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1.

電子ブック

EB
Lawrence C. Kuo
出版情報: Elsevier ScienceDirect Books , Elsevier Science & Technology, 2011
所蔵情報: loading…
目次情報: 続きを見る
Tools / Part I:
Designing a Diverse High Quality Library for Crystallography Based FBDD Screening / Brett A. Tounge ; Michael H. Parker1:
Preparation of Protein Samples for NMR Structure, Function, and Small-Molecule Screening Studies / Thomas B. Acton ; Rong Xiao ; James Aramini ; William A. Buchwald ; Colleen Ciccosanti ; Ken Conover ; Keith Hamilton ; Yuanpeng Janet Huang ; Haleema Janjua ; Paolo Rossi ; Seema Sharma ; G.V.T.Swapna ; Huang Wang ; Li Zhao ; Gaetano T. Montelione2:
Key Factors for Successful Generation of Protein-Fragment Structures: Requirements on Protein, Crystals, and Technology / Anja Jestel ; Stefan Steinbacher3:
Automated Crystal Amplification and Compound Dispensation for FBDD Analysis / Francis A. Lewandowski ; Cynthia M. Milligan4:
Hardware and Protocols for Rapid Fragment Based Structure Determination / Richard S. Alexander ; John C. Spurlino5:
Using Computational Techniques in Fragment-Based Drug Discovery / Renee L. DesJarlais6:
Computational Approaches to De Novo Discovery of Fragment Binding for Unprecedented Protein States / Zenon D. Konteatis ; Jinming Zou ; Anthony E. Klon ; Siavash Meshkat7:
Practical Approaches / Part II:
How to Avoid Rediscovering the Known / Lawrence C. Kuo8:
From Experimental Design to Data Analysis: A Comprehensive Walk-Through of Fragment Identification Using Surface Plasmon Resonance / Anthony M. Giannetti9:
Practical Aspects of NMR Based Fragment Screening / Christopher Lepre10:
Fluorescent Protein Thermal Shifts to Identify Low Molecular Weight Fragments / James K. Kranz ; Matthew J. Todd11:
A HTS Reporter Displacement Assay for Fragment Screening and Fragment Evolution Towards Leads with Optimized Binding Affinity, Binding Kinetics, and Kinetic Selectivity / Lars Neumann12:
Fragment Screening of Stabilized G-Protein Coupled Receptors Using Biophysical Methods / Miles Congreve ; Fiona H. Marshall ; David Myszka ; Gregg Siegal13:
Predicting the Success of a Fragment Screening by X-Ray Crystallography / Douglas Davies ; Lance Stewart14:
Fragment Screening Purely with Protein Crystallography / 15:
Structure Density Relationship Based FBDD / Marta C. Abad ; Xuqing Zhang ; Alan C. Gibbs16:
Lead Generation Examples / Part III:
Lead Generation and Examples - Opinions Regarding How to Follow Up Hits / Masaya Orita ; Kazuki Ohno ; Masaichi Warizaya ; Yasushi Amano ; Tatsuya Niimi17:
High Throughput Thermodynamics for Selection of Fragment Hits and Guidance of Fragment Evolution / 18:
Medicinal Chemistry Inspired Fragment Based Drug Discovery / James C. Lanter ; Zhihua Sui19:
Experiences in Fragment-Based Lead Discovery / Roderick E. Hubbard ; James B. Murray20:
Advancing Fragment Binders to Lead Like Compounds Using Ligand and Protein Based NMR Spectroscopy / Till Maurer21:
Effective Progression of NMR-Directed Fragment Hits / Hugh Eaton ; Daniel Wyss22:
Fragment Screening of Infectious Disease Targets in a Structural Genomics Environment / 23:
Tools / Part I:
Designing a Diverse High Quality Library for Crystallography Based FBDD Screening / Brett A. Tounge ; Michael H. Parker1:
Preparation of Protein Samples for NMR Structure, Function, and Small-Molecule Screening Studies / Thomas B. Acton ; Rong Xiao ; James Aramini ; William A. Buchwald ; Colleen Ciccosanti ; Ken Conover ; Keith Hamilton ; Yuanpeng Janet Huang ; Haleema Janjua ; Paolo Rossi ; Seema Sharma ; G.V.T.Swapna ; Huang Wang ; Li Zhao ; Gaetano T. Montelione2:
2.

