List of Contributors |
Preface |
Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics / Jiyuan Yang ; Jindrich Kopecek1: |
Introduction / 1.1: |
Water-Soluble Polymers as Carriers of Anticancer Drugs / 1.2: |
First Generation Conjugates - Design, Synthesis, and Activity / 1.2.1: |
Analysis of Design Factors That Need Attention / 1.2.2: |
Design of Conjugates for the Treatment of Noncancerous Diseases / 1.2.2.1: |
Combination Therapy Using Polymer-Bound Therapeutics / 1.2.2.2: |
New Targeting Strategies / 1.2.2.3: |
Relationship Between Detailed Structure of the Conjugates and Their Properties / 1.2.2.4: |
Impact of Binding a Drug to a Polymer on the Mechanism of Action / 1.2.2.5: |
Mechanism of Internalization and Subcellular Trafficking / 1.2.2.6: |
Relationship Between the Molecular Weight of the Carrier and the Efficacy of the Conjugate / 1.2.2.7: |
Design of Second Generation Conjugates - Long-Circulating and Backbone Degradable / 1.2.3: |
RAFT Copolymerization for the Synthesis of Conjugates / 1.2.3.1: |
Click Reactions for Chain Extension into Multiblock Copolymers / 1.2.3.2: |
Biological Properties of Long-Circulating Macromolecular Therapeutics / 1.2.3.3: |
Summary of Part 2 and Future Prospects / 1.2.4: |
Drug-Free Macromolecular Therapeutics - A New Paradigm in Drug Delivery / 1.3: |
Biorecognition in Hybrid Polymer Systems / 1.3.1: |
Coiled-Coils in Biomedical Systems / 1.3.2: |
Coiled-Coil Based Drug-Free Macromolecular Therapeutics: Design, In Vitro, and In Vivo Activity / 1.3.3: |
Potential, Limitations, and Future Prospect of Drug-Free Macromolecular Therapeutics / 1.3.4: |
General Summary and Outlook / 1.4: |
Acknowledgments |
References |
Dendritic Polymers as Targeting Nanoscale Drug Delivery Systems for Cancer Therapy / Kui Luo ; Zhongwei Gu2: |
Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect / 2.1: |
Functional Dendritic Polymers for Encapsulation of Anticancer Drugs / 2.2.1: |
Chemical Conjugation Functional Dendritic Polymers as Drug Delivery Systems / 2.2.2: |
Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy / 2.3: |
Conclusion / 2.4: |
Composite Colloidal Nanosystems for Targeted Delivery and Sensing / Pilar Rivera Gil ; Moritz Nazarenus ; Wolfgang J. Parak3: |
Working Toolkit / 3.1: |
Engineering a Multifunctional Carrier / 3.1.2: |
Objective / 3.2: |
Cellular Behavior of the Carrier / 3.3: |
Intracellular Fate / 3.3.1: |
Biocompatibility / 3.3.2: |
Applications / 3.4: |
Delivery with Multifunctional PEM Capsules / 3.4.1: |
Magnetic Targeting and Magnetofection / 3.4.1.1: |
Strategies for Controlled Opening / 3.4.1.2: |
Intracellular Ion Sensing / 3.4.2: |
Conclusions / 3.5: |
Abbreviations |
Polymeric Micelles for Cancer-Targeted Drug Delivery / Huabing Chen ; Zhishen Ge ; Kazunori Kataoka4: |
Micelle Formulations in Clinical Development / 4.1: |
Particle Size of Micelles / 4.3: |
Morphology of Micelles / 4.4: |
Targeting Design of Micelles for Enhanced Accumulation and Cell Internalization / 4.5: |
Functional Designs of Micelles / 4.6: |
Design of Micelles for Gene Delivery / 4.7: |
Challenge and Future Perspective 103 / 4.8: |
Biomimetic Polymers for in Vivo Drug Delivery / Wenping Wang ; Kinam Park5: |
Commonly Used Biomimetic Polymers and Their Applications in DDS / 5.1: |
Polylactones and Their Modifications / 5.2.1: |
Poly(lactic acid) (PLA) / 5.2.1.1: |
Poly(lactic-co-glycolic acid) (PLGA) / 5.2.1.2: |
Poly(ε-caprolactone) (PCL) / 5.2.1.3: |
Dendrimer / 5.2.2: |
Structure and Properties of Dendrimers / 5.2.2.1: |
Types of Dendrimers / 5.2.2.2: |
Applications of Dendrimers as Carriers in Drug Delivery Systems / 5.2.2.3: |
Synthetic Polypeptides / 5.2.3: |
Challenges and Perspectives / 5.3: |
Drug Delivery from Protein-Based Nanoparticles / Dan Ding ; Xiqun Jiang6: |
Preparation of Protein-Based Nanoparticles / 6.1: |
Desolvation / 6.2.1: |
Emulsification / 6.2.2: |
Coacervation / 6.2.3: |
Polymer-Monomer Pair Reaction System / 6.2.4: |
Drug Delivery from Albumin-Based Nanoparticles / 6.3: |
Albumin-Based Nanoparticles as Drug Carriers / 6.3.1: |
Targeting Ligand-Functionalized Albumin-Based Nanoparticles / 6.3.2: |
Nanoparticle Albumin-Bound (nab) Technology / 6.3.3: |
Drug Delivery from Gelatin-Based Nanoparticles / 6.4: |
Gelatin-Based Nanoparticles as Drug Carriers / 6.4.1: |
Targeting Ligand-Functionalized Gelatin-Based Nanoparticles / 6.4.2: |
Site-Specific Drug Delivery System / 6.4.3: |
Drug Delivery from Other Protein-Based Nanoparticles / 6.5: |
Polymeic Gene Carriers / Xuesi Chen ; Huayu Tian ; Xiuwen Guan7: |
Gene Therapy and Gene Carriers / 7.1: |
Gene Therapy / 7.1.1: |
The Concept of Gene Therapy / 7.1.1.1: |
Development and the Present Situation of Gene Therapy / 7.1.1.2: |
Methods and Strategies of Gene Therapy / 7.1.1.3: |
Research Contents and Challenges of Gene Therapy / 7.1.1.4: |
Gene Carriers / 7.1.2: |
The Concept of Gene Carrier / 7.1.2.1: |
The Necessity of the Gene Carrier / 7.1.2.2: |
Requirements of Gene Carrier / 7.1.2.3: |
Classification of Gene Carrier / 7.1.2.4: |
Polymeric Gene Carriers / 7.2: |
Cationic Polymer Gene Carriers / 7.2.1: |
Process of the Polycation Vector Mediated Gene Delivery / 7.2.1.1: |
Categories and Research Situation of the Cationic Polymer Gene Vector / 7.2.1.2: |
PEI Grafting Modification Polymeric Gene Carriers / 7.3: |
Amino Acid Derivatives Modified Polymeric Gene Carriers / 7.3.1: |
Poly(glutamic acid) Derivatives Modified PEI / 7.3.1.1: |
Polyphenyialanine Derivatives Modified PEI / 7.3.1.2: |
PEG Modified Hyperbranched PEI / 7.3.2: |
Low Molecular Weight (LWM) PEI Base Polymeric Gene Carriers / 7.4: |
Crosslinked Polycations / 7.4.1: |
Crosslinlced Polycation OEI-CBA / 7.4.1.1: |
Crosslinked Polycation OEI-PBLG-PEGDA / 7.4.1.2: |
Hexachlorotriphosphazene Crosslinked Polycation / 7.4.1.3: |
Grafted Polycations / 7.4.2: |
Grafted Cationic Polymer MP-g-OEI / 7.4.2.1: |
Graft Cationic Polymer N-PAE-g-OEI / 7.4.2.2: |
Graft Cationic Polymer mPEGT-PMCC-g-OEI / 7.4.2.3: |
Targeted Shielding System for Polymeric Gene Carriers / 7.5: |
Static Shielding System / 7.5.1: |
Poly(glutamine acid) Shielding System and PEGylations / 7.5.1.1: |
Sulfonamides Related Shielding System / 7.5.1.2: |
Other Design Strategies of Cationic Gene Carrier / 7.5.2: |
pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging / Yi Li ; Guang Hui Gao ; Ick Chan Kwon ; Doo Sung Lee7.6: |
pH-Sensitive Polymers / 8.1: |
pH-Sensitive Anionic Polymers / 8.2.1: |
pH-Sensitive Cationic Polymers / 8.2.2: |
pH-Sensitive Neutral Polymers / 8.2.3: |
pH-Sensitive Polymers as Drug Carriers / 8.3: |
pH-Sensitive Polymer-Drug Conjugates / 8.3.1: |
pH-Sensitive Polymeric Micelles / 8.3.2: |
pH-Sensitive Polymersomes / 8.3.3: |
pH-Sensitive Polymer-Inorganic Hybrid Nanoparticles / 8.3.4: |
pH-Sensitive Dendrimers / 8.3.5: |
pH-Sensitive Polymers for Bioimaging / 8.4: |
Charge-Reversal Polymers for Biodelivery / Bo Zhan ; Kai Wang ; Jingxing Si ; Meihua Sui ; Youqing Shen8.5: |
Applications of Cationic Polymers in Biodelivery / 9.1: |
Barriers for Cationic Polymers in In vitro and In vivo Applications / 9.2: |
Characteristic pH Gradients in Tumor Interstitium and Endo/Lyso somes / 9.3: |
Chemistry of Charge-Reversal Polymers Based on Acid-Labile Amides / 9.4: |
pHe-Triggered Charge-Reversal / 9.4.1: |
pHL-Triggered Charge-Reversal / 9.4.2: |
Applications of Charge-Reversal Polymers in Biodelivery Systems / 9.5: |
Charge-Reversal in Cancer Drug Delivery / 9.5.1: |
Charge-Reversal in Gene Delivery / 9.5.2: |
Charge-Reversal in Protein Delivery / 9.5.3: |
Charge-Reversal Incorporated with Inorganic Materials / 9.5.4: |
Perspectives / 9.6: |
Phenylbaronic Acid-Containing Glucose-Responsive Polymer Materials: Synthesis and Applications in Drug Delivery / Rujiang Ma ; Linqi Shi10: |
PBA-Containing Polymers Operating Under Physiological Conditions / 10.1: |
Chemically Crosslinked PBA-Based Gels / 10.3: |
Self-Assembled PBA-Based Polymer Micelles / 10.4: |
Self-Assembled PBA-Based Polymersomes / 10.5: |
Extracellular pH-Activated Nanocarriers for Enhanced Drug Delivery to Tumors / You-Yong Yuan ; Cheng-Qiong Mao ; Jin-Zhi Du ; Xian-Zhu Yang ; Jun Wang10.6: |
Passive and Active Tumor Targeting / 11.1: |
Targeting the Extracellular pH (pHe) in Tumors / 11.3: |
Extracellular pH-Induced Drug Delivery to Tumors / 11.4: |
Ligand Exposure by a Shielding/Deshielding Method / 11.5: |
Surface Charge Reversing Nanoparticles / 11.6: |
Enhanced Cellular Uptake by Surface Charge Reversing Nanoparticles / 11.6.1: |
Overcoming MDR by Surface Charge Reversing Nanoparticles / 11.6.2: |
Enhanced Delivery of siRNA by Surface-Charge Reversing Nanoparticles / 11.6.3: |
Stimulation-Sensitive Drug Delivery Systems / Xintao Shuai ; Du Cheng11.7: |
pH-Sensitive Delivery Systems / 12.1: |
pH-Sensitive Micellar Delivery Systems / 12.2.1: |
pH-Sensitive Liposomes / 12.2.2: |
Thermo-Sensitive Delivery Systems / 12.3: |
Biomolecule-Sensitive Delivery Systems / 12.4: |
Enzyme-Sensitive Nanocarriers / 12.4.1: |
Reduction-Responsive Conjugates / 12.4.2: |
Other Environmentally Sensitive Nanocarriers / 12.5: |
Outlook / 12.6: |
Index |
List of Contributors |
Preface |
Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics / Jiyuan Yang ; Jindrich Kopecek1: |