
Tolerance and Autoimmunity: Lessons at the Bedside of Primary Immunodeficiencies / Magda Carneiro-Sampaio ; Antonio Coutinho
PIDs Systematically Associated with Clinical AI
PIDs Strongly Associated with Clinical AI
PIDs that Are Mildly Associated with Clinical AI
PIDs that Are Not Associated with AID
B-Cell Self-Tolerance in Humans / Hedda Wardemann ; Michel C. Nussenzweig
Antibody Diversity
Antibodies and Self-Tolerance
Marginal Zone B Cells
B-Cell Memory
Manipulation of Regulatory T-Cell Number and Function with CD28-Specific Monoclonal Antibodies / Thomas Hunig
Aims of this Review
Positive and Negative Regulation of T-Cell Responses by the CD28/CTLA-4 System
The Importance of CD28 and CTLA-4 for the Generation and Homeostasis of Treg Cells
Manipulating the CD28 Pathway: General Considerations
Conventional and Superagonistic mAb To the Costimulatory Receptor CD28
In Vitro Expansion of Treg Cells with the Help of CD28-Specific mAb
In Vivo Effects of Conventional CD28-Specific mAb
In Vivo Effects of CD28 Superagonists: Predominance of Treg-Cell Activation
Treatment of Autoimmune and Inflammatory Model Diseases with CD28 Superagonists / 9:
TGN1412-A Superagonistic mAb to Human CD28 / 10:
Conclusions / 11:
Osteoimmunology: A View from the Bone / Jean-Pierre David
Opening Remarks: The Old and the New
Osteoimmunology: A Developmental Encounter
The TNF Superfamily: A Developmental Link Between Bone and Immune System
IFNs: Linking Bone Homeostasis to Immunity and T Cells
B Cells and Bone
A Bone Quality Control of the Immune Response
Mast Cell Proteases / Gunnar Pejler ; Magnus Abrink ; Maria Ringvall ; Sara Wernersson
Expression of MC Proteases
Genetic Organization and Regulation of Transcription
Evolution of MC Proteases
Protein Organization and Processing
Three-Dimensional Structure
Cleavage Specificity
Interaction of MC Proteases with PGs: Implications for Storage, Activity, and Processing
Substrates for MC Proteases
In Vivo Function
MC Protease Inhibitors
Summary and Future Perspectives / 13:
Index
Content of Recent Volumes
A Reappraisal of Humoral Immunity Based on Mechanisms of Antibody-Mediated
Protection Against Intracellular Pathogens Accessibility Control of V(D)J Recombination
Targeting Integrin Structure and Function in Disease
Endogenous TLR-ligands and Autoimmunity Genetic Analysis of Innate
Immunity TIM family of genes in Immunity and Tolerance
Inhibition of Inflammatory Responses by Leukocyte Ig-like Receptors
Engineered cellular vaccines
Blockade of T cell checkpoints
Serex in the identification of target antigens
New approaches to tumor immunotherapy
Melanoma antigens
Antibodies and chimeric molecules
Tumor Immunosurveillance
Dendritic Cells
Strategies for Tumor
Vaccination DNA vaccines
Preface
Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory / Masamichi Muramatsu ; Hitoshi Nagaoka ; Reiko Shinkura ; Nasim A. Begum ; Tasuku Honjo
Abstract
Identification of AID as a Key Molecule in CSR and SHM
AID Is the Only B-Cell-Specific Factor Required for Both CSR and SHM
Functional Domains of AID
AID Is Involved in a DNA Cleavage Step
Major Hypotheses for the Action of AID
Critical Examination of the DNA Deamination Model
Evidence for a Novel Function of UNG in CSR
Conclusion
DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives / Silvestro G. Conticello ; Marc-Andre Langlois ; Zizhen Yang ; Michael S. Neuberger
AID: The DNA Deaminase Trigger for Antibody Diversification
The Zn-Dependent Deaminase Superfamily
Timeline of AID/APOBEC Evolution
APOBEC1: An RNA-Editing Enzyme That Can Also Act on DNA
APOBEC2: A Muscle-Specific Family Member of Unknown Function/Activity
APOBEC4: A Distant or Ancestral Member of the AID/APOBEC Family
APOBEC3s: DNA Deaminases Active in Viral Restriction
The Role of Activation-Induced Deaminase in Antibody Diversification and Chromosome Translocations / Almudena Ramiro ; Bernardo Reina San-Martin ; Kevin McBride ; Mila Jankovic ; Vasco Barreto ; Andre Nussenzweig
Events Preceding the DNA Lesion
The DNA Lesion
DNA Damage Detection and Resolution During CSR
AID and Lymphomagenic Lesions
Conclusions and Perspectives
Targeting of AID-Mediated Sequence Diversification by cis-Acting Determinants / Shu Yuan Yang ; David G. Schatz
The Link Between Transcription and AID-Mediated Sequence Diversification
Other cis-Acting Determinants Involved in the Targeting of AID
Future Outlook
AID-Initiated Purposeful Mutations in Immunoglobulin Genes / Myron F. Goodman ; Matthew D. Scharff ; Floyd E. Romesberg
Biochemical Basis of C Deamination by APOBEC Enzymes
How and Why Might AID-Specific Mutations Be Targeted?
