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1.

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EB
John N. Abelson, Lester Packer, Helmut Sies, Melvin I. Simon
出版情報: Elsevier ScienceDirect Books , Burlington : Elsevier, 2000
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2.

電子ブック

EB
Lester Packer, Helmut Sies
出版情報: Elsevier ScienceDirect Books , Burlington : Elsevier, 2001
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3.

電子ブック

EB
Lester Packer, Helmut Sies
出版情報: Elsevier ScienceDirect Books , Burlington : Elsevier, 2002
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4.

電子ブック

EB
Lester Packer, Helmut Sies
出版情報: Elsevier ScienceDirect Books , Burlington : Elsevier, 2002
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5.

電子ブック

EB
Lester Packer, Helmut Sies
出版情報: Elsevier ScienceDirect Books , Burlington : Elsevier, 2004
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6.

電子ブック

EB
Lester Packer, Helmut Sies
出版情報: Elsevier ScienceDirect Books , Burlington : Elsevier, 2004
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7.

電子ブック

EB
Lester Packer, Helmut Sies
出版情報: Elsevier ScienceDirect Books , 2005
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目次情報: 続きを見る
Contributors to Volume 400
Preface
Volumes in Series
UDP-Glucuronosyltransferases: Gene Structures of UGT1 and UGT2 Families / Ida S. Owens ; Nikhil K. Basu ; Rajat Banerjee1:
Identification and Characterization of Functional Hepatocyte Nuclear Factor 1-Binding Sites in UDP-Glucuronosyltransferase Genes / Dione A. Gardner-Stephen ; Philip A. Gregory ; Peter I. Mackenzie2:
Substrate Specificity of Human Hepatic UDP-Glucuronosyltransferaes / Brian Burchell ; David J. Lockley ; Adam Staines ; Yoshihiro Uesawa ; Michael W. H. Coughtrie3:
UDP-Glucuronosyltransferase 1A6: Structural, Functional, and Regulatory Aspects / Karl Walter Bock ; Christoph Kohle4:
The Role of Ah Receptor in Induction of Human UDP-Glucuronosyltransferase 1A1 / Mei-Fei Yueh ; Jessica A. Bonzo ; Robert H. Tukey5:
Regulation of the Human UGT1A1 Gene by Nuclear Receptors Constitutive Active/Androstane Receptor, Pregnane X Receptor, and Glucocorticoid Receptor / Junko Sugatani ; Tatsuya Sueyoshi ; Masahiko Negishi ; Masao Miwa6:
Isoform-Selective Probe Substrates for In Vitro Studies of Human UDP-Glucuronosyltransferases / Michael H. Court7:
Structure of UDP-Glucuronosyltransferases in Membranes / Anna Radominska-Pandya ; Mohamed Ouzzine ; Sylvie Fournel-Gigleux ; Jacques Magdalou8:
Human SULT1A Genes: Cloing and Activity Assays of the SULT1A Promoters / Nadine Hempel ; Michael E. McManus9:
Vitamin D Receptor Regulation of the Steroid/Bile Acid Sulfotransferase SULT2A1 / Bandana Chatterjee ; Ibtissam Echchgadda ; Chung Seog Song10:
Screening and Characterizing Human NAT2 Variants / Mihaela R. Savulescu ; Adeel Mushtaq ; P. David Josephy11:
Inactivation of Human Arylamine N-Acetyltransferase 1 by Hydrogen Peroxide and Peroxynitrite / Jean-Marie Dupret ; Julien Dairou ; Noureddine Atmane ; Fernando Rodrigues-Lima12:
