close
1.

図書

図書
Gerald E. Farin
出版情報: Natick, Mass : A.K. Peters, c1999  xv, 267 p. ; 25 cm
所蔵情報: loading…
2.

図書

図書
Ann Majchrzak ... [et al.]
出版情報: Philadelphia : Taylor & Francis, 1987  ix, 278 p. ; 24 cm
所蔵情報: loading…
3.

図書

図書
Thomas L. Obermeyer
出版情報: New York : Gregg Division, McGraw-Hill, c1986  vi, 210 p. ; 28 cm
所蔵情報: loading…
4.

図書

図書
Karen A. Vagts
出版情報: Reading, Mass. ; Tokyo : Addison-Wesley Pub., c1996  xxii, 490 p. ; 24 cm.
所蔵情報: loading…
5.

図書

図書
edited by Derek A. Linkens
出版情報: New York : Marcel Dekker, c1993  xiii, 584 p. ; 24 cm
所蔵情報: loading…
目次情報: 続きを見る
Modeling and Identification Integrated Continuous-System Modeling and Simulation Environments / Francois E. Cellier
Object-Oriented Modeling and Simulation / Sven Erik Mattsson ; Mats Andersson ; Karl Johan
AstrOm An Artificial Intelligence Approach to Environments for Modeling and Simulation / Derek A. Linkens
Qualitative Modeling in Control / Roy Leitch
Symbolic Modeling in Control / P. J. Gawthrop
Identification of Linear Systems / Lennart Ljung
Computer-Aided Analysis of Nonlinear
Modeling and Identification Integrated Continuous-System Modeling and Simulation Environments / Francois E. Cellier
Object-Oriented Modeling and Simulation / Sven Erik Mattsson ; Mats Andersson ; Karl Johan
AstrOm An Artificial Intelligence Approach to Environments for Modeling and Simulation / Derek A. Linkens
6.

図書

図書
Yvon Gardan and Michel Lucas ; [translated by Meg Tombs]
出版情報: London : Kogan Page, 1984  256 p., [8] p. of plates ; 25 cm
所蔵情報: loading…
7.

図書

図書
editors: D. Sriram, R.A. Ade
出版情報: Southampton : Computational Mechanics Publications, c1987  459 p. ; 24 cm
所蔵情報: loading…
8.

図書

図書
Hojjat Adeli
出版情報: Englewood Cliffs, N.J. : Prentice Hall, c1988  xx, 322 p., [1] leaf of plates ; 25 cm
所蔵情報: loading…
9.

図書

図書
edited by Thomas J. Perun, C.L. Propst
出版情報: New York : Marcel Dekker, c1989  xii, 493 p. ; 24 cm
所蔵情報: loading…
目次情報: 続きを見る
Preface
Contributors
Introduction to Computer-Aided Drug Design / C. L. Propst ; Thomas J. Perun1.:
Introduction / I.:
How Drugs Are Discovered / II.:
The Basics of Mechanistic Drug Design / III.:
Important Techniques for Drug Design / IV.:
Conclusions and Future Perspectives / V.:
References
Methods
Uses of Computer Graphics in Computer-Assisted Drug Design / T. J. O'Donnell2.:
Computer Graphic Displays
Computed Molecular Models
Molecular Modeling Systems for Drug Design
Uses of Computer-Assisted Drug Design
Extending Molecular Modeling / VI.:
Theoretical Aspects of Drug Design: Molecular Mechanics and Molecular Dynamics / Stanley K. Burt ; Donald Mackay ; Arnold T. Hagler3.:
Potential Energy Function
Nonbonded Energy Terms
Electrostatic Energy (V[subscript es])--Theoretical Considerations
Hydrogen Bonds
Energy Minimization
Applications of Theoretical Techniques to Drug Design / VII.:
Future Directions / VIII.:
X-Ray Crystallography and Drug Design / Donald J. Abraham4.:
Methodology
Examples of Crystallographic Studies
Hemoglobin as a Model System for Drug-Protein Interactions and Drug Design: Antisickling and Antiischemic Agents
Conclusions
Approaches to Drug Design Using Nuclear Magnetic Resonance Spectroscopy / Stephen W. Fesik5.:
Conformational Analysis
Small Molecule-Large Molecule Interactions
Enzyme Reactions
Enzyme Kinetics in Drug Design: Implications of Multiple Forms of Enzymes on Substrate and Inhibitor Structure-Activity Correlations / Daniel H. Rich ; Dexter B. Northrop6.:
Introduction: Evidence for Multiple Forms of Enzyme
Derivation of a General Model for Enzyme-Substrate Interaction
Slow-Binding and Tight-Binding Enzyme Inhibitors
Effects of Multiple Forms on Enzyme Inhibition: Strategies of Experimental Design and Guides for Evaluating Kinetic Data
Summary
Appendix 1
Appendix 2
Applications
Computer-Aided Design and Evaluation of Angiotensin-Converting Enzyme Inhibitors / David G. Hangauer7.:
Design of Captopril with the Aid of a Conceptual Model for Angiotensin-Converting Enzyme
Molecular Mechanics-Aided Design of Conformationally Restricted Captopril Analogs
Molecular Mechanics-Aided Design of Conformationally Restricted Enalaprilat Analogs
Computer-Aided Design of Cilazapril
Mapping the Angiotensin-Converting Enzyme Active Site from a Conformational Analysis of Diverse Inhibitors
Thermolysin as a Model for Angiotensin-Converting Enzyme
Role of Computer-Aided Molecular Modeling in the Design of Novel Inhibitors of Renin / Giorgio Bolis ; Jonathan Greer8.:
Modeling of the Receptor and Substrate
Working with the Receptor-Inhibitor Model
Applications and Examples
Inhibitors of Dihydrofolate Reductase / Lee F. Kuyper9.:
The Enzyme
Enzyme-Inhibitor Interactions
Inhibitor Design
Approaches to Antiviral Drug Design / Thomas J. Smith10.:
Rhinovirus as a Drug Receptor
Designing Antiviral Drugs
Conformation Biological Activity Relationships for Receptor-Selective, Conformationally Constrained Opioid Peptides / Victor J. Hruby ; B. Montgomery Pettitt11.:
General Considerations
Design of Conformationally Constrained Delta Opioid Receptor-Selective Peptides
Design of Conformationally Constrained [mu] Opioid Receptor-Selective Peptides
Problems and Prospects for Rational Design of Receptor-Selective Peptides
Design of Conformationally Restricted Cyclopeptides for the Inhibition of Cholate Uptake of Hepatocytes / Horst Kessler ; A. Haupt ; Martin Will12.:
General Remarks
Uptake of Organic Substrates by Hepatocytes
Structure-Activity Relationships for Hepatocellular Cholate Uptake Inhibition
Possible Applications
Index
Preface
Contributors
Introduction to Computer-Aided Drug Design / C. L. Propst ; Thomas J. Perun1.:
10.

図書

図書
edited by Gerald J. Herskowitz, Ronald B. Schilling
出版情報: New York : McGraw-Hill, c1972  xiv, 360 p. ; 24 cm
所蔵情報: loading…
文献の複写および貸借の依頼を行う
 文献複写・貸借依頼