Selection of AID-Induced Mutations During Ab Maturation
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism / Jayanta Chaudhuri ; Uttiya Basu ; Ali Zarrin ; Catherine Yan ; Sonia Franco ; Thomas Perlot ; Bao Vuong ; Jing Wang ; Ryan T. Phan ; Abhishek Datta ; John Manis ; Frederick W. Alt
Overview of Genetic Alterations in B Lymphocytes
Activation-Induced Cytidine Deaminase
Role of Germ Line Transcription and Switch Regions in CSR
Posttranscriptional Regulation of AID
Mechanisms Involved in Synapsis of AID Initiated DSBs in Widely Separated S Regions
General DNA Repair Systems in the Joining Phase of CSR
Evolution of CSR
Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection / Brad R. Rosenberg ; F. Nina Papavasiliou
Evolution of the AID/APOBEC Cytidine Deaminase Family
APOBEC3: A Subfamily of Antiviral Cytidine Deaminases
AID in the Host Response to Viral Infection
Role of AID in Tumorigenesis / Il-mi Okazaki ; Ai Kotani
AID Transgenic Mouse Models
Role of AID in Chromosomal Translocation and Subsequent Lymphomagenesis
AID Expression in Human B-Cell Malignancies
Mechanism of AID Expression in Normal and Malignant B Cells
AID Expression in Normal and Malignant Nonlymphoid Cells
Pathophysiology of B-Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies / Anne Durandy ; Nadine Taubenheim ; Sophie Peron ; Alain Fischer
Ig-CSR Deficiency Type 1 Caused by Activation-Induced Cytidine Deaminase Deficiency
Ig-CSR Deficiency Type 2 Caused by UNG Deficiency
Molecularly Undefined Ig-CSR Deficiency with Normal SHM
Contents of Recent Volumes
Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease / Anna-Marie Fairhurst ; Amy E. Wandstrat ; Edward K. Wakeland
Immunological Alterations in SLE
Genetics of SLE Susceptibility in Humans
Murine Models of SLE
Modeling Disease Development
Avian Models with Spontaneous Autoimmune Diseases / Georg Wick ; Leif Andersson ; Karel Hala ; M. Eric Gershwin ; Carlo Selmi ; Gisela F. Erf ; Susan J. Lamont ; Roswitha Sgonc
Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders
The OS Chicken: Model for Human Hashimoto Disease
The UCD-200 Line of Chickens: A Model for Human Systemic Sclerosis
The SL Chicken Model for Human Autoimmune Vitiligo
Conclusions and Outlook
Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity / Megan K. Levings ; Sarah Allan ; Eva d'Hennezel ; Ciriaco A. Piccirillo
Phenotype of CD4[superscript +]CD25[superscript +] nTreg Cells
Factors Regulating the Expansion and Specificity of nTreg Cells
Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells
Growth Factor-Mediated Control of nTreg Cell Development, Function, and Homeostasis
Control of Autoimmune Responses by nTreg Cells
Summary and Conclusions
BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation / Maya Gavrieli ; John Sedy ; Christopher A. Nelson ; Kenneth M. Murphy
Overview of BTLA and HVEM Ligand Discovery
Structural Characterization of BTLA Bound to HVEM
Viral Modulators of the HVEM-BTLA Pathway
Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCs
Mechanisms of the CD28 Family Inhibitory Receptors
Consequences of HVEM Ligation
BTLA and HVEM in Models of Disease
The Human T Cell Response to Melanoma Antigens / Pedro Romero ; Jean-Charles Cerottini ; Daniel E. Speiser
Melanoma Antigens
Measurement of Antigen-Specific T Cell Responses
Naturally Acquired Tumor Antigen-Specific T Cell Responses
Vaccine-Induced T Cell Responses
Regulation of Tumor Antigen-Specific T Cell Responses
Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions / Joana Loureiro ; Hidde L. Ploegh
Host-Pathogen Interactions
Manipulation of the Host Response by Pathogens: Some General Considerations
Antigen Presentation
Class I MHC Antigen Presentation
Pathogen Recognition by CD8[superscript +] T Cells and NK Cells
Class II MHC Antigen Presentation
Ubiquitin-Proteasome System
The Ubiquitin Conjugation Cascade
Ubiquitin Ligases
Ubiquitin Chains and Ubiquitin-Like Modifiers (Ubls)
Deubiquitinating Enzymes
The Proteasome / 12:
ER Quality Control and Degradation
ERAD Substrate Recognition / 14:
ERAD E3 Ligases / 15:
Mammalian ERAD E3s / 16:
The Elusive Dislocon / 17:
Driving Dislocation and the Ub-Binding Route to the Proteasome / 18:
Peptide N-Glycanase / 19:
Viral Interference with Class I MHC Antigen Presentation / 20:
Human Cytomegalovirus / 21:
HCMV Interference with Class I MHC Antigen Presentation / 22:
Dislocation from the ER: HCMV US11 and US2 / 23:
Signal Peptide Peptidase Is Required for Dislocation from the ER / 24:
SPP and Generation of HLA-E Epitopes / 25:
SPP and Processing of the Hepatitis C Virus Core Protein / 26:
SPP and Calmodulin Signaling / 27:
SPP Peptide Peptidase and Development / 28:
SPP and ER Quality Control / 29:
Three Routes of Pathogen-Mediated ER Protein Disposal / 30:
Pathogen Interference with Class II MHC Antigen Presentation / 31:
Inhibition of Recognition at the Surface of the APC / 32:
Class II MHC Downregulation from the Surface of the APC / 33:
CD4 Downregulation from the Surface of the CD4[superscript +] T Cell / 34:
Pathogen Manipulation of the Ubiquitin-Proteasome System / 35:
Interference with Proteasomal Proteolysis / 36:
Control of Infection / 37:
Virus Budding / 38:
Bacterial Chromosome Integration / 39:
ISGylation and deISGylation / 40:
Control of Inflammation / 41:
Posttranscriptional Gene Silencing / 42:
Downregulation of Cell Surface Receptors by Pathogen-Encoded E3s / 43:
Programmed Cell Death in Plants / 44:
Cytokine Responses / 45:
Pathogen-Encoded DUBs / 46:
Conclusions and Future Directions / 47:
C-Kit Receptor Ligand / M.D. Cooper ; Its Receptor ; J.C. Renauld et al
The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling / S.M. Lewis T.R. Mosmann ; E.B. Kopp
IL8 and Related Chemotactic Cytokines / C. van Kooten ; H. Karasuyama ; K. Tanaka ; L.B. Justement J. Hammer ; J.S. Malter G. Kroemer ; H.-R. Rodewald ; D.M. Willerford ; Bernard Malissen ; K. Ishizaka
TGF-B Receptors / N. Ramesh ; Membrane Lipid Microdomains ; R.P. Bucy ; J.M. Woof ; D.P. Gearing ; S. Akira et al
Properties Functions of Interleukin-10
Proteasomes and Antigen Processing / S. Ghosh D.T. Weaver ; J ; A. Rolink
B Cell Activation / T. Sturniolo ; J.M. Penninger ; F. Alt ; B.H. Nelson G. Trinchieri ; Laurence Ardouin ; Y. Ishii
The Mechanism of V(D)J Joining
Banchereault, CD40-CD40 Ligand / R.S. Geha
Human Antibody Effector Function / A.G. Bassuk ; T Cell signal Transduction ; Avian T Cell Ontogeny
The Leukemia Inhibitory Factor
Interleukin-6 Biology and Medicine
CD5+B Cells
Lessons from Molecular, Immunologicaland Comparative
NF-kB and Rel Proteins in Innate Immunity
Mrnas Relevant to T-Cell Function / Pair ; F ; F. Sinigaglia
The Biology of the Interlukin-2 Receptor / J.R. Gorman
The Biology of the Interleukin-2 Receptor
NK Cell Mediated Allorecognition / Shih-Yao Lin ; T. Nakano ; E.V. Rothenberg ; CD8 in T Cell Activation ; B.L. Kotzin et al
A Multifunctional Receptor-Ligand / S.J. Anderson ; P. Kisielow ; J.N. Ihle
Melcherslt
Imice Lacking Class I MHC Genes / J.M. Leiden ; R.B. Lobell ; C.B. Thompson ; S.C.P. Morley ; J.J. CohenC.B. ThompsonT.H. Rabbitts
J. Stavnezerlt
Surrogate Light Chain in B Cell Development
The Role of CD45 in Signal Transduction
Molecular and Cellular Events in Early Thymocyte Development
The Development of Functionally Responsive T Cells / Anne Gillet ; K. Sugielt M. Carrolllt
Interleukin-9 / Differentiation
Mice Lacking Class II MHC Genes
R. Fuleihan / S.D. Levin ; H. von Boehmer
M. Gellert, Recent Advances in Understanding V(D)J / L.M. Karnitz ; T.M. Foy
The Pharmacology of T-Cell Apoptosis / C.E. Hack
X-Linked Agammaglobulinemia and Immunoglobulin Deficiency with Normal or ElevatedIgM: Immunodeficiencies of B Cell Development and Differentiation / N. Isakov ; A.J. Minn ; B.E. Bierer ; T. Boehm ; H. Yagita ; M.C. Miceli ; W.P. Arend
Prenylation of Ras GTPase Superfamily Proteins and Their Function in / T.H. Hansen
Biochemical Basis of Antigen-Specific Suppressor T Cells Factors / Marie Malissen
V(D)J Recombination and Double-Strand Break Repair
Regulation of Ig Light Chain Isotype Expression / N. Inoue ; R.T. Abrahamlt ; R.J. Noellelt ; L.A. Aarden ; F. Momburg
The Role of Complement in B Cell Activation and Tolerance D. Nemazeelt / R.E. Swain
The Actin Cytoskeleton
Programmed Cell Death in The Immune SystemC.-I.H. Chen
Superantigens and Their Potential Role in Human Disease / M. Nakata ; J.R. Parnes
Amon Altman and Marcel Derkert, The Functions of Small GTPases in Signaling by Immune Recognition and Other Leukocyte Receptors / G. Kroemer ; D.R. Lee ; G.J. Arlaud
Antibody Class Switching / B. Moser ; T. Harder ; D.E. Mosier ; R.L. Coffman et al ; R.M ; J. Takeda
L. Clark
The Role of CD4 / L.G. Thijis ; G.J. Hammerling ; A. Ma ; Jeffery V. Ravetch ; A. Kawasaki
Analyses
Development and Selection of T Cells: Facts and Puzzles
The Role of Ets Transcription Factors in the Development and Function of Mammalian Immune System / M.K. Liszewski ; D.E. Mosierlt
Raft Membrane Domains and Immunoreceptor Functions / Y. Xu ; and P. Loetscherlt
Structural and Functional Chimerism Results from Chromosomal Translocation in Lymphoid Tumors
Interleukin-1 Receptor Antagonist
T. Kinoshita / K.L. Knight ; G.-K. Sim
HLA Class II Peptide Binding Specificity and Autoimmunity / M. Salmi
Immunobiology
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Adoptive Transfer of Human Lymphoid Cells to Severely Immunodeficient Mice: Models for Normal Human Immune Function / Silvia Bolland ; J.T. Schroeder
Defective Glycosyl Phosphatidylinositol Anchor Synthesis and Paroxysmal Nocturnal Hemoglobinuria / Y. Shinkai ; J. Lesley et al. CD44 and Its Interaction with the Extracellular Matrix
CD40 and Its Ligand / T.C. Farries
Recent Progress on the Regulation of Apoptosis by Bcl-2 Family Members / C.N. Metz ; T. Brocker ; J.E. ; H. Okamura
Receptor Editing in B Cells M. Baggiolini
Autoimmunity
The Pharmacology of T Cell Apoptosis / F. Melchers ; Sakaguchi et al ; M.A
Human Immunodeficiency Virus Infection of Human Cells Transplanted to / G.A. Oliveira
Function of the CD3 Subunits of the Pre-TCR and TCR Complexes During T-Cell Development / S. Jalkanen ; Volanakis ; A. Oxenius
The Mechanism and Regulation of Immunoglobulin Isotype Switching / F.M. Marincola ; D.W. MacGlashan Jr. ; and K. Okumura
Perlmutter and Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development
Severe Combined Immunodeficient Mice / B.A. Imhof ; D.M. Lublin
Inhibitory Pathways Triggered by ITIM-Containing Receptors / R. Bucala ; K. Karjalainen ; V. Rossi ; H. Tsutsui
B Lymphopoiesis in the Mouse
Mechanism of Class I Assembly with (2m and Loading with Peptide / D.N. Scott ; A. Gaur ; J.M. Calvo-Calle ; A. Rebollo
Role of Perforin in Lymphocyte-Mediated Cytolysis / R.M. Zinkernagel ; Yang Xu ; E. Jaffee ; L.M. Lichtenstein ; J.L. Andreu
Compartmentalization of the Peripheral Immune System
The Roleof Cytokines in Sepsis / D. Dunon ; I.A. Rooney ; N. Nishimoto
Generation and TAP-mediated Transport of Peptides for MHC Class I Molecules
Immunoglobulin Receptor (IgR)-Associated Molecules / N.M. Thielens ; S. Kashiwamura ; F. Schriever
ATM in Lymphoid Development and Tumorigenesis / C.G. Fathman ; R.S. Nussenzweig ; J. Gomezlt ; A.P. Kaplan ; A.J. McNight ; H. Hengartner
Human Basophils: Mediator Release and Cytokine Production / D.J. Hicklinlt
Analysis of B-Cell Tolerance in vitro / J.A. Gonzalo
Intraepithelial Lymphocytes and the Immune System
Crane and Generating the Antibody Repertoire in Rabbit / J.P. Atkinsonlt ; S. Suematsu ; S.V.L. Narayana ; T. Yoshimoto ; Lisa A. Harris ; S. Tsukada ; L.M. Nadler ; E. Cuende
E.H. Nardin / G. Dranoff
C. Martinez-A.
Interleukin-18 (IL-18): A Novel Cytokine that Augments Both Innate and Acquired Immunity / K. Joseph ; S. Gordon
Chemokines and Their Receptors in Lymphocyte Traffic and HIV Infection S. Ferrone
The Use of Multiple Antigen Peptides in the Analysis and Induction of Protective Immune Responses against Infectious Diseases / J.C. Gutierrez-Ramos ; F.D.
Interleukin-2 Receptor Signaling Mechanisms
The Role of Immunoreceptor Tyrosine-based Activation Motif (ITAM) in Signal Transduction from Antigen and Fc Receptors / D. Opsteltenlt ; T. Kishimoto
CD4 + T Cell Induction and Effector Functions / K. Nakanishi
Escape of Human Solid Tumors from T Cell Recognition: Molecular Mechanisms and Functional Significance W. Solbach and Y. Laskaylt / Steven B. Larson
The Central Role of Follicular Dendritic Cells in Lymphoid Tissues / Y. Baba
Adoptive Tumor Immunity Mediated by Lymphocytes Bearing Modified Antigen Specific Receptors / and C. Martinez ; Moore Jr ; R.C. Mulligan ; R. Moqbel ; K. Schwarz ; Y. Shibayama
The Host Response to Leishmania Infection / R. Tripathi ; P.J. Peters
Lessons from Immunologicale Biochemical, and Molecular Pathways of the Activation Mediated by IL-2 and IL-4 / C. Martinez-A ; Related Strains
How Do Lymphocytes Know Where to Go: Current Concepts and Enigmas of Lymphocyte Homing
Alexander McPherson / G.T. Nepom
Immunological Memory / D. Watanabe
Immunotherapeutic Strategies Directed at the Trimolecular Complex
Leukocyte Migration and Adhesion
Lymphomagenesis, AIDS / A.B. Kay ; C.R. Bartramlt ; R. Fernandez-Botran ; M. Feldman ; S. Reddigari ; N. Mathieu ; V.W. Hsu ; Eugene C. Butcher
Gene Transfer as Cancer Therapy / H. Kikutani ; C.R. Mackay ; G.A. Pietersz
Membrane Molecules as Differentiation Antigens of Murine Macrophages
Btk and BLNK in B Cell Development
Interleukin-2
A.J. Wardlaw
Control of the Complement System
A Comparison of Immunity Against Soluble Antigens and Viral Infections / P.M. Chilton ; M.J. Elliott ; B. Ghebrehiwet ; J.R. Kalden ; I. Leduc
Eosinophils: Biology and Role in Disease / Marna Williams ; M. Murakami ; S. Makino ; A. Rowland
Current Views in Intracellular Transport / V. Steimle
G. Kelsoe / R.J. Ulevitch
Interleukin-18 (IL-18): A Novel Cytokine that Augments Both Innate and Acquired Immunity A. Oxenius / Y. Malt ; J.N. Woody ; M. Silverberg ; F.C. Breedveld ; W.M. Hempel
The Murine Autoimmune Diabetes Model: NOD / J.J. Marchalonis ; Kenneth Youngman ; I. Kudo
In Situ Studies of the Germinal Center Reaction / M.J. Smyth
Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms / W. Reith ; J.P. Arm
B Lymphocyte Development and Transcription Regulation in Vivolt / H. Kojima
The Role of MIF in the Regulation of the Immune Response / R.N. Maini
Diversity and Regulatory Functions of Mammalian Secretory Phospholipase A,sub>2S / H. Burkhardt ; P. Ferrier ; S.F. Schulter ; Lusijah Rott
Cell Adhesion Molecules as Targets of Autoantibodies in Pemphigus / M. Baeza
The Intrinsic Coagulation-Kinin Forming Cascade:Assembly in Plasma and Cell / I.F.C ; B. Machlt ; L.B. Ivashkivlt
Therapeutic Regulation of the Complement System in Acute Injury States / P.W.H.I. Parren and D.R. Burton ; T.H. Lee ; J.R. Stanley
Plasma Cell Dyscraisas / N. Shinohara
The Atypical Serine Proteases of the Complement System / O.O. Yang ; G.R. Burmester
V(D)J Recombination Pathology / R.M. Bernstein ; Michael Briskin ; P. Kuna ; R. Winchester
Soluble Cytokine Receptors: Their Roles in Immunoregulatione Disease and Therapy
Anti TNF( Therapy of Rheumatoid Arthritis
The Antiviral Activity of Antibodies in Vitro and in Vivo / J.S. Bromberg
The Pathobiology of Bronchial Asthma
Pemphigoid Bullous diseases Due to Defective Epidermal Cell Adhesion
H. Takayama
Major Histocompatibility Complex Class II Deficiency: A Disease of Gene Regulation
Chapter References / R. Kooijman
MHC-Directed Susceptibility to Rheumatoid Arthritis / B.D. Walker, CD8+ Cells in HIV Pathogenesis
Comparison of Intact Antibody Structures and the Implications for Effector Function / S. Shen
Autotolerance, and Autoimmunity / C.M. Lloyd
McKenzie and Chemoimmunoconjugates for the Treatment of Cancer
Cytotoxic T Lymphocytes: The Newly Identified Fas (CD95)-Mediated Killing Mechanism and a Novel Aspect of Their Biological Functions
Immunological Treatment of Autoimmune Diseases / B.M. Stadlerlt
C.R. Lyons / L. Qin ; Jaques Banchereau ; C.A. Janeway ; P.E. Neiman
Surfaces in Inflammation / E.L. Hooghe-Peters
The Role of Nitric Oxide in Inflammation / A.B. Edmundson ; J.-A. Gonzalo
I. Aebischer
Cytolytic and Non-Cytolytic Inhibition of Viral Replication
Histamine-Releasing Factors and Cytokine-Dependent Activation of Basophils and Mast Cells / L.A. DeBruyne ; Diana Bell
The Molecular Basis of Susceptibility to Rheumatoid Arthritis
TH1-TH2 Cells in Allergic Responses: At the Limits of a Concept
Insights From Studies in Immunology / R. Hooghelt
Retrovirus-Induced B Cell Neoplasia in the Bursa of Fabricus / A.J. Coyle ; J.S. Pober
Accessibility Control of V(D)J Recombination: Lessons from Gene Targeting
Cytokine Expression and Cell Activation in Inflammatory Arthritis / D. Kandiah ; James W. Young
Interactions Between the Immune System and Gene Therapy Vectors
Prolactine Growth Hormonee and Insulin-like Growth Factor-I in the Immune System / J.-C. Gutierrez-Ramos ; R.S. Cotran
Lymphocyte Trafficking and Regional Immunity / D. Penn ; A. Sali
Mouse Models of Allergic Airway Disease / Yoji Shimizu
Selective Elements for the V*gb Region of the T Cell Receptor: Mis and the Bacterial Toxic Mitogens
Immunologic Interactions of T Lymphocytes with Vascular Endothelium / W. Potts ; Y. Sheng ; J. Chun
Bidirectional Regulation of Response and Expression / David M. Rose
Selected Comparison of Immune and Nervous System Development / E.J. Victoria
Insights from Studies in Immunology / A. Chess
Phylogenetic Emergence and Molecular Evolution of the Immunoglobulin Family / Mark H. Ginsberg
MHC Genes Influence Individual Odors and Mating Preferences / D.M. Marquis
Dendrite Cells
Olfactory Receptor Gene Regulation
Integrins in the Immune System / S.M. Coutts
Phylogenetic Emergence and Molecular Evolution of the Immunogolbulin Family
Current Insights Into the 'Antiphospholipid' Syndrome
Clinical, Immunological, and Molecular Aspects
Current Insights Into the 'Antiphospholipid' Syndrome
Clinical, Immunological and Molecular Aspects
CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction / Thomas F. Tedder ; Jonathan C. Poe ; Karen M. Haas
CD22 Expression
CD22 Structure
CD22-A Receptor for Diverse Sialylated Ligands
Effects of CD22 Engagement on B-Cell Activation and Function In Vitro
CD22 Ligand Binding Regulates B-Cell Survival and Proliferation
The CD22 Cytoplasmic Domain Regulates B-Cell Signal Transduction
CD22-Directed Therapies and Clinical Trials in Oncology
CD22-Directed Therapies and Clinical Trials in Autoimmunity
Tetramer Analysis of Human Autoreactive CD4-Positive T Cells / Gerald T. Nepom
pMHC Tetramers Identify Human Autoreactive T Cells
Autoantigen pMHC Tetramers from Mouse to Man
Tetramer-Induced Autoreactivity
Regulation of Phospholipase C-[gamma]2 Networks in B Lymphocytes / Masaki Hikida ; Tomohiro Kurosaki
From the BCR to PLC-[gamma]
Roles for PLC-[gamma]
Regulation of IP[subscript 3] Receptors
Coupling Between Calcium Release and Calcium Influx
Looking for Ca[superscript 2+] Entry Channels
NFAT and NF-kB
Modulation of Calcium Signaling
Role of Human Mast Cells and Basophils in Bronchial Asthma / Gianni Marone ; Massimo Triggiani ; Arturo Genovese ; Amato De Paulis
Human Mast Cells
Human Basophils
Experimental Evidence for Mast Cells in Bronchial Asthma
Experimental Evidence for Basophils in Bronchial Asthma
Mast Cell and Basophil Recruitment to Asthmatic Airways
Anatomical and Functional Evidence for Mast Cells and Basophils in Asthma
Superallergens in Bronchial Asthma
Angiogenesis in Bronchial Asthma
Tissue Remodeling in Bronchial Asthma
Pharmacologic Modulation of Human Mast Cells and Basophils in the Treatment of Bronchial Asthma
Conclusions and Implications
A Novel Recognition System for MHC Class I Molecules Constituted by PIR / Toshiyuki Takai
PIR and LILR in Ig-like Receptor Family
PIR Genes and Protein Structure
Ligand for PIR
3D Structure of PIR and LILR and Their Interaction with MHC Class I
Activation Signal via PIR-A
Inhibitory Signal via PIR-B
Dominant Expression of PIR-B In Vivo
Pirb[superscript -/-] B Cells, Neutrophils, and Macrophages are Hyperresponsive
Modulated Cytokine Signaling in PIR-B Deficiency
PIR in Transplantation
Dendritic Cell Biology / Francesca Granucci ; Maria Foti ; Paola Ricciardi-Castagnoli
DC Subtypes
Deciphering DC Biology with Genomic Approaches
DC Interactions with the Microbial World
DC Functions
The Murine Diabetogenic Class II Histocompatibility Molecule I-A[superscript g7]: Structural and Functional Properties and Specificity of Peptide Selection / Anish Suri ; Emil R. Unanue
Structural Features of I-A[superscript g7] and DQ8
Biochemical Basis of Peptide Selection by I-A[superscript g7]
Why Is There a Difference in Results Between Binding and Peptide Selection?
The Biological Role of I-A[superscript g7]
RNAi and RNA-Based Regulation of Immune System Function / Dipanjan Chowdhury ; Carl D. Novina
Short RNAs in the Mammalian Immune System
miRNAs in Mammalian Virus Infection
RNAi, NMD, and TCR
NMD and TCR Expression
RNAi and NMD Are Genetically Linked
RNAi, ADARs, and Viruses
Early Lymphoid Progenitor Subsets - Lineage Commitment and Developmental Plasticity
The CD4/CD8 Lineage Choice: New Insights Analysis of the CD4/CD8
Lineage Decision Development and Function of T Helper 1 Cells Th2 cells
Orchestrating Barrier Immunity Memory T. Cells -Generation, Maintenance, and Function
An Integrated Model of Immunoregulation
37-65
Cumulative Subject Index, Volumes 37-65
Learning from Leprosy: Insight into the Human Innate Immune Response / Dennis Montoya ; Robert L. Modlin
Leprosy as a Model
Recognition of M. leprae by the Innate Immune System
Phagocytosis of Mycobacteria
Antimicrobial Activity
Dendritic Cell Function in Leprosy
The Immunological Functions of Saposins / Alexandre Darmoise ; Patrick Maschmeyer ; Florian Winau
Saposins in Lysosomal Glycosphingolipid Degradation and Membrane Digestion
Saposins Facilitate Lipid Presentation to CD1-Restricted T Lymphocytes
SAPs Stimulate the Processing of Lipid Antigens by Lysosomal Glycosidases
Saposins Disrupt Vesicles Released by Apoptotic Cells
SAP-Like Proteins in Antimicrobial Defense
OX40-OX40 Ligand Interaction in T-Cell-Mediated Immunity and Immunopathology / Naoto Ishii ; Takeshi Takahashi ; Pejman Soroosh ; Kazuo Sugamura
Impact of the OX40 Costimulatory Signal in Immune Responses
OX40 in the Function and Development of Regulatory T Cells
OX40-OX40L Interaction in the Generation and Homeostasis of Memory T Cells
The OX40 and OX40L Interaction in Disease
Introduction: The Role of IL-10 in Controlling Inflammation / Keishi Fujio ; Tomohisa Okamura ; Kazuhiko Yamamoto
IL-10-Producing T Cells Induced in Vitro
Naturally Present IL-10-Secreting T Cells
Artificial Engineering of Secondary Lymphoid Organs / Jonathan K. H. Tan ; Takeshi Watanabe
Lymphoid Structure and Elicitation of Immune Responses
Organogenesis of Secondary Lymphoid Tissues
Engineering Artificial Secondary Lymphoid Tissue
Future Prospects
AID and Somatic Hypermutation / Robert W. Maul ; Patricia J. Gearhart
AID, The Master Catalyst
The Targeting Enigma
Rogue Uracils
BCL6: Master Regulator of the Germinal Center Reaction and Key Oncogene in B Cell Lymphomagenesis / Katia Basso ; Riccardo Dalla-Favera
Germinal Center: The Site of BCL6 Expression in B cells
BCL6 and its Function
Regulation of BCL6
Discovery of BCL6 Targets
Cellular Pathways Regulated by BCL6
BCL6 and Lymphomagenesis
Regulation of Gene Expression in Peripheral T Cells by Runx Transcription Factors / Ivana M. Djuretic ; Fernando Cruz-Guilloty ; Anjana Rao
Multiple Factors Regulate Transcription in Eukaryotic Organisms
Runx Proteins as Transcriptional Regulators
Runx Proteins Regulate Thymic T-Cell Development
Runx7 and Runx3 at the Cd4 Silencer
Concluding Remarks-Runx Proteins in Human Disease and Immunity
Long Noncoding RNAs: implications for Antigen Receptor Diversification / Grace Teng
Noncoding RNAs
ncRNAs and the Adaptive immune System
Perspective
Pathogenic Mechanisms of Allergic Inflammation: Atopic Asthma as a Paradigm / Patrick G. Holt ; Deborah H. Strickland ; Anthony Bosco ; Frode L Jahnsen
Development of Asthma-Related Phenotypes in Early Life
Dendritic Cells and Asthma
T-Regulatory (Treg) Cells
Interactions Between Anti-viral and Atopic Inflammatory Pathways: Insight From Studies on Acute Severe Asthma Exacerbations in School Children
The Search for New Asthma Drug Targets within the Th2 Cascade
The Amplification Loop of the Complement Pathways / Peter J. Lachmann
The Amplication Loop: The C3b Feedback and Breakdown Cycles
The Evolutionary History of Complement
The Alternative Pathway: A Rate-Governed Reaction
Regulation of the C3b Breakdown Cycle
Immunopathology of the Alternative Pathway
The Physiological Role of Lysyl tRNA Synthetase in the Immune System / Hovav Nechushtan ; Sunghoon Kim ; Gillian Kay ; Ehud Razin
Gene Sharing and Noncanonical Protein Roles
Aminoacyl-tRNA Synthetases (AaRSs) and the Multisynthetase Complex
LysRS
Kill the Bacteria&hellips; and Also Their Messengers? / Robert Munford ; Mingfang Lu ; Alan Varley29
Lipopolysaccharide (LPS) Sensing by MD-2-TLR4
Acyloxyacyl Hydrolase
LPS Deacylation In Vivo
Inactivating LPS In Vivo
Potential Clinical Connections
Role of SOCS in Allergic and Innate Immune Responses / Suzanne L. Cassel ; Paul B. Rothman
A topic Immune Responses
SOCS Family
SOCS Genes
Multitasking by Exploitation of Intracellular Transport Functions: The Many Faces of FcRn / E. Sally Ward ; Raimund J.Ober
FcRn: A Historical Perspective
FcRn is a Multitasking Receptor
The Molecular Nature of FcRn-IgG Interactions
The Intracellular Trafficking of FcRn
Regulation of FcRn Expression
The Complexity of Engineering FcRn-IgG Interactions
Cross-Species Differences in FcRn-Binding Specificity and Implications for Preclinical Models
Antigen Presentation by CD1: Lipids, T Cells, and NKT Cells in Microbial Immunity / Nadia R. Cohen ; Salil Garg ; Michael B. Brenner
The CD1 Antigen Presentation Pathway: Chemistry, Structure, and Cell Biology
Group I CD1: CD1a, b, and c Molecules and T Cells
Group II CD1: CD1d-Restricted T Cells: Activation, Function, and Role in Antimicrobial Immunity
Role of CD1d-Restricted NKT Cells in Specific Microbial Infections
How the Immune System Achieves Self-Nonself Discrimination During Adaptive Immunity / Hong Jiang ; Leonard Chess
Is Peripheral Immune Regulation Necessary for Self-Nonself Discrimination?
Self-Nonself Discrimination Achieved During Thymic Negative Selection Determines How the Adaptive Immunity Is Regulated in the Periphery to Maintain Self-tolerance
The Impact of the Conceptual Framework of the "Avidity Model" on the Development and Control of Pathogenic Autoimmunity
Cellular and Molecular Mechanisms in Atopic Dermatitis / Michiko K. Oyoshi ; Rui He ; Lalit Kumar ; Juhan Yoon ; Raif S. Geha
Physiology and Immunology of Normal Skin
Clinical Aspects of AD
Epidemiology
Genetics
Pathophysiology of AD
Animal Models of AD
Treatment of AD
Micromanagers of Immune Cell Fate and Function / Fabio Petrocca ; Judy Lieberman
miRNA Biogenesis
miRNA Regulation of Gene Expression
miRNA Target Genes
miRNAs Regulate Hematopoietic Differentiation and Immune Function
miRNA Regulation of Lymphocyte Development and Function
miRNA Regulation of Inflammatory Responses
Viruses Harness the miRNA Machinery
Some Viral miRNAs Mimic Host miRNAs
Host miRNAs also Regulate Viral Replication
Prospects for Manipulating miRNA Function for Immunomodulatory Therapy
Acknowledgment
Immune Pathways for Translating Viral Infection into Chronic Airway Disease / Michael J. Holtzman ; Derek E. Byers ; Loralyn A. Benoit ; John T. Battaile ; Yingjian You ; Eugene Agapov ; Chaeho Park ; Mitchell H. Grayson ; Edy Y. Kim ; Anand C. Patel
Background for the Model
cDC T Cell Immune Axis
NKT Cell-Macrophage Immune Axis
Summary
The Role of Innate Immunity in B Cell Acquisition of Antigen Within LNs / Santiago F. Gonzalez ; Michael P. Kuligowski ; Lisa A. Pitcher ; Ramon Roozendaal ; Michael C. Carroll
FDC are a Major Reservoir for Membrane-Bound Antigen
How do Antigens Arrive at FDC?
Role of LN Resident DC in Transport of Antigen
Nuclear Receptors, Inflammation, and Neurodegenerative Diseases / Kaoru Saijo ; Andrea Crotti ; Christopher K. Glass
Nuclear Receptors: Family Members and Molecular Functions
Immune Cells in the CNS-Microglia, Astrocytes, and Lymphocytes
Inflammatory Components of Neurodegenerative Diseases
Summary and Perspectives
Novel Tools for Modulating Immune Responses in the Host-Polysaccharides from the Capsule of Commensal Bacteria / Suryasarathi Dasgupta ; Dennis L. Kasper
Introduction: The Intestinal Microflora
The Polysaccharide Capsule and Bacterial Colonization of the Host
Professional APCs in Gut-Associated Lymphoid Tissue and Shaping of Mucosal Immunity by Commensal Microbes
Intestinal Inflammation and Immunoregulation
Polysaccharide A from B. fragilis
The Role of Mechanistic Factors in Promoting Chromosomal Translocations Found in Lymphoid and Other Cancers / Yu Zhang ; Monica Gostissa ; Dominic G. Hildebrand ; Michael S. Becker ; Cristian Boboila ; Roberto Chiarle ; Susanna Lewis
Chromosomal Translocations in Cancer
DNA Recombination in B and T Cell Development
Mechanistic Factors that Influence the Appearance of Chromosomal Translocations
Contents os Recent Volumes
Modeling a Complex Disease: Multiple Sclerosis / Florian C. Kurschus ; Simone Wörtge ; Ari Waisman
The IgH Locus 3' Regulatory Region: Pulling the Strings from Behind / Eric Pinaud ; Marie Marquet ; Rémi Fiancette ; Sophie Péron ; Christelle Vincent-Fabert ; Yves Denizot ; Michel Cogné
Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice / Ichiro Taniuchi ; Wilfried Ellmeier
Autoinflammation by Endogenous DNA / Shigekazu Nagata ; Kohki Kawane
AID targeting in Antibody Diversity / Rushad Pavri
New Insights into Adaptive Immunity in Chronic Neuroinflammation / Volker Siffrin ; Alexander U. Brandt ; Josephine Herz ; Frauke Zipp
Introduction: Multiple Sclerosis Is a Heterogeneous Inflammatory Disease of the Nervous System
Experimental Autoimmune Encephalomyelitis as a Model for MS
Current Knowledge About Induction and Perseveration of Chronic Neuroinflammation
Therapeutic Approaches to Chronic Neuroinflammation
Regulation of Interferon-[gamma] During Innate and Adaptive Immune Responses / Jamie R. Schoenborn ; Christopher B. Wilson
IFN-[gamma]-Producing Cells
Signaling Pathways Controlling IFN-[gamma] Production by NK Cells
Control of IFN-[gamma] Production by NKT Cells
Signaling Pathways in the Differentiation of CD4 and CD8 T Cells
Transcription Factors Downstream of the TCR, Activating NK Receptors, and Cytokine Receptors
Epigenetic Processes Govern Plasticity of Cell Fate Choices and Help to Identify Distal Regulatory Elements
Transcriptional Regulatory Elements Within the Ifng Gene
Functional Analysis of Candidate Distal Regulatory Elements in the Ifng Locus
The Expansion and Maintenance of Antigen-Selected CD8+ T Cell Clones / Douglas T. Fearon
Background
The Behavior of the CD8+ T Cell in Persistent Viral Infections
Clarifying the Role of IL-2 in the Clonal Expansion and Effector Differentiation of the CD8+ T Cell
Coreceptors Mediating IL-2-Independent CD8+ T Cell Clonal Expansion
Modifying the Antiproliferative Effects of Types I and II IFN
Transcriptional Control of Replicative Senescence: Bmi-1, Blimp-1, and BCL6/BCL6b
A Refined Model for CD8+ T Cell Clonal Expansion: Sequential Phases of CD27-Dependent Self-Renewal and IL-2-Dependent Differentiation
Clinical Extensions of the TCR/CD27 Pathway: Adoptive CD8+ T Cell Therapy
Inherited Complement Regulatory Protein Deficiency Predisposes to Human Disease in Acute Injury and Chronic Inflammatory States / Anna Richards ; David Kavanagh ; John P. Atkinson
Altered Self Triggers Innate Immunity
Regulation of the Alternative Complement Pathway
Lessons from Homozygous Complement Regulatory Protein Deficiencies
Complement and Atypical Hemolytic Uremic Syndrome
Complement and Age-Related Macular Degeneration
Immunopathogenesis of aHUS and AMD
Treatment of aHUS and AMD
Conclusions: Lessons and Implications
Fc-Receptors as Regulators of Immunity / Falk Nimmerjahn ; Jeffrey V. Ravetch
The Family of Activating and Inhibitory FcRs
Activating and Inhibitory FcR Signaling Pathways
The Role of Activating and Inhibitory FcRs on Innate Immune Effector Cells
Modulation of Antibody Activity
Activating and Inhibitory FcR Expression on DCs
Fc[gamma]RIIB as a Master Regulator of Humoral Tolerance and Plasma Cell Survival
Summary and Outlook
TSLP in Epithelial Cell and Dendritic Cell Cross Talk / Yong-Jun Liu
Thymic Stormal Lymphopoietin (TSLP) and TSLP Receptor (TSLPR)
TSLP in Lymphocyte Development in Mice
TSLP Activates Human Myeloid Dendritic Cells
TSLP in Allergic Inflammation
TSLP in Peripheral CD4+ T Cell Homeostasis
TSLP in the Development of Regulatory T Cells in Thymus
Natural Killer Cell Tolerance: Licensing and Other Mechanisms / A. Helena Jonsson ; Wayne M. Yokoyama
Introduction: Natural Killer Cells and "Missing Self"
NK Cell Receptors: The KIR and Ly49 Families
Early Models of NK Cell Self-Tolerance
NK Cell Licensing
NK Cell Tolerance in MHC Class I Chimeric and Mosaic Mice
Other Safeguards of NK Cell Tolerance to Self
NK Cell Tolerance Mechanisms in the Clinic
Biology of the Eosinophil / Carine Blanchard ; Marc E. Rothenberg
The Eosinophil: From a Hematopoietic Stem Cell to a Mature Eosinophil
A Role for Eosinophils at Baseline
Eosinophils and Immune Regulation
Eosinophil Trafficking
Role of Eosinophils in Disease
Antieosinophil Therapeutics
Basophils: Beyond Effector Cells of Allergic Inflammation / John T. Schroeder
Development and Inflammatory Mediator Content
Cell-Surface Markers
Human Basophil Cytokine Secretion
Basophil Participation in Human Disease
Basophils in Mouse Models of Th2 Inflammation
DNA Targets of AID: Evolutionary Link Between Antibody Somatic Hypermutation and Class Switch Recombination / Jason A. Hackney ; Shahram Misaghi ; Kate Senger ; Christopher Garris ; Yonglian Sun ; Maria N. Lorenzo ; Ali A. Zarrin
Experimental Systems to Study S Regions
S Regions
V Regions
Sequence Comparison of V, S, and Non-Ig AID Targets
The Susceptibility of Non-S Regions to Mediate CSR
AID Recruitment to Target Sequences
Role of DNA Double Strand Break (DSB)
Evolutionary Link between SHM and CSR
Interleukin 5 in the Link Between the Innate and Acquired Immune Response / Kiyoshi Takatsu ; Taku Kouro ; Yoshinori Nagai
IL-5 and Signal Transduction
IL-5-Receptor-Mediated Signaling
IL-5 Augments Innate Immune Response
IL-5 Modulates Acquired Immune Response
IL-5 Links Innate and Acquired Immunity In Disease Model
Future Perspectives
Contents of Recent Volumes See Color Plate Section in the back of this book
Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus
The Immunoglobulin Heavy Chain Locus
V(D)J Recombination During B-Cell Development
Class Switch Recombination and Somatic Hypermutation
IgH Rearrangements and Allelic Exclusion
Accessibility Control
IgH Locus Control Through Cis-Regulatory Elements
DNA-PK: The Means to Justify the Ends? / Katheryn Meek ; Van Dang ; Susan P. Lees-Miller
Composition
DNA Binding and Kinase Activation
Structural Studies of DNA-PK
Targets of DNA-PK's Enzymatic Activity
DNA-PK's Autophosphorylation is Functionally Complex
Autophosphorylation Within Two Clusters Reciprocally Regulates DNA End Access
Further DNA-PK Autophosphorylation is Required During NHEJ
Model of DNA-PK Activation
End Processing to Promote End Conservation
Does DNA-PK Regulate Dsbr Repair Pathway Choice?
Why is DNA-PK So Abundant?
Thymic Microenvironments for T-Cell Repertoire Formation / Takeshi Nitta ; Shigeo Murata ; Tomoo Ueno ; Keiji Tanaka ; Yousuke Takahama
Trafficking of Developing Thymocytes
Cortical Microenvironment
Medullary Microenvironment
Pathogenesis of Myocarditis and Dilated Cardiomyopathy / Daniela Cihakova ; Noel R. Rose
Human Myocarditis
The Evidence for an Autoimmune Process in Myocarditis
Mouse Models of Myocarditis
Role of Proinflammatory Cytokines in Myocarditis
Role of T Helper Cells in Myocarditis
The Divergent Role of Macrophages in Myocarditis
Conclusions/Directions for future Research
Emergence of the Th17 Pathway and Its Role in Host Defense / Darrell B. O'Quinn ; Matthew T. Palmer ; Yun Kyung Lee ; Casey T. Weaver
Emergence of the Th17 Pathway
Functions of the Th17-Derived Cytokines
IL-23/IL-17-Mediated Innate Immunity
Th17 Cells and Innate Immunity
Th17 Cells and Acquired Immunity
IL-23/IL-17-Mediated Responses in Specific Microbial Infections
Closing Remarks
Peptides Presented In Vivo by HLA-DR in Thyroid Autoimmunity / Laia Muixi ; Inaki Alvarez ; Dolores Jaraquemada
Natural Peptides: The Constitutive Ligands of MHC Molecules
Natural Ligands for HLA Class II in Autoimmune Thyroid Tissue
Immune Regulation by B Cells and Antibodies: A View Towards the Clinic / Kai Hoehlig ; Vicky Lampropoulou ; Toralf Roch ; Patricia Neves ; Elisabeth Calderon-Gomez ; Stephen M. Anderton ; Ulrich Steinhoff ; Simon Fillatreau
Prevention of Rhesus D Hemolytic Disease of the Newborn with Anti-D Antibodies
Antibody-Based Treatment of Immune Thrombocytopenia Purpura
Immune Regulating Functions of Naive and Activated B Cells
Cumulative Environmental Changes, Skewed Antigen Exposure, and the Increase of Allergy / Tse Wen Chang ; Ariel Y. Pan
Antigen Exposure during Times When the Immune System Evolved
Did Allergy Play a Role in the Evolution of the Human Immune System?
Environmental and Lifestyle Changes Alter Humans' Antigen Exposure
Significant Changes in Lifestyle and Environment since H. sapiens Stated to Use Fire
Significant Lifestyle and Environmental Changes since the Industrial Revolution
The Increase in Proportions of Environmental Antigens of Limited Varieties
Prevalence of Allergy is Related to Changes in Antigen Exposure
The Hygiene Hypothesis and Its Immunological Basis
Key Factors Affecting the IgE-Mediated Pathway in Allergic Responses
Total IgE vs. Allergen-Specific IgE
Allergenic Substances Become Dominant Mucosal IgE Stimulators
Molecular Mechanisms Delineating the Effects of the Skewed Antigen Exposure on the Sensitization of the IgE Pathway
New Insights on Mast Cell Activation via the High Affinity Receptor for IgE / Juan Rivera ; Nora A. Fierro ; Ana Olivera ; Ryo Suzuki
A General Outline of Fc[epsilon]RI Proximal Signaling
Recent Advances in Fc[epsilon]RI Proximal Signaling
Regulation of Calcium Mobilization in Mast Cells
Sphingosine-1-phosphate: A Co-stimulatory Signal in Fc[epsilon]RI-mediated Mast Cell Activation
The Role of Genetics in Mast Cell Responsiveness
B Cells and Autoantibodies in the Pathogenesis of Multiple Sclerosis and Related Inflammatory Demyelinating Diseases / Katherine A. McLaughlin ; Kai W. Wucherpfennig
MS and Related Inflammatory Demyelinating CNS Diseases
Therapeutic Depletion of B Cells in MS with Rituximab
Which B Cell Functions are Critical in the Pathogenesis of MS?
