| Preface |
| Vitamins C and E and LDL Oxidation / B. Frei ; J.F. Keaney, Jr ; K.L. Retsky ; K. Chen |
| Antioxidant Vitamins and Human Immune Responses / A. Bendich |
| Cytokine Regulation of Bone Cell Differentiation / M. Alsina ; T.A. Guise ; G.D. Roodman |
| The Molecular Pharmacology of Ovarian Steroid Receptors / E. Vegeto ; B.L. Wagner ; M.O. Imhof ; D.P. McDonnell |
| Signal Transduction Pathways Combining Peptide Hormones and Steroidogenesis / M.R. Waterman ; D.S. Keeney |
| The Roles of 14-3-3 Proteins in Signal Transduction / G.W. Reuther ; A.M. Pendergast |
| Physiological Roles for Parathyroid Hormone-Related Protein: Lessons from Gene Knockout Mice / A.C. Karaplis ; H.M. Kronenberg |
| Index |
| The Steroid/Nuclear Receptors: From Three Dimensional Structure to Complex Function / B.F. Luisi ; J.W.R. Schwabe ; L.P. Freedman |
| Function/Activity of Specific Amino Acids in Glucocorticoid Receptors / S.S. Simons, Jr. |
| Genetic Diseases of Steroid Metabolism / P.C. White |
| Structure, Function and Regulation of Androgen-Binding Protein/Sex Hormone-Binding Globulin / D.R. Joseph |
| Molecular Biology of Vitamin D Acation / T.K. Ross ; H.D. Darwish ; H.F. Deluca |
| Nuclear Retinoid Receptors and Their Mechanism of Action / M. Pfahlr ; R. Apfel ; I. Bendik ; A. Fanjul ; G. Graupner ; M.-O. Lee ; N. La-Vista ; X.-P. Lu ; J. Piedrafita ; A. Ortiz-Caseda ; G. Salbert ; X.-K. Zhang |
| Molecular Mechanisms of Androgen Action / J. Lindzey ; M.V. Kumar ; M. Grossman ; C. Young ; D.J. Tindall |
| Role of Androgens in Prostatic Cancer / J.T. Isaacs |
| Cumulative Index, Volumes 30-55 |
| Subject Index |
| Author Index |
| Contributors |
| Neuroendocrine and Behavioral Development During Puberty: A Tale of Two Axes / Russell D. Romeo1： |
| Introduction / I： |
| HPG Axis / II： |
| HPA Axis / III： |
| Conclusions and Future Directions / IV： |
| References |
| Regulation of Oxytocin Secretion / Gareth Leng ; Celine Caquineau ; Nancy Sabatier2： |
| The Hypothalamo-Neurohypophysial Oxytocin System |
| The Milk-Ejection Reflex |
| Control of Oxytocin Secretion at Parturition |
| Oxytocin Secretion and Stress |
| Osmotic Regulation of Oxytocin Secretion / V： |
| Oxytocin Secretion and Behavior / VI： |
| Conclusions / VII： |
| Gonadotropin-Releasing Hormone: Gene Evolution, Expression, and Regulation / Denise D. Belsham ; David A. Lovejoy3： |
| The GnRH Genes |
| Early Formation and Migration of GnRH Neurons |
| Analysis of GnRH Gene Expression |
| Regulation of GnRH Gene Expression |
| Future Directions and Critical Studies |
| Thyroid Hormones and Brain Development / Juan Bernal4： |
| Morphological Aspects |
| Control of Local Brain Thyroid Hormone Concentrations |
| Role of Thyroid Hormone Receptors |
| Regulation of Brain Gene Expression by Thyroid Hormone |
| Estrogen Signaling in the Hypothalamus / Martin J. Kelly ; Jian Qui ; Oline K. Ronnekleiv5： |
| Hypothalamus and Feedback of E[subscript 2] on the Hypothalamic-Pituitary Axis |
| Transcriptional Signaling of Estrogen in Hypothalamic Neurons |
| Membrane-Initiated Signaling by Estrogen in Hypothalamic Neurons |
| Coupling of a Membrane Estrogen Receptor to Signaling Cascades |
| Cross-Talk between E[subscript 2] Signaling with other Signaling Cascades |
| Hormonal Influences on Cancer Progression and Prognosis / G. V. Sherbet6： |
| Hormone-Mediated Induction of Invasive Behavior |
| Estrogens and Progestins on Breast Cancer Progression and Prognosis |
| Androgen Receptors in Prostate Cancer |
| Vitamin D3 in Cell Proliferation, Apoptosis, and Differentiation |
| RA and Its Receptors in Cell Differentiation, Proliferation, and Survival |
| General Conclusions and Reflections on Cancer Progression |
| Antiestrogens, Aromatase Inhibitors, and Apoptosis in Breast Cancer / Rebecca B. Riggins ; Amy H. Bouton ; Minetta C. Liu ; Robert Clarke7： |
| Estrogen and ERs |
| Antiestrogens |
| Aromatase Inhibitors, Estrogen Independence, and Antiestrogens |
| Antiestrogens versus Aromatase Inhibitors as Endocrine Therapies |
| Apoptosis |
| Antiestrogen Resistance and Defects in Apoptosis |
| De Novo Antiestrogen Resistance / VIII： |
| Summary and Future Directions / IX： |
| Glucocorticoid Receptor and Heat Shock Factor 1: Novel Mechanism of Reciprocal Regulation / Dapei Li ; Edwin R. Sanchez8： |
| GR and HSF1 are Chaperoned by Similar Hsp90/TPR Protein Complexes |
| Stress Potentiation of Glucocorticoid Receptor-Mediated Gene Expression |
| GR Regulation of HSF1 |
| Speculations on GR and HSF1 Reciprocal Regulation |
| C[subscript 19]-5-ene Steroids in Nature / Henry Lardy ; Ashok Marwah ; Padma Marwah9： |
| Dehydroepiandrosterone |
| Androstenediol (androst-5-ene-3[beta],17[beta]-diol; Adiol) |
| 7-Oxygenated Steroids |
| 16-Hydroxydhea |
| The Androgen Receptor: Unlocking the Secrets of Its Unique Transactivation Domain / Howard C. Shen ; Gerhard A. Coetzee10： |
| The Androgen Signaling Axis |
| The Role of AR in Prostate Cancer |
| Overview of AR Structure |
| The AR LBD |
| The AR DBD |
| The AR NTD |
| AR AF-1 and AF-5 |
| Q and G Repeats |
| AR NTD Signature Sequence |
| FxxLF and WxxLF Motifs / X： |
| Phosphorylation of the AR NTD / XI： |
| Sumoylation at NRM1 and NRM2 / XII： |
| AR NTD-Associated Cofactors / XIII： |
| The Focus on AR NTD / XIV： |
| Cytokine Recognition by Human Interleukin 5 Receptor / Tetsuya Ishino ; Noreen Robertson ; Irwin Chaiken11： |
| Assembly and Activation Mechanism of IL-5 Receptor |
| Relationship of Cytoplasmic Signaling by IL-5 to Receptor Organization |
| Structure and Function of IL-5 |
| Mapping of Binding Epitope on IL-5 Receptor [alpha] |
| Peptide Approach to IL-5 Mimetics |
| Conclusion-Future Study for Cytokine Recognition |
| Leptin: Structure, Function and Biology / Faming Zhang ; Yanyun Chen ; Mark Heiman ; Richard DiMarchi12： |
| Leptin |
| Leptin Structure |
| Leptin Receptor |
| Leptin-Binding Protein |
| Leptin-Receptor Binding Model |
| Leptin Signal Transduction |
| Therapeutic Application |
| Conclusion |
| Leptin Gene Polymorphisms and Their Phenotypic Associations / T. van der Lende ; M. F. W. te Pas ; R. F. Veerkamp ; S. C. Liefers13： |
| Structural Organization of the Leptin Gene and Leptin Protein |
| Polymorphisms in the Human Leptin Gene |
| Polymorphisms in the Bovine Leptin Gene |
| Polymorphisms in the Porcine Leptin Gene |
| Concluding Remarks |
| Ghrelin, the Same Peptide for Different Functions: Player or Bystander? / Francisca Lago ; Jose Ramon Gonzalez-Juanatey ; Felipe F. Casanueva ; Juan Gomez-Reino ; Carlos Dieguez ; Oreste Gualillo14： |
| Ghrelin, the First Orexigenic Gastrointestinal Acylated Peptide: Isolation, Identification, and Structures |
| Tissue Distribution and Regulation |
| Mechanism of Action |
| Biological Action |
| Ghrelin and Ghrelin Receptor Knockout: Relevant or Redundant? |
| Cholecystokinin and Adrenal-Cortex Secretion / Gastone G. Nussdorfer ; Raffaella Spinazzi ; Giuseppina Mazzocchi15： |
| Biology of CCK and Adrenocortical Cells |
| CCK and Its Receptors in the HPA Axis |
| Effects of CCK on Adrenal-Cortex Secretion |
| Preface |
| Vitamins C and E and LDL Oxidation / B. Frei ; J.F. Keaney, Jr ; K.L. Retsky ; K. Chen |
| Antioxidant Vitamins and Human Immune Responses / A. Bendich |
| Cytokine Regulation of Bone Cell Differentiation / M. Alsina ; T.A. Guise ; G.D. Roodman |
| The Molecular Pharmacology of Ovarian Steroid Receptors / E. Vegeto ; B.L. Wagner ; M.O. Imhof ; D.P. McDonnell |
| Signal Transduction Pathways Combining Peptide Hormones and Steroidogenesis / M.R. Waterman ; D.S. Keeney |