図書

図書
edited by Lawrence C. Kuo, David B. Olsen, Steven S. Carroll
出版情報: San Diego ; Tokyo : Academic Press, c1996  xxx, 658 p., [1] leaf of plate ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 275
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目次情報: 続きを見る
Expression, Purification, and Characterization / V. Sardana ; M. Sardana
Purification of Viral Polymerases: General Considerations / P.E. Boehmer
Expression, Purification, and Characterization of the HerpesSimplex Virus Type-1 DNA Polymerase / D.J. Barton ; B.J. Morasco ; J.B. Flanegan
Assays for Poliovirus Polymerase, 3D pol, and Authentic RNA Replication in HeLa S10 Extracts / R. de Francesco ; S.-E. Behrens ; L. Tomei ; S. Altamura ; J. Jiricny
RNA-Dependent RNA Polymerase of Hepatitus C Virus / J. Herold ; S. Siddell ; J. Ziebuhr
Characterization of Coronavirus RNA Polymerase Gene Products / J. Tomassini
Expression, Purification, and Characterization of Orthomyxovirus: Influenza Transcriptase / T. Das ; B.P. De ; A.K. Banerjee
Expression, Purification, and Characterization of Rhabdovirus Polymerase / M.W. Stahlhut ; D.B. Olsen
Expression and Purification of Retroviral HIV-1 Reverse Transcriptases / L.H.Malkas ; R.J. Hickey
Expression, Purification, and Characterization of DNA Polymerases Involved in Papovavirus Replication / M. Ramachandra ; Y. Sasaguri ; R. Nakano ; R. Padmanabhan
Heterologous Expression, Purification, and Characterization of Adenovirus DNA Polymerase and Preterminal Protein / J. Hu ; C. Seeger
Expression and Characterization of Hepadnavirus Reverse Transcriptases / P. Gershon ; B. Moss
Expression, Purification, and Characterization of Vaccinia Virus Encoded RNA and Poly(A)Polymerases / J.R. Sayers
Viral Polymerase-Associated 5-3 Exonucleases: Expression, Purification, and Uses
Activity Assays: Kinetic and Screening / R.D. Kuchta
Isotopic Assays of Viral Polymerases and Related Proteins / J. Eberle ; C. W. Knopf
Nonisotopic Assays of Viral Polymerases and Related Proteins / S. Gabbara ; J.A. Peliska
Catalytic Activities Associated with Retroviral and Viral Polymerases / J.L. Cole
Approaches to High Volume ScreeningAssays of Viral Polymerases and Related Proteins / S.M. Oberhaus ; J.E. Newbold
In Situ DNA Polymerase and RNase H Activity Gel Assays as Applied to Hepadnavirus Particles / V. Byrnes ; D. Hazuda
A System to Analyze and Identify Inhibitorsof HIV-1 Gene Regulation with Defective Integrated Provirus
Design and Analysis of Substrates and Inhibitors / S.S. Carroll ; F. Benseler
Preparation and Use of Synthetic Oligoribonucleotides as Tools for Study of Viral Polymerases / V.V. Gurevich
Use of Bacteriophage RNA Polymerase in RNA Synthesis / J.E. Wilson ; D.J.T. Porter ; J.E. Reardon
Inhibition of Viral Polymerases by Chain Terminating Substrates: A Kinetic Analysis / E.J. Prisbe ; M.S. Chen
Design of Nucleoside Analogue Inhibitors of Herpesvirus Polymerases / T.J. Tucker ; W.C. Lumma ; J.C. Culberson
Development of Nonnucleoside HIV Reverse Transcriptase Inhibitors / J. Balzarini ; E. De Clerq
Analysis of Inhibition of Retroviral Reverse Transcriptase / H. Chen ; D. Brown ; L. Gold
Novel Methods of Generating Specific Oligonucleotide Inhibitors of Viral Polymerases
Molecular and Structural Characterizations / J.C. Boyer ; K. Bebenek ; T.A. Kunkel
AnalyzingFidelity of Transcription and Reverse Transcription / P.L. Boyer ; S.H. Hughes
Site-Directed Mutagenic Analysis of Viral Polymerases and Related Proteins / J.S. Oxford ; A.A. Al-Jabri ; P. Levantis
Analysis of Resistance Mutants of ViralPolymerases
Author Ind
Expression, Purification, and Characterization / V. Sardana ; M. Sardana
Purification of Viral Polymerases: General Considerations / P.E. Boehmer
Expression, Purification, and Characterization of the HerpesSimplex Virus Type-1 DNA Polymerase / D.J. Barton ; B.J. Morasco ; J.B. Flanegan
3.

図書

図書
edited by Lawrence C. Kuo, Jules A. Shafer
出版情報: San Diego ; Tokyo : Academic Press, c1994  xxv,432 p., [19] p. of plates ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 241
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目次情報: 続きを見る
Bacterial Expression and Enzymatic Assays / J. Stebbins ; C. Debouck
Expression Systems for Retroviral Proteases / C.J. Rizzo ; B.D. Korant
Genetic Approaches Designed to Minimize Cytotoxicity of Retroviral Protease / E. Chen
Host Strain Selection for Bacterial Expression of Toxic Proteins / C.U.T. Hellen
Assay Methods for Retroviral Proteases / A.H. Kaplan ; M. Manchester ; L. Everitt ; R. Swanstrom
Analysis of Human Immunodeficiency Virus 1 Protease Activity in Eukaryotic and Bacterial Cells / G. A. Krafft ; G.T. Wang
Synthetic Approaches to Continuous Assays of Retroviral Proteases
Purification and Characterization / K. von der Helm ; S. Seelmeier ; A. Kisselev ; H.Nitschko
Identification, Purification, and Cell Culture Assays of Retroviral Proteases / P.L. Darke
Stability of Dimeric Retroviral Proteases / T.D. Meek ; E.J. Rodriguez ; T.S. Angeles
Use of Steady State Kinetic Methods to Elucidate the Kinetic and Chemical Mechanisms of Retroviral Proteases / D. Ringe
X-Ray Structures of Retroviral Proteases and Their Inhibitor-Bound Complexes / W.E. Harte, Jr ; D.L. Beveridge
Probing Structure--Function Relationships in Human Immunodeficiency Virus 1 Protease via Molecular Dynamics Simulation / X.-L. Lin ; Y.-Z. Lin ; J. Tang
Relationships of Human Immunodeficiency Virus Protease with Eukaryotic Aspartic Proteases
Substrate Specificity and Inhibitor Design / C. Carter ; G. Zybarth
Processing of Retroviral Gag Polyproteins: An in Vitro Approach / B.M. Dunn ; A. Gustchina ; A. Wlodawer ; J. Kay
Subsite Preferences of Retroviral Proteinases / A.G. Tomasselli ; R.L. Heinrikson
Specificity of Retroviral Proteases: An Analysis of Viral and Nonviral Protein Substrates / F.R. Masiarz ; B.A. Malcolm
Rapid Determination of Endoprotease Specificity Using Peptide Mixtures and Edman Degradation Analysis / J.P. Vacca
Design of Tight-Binding Human Immunodeficiency Virus Type 1 Protease Inhibitors / D.J. Kempf
Design of Symmetry-Based, Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease / M.D. Miller ; R.P. Sheridan ; S.K. Kearsley ; D.J. Underwood
Advances in Automated Docking Applied to Human Immunodeficiency Virus Type 1 Protease / M.A. McCarrick ; P. Kollman
Use of Molecular Dynamics and Free Energy Pertubation Calculations in Anti- Human Immunodeficiency Virus Drug Design / J.C. Culberson ; B.L. Bush ; V.V. Sardana
Qualitative Study of Drug Resistance in Retroviral Protease Using Structural Modeling and Site-Directed Mutagenesis
Author Index
Subject Index
Bacterial Expression and Enzymatic Assays / J. Stebbins ; C. Debouck
Expression Systems for Retroviral Proteases / C.J. Rizzo ; B.D. Korant
Genetic Approaches Designed to Minimize Cytotoxicity of Retroviral Protease / E. Chen
4.

電子ブック

EB
Kuo, Lawrence C. Kuo
出版情報: Elsevier ScienceDirect Books Complete , Academic Press, 2011
所蔵情報: loading…
目次情報: 続きを見る
Tools / Part I:
Designing a Diverse High Quality Library for Crystallography Based FBDD Screening / Brett A. Tounge ; Michael H. Parker1:
Preparation of Protein Samples for NMR Structure, Function, and Small-Molecule Screening Studies / Thomas B. Acton ; Rong Xiao ; James Aramini ; William A. Buchwald ; Colleen Ciccosanti ; Ken Conover ; Keith Hamilton ; Yuanpeng Janet Huang ; Haleema Janjua ; Paolo Rossi ; Seema Sharma ; G.V.T.Swapna ; Huang Wang ; Li Zhao ; Gaetano T. Montelione2:
Key Factors for Successful Generation of Protein-Fragment Structures: Requirements on Protein, Crystals, and Technology / Anja Jestel ; Stefan Steinbacher3:
Automated Crystal Amplification and Compound Dispensation for FBDD Analysis / Francis A. Lewandowski ; Cynthia M. Milligan4:
Hardware and Protocols for Rapid Fragment Based Structure Determination / Richard S. Alexander ; John C. Spurlino5:
Using Computational Techniques in Fragment-Based Drug Discovery / Renee L. DesJarlais6:
Computational Approaches to De Novo Discovery of Fragment Binding for Unprecedented Protein States / Zenon D. Konteatis ; Jinming Zou ; Anthony E. Klon ; Siavash Meshkat7:
Practical Approaches / Part II:
How to Avoid Rediscovering the Known / Lawrence C. Kuo8:
From Experimental Design to Data Analysis: A Comprehensive Walk-Through of Fragment Identification Using Surface Plasmon Resonance / Anthony M. Giannetti9:
Practical Aspects of NMR Based Fragment Screening / Christopher Lepre10:
Fluorescent Protein Thermal Shifts to Identify Low Molecular Weight Fragments / James K. Kranz ; Matthew J. Todd11:
A HTS Reporter Displacement Assay for Fragment Screening and Fragment Evolution Towards Leads with Optimized Binding Affinity, Binding Kinetics, and Kinetic Selectivity / Lars Neumann12:
Fragment Screening of Stabilized G-Protein Coupled Receptors Using Biophysical Methods / Miles Congreve ; Fiona H. Marshall ; David Myszka ; Gregg Siegal13:
Predicting the Success of a Fragment Screening by X-Ray Crystallography / Douglas Davies ; Lance Stewart14:
Fragment Screening Purely with Protein Crystallography / 15:
Structure Density Relationship Based FBDD / Marta C. Abad ; Xuqing Zhang ; Alan C. Gibbs16:
Lead Generation Examples / Part III:
Lead Generation and Examples - Opinions Regarding How to Follow Up Hits / Masaya Orita ; Kazuki Ohno ; Masaichi Warizaya ; Yasushi Amano ; Tatsuya Niimi17:
High Throughput Thermodynamics for Selection of Fragment Hits and Guidance of Fragment Evolution / 18:
Medicinal Chemistry Inspired Fragment Based Drug Discovery / James C. Lanter ; Zhihua Sui19:
Experiences in Fragment-Based Lead Discovery / Roderick E. Hubbard ; James B. Murray20:
Advancing Fragment Binders to Lead Like Compounds Using Ligand and Protein Based NMR Spectroscopy / Till Maurer21:
Effective Progression of NMR-Directed Fragment Hits / Hugh Eaton ; Daniel Wyss22:
Fragment Screening of Infectious Disease Targets in a Structural Genomics Environment / 23:
Tools / Part I:
Designing a Diverse High Quality Library for Crystallography Based FBDD Screening / Brett A. Tounge ; Michael H. Parker1:
Preparation of Protein Samples for NMR Structure, Function, and Small-Molecule Screening Studies / Thomas B. Acton ; Rong Xiao ; James Aramini ; William A. Buchwald ; Colleen Ciccosanti ; Ken Conover ; Keith Hamilton ; Yuanpeng Janet Huang ; Haleema Janjua ; Paolo Rossi ; Seema Sharma ; G.V.T.Swapna ; Huang Wang ; Li Zhao ; Gaetano T. Montelione2:
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