Human B Cell Subsets / Stephen M. Jackson ; Patrick C. Wilson ; Judith A. James ; J. Donald Capra
Human B Cell Subsets: Current Separation Schemes
Transitions in Peripheral B cell Development
Monoclonal Antibodies from Human B Cell Subsets: Insights into Autoreactivity and Function
Vaccine-Induced Plasma Cells and Recombinant Antibodies: A Rapid Source of Fully Human Mabs
Autoimmune Disease and Human B Cell Subsets
T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other / Timothy S. Gomez ; Daniel D. Billadeau
TCR Signaling Leading to Actin Cytoskeletal Remodeling
Cytoskeletal Control of IS Formation
Regulation of TCR-Mediated MTOC Polarization
F-Actin-Mediated Regulation of Integrins
Cytoskeletal Dynamics and Cell Migration
HLA Class II Transgenic Mice Mimic Human Inflamamtory Diseases / Ashutosh K. Mangalam ; Govindarajan Rajagopalan ; Veena Taneja ; Chella S. David
Expression and Function of HLA-DQ Transgenes in Mice
HLA-DQ Transgenic Mice as Models for Human Allergies
Expression and Function of HLA-DR Transgenic Mice
HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis-Derived Proteins as Humans
Collagen-Induced Arthritis - Model for Human Rheumatoid Arthritis
Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis
Spontaneous Models for Human Type I Diabetes
Experimental Autoimmune Myasthenia Gravis
HlA and Gluten Sensitivity-Celiac Disease and Dermatitis herpetiformis
Relapsing Polychondritis
Spontaneous Autoimmune Myocarditis
Experimental Autoimmune Thyroiditis (Adapted from Kong et al., 2007)
Experimental Autoimmune Uveitis (Adapted from Pennesi et al., 2003)
Bacterial Superantigens and Toxic Shock Syndrome
Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule / Toshio Hirano ; Masaaki Murakami ; Toshiyuki Fukada ; Keigo Nishida ; Satoru Yamasaki ; Tomoyuki Suzuki
Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease
Role of Zn in the Immune Response
Role of Zn in Mast Cells
Zn Signaling
Conclusion and Future Prospects
Acknowledgements
The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses / Silvia Calpe ; Ninghai Wang ; Xavier Romero ; Scott B. Berger ; Arpad Lanyi ; Pablo Engel ; Cox Terhorst
Structure, Ligands, and Expression of the SLAM-Family Receptors
The SLAM-Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus
The SLAM-Associated Protein
The Protective Role of SAP in X-Linked Lympho-Proliferative Disease
The SAP-Related Single SH2-Domain Proteins EAT-2A and EAT-2B
The SLAM-Family Receptors in NK Cell Responses
The Role of the SLAM-Family in Lymphoid Cells
The Role of the SLAM-Family on Nonlymphoid Cells
Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes / Niklas Engels ; Michael Engelke ; Jurgen Wienands
A Minimal Signaling Kit Couples to Proximal Transducer Enzymes
Signal Initiation: BCR Clusters with an Open Conformation
SLP-65: A Gateway to Intracellular Signaling Pathways
Dynamic Regulation of the BCR-Triggered Ca[superscript 2+] Response
Mechanism and Function of BCR-Induced Ras Activation
The Immunobiology of IL-27 / Aisling O'Hara Hall ; Jonathan S. Silver ; Christopher A. Hunter
Autoimmune Arthritis: The Interface between the Immune System and Joints / Noriko Komatsu ; Hiroshi Takayanagi
Immunological Tolerance during Fetal Development: From Mouse to Man / Jeff E. Mold ; Joseph M. McCune
Mapping Lupus Susceptibility Genes in the NZM2410 Mouse Model / Laurence Morel
Functional Heterogeneity in the Basophil Cell Lineage / Mark C. Siracusa ; Elia D. Tait Wojno ; David Artis
An Emerging Role of RNA-Binding Proteins as Multifunctional Regulators of Lymphocyte Development and Function / Martin Turner ; Daniel Hodson
Active and Passive Anti-cytokine Immune Therapies Current Status and Development / Helene Le Buanec ; Armand Bensussan ; Martine Bagot ; Robert C. Gallo ; Daniel Zagury
Classical and Alternative End Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks / Bjoern Schwer
The Leukotrienes Immune Modulating Lipid Mediators of Disease / Antonio Di Gennaro ; Jesper Z. Haeggström
Gut Microbiota Drives Metabolic Diseases in Immunologically Altered Mice / Benoit Chassaing ; Jesse D Aitken ; Andrew T Gewirtz ; Matam Vijay-Kumar
What is Unique about the IgE Response? / Huizhong Xiong ; Maria A. Curotto de Lafaille ; Juan J. Lafaille
Prostanoids as Regulators of Innate and Adaptive Immunity / Takako Hirata ; Shuh Narumiya
Lymphocyte Developmental: Integration of DNA Damage Response Signaling / Jeffrey J. Bednarski ; Barry P. Sleckman
Molecular Basis of Fc Receptor Function / M.D. Hulett ; P.M. Hogarth
Fas and Fas Ligand: A Death Factor and Its Receptor / S. Nagata
Interleukin-5 and Its Receptor System: Implications in the Immune System and Inflammation / K. Takatsu ; S. Takaki ; Y. Hitoshi
6.

図書

図書
edited by Klaus Friedrich
出版情報: Amsterdam ; Tokyo : Elsevier, 1986  xii, 465 p. ; 25 cm
シリーズ名: Composite materials series ; 1
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7.

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図書
edited by Masao Kotani
出版情報: Tokyo : University of Tokyo Press , Baltimore : University Park Press, 1970-  v. ; 24 cm
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8.

図書

図書
edited by D.A. King and D.P. Woodruff
出版情報: Amsterdam : Elsevier Scientific, 1983  384 p. ; 25 cm
シリーズ名: The Chemical physics of solid surfaces and heterogeneous catalysis / edited by D.A. King and D.P. Woodruff ; v. 2
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9.

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図書
edited by D.A. King and D.P. Woodruff
出版情報: Amsterdam : Elsevier Scientific, 1982  468 p. ; 25 cm
シリーズ名: The Chemical physics of solid surfaces and heterogeneous catalysis / edited by D.A. King and D.P. Woodruff ; v. 4
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図書
G.L. Moore
出版情報: Amsterdam ; New York : Elsevier, 1989  xi, 340 p. ; 25 cm
シリーズ名: Analytical spectroscopy library ; v. 3
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