Sulfotransferases and Acetyltransferases in Mutagenicity Testing: Technical Aspects / Hansruedi Glatt ; Walter Meinl13:
A Comparative Molecular Field Analysis-Based Approach to Prediction of Sulfotransferase Catalytic Specificity / Vyas Sharma ; Michael W. Duffel14:
Glucuronidase Deconjugation in Inflammation / Kayoko Shimoi ; Tsutomu Nakayama15:
Three-Dimensional Structures of Sulfatases / Debashis Ghosh16:
Estrogen Sulfatase / Masao Iwamori17:
Analysis for Localization of Steroid Sulfatase in Human Tissues / Takashi Suzuki ; Yasuhiro Miki ; Tsuyoshi Fukuda ; Taisuke Nakata ; Takuya Moriya ; Hironobu Sasano18:
Metabolism of Phytoestrogen Conjugates / Tracy L. D'Alessandro ; Brenda J. Boersma-Maland ; T. Greg Peterson ; Jeff Sfakianos ; Jeevan K. Prasain ; Rakesh P. Patel ; Victor M. Darley-Usmar ; Nigel P. Botting ; Stephen Barnes19:
Sulfation and Glucuronidation of Phenols: Implications in Coenzyme Q Metabolism / Nandita Shangari ; Tom S. Chan ; Peter J. O'Brien20:
Synthesis of Bile Acid Coenzyme A Thioesters in the Amino Acid Conjugation of Bile Acids / Erin M. Shonsey ; James Wheeler ; Michelle Johnson ; Donging He ; Charles N. Falany ; Josie Falany21:
Bile Acid Coenzyme A: Amino Acid N-Acyltransferase in the Amino Acid Conjugation of Bile Acids / Mindan Sfakianos ; David J. Merkler22:
Multidrug Resistance Protein 1-Mediated Export of Glutathione and Glutathione Disulphide from Brain Astrocytes / Johannes Hirrlinger ; Ralf Dringen23:
The Genetics of ATP-Binding Cassette Transporters / Michael Dean24:
Functional Analysis of Detergent-solubilized and Membrane-Reconstituted ATP-Binding Cassette Transporters / Bert Poolman ; Mark K. Doeven ; Eric R. Geertsma ; Esther Biemans-Oldehinkel ; Wil N. Konings ; Douglas C. Rees25:
Yeast ATP-Binding Cassette Transporters: Cellular Cleaning Pumps / Robert Ernst ; Robin Klemm ; Lutz Schmitt ; Karl Kuchler26:
High-Speed Screening of Human ATP-Binding Cassette Transporter Function and Genetic Polymorphisms: New Strategies in Pharmacogenomics / Toshihisa Ishikawa ; Aki Sakurai ; Yoichi Kanamori ; Makoto Nagakura ; Hiroyuki Hirano ; Yutaka Takarada ; Kazunari Yamada ; Kazuhisa Fukushima ; Masato Kitajima27:
Coordinate Transcriptional Regulation of Transport and Metabolism / Jyrki J. Eloranta ; Peter J. Meier ; Gerd A. Kullak-Ublick28:
Uptake and Efflux Transporters for Conjugates in Human Hepatocytes / Dietrich Keppler29:
Biliary Transport Systems: Short-Term Regulation / Ralf Kubitz ; Angelika Helmer ; Dieter Haussinger30:
Inborn Errors of Biliary Canalicular Transport Systems / Verena Keitel31:
Epoxide Hydrolases: Structure, Function, Mechanism, and Assay / Michael Arand ; Annette Cronin ; Magdalena Adamska ; Franz Oesch32:
Pregnane X Receptor-Mediated Transcription / Thomas K. H. Chang ; David J. Waxman33:
Animal Models of Xenobiotic Receptors in Drug Metabolism and Diseases / Haibiao Gong ; Michael W. Sinz ; Yan Feng ; Taosheng Chen ; Raman Venkataramanan ; Wen Xie34:
Cancer and Molecular Biomarkers of Phase 2 / Kim Dalhoff ; Kaspar Buus Jensen ; Henrik Enghusen Poulsen35:
Author Index
Subject Index
Contributors to Volume 400
Preface
Volumes in Series
8.

電子ブック

EB
Lester Packer, Helmut Sies
出版情報: Elsevier ScienceDirect Books , 2005
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Contributors to Volume 401
Preface
Volumes in Series
Nomenclature for Mammalian Soluble Glutathione Transferases / Bengt Mannervik ; Philip G. Board ; John D. Hayes ; Irving Listowsky ; William R. Pearson1:
Human Alpha Class Glutathione S-Transferases: Genetic Polymorphism, Expression, and Susceptibility to Disease / Brian F. Coles ; Fred F. Kadlubar2:
Regulation of GST-P Gene Expression During Hepatocarcinogenesis / Masaharu Sakai ; Masami Muramatsu3:
Human Glutathione Transferase Zeta / M. W. Anders4:
Characterization of the Omega Class of Glutathione Transferases / Astrid K. Whitbread ; Amir Masoumi ; Natasha Tetlow ; Erica Schmuck ; Marjorie Coggan5:
Alternative Splicing of Glutathione S-Transferases / Jantana Wongsantichon ; Albert J. Ketterman6:
Disruption of the Glutathione Transferase Pi Class Genes / Colin J. Henderson ; C. Roland Wolf7:
Microsomal Glutathione Transferase 1 / Ralf Morgenstern8:
Human Microsomal Prostaglandin E Synthase 1: A Member of the MAPEG Protein Superfamily / Par L. Pettersson ; Staffan Thoren ; Per-Johan Jakobsson9:
Two-Dimensional Crystallization and Electron Crystallography of MAPEG Proteins / Hans Hebert ; Caroline Jegerschold ; Priyaranjan Bhakat ; Peter J. Holm10:
Plant Glutathione Transferase / Robert Edwards ; David P. Dixon11:
Phylogenies of Glutathione Transferase Families / 12:
Drosophila Glutathione S-Transferases / Chen-Pei D. Tu ; Bunyamin Akgul13:
Mosquito Glutathione Transferases / Hilary Ranson ; Janet Hemingway14:
Glutathione S-transferase from Malarial Parasites: Structural and Functional Aspects / Marcel Deponte ; Katja Becker15:
Optimizing of Heterologous Expression of Glutathione Transferase / 16:
Human Glutathione Transferase A3-3 Active as Steroid Double-Bond Isomerase / Francoise Raffalli-Mathieu17:
A Subclass of Mu Glutathione S-Transferases Selectively Expressed in Testis and Brain / 18:
Glutathione S-Transferases as Regulators of Kinase Pathways and Anticancer Drug Targets / Danyelle M. Townsend ; Victoria L. Findlay ; Kenneth D. Tew19:
Modification of N-Acetyltransferases and Glutathione S-Transferases by Coffee Components: Possible Relevance for Cancer Risk / Wolfgang W. Huber ; Wolfram Parzefall20:
Activation of Alkyl Halides by Glutathione Transferases / F. Peter Guengerich21:
Peptide Phage Display for Probing GST-Protein Interactions / Maryam H. Edalat22:
Fosfomycin Resistance Proteins: A Nexus of Glutathione Transferases and Epoxide Hydrolases in Metalloenzyme Superfamily / Rachel E. Rigsby ; Kerry L. Fillgrove ; Lauren A. Beihoffer ; Richard N. Armstrong23:
Regulation of 4-Hydroxynonenal Mediated Signaling by Glutathione S-Transferases / Yogesh C. Awasthi ; G. A. S. Ansari ; Sanjay Awasthi24:
Gene Expression of [gamma]-Glutamyltranspeptidase / Yoshitaka Ikeda ; Naoyuki Taniguchi25:
[gamma]-Glutamyltranspeptidase: Disulfide Bridges, Propeptide Cleavage, and Activation in the Endoplasmic Reticulum / Carol L. Kinlough ; Paul A. Poland ; James B. Bruns ; Rebecca P. Hughey26:
Gamma-Glutamyl Transpeptidase Substrate Specificity and Catalytic Mechanism / Jeffrey W. Keillor ; Roselyne Castonguay ; Christian Lherbet27:
[gamma]-Glutamyl Transpeptidase in Glutathione Biosynthesis / Hongqiao Zhang ; Henry Jay Forman ; Jinah Choi28:
Prooxidant Reactions Promoted by Soluble and Cell-Bound [gamma]-Glutamyltransferase Activity / Silvia Dominici ; Aldo Paolicchi ; Alessandro Corti ; Emilia Maellaro ; Alfonso Pompella29:
Author Index
Subject Index
Contributors to Volume 401
Preface
Volumes in Series
9.

電子ブック

EB
Dieter Haeussinger, Dieter Häussinger, Helmut Sies
出版情報: Elsevier ScienceDirect Books , Burlington : Elsevier, 2007
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Water compartments in cells / Gary D. Fullerton ; Ivan L. CameronChapter 1:
Yeast osmoregulation / Stefan Hohmann ; Marcus Krantz ; Bodil NordlanderChapter 2:
Physiological Analysis of Bacterial Mechanosensitive Channels / Ian R Booth ; Michelle D Edwards ; Susan Black ; Ulrike Schumann ; Wendy Bartlett ; Tim Rasmussen ; Akiko Rasmussen ; Samantha MillerChapter 3:
Control of Cell Cycle in Response to Osmostress : Lessons from Yeast / Josep Clotet ; Francesc PosasChapter 4:
Bacterial Osmosensing Transporters / Janet M. WoodChapter 5:
Plant Gene Networks in Osmotic Stress Response: from genes to regulatory networks / Lam-Son Phan Tran ; Kazuo Nakashima ; Kazuo Shinozak ; Kazuko Yamaguchi-ShinozakiChapter 6:
Osmosensing by integrins in rat liver / Freimut Schliess ; Dieter Hauml;ussingerChapter 7:
Hyperosmotic activation of the CD95 system / Roland ReinehrChapter 8:
New Approaches for Determining Apoptotic Volume Decrease (AVD) in Cells / Carl D. Bortner ; Maria I. Sifre ; John A. CidlowskiChapter 9:
Transient Receptor Potential channels in mechanosensing and cell volume regulation / Stine Falsig Pedersen ; Bernd NiliusChapter 10:
Cell volume regulatory ion channels in cell proliferation and cell death / Florian Lang ; Michael Fouml;ller ; Karl Lang ; Philipp Lang ; Markus Ritter ; Alexey Vereninov ; Ildiko Szabo ; Stephan M. Huber ; Erich GulbinsChapter 11:
Actin Cytoskeleton Architecture and Signaling in Osmosensing / Evangelia A. Papakonstanti ; Christos StournarasChapter 12:
Osmotic stress and DNA damage / Natalia I. Dmitrieva ; Maurice B. BurgChapter 13:
Transcriptional activator TonEBP in cellular protection and differentiation / Jeong Ah Kim ; Un Sil Jeon ; Min Seong Kwon ; Sun Woo Lim ; H. Moo KwonChapter 14:
Desiccation Response of Mammalian Cells: Anhydrosignalling / Zebo Huang ; Alan TunnacliffeChapter 15:
Tonicity-regulated gene expression / Joan FerrarisChapter 16:
Hyperosmotic Induction of MAP Kinase Scaffolding / Thomas L. Hilder ; Michael H. Malone ; Gary L. JohnsonChapter 17:
(Not here yet, title confirmed) Osmoregulation of bile formation / Ralf KubitzChapter 18:
Osmosignaling And Volume Regulation In Intestinal Epithelial Cells / Christina H. Lim ; G. M. Bot ; Hugo R. de Jonge ; Ben C. TillyChapter 19:
Osmotic regulation of cellular glucose uptake / Philippe Gual ; Teresa ; Gonzalez ; Thierry Greameaux ; Yannick Le Marchand-Brustel ; Jean-Francois TantiChapter 20:
Effects of osmolytes on protein folding in cells / Zoya Ignatova ; Lila M. GieraschChapter 21:
Simulations of Macromolecules in Protective and Denaturing Osmolytes: Properties of Mixed Solvent Systems and their Effects on Water and Protein Structure and Dynamics / David A. C. Beck ; Brian J. Bennion ; Darwin O. V. Alonso ; Valerie DaggettChapter 22:
Application of the Transfer Model to Understand How Naturally Occurring Osmolytes Affect Protein Stability / Matthew Auton ; David W. BolenChapter 23:
Mechanisms of high salinity tolerance in plants / Narendra TutejaChapter 24:
Phenotype of the taurine transporter knockout mouse / Ulrich Warskulat ; Birgit-Heller-Stilb ; Evelyn Oermann ; Karl Zilles ; Helmut Haas ; Florian Lang Dieter Hauml;ussingerChapter 25:
Molecular basis of osmolyte effects on protein and metabolites / Jouml;rg Rouml;sgenChapter 26:
Methods of Changing Biopolymer Volume Fraction and Cytoplasmic Solute Concentrations for In Vivo Biophysical Studies / Michael C. Konopka ; James C. Weisshaar ; M. Thomas RecordChapter 27:
Characterization of Plant Aquaporins / Ralf Kaldenhoff ; Adam Bertl ; Beate Otto ; Menachem Moshelion ; Norbert UehleinChapter 28:
Aquaporins / Landon S. KingChapter 29:
Physiology and pathophy / Chapter 30:
Water compartments in cells / Gary D. Fullerton ; Ivan L. CameronChapter 1:
Yeast osmoregulation / Stefan Hohmann ; Marcus Krantz ; Bodil NordlanderChapter 2:
Physiological Analysis of Bacterial Mechanosensitive Channels / Ian R Booth ; Michelle D Edwards ; Susan Black ; Ulrike Schumann ; Wendy Bartlett ; Tim Rasmussen ; Akiko Rasmussen ; Samantha MillerChapter 3:
10.

電子ブック

EB
Bernard Bruene, Bernhard Brüne, Helmut Sies
出版情報: Elsevier ScienceDirect Books , 2007
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目次情報: 続きを見る
Contributors
Preface
Volumes in Series
Hypoxia-Inducible Factor / Section I:
Hypoxia-Inducible Factors P[superscript ER]/ARNT/S[superscript IM] Domains: Structure and Function / Thomas H. Scheuermann ; Jinsong Yang ; Lei Zhang ; Kevin H. Gardner ; Richard K. Bruick1:
Introduction
Delineation of the HIF PAS Domains / 2:
Expression and Characterization of HIF PAS Domains / 3:
Assessing PAS Domain Protein-Protein Interactions / 4:
Discussion / 5:
Acknowledgments
References
Hypoxia-Inducible Factor Prolyl-Hydroxylase: Purification and Assays of PHD2 / Kirsty S. Hewitson ; Christopher J. Schofield ; Peter J. Ratcliffe
of Purified PHD2 from a Bacterial Source
Assaying of PHD2 Activity
Indirect Measurements of PHD2 Activity
Direct Measurements of PHD2 Hydroxylation Activity
Binding Assays / 6:
Comparison of Assay Formats / 7:
Determination and Modulation of Prolyl-4-Hydroxylase Domain Oxygen Sensor Activity / Renato Wirthner ; Kuppusamy Balamurugan ; Daniel P. Stiehl ; Sandra Barth ; Patrick Spielmann ; Felix Oehme ; Ingo Flamme ; Dorthe M. Katschinski ; Roland H. Wenger ; Gieri Camenisch
Production of Functionally Active PHDs
Determination of PHD by VHL Binding to Peptides Derived from the HIF-1[alpha] ODD Domain
Determination of Prolyl-4-Hydroxylation by Oxidative Decarboxylation of 2-Oxoglutarate
Crude Tissue Extracts are not a Suitable Source of PHD Activity for the 2-Oxoglutarate Conversion Assay
Thin Layer Chromatography to Assess the Purity of [5-[superscript 14] C]2-Oxoglutarate
Application of the 2-Oxoglutarate Conversion Assay to Protein Targets
Conclusions / 8:
Characterization of Ankyrin Repeat-Containing Proteins as Substrates of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Transcription Factor / Sarah Linke ; Rachel J. Hampton-Smith ; Daniel J. Peet
Experimental Techniques
Discussion/Conclusion
Transgenic Models to Understand Hypoxia-Inducible Factor Function / Andrew Doedens ; Randall S. Johnson
Hypoxia Response Pathway Genes and Development
HIF in Physiology
HIF Function in Tumor Biology
Summary
The Silencing Approach of the Hypoxia-Signaling Pathway / Edurne Berra ; Jacques Pouyssegur
A Brief History of RNAi
The Hypoxia-Signaling Pathway
HIF-[alpha] Stability
HIF Activity
HIF-1/HIF-2 Target Gene Specificity
RNAi as a New Potential Therapeutic Strategy
Cellular and Developmental Adaptations to Hypoxia: A Drosophila Perspective / Nuria Magdalena Romero ; Andres Dekanty ; Pablo Wappner
Drosophila melanogaster as a Model System to Study Physiological Responses to Hypoxia
Experimental Advantages of the Model System
The Drosophila Respiratory System
Occurrence of a Drosophila System Homologous to Mammalian HIF
Regulation of Sima by Oxygen Levels
Role of Sima and Fatiga in Drosophila Development
Hypoxia-Inducible Genes and the Adaptation of Drosophila to Oxygen Starvation
Regulation of Sima by the PI3K and TOR Pathways / 9:
Role of the HIF System in Growth Control and Cell Size Determination / 10:
Concluding Remarks / 11:
Erythropoietin / Section II:
Constitutively Overexpressed Erythropoietin Reduces Infarct Size in a Mouse Model of Permanent Coronary Artery Ligation / Giovanni G. Camici ; Thomas Stallmach ; Matthias Hermann ; Rutger Hassink ; Peter Doevendans ; Beat Grenacher ; Alain Hirschy ; Johannes Vogel ; Thomas F. Luscher ; Frank Ruschitzka ; Max Gassmann
Material and Methods
Results
Use of Gene-Manipulated Mice in the Study of Erythropoietin Gene Expression / Norio Suzuki ; Naoshi Obara ; Masayuki Yamamoto
Materials
Methods and Results
Conclusion
Control of Erythropoietin Gene Expression and its Use in Medicine / Wolfgang Jelkmann
Native EPO Gene Expression and its Pharmacologic Stimulation
EPO Gene Transfer
Recombinant EPOS
Role of Hypoxia-Inducible Factor-2[alpha] in Endothelial Development and Hematopoiesis / Osamu Ohneda ; Masumi Nagano ; Yoshiaki Fujii-Kuriyama
Vasculogenesis/Angiogenesis and HIFs
HIF-1[beta]/ARNT Null Mice
Neovascularization and HIFs
Hematopoiesis and HIFs
Hypoxia and Adaptation / Section III:
Organ Protection by Hypoxia and Hypoxia-Inducible Factors / Wanja M. Bernhardt ; Christina Warnecke ; Carsten Willam ; Tetsuhiro Tanaka ; Michael S. Wiesener ; Kai-Uwe Eckardt12:
From Ischemic to Hypoxic Preconditioning
Hypoxia-Inducible Transcription Factors
Strategies to Activate HIF and HIF Target Genes
Hypoxic Preconditioning and HIF
HIF in Chronic Hypoxic/Ischemic Diseases
Conclusions and Perspectives
Hypoxia and Regulation of Messenger RNA Translation / Marianne Koritzinsky ; Bradly G. Wouters13:
Changes in Global mRNA Translation During Hypoxia
Molecular Mechanisms that Regulate mRNA Translation During Hypoxia
Methods Employed to Study mRNA Translation During Hypoxia
Protocols
Hypoxia and the Unfolded Protein Response / Constantinos Koumenis ; Meixia Bi ; Jiangbin Ye ; Douglas Feldman ; Albert C. Koong14:
Methods Employed in Detecting Hypoxic Induction of ER Stress
Hypoxia and Tumor Biology / Section IV:
Tumor Hypoxia in Cancer Therapy / J. Martin Brown15:
Hypoxia in Human Tumors
The Dynamic Nature of Hypoxia in Tumors
Consequences of Tumor Hypoxia for Cancer Treatment
Size of the Oxygen Effect with Radiation
The Influence of Tumor Hypoxia on Cancer Treatment by Radiotherapy
Influence of Tumor Hypoxia on Response to Chemotherapy
Exploiting Hypoxia in Cancer Treatment
HIF Gene Expression in Cancer Therapy / Denise A. Chan ; Adam J. Krieg ; Sandra Turcotte ; Amato J. Giaccia16:
Experimental Procedures
Analysis of Hypoxia-Inducible Factor-1[alpha] Expression and its Effects on Invasion and Metastasis / Balaji Krishnamachary ; Gregg L. Semenza17:
Protocol 1: HIF-1[alpha] Immunohistochemistry
Protocol 2: Invasion Assay
Protocol 3: Transepithelial Resistance Measurement of Cell-Cell Adhesion
Protocol 4: Analysis of MRNA Expression by QRT-PCR
Macrophage Migration Inhibitory Factor Manipulation and Evaluation in Tumoral Hypoxic Adaptation / Millicent Winner ; Lin Leng ; Wayne Zundel ; Robert A. Mitchell18:
Modulation of MIF Levels by Targeted shRNAs and Assessment of Knockdown Efficiency
Analysis of MIF-Dependent CSN5 and COP9 Signalosome Function
Determination of Tumor-Associated MIF Expression and MIF Polymorphic Disparity
The Von Hippel-Lindau Tumor Suppressor Protein: An Update / William G. Kaelin, Jr.19:
Regulation of Epithelial Differentiation by pVHL
Crosstalk Between c-Met and VHL
Regulation of Neuronal Apoptosis by pVHL
Possible Links Between p53 and pVHL
Regulation of pVHL by Phosphorylation
Polyubiquitylation of pVHL
Mouse Models for Studying pVHL Function
Hypoxia-Inducible Factor 1 Inhibitors / Giovanni Melillo20:
Cell-Based High Throughput Screens
Cell-Free Assays
Bioassay-Directed Isolation of Natural Product HIF-1 Inhibitors
Hypoxia and Inflammatory Mediators / Section V:
Regulation of Hypoxia-Inducible Factors During Inflammation / Stilla Frede ; Utta Berchner-Pfannschmidt ; Joachim Fandrey21:
Regulation of HIF at the Transcriptional Level
Regulation of HIF at the Translational Level
Regulation of HIF-1[alpha] at the Posttranslational Level
Regulation of HIF-1 Activity
Perspectives
Superoxide and Derived Reactive Oxygen Species in the Regulation of Hypoxia-Inducible Factors / Agnes Gorlach ; Thomas Kietzmann22:
Reactive Oxygen Species Act as Signaling Molecules
HIFs are Sensitive to Oxygen
Reactive Oxygen Species Modulate HIF
How are HIFs Regulated by Reactive Oxygen Species?
Methods
The Cytochrome C Reduction Assay for Detection of Extracellular Reactive Oxygen Species
Chemiluminescence Assay for Detection of Extracellular Reactive Oxygen Species
Measuring Intracellular Production of Reactive Oxygen Species using Fluorescent Dyes
Detection of Reactive Oxygen Species by Electron Paramagnetic Resonance
Genetics of Mitochondrial Electron Transport Chain in Regulating Oxygen Sensing / Eric L. Bell ; Navdeep S. Chandel23:
Detecting HIF-1[alpha] Protein Levels
Detecting Intracellular ROS Levels
Method 1: Examining Hypoxic Stabilization of HIF-1[alpha] Protein in Cells Containing RNAI against the Rieske Fe-S Protein
Method 2: Examining the Role of ROS Generated from Mitochondrial Electron Transport in Hypoxic Stabilization of HIF-1[alpha] Protein
Hypoxia-Inducible Factor-1[alpha] Under the Control of Nitric Oxide / Bernhard Brune ; Jie Zhou24:
HIF-1 and Oxygen Sensing
Nitric Oxide: A Multifunctional Messenger
Accumulation of HIF-1[alpha] and Activation of HIF-1 by NO
Superoxide Stabilizes HIF-1[alpha] but Antagonizes NO Actions
Hypoxic Signal Transmission is Antagonized by NO
Summary and Conclusions
Hypoxic Regulation of NF-[kappa]B Signaling / Eoin P. Cummins ; Katrina M. Comerford ; Carsten Scholz ; Ulrike Bruning ; Cormac T. Taylor25:
Background
Treatment Protocols for Cellular Hypoxia Studies
Measurement of NF-[kappa]B Activity in Cultured Cells
Summary/Conclusions
Author Index
Subject Index
Contributors
Preface
Volumes in Series
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