Preface |
Acknowledgement |
About the Author |
Introduction to Modern Molecular Biology / 1: |
Cells store large amounts of information in DNA / 1.1: |
Cells process complex information / 1.2: |
Cellular life is chemically complex and somewhat stochastic / 1.3: |
Challenges in analyzing complex biodata / 1.4: |
References |
Biodata Explosion / 2: |
Primary sequence and structure data / 2.1: |
DNA sequence databases / 2.1.1: |
Protein sequence databases / 2.1.2: |
Molecular structure databases / 2.1.3: |
Secondary annotation data / 2.2: |
Motif annotations / 2.2.1: |
Gene function annotations / 2.2.2: |
Genomic annotations / 2.2.3: |
Inter-species phylogeny and gene family annotations / 2.2.4: |
Experimental and personalized data / 2.3: |
DNA expression profiles / 2.3.1: |
Proteomics data and degradomics / 2.3.2: |
Protein expression profiles, 2D gel and protein interaction data / 2.3.3: |
Metabolomics and metabolic pathway databases / 2.3.4: |
Personalized data / 2.3.5: |
Semantic and processed text data / 2.4: |
Ontologies / 2.4.1: |
Text-mined annotation data / 2.4.2: |
Integrated and federated databases / 2.5: |
Local Pattern Discovery and Comparing Genes and Proteins / 3: |
DNA/RNA motif discovery / 3.1: |
Single motif models: MEME, AlignAce etc. / 3.1.1: |
Multiple motif models: LOGOS and MotifRegressor / 3.1.2: |
Informative k-mers approach / 3.1.3: |
Protein motif discovery / 3.2: |
InterProScan and other traditional methods / 3.2.1: |
Protein k-mer and other string based methods / 3.2.2: |
Genetic algorithms, particle swarms and ant colonies / 3.3: |
Genetic algorithms / 3.3.1: |
Particle swarm optimization / 3.3.2: |
Ant colony optimization / 3.3.3: |
Sequence visualization / 3.4: |
Global Pattern Discovery and Comparing Genomes / 4: |
Alignment-based methods / 4.1: |
Pairwise genome-wide search algorithms: LAGAN, AVID etc. / 4.1.1: |
Multiple alignment methods: MLAGAN, MAVID, MULTIZ etc. / 4.1.2: |
Dotplots / 4.1.3: |
Visualization of genome comparisons / 4.1.4: |
Global motif maps / 4.1.5: |
Alignmentless methods / 4.2: |
K-mer based methods / 4.2.1: |
Average common substring and compressibility based methods / 4.2.2: |
2D portraits of genomes / 4.2.3: |
Genome scale non-sequence data analysis / 4.3: |
DNA physical structure based methods / 4.3.1: |
Secondary structure based comparisons / 4.3.2: |
Molecule Structure Based Searching and Comparison / 5: |
Molecule structures as graphs or strings / 5.1: |
3D to 1D transformations / 5.1.1: |
Graph matching methods / 5.1.2: |
Graph visualization / 5.1.3: |
Graph grammars / 5.1.4: |
RNA structure comparison and prediction / 5.2: |
Image comparison based methods / 5.3: |
Gabor filter based methods / 5.3.1: |
Image symmetry set based methods / 5.3.2: |
Other graph topology based methods / 5.3.3: |
Function Annotation and Ontology Based Searching and Classification / 6: |
Annotation ontologies / 6.1: |
Gene Ontology based mining / 6.2: |
Sequence similarity based function prediction / 6.3: |
Cellular location prediction / 6.4: |
New integrative methods: Utilizing networks / 6.5: |
Text mining bioliterature for automated annotation / 6.6: |
Natural language processing (NLP) / 6.6.1: |
Semantic profiling / 6.6.2: |
Matrix factorization methods / 6.6.3: |
New Methods for Genomics Data: SVM and Others / 7: |
SVM kernels / 7.1: |
SVM trees / 7.2: |
Methods for microarray data / 7.3: |
Gene selection algorithms / 7.3.1: |
Gene selection by consistency methods / 7.3.2: |
Genome as a time series and discrete wavelet transform / 7.4: |
Parameterless clustering for gene expression / 7.5: |
Transductive confidence machines, conformal predictors and ROC isometrics / 7.6: |
Text compression methods for biodata analysis / 7.7: |
Integration of Multimodal Data: Toward Systems Biology / 8: |
Comparative genome annotation systems / 8.1: |
Phylogenetics methods / 8.2: |
Network inference from interaction and coexpression data / 8.3: |
Bayesian inference, association rule mining and Petri nets / 8.4: |
Future Challenges / 9: |
Network analysis methods / 9.1: |
Unsupervised and supervised clustering / 9.2: |
Neural networks and evolutionary methods / 9.3: |
Semantic web and ontologization of biology / 9.4: |
Biological data fusion / 9.5: |
Rise of the GPU machines / 9.6: |
Index |