organized by IEEE Serbia and Montenegro Section - ED/SSC Chapter ; under the co-sponsorship of IEEE Electron Devices Society ; with the cooperation of IEEE Solid-State Circuits Society
出版情報:
Piscataway, N.J. : Electron Devices Society of the IEEE, c2008 v. ; 28 cm
sponsored by Pavements Committee of the Geo-Institute, American Society of Civil Engineers ... [et al.] ; edited by Zhanping You, Ala R. Abbas, Linbing Wang
出版情報:
Reston, Va. : American Society of Civil Engineers, c2008 x, 167 p. ; 22 cm
Geotechnical Earthquake Engineering and Soil Dynamics ; American Society of Civil Engineers
出版情報:
Reston, VA : American Society of Civil Engineers , Red Hook, NY : Printed from e-media with permission by Curran Associates, c2008 p. 1543-2319 ; 28 cm
U.S. Symposium on Rock Mechanics ; US-Canada Rock Mechanics Symposium ; American Rock Mechanics Association
出版情報:
Alexandria, Va. : American Rock Mechanics Association , Red Hook, NY : Printed from e-media with permission by: Curran Associates, c2008 653 p. ; 27 cm
U.S. Symposium on Rock Mechanics ; US-Canada Rock Mechanics Symposium ; American Rock Mechanics Association
出版情報:
Alexandria, Va. : American Rock Mechanics Association , Red Hook, NY : Printed from e-media with permission by: Curran Associates, c2008 p. 654-1308 ; 27 cm
U.S. Symposium on Rock Mechanics ; US-Canada Rock Mechanics Symposium ; American Rock Mechanics Association
出版情報:
Alexandria, Va. : American Rock Mechanics Association , Red Hook, NY : Printed from e-media with permission by: Curran Associates, c2008 p. 1309-1953 ; 27 cm
Arsenite Resistance in Leishmania and Possible Drug Targets / Gaganmeet Singh ; K.G. Jayanarayan ; Chinmoy S. Dey1:
Abstract
Introduction
Arsenite Resistance in Leishmania
Potential Drug Targets
Conclusion
Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets in Trypanosomatids / Dotan Sela ; Neta Milman ; Irit Kapeller ; Aviad Zick ; Rachel Bezalel ; Nurit Yaffe ; Joseph Shlomai2:
Reevaluating the Kinetoplast as a Potential Target for Anti-Trypanosomal Drugs
The kDNA Network and Its Monomeric Components
Unique Characteristics of the kDNA Replication System
Replication of Free kDNA Minicircles and Catenated Maxicircles
Regulation of kDNA Replication
Concluding Remarks
Drugs and Transporters in Kinetoplastid Protozoa / Scott M. Landfear3:
Roles of Membrane Transport Proteins among the Kinetoplastida
Leishmania Glucose Transporters
Leishmania Purine Transporters
Selective Lead Compounds Against Kinetoplastid Tubulin / R.E. Morgan ; K.A. Werbovetz4:
Oryzalin as a Lead Compound against Kinetoplastid Tubulin
Aromatic Thiocyanates as Lead Compounds
Generating New Leads
Fishing for Anti-Leishmania Drugs: Principles and Problems / Emanuela Handman ; Lukasz Kedzierski ; Alessandro D. Uboldi ; James W. Goding5:
The Disease Burden of Leishmaniasis
Transmission and Epidemiology
Disease Manifestations
Management and Control of Leishmaniasis
The Impact of New Technologies on Drug Discovery
High Throughput Screening
Structure-Based Drug Discovery
Proteomics
Monoclonal Antibodies
Natural Products
Target Selection and Validation
Proteins and Metabolic Pathways Unique to the Parasite
Proteins Essential for Parasite Survival and Virulence Factors
Target Validation
Sterol 14-Demethylase Inhibitors for Trypanosoma Cruzi Infections / Frederick S. Buckner6:
Chagas Disease
Drug Development for Changes Disease
Sterol Biosynthesis-Overview
Sterol 14-Demethylase (CYP51) and Azole Inhibitors
Sterols of T. cruzi
Activity of Azole Compounds against T. cruzi
The Development Status of Sterol 14-Demethylase Inhibitors
Can a Better Sterol 14-Demethylase Inhibitor Be Developed against T. cruzi?
Summary
Histone Deacetylases / David Horn7:
The Deacetylases
The Inhibitors
Current Research
Targeting Glycoproteins or Glycolipids and their Metabolic Pathways for Antiparasite Therapy / Sumi Mukhopadhyay nee Bandyopadhyay ; Chitra Mandal8:
An Introduction to the Kinetoplastid Parasites
Trypanosomiasis
Leishmaniasis
Why Target Glycoproteins and Glycolipids?
Glycoconjugates of Trypanosomes
Biological Relevance of Glycoconjugates in Trypanosomiasis
Targeting VSG Epitopes
Targeting Mucin Glycoproteins
Lactose Derivatives Are Inhibitors of Trans-Sialidase Present in the Mucins
Glycoconjugate Biosynthetic Machinery in Trypanosome
Targeting Enzymes of the Biosynthetic Pathway
Glycoconjugates of Leishmania
Biological Relevance
Development of Anti-Leishmanials by Targeting
gp63 Producing Enzymes
Galactofuranose on LPG
Sialoglycans
Other Glyoconjugates
PPG
Glycosylphosphatidylinositol (GPI) Lipids
Enzymes Producting Glycoproteins
As Drug Carrier
Perspective
DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy / Benu Brata Das ; Agneyo Ganguly ; Hemanta K. Majumder9:
DNA Topoisomerases: The Wonder Enzyme
Classification of DNA Topoisomerases
Topoisomerases of Kinetoplastid Parasites
Topoisomerases as Therapeutic Targets
Antiparasitic Chemotherapy: Tinkering with the Purine Salvage Pathway / Alok Kumar Datta ; Rupak Datta ; Banibrata Sen10:
General Strategies for Development and Characterisation of Drug Targets in Trypanosomatids
Acquisition and Assimilation of Purines in L. donovani Promastigotes
Purine Metabolism in L. donovani Amastigotes
Purine Salvage Enzymes as Targets for Structure-Based Inhibitor Design
Prospects of Adenosine Kinase (AdK) as the Drug Target
General Biochemical Properties of the L. donovani AdK
Structure of AdK from Different Sources
Sequence Characteristics of LdAdK Gene and Homology Model-Based Structural Analysis of the Protein
Identification of Potential Amino Acid Residues Involved in Catalysis
Mechanism of Ado Binding
Mechanism of Phosphate Transfer
Product-Mediated Enzyme Regulation
Conclusions and Perspectives
Searching The Tritryp Genomes for Drug Targets / Peter J. Myler11:
Tritryp Genome Content
Computational Approaches for Drug Target Selection
Databases of Tritrype Metabolism
Identification of Metabolic "Choke-Points"
Searching for Parasite Orthologues of Known Drug Targets
Matching Drug-Like Chemicals to Parasite Proteins
Purine and Pyrimidine Metabolism in Leishmania / Nicola S. Carter ; Phillip Yates ; Cassandra S. Arendt ; Jan M. Biotz ; Buddy Ullman12:
Nomenclature
Purine Metabolism
Purine Transport in Leishmania
Purine Transporters as Drug Targets in Leishmania
Structure-Function Studies on Purine Transporters
Purine Salvage Enzymes of Leishmania
Purine Salvage Enzymes as Drug Targets in Leishmania
The Compartmentalization of Purine Salvage in Leishmania
Pyrimidine Metabolism
Pyrimidine Biosynthesis in Leishmania
Pyrimidine Salvage and Nucleotide Synthesis in Leishmania
The Pyrimidine Pathway as a Drug Target in Leishmania
Index
Arsenite Resistance in Leishmania and Possible Drug Targets / Gaganmeet Singh ; K.G. Jayanarayan ; Chinmoy S. Dey1: