| Basics / 1： |
| Polymer Materials for Biomedical Applications / Violeta Malinova ; Wolfgang MeierChapter 1： |
| Introduction / 1.1： |
| Polymers as biomaterials / 1.2： |
| Natural and Synthetic Polymers / 1.2.1： |
| Complicated Polymer Architectures / 1.2.2： |
| Factors Influencing the Polymer's Applicability in Biomedical Fields / 1.3： |
| References |
| Strategies for Transmembrane Passage of Polymer-based Nanostructures / Emmanuel O. AkalaChapter 2： |
| Peptides and Proteins Delivery / 2.1： |
| Gene Delivery / 2.1.2： |
| General Vaccines Delivery / 2.1.3： |
| Nanoparticles / 2.2： |
| Gastrointestinal Transepithelial Permeability of Polymer-based Nanostructures / 2.3： |
| Mechanisms of Transepithelial Transport of Nanoparticles / 2.3.2： |
| Strategies for Transepithelial Permeability of Polymer-based Nanostructures through the Paracellular Pathway / 2.3.3： |
| Strategies for Transepithelial Permeability of Polymer-based Nanostructures through the Transcellular Pathway / 2.3.4： |
| Strategy Based on the Understanding and the Use of the Right Animal Model and Conversion of Epithelial Cells to M Cells / 2.3.5： |
| Strategies for Gastrointestinal Delivery of Nanoparticles Using Bio-(Muco-) Adhesion Mechanism / 2.3.6： |
| The Use Permeability or Absorption Enhancers as a Strategy for Transepithelial Permeability of Nanoparticles / 2.3.7： |
| Strategy Based on the Influence of Particle Size on Transepithelial Permeability of Nanoparticles / 2.3.8： |
| Strategies Based on the Influence of Particle Surface Properties (Charge and Hydrophobicity) on Transepithelial Permeability of Nanoparticles / 2.3.9： |
| Strategies Based on Protein Transduction / 2.3.10： |
| Strategy for Permeability of Nanostructures Across Other Mucosal Epithelia / 2.4： |
| Transepithelial Permeability of Polymer-based Nanostructures Across the Lung Epithelium / 2.4.1： |
| Nasal Route / 2.4.2： |
| Ophthalmic Route / 2.4.3： |
| Strategies for Permeability of Polymer-based Nanostructures Across the Blood-Brain Barrier / 2.5： |
| Surfactant / 2.5.1： |
| Surface Charge / 2.5.2： |
| Particle Size / 2.5.3： |
| Antibody for Targeting the Blood-Brain Barrier / 2.5.4： |
| Lectin for Targeting the Blood-Brain Barrier / 2.5.5： |
| Nanogel for Targeted Delivery of Drugs Aand Macromolecules to the Brain / 2.5.6： |
| Nanoparticle Engineering for the Lymphatic System and Lymph Node Targeting / Seyed M. MoghimiChapter 3： |
| Nanoparticle Size / 3.1： |
| Nanoparticle Surface Engineering / 3.3： |
| Surface Modification with Serum / 3.3.1： |
| Surface Manipulation with Block Copolymers / 3.3.2： |
| Recent Trends in Vesicular Surface Engineering / 3.4： |
| Platform Nanotechnologies / 3.5： |
| Conclusions / 3.6： |
| Strategies for Intracellular Delivery of Polymer-based Nanosystems / Jaspreet K. Vasir ; Chiranjeevi Peetla ; Vinod LabhasetwarChapter 4： |
| Barriers to Cellular Transport of Nanosystems / 4.1： |
| Nanosystem-Cell Interactions and Cellular Internalization / 4.3： |
| Intracellular Trafficking of Nanosystems / 4.4： |
| Challenges / 4.5： |
| Strategies for Triggered Release from Polymer-based Nanostructures / Lucy Kind ; Mariusz GrzelakowskiChapter 5： |
| Stimuli Applied for Triggered Release / 5.1： |
| Temperature / 5.2.1： |
| pH / 5.2.2： |
| Other Stimuli / 5.2.3： |
| Polymer-Based Nanostructures for Diagnostic Applications / 2： |
| Polymeric Nanoparticles for Medical Imaging / Egidijus E. UzgirisChapter 6： |
| Polymeric Particles in Medical Imaging / 6.1： |
| MRI Contrast Agents / 6.1.2： |
| Type I, Linear Chains, Polylysine Backbone / 6.2： |
| Motivation / 6.2.1： |
| Synthesis and Conformation / 6.2.2： |
| Role of Electric Dipole Centers on the Polymer Chain / 6.2.3： |
| Scaling Law / 6.2.4： |
| Trans-endothelial Transport: the New Mechanism / 6.2.5： |
| Tumor Assessment / 6.2.6： |
| Type I, Linear Chains, Dextran Backbone / 6.3： |
| Motivation and Early Results / 6.3.1： |
| DOTA-lmked Dextran / 6.3.2： |
| New DTPA-dextran Constructs / 6.3.3： |
| Dextran Constructs for Nuclear and Optical Imaging / 6.3.4： |
| Summary / 6.3.5： |
| Type II, Dendrimers and Globular Particles / 6.4： |
| Structures and Synthesis of Principal Classes of Dendrimers for Imaging / 6.4.1： |
| Principal Characteristics of DTPA-dendrimers / 6.4.3： |
| The DOTA-linked Dendrimer, Gadomer 17 / 6.4.4： |
| Dendrimer Elimination and Safety / 6.4.5： |
| Applications / 6.4.6： |
| Other Constructs, Targeting, and CT / 6.4.7： |
| Globular Agents and Endothelial Pore Size Distribution / 6.5： |
| Tumor Endothelial Leakiness, Large Pore Dominance Model / 6.5.1： |
| Theoretical / 6.5.2： |
| Pore Size Distribution in Rat Mammary Tumors / 6.5.3： |
| PEG-linked Gd-DTPA-polylysine / 6.5.4： |
| Iron Oxide Nanopaiticles / 6.6： |
| Summary Overview / 6.6.1： |
| Developments / 6.6.2： |
| Labeling of Cells / 6.6.3： |
| Cell Trafficking / 6.6.4： |
| Cell Labeling II and Detection Limits / 6.6.5： |
| Lymphography / 6.6.6： |
| Gene Expression / 6.6.7： |
| Targeting / 6.6.8： |
| Polymeric Vesicles/Capsules for Diagnostic Applications in Medicine / Margaret A. Wheatley6.6.9： |
| Ex vivo Diagnostics / 7.1： |
| Polymeric Nanoparticles / 7.2.1： |
| Diagnostic Imaging / 7.3： |
| X-Ray / 7.3.1： |
| Magnetic Resonance Imaging-contrast / 7.3.2： |
| Ultrasound Contrast Agents / 7.3.3： |
| Optical Imaging / 7.3.4： |
| Radionuclide Imaging / 7.3.5： |
| Conclusion / 7.4： |
| Polymer-Based Nanostructures for Therapeutic Applications / 3： |
| Polymeric Micelles for Therapeutic Applications in Medicine / Vladimir P. TorchilinChapter 8： |
| Solubilization by Micelles / 8.1： |
| Polymeric Micelles / 8.3： |
| Micelle Preparation, Morphology, and Drug Loading / 8.4： |
| Drug-loaded Polymeric Micelles In vivo: Targeted and Stimuli-sensitive Micelles / 8.5： |
| Other Applications of Polymeric Micelles / 8.6： |
| Micelles in Immunology / 8.6.1： |
| Micelles as Carriers of Contrast Agents / 8.6.2： |
| Anti-Cancer Polymersomes / Shenshen Cai ; David A. Christian ; Manu Tewari ; Tamara Minko ; Dennis E. Discher8.7： |
| Polymersome Structure and Properties / 9.1： |
| Controlled Release Polymersomes / 9.3： |
| Small Molecule Chemotherapeutics for Shrinking Tumors / 9.4： |
| Efforts to Target Polymersomes / 9.5： |
| Conclusