Preface |
Acknowledgments |
List of Contributors |
Theoretical Introduction / Part I: |
Introduction / 1: |
Bioprocesses / 1.1: |
History of Biotechnology and Today's Situation / 1.1.1: |
Future Perspectives / 1.1.2: |
Modeling and Assessment in Process Development / 1.2: |
Development of Bioprocesses / 2: |
Types of Bioprocess and Bioproduct / 2.1: |
Biocatalysts and Process Types / 2.1.1: |
Raw Materials / 2.1.2: |
Bioproducts / 2.1.3: |
Bioreaction Stoichiometry, Thermodynamics, and Kinetics / 2.2: |
Stoichiometry / 2.2.1: |
Thermodynamics / 2.2.2: |
Kinetics / 2.2.3: |
Elements of Bioprocesses (Unit Operations and Unit Procedures) / 2.3: |
Upstream Processing / 2.3.1: |
Bioreactor / 2.3.2: |
Downstream Processing / 2.3.3: |
Waste Treatment, Reduction and Recycling / 2.3.4: |
The Development Process / 2.4: |
Development Steps and Participants / 2.4.1: |
Modeling and Simulation of Bioprocesses / 3: |
Problem Structuring, Process Analysis, and Process Scheme / 3.1: |
Model Boundaries and General Structure / 3.1.1: |
Modeling Steps / 3.1.2: |
Implementation and Simulation / 3.2: |
Spreadsheet Model / 3.2.1: |
Modeling using a Process Simulator / 3.2.2: |
Uncertainty Analysis / 3.3: |
Scenario Analysis / 3.3.1: |
Sensitivity Analysis / 3.3.2: |
Monte Carlo Simulation / 3.3.3: |
Sustainability Assessment / 4: |
Sustainability / 4.1: |
Economic Assessment / 4.2: |
Capital-Cost Estimation / 4.2.1: |
Operating-Cost Estimation / 4.2.2: |
Profitability Assessment / 4.2.3: |
Environmental Assessment / 4.3: |
Structure of the Method / 4.3.1: |
Impact Categories and Groups / 4.3.3: |
Calculation of Environmental Factors / 4.3.4: |
Calculation of Indices / 4.3.5: |
Example Cleavage of Penicillin G / 4.3.6: |
Assessing Social Aspects / 4.4: |
Indicators for Social Assessment / 4.4.1: |
Interactions between the Different Sustainability Dimensions / 4.5: |
Bioprocess Case Studies / Part II: |
Introduction to Case Studies |
Citric Acid - Alternative Process using Starch / 5: |
Fermentation Model / 5.1: |
Process Model / 5.3: |
Inventory Analysis / 5.4: |
Conclusions / 5.5: |
Pyruvic Acid - Fermentation with Alternative Downstream Processes / 6: |
Bioreaction and Upstream / 6.1: |
L-Lysine - Coupling of Bioreaction and Process Model / Arnd Knoll ; Jochen Buechs6.3.2: |
Basic Strategy / 7.1: |
Bioreaction Model / 7.3: |
Coupling of Bioreaction and Process Model / 7.4: |
Assumptions / 7.5.1: |
Results and Discussion / 7.6: |
Riboflavin - Vitamin B[subscript 2] / Wilfried Storhas ; Rolf Metz8: |
Biosynthesis and Fermentation / 8.1: |
Production Process and Process Model / 8.3: |
Fermentation / 8.3.1: |
Ecological Assessment / 8.3.3: |
Discussion and Concluding Remarks / 8.6: |
[Alpha]Cyclodextrin / 9: |
Reaction Model / 9.1: |
Solvent Process / 9.3: |
Non-solvent Process / 9.3.2: |
Penicillin V / 9.4: |
Modeling Base Case / 10.1: |
Monte Carlo Simulations / 10.2.1: |
Objective Functions, Variables, and Probability Distributions / 10.6.1: |
Results / 10.6.2: |
Recombinant Human Serum Albumin / M. Abdul Kholiq ; Elmar Heinzle10.7: |
Multi-stage Fermentation and Feeding Plan / 11.1: |
Total Broth Volume in Production Scale and Raw Material Consumption / 11.2.3: |
Bioreaction / 11.3: |
Recombinant Human Insulin / Demetri Petrides11.3.2: |
Two-chain Method / 12.1: |
Proinsulin Method / 12.1.2: |
Market Analysis and Design Basis / 12.2: |
Process Description / 12.2.1: |
Inventory Analysis and Environmental Assessment / 12.2.2: |
Production Scheduling / 12.2.3: |
Throughput-Increase Options / 12.3: |
Monoclonal Antibodies / 12.5: |
Scenarios / 13.1: |
[Alpha]-1-Antitrypsin from Transgenic Plant Cell Suspension Cultures / Elizabeth Zapalac ; Karen McDonald13.6.2: |
Model Description / 14.1: |
Discussion / 14.4: |
Plasmid DNA / Sindelia S. Freitas ; Jose A. L. Santos ; D. Miguel F. Prazeres14.5: |
General / 15.1: |
Case Introduction / 15.1.2: |
Bioreaction Section / 15.1.3: |
Downstream Sections / 15.2.2: |
Index / 15.3: |