| Preface to the Series |
| Preface to Volume 30 |
| Contributors |
| Contents of Previous Volumes |
| Handbook on Toxicity of Inorganic Compounds |
| Handbook on Metals in Clinical and Analytical Chemistry |
| Free Radicals and Metalloenzymes: General Considerations / Ei-Ichiro OchiaiChapter 1： |
| Introduction: A Survey of Biologically Relevant Free Radicals / 1.： |
| Necessity of Free Radicals and Metal Ions / 2.： |
| Reactivities of Free Radicals / 3.： |
| Summary of Free Radical-Dependent Metalloenzymes / 4.： |
| Abbreviations |
| References |
| Peroxidases: Structure, Function, and Engineering / Thomas L. Poulos ; Roger E. FennaChapter 2： |
| Introduction |
| Peroxidase Crystal Structures |
| Peroxidase Catalytic Mechanisms |
| Peroxidase Engineering |
| Conclusions / 5.： |
| Photosystem II / Curtis W. Hoganson ; Gerald T. BabcockChapter 3： |
| Identification and Spectroscopic Studies of the Tyrosine Radicals |
| Electron Transfer Reactions of the Tyrosine Radicals--Both O[subscript 2]-Evolving and Inhibited Photosystem II |
| Other Radicals in Photosystem II |
| Concluding Remarks |
| Ribonucleotide Reductase in Mammalian Systems / Lars Thelander ; Astrid GraslundChapter 4： |
| Mammalian Ribonucleotide Reductase |
| Herpes Simplex Virus Ribonucleotide Reductase |
| Comparison of Amino Acid Sequences and Spectroscopic Properties for Different Species |
| Formation, Properties, and Stability of the Fe-Tyrosyl Radical Center |
| Inhibitors; Radical Scavengers; Iron Chelators; Specific Peptides / 6.： |
| Subunit Interaction and Electron Transfer / 7.： |
| Manganese-Dependent Ribonucleotide Reduction and Overproduction of Nucleotides in Coryneform Bacteria / Georg Auling ; Hartmut FollmannChapter 5： |
| Introduction: The Diversity of Ribonucleotide Reductase Systems |
| Effects of Manganese Depletion in Coryneform Bacteria |
| The Manganese-Containing Ribonucleotide Reductase of Brevibacterium ammoniagenes |
| Distribution of Manganese Ribonucleotide Reductases |
| Concluding Remarks--Ribonucleotide Reduction: Universal but Not Uniform |
| Prostaglandin Endoperoxide Synthases / William L. Smith ; Lawrence J. MarnettChapter 6： |
| PGH Synthase Isozymes |
| Cyclooxygenase Catalysis |
| Peroxidase Catalysis |
| Cyclooxygenase-Peroxidase Interrelationships |
| PGH Synthase Structure |
| Diol Dehydrase from Clostridium Glycolicum: The Non-B[subscript 12]-Dependent Enzyme / Maris G. N. HartmanisChapter 7： |
| Diol Metabolism in C. glycolicum |
| Properties of Membrane bound Diol Dehydrase from C. glycolicum |
| Characterization of Diol Dehydrase |
| Diol Dehydrase and Glycerol Dehydrase, Coenzyme B[subscript 12]-Dependent Isozymes / Tetsuo TorayaChapter 8： |
| Purification, Properties, and Structures |
| Catalytic Properties and Mechanism of Action |
| Formation of Free Radicals |
| Inactivation and Reactivation |
| Physiological Roles |
| Adenosylcobalamin (Vitamin B[subscript 12] Coenzyme)-Dependent Enzymes / Chapter 9： |
| Survey of Adenosylcobalamin-Dependent Enzymes |
| Mechanisms of the Co-C Bond Cleavage |
| Mechanisms of the Subsequent Reactions |
| Conclusion |
| S-Adenosylmethionine-Dependent Radical Formation in Anaerobic Systems / Kenny K. Wong ; John W. KozarichChapter 10： |
| Pyruvate Formate Lyase-Activating Enzyme |
| Lysine 2,3-Aminomutase |
| Anaerobic Ribonucleotide Reductase |
| The Free Radical-Coupled Copper Active Site of Galactose Oxidase / James W. WhittakerChapter 11： |
| Historical Survey |
| Recent Developments |
| Model Reactions and the Role of the Radical in Catalysis |
| Abbreviations and Definitions |
| Amine Oxidases / Peter F. Knowles ; David M. DooleyChapter 12： |
| Structural Properties of Amine Oxidases |
| Catalytic Mechanism of Amine Oxidases |
| Biological Roles of Amine Oxidases |
| Conclusions and Prospects |
| Bacterial Transport of and Resistance to Copper / Nigel L. Brown ; Barry T. O. Lee ; Simon SilverChapter 13： |
| Copper in Bacterial Nutrition |
| Copper Transport and Uptake |
| Bacterial Systems Conferring Resistance to Excess Copper |
| Definitions and Abbreviations |
| Author Index |
| Subject Index |
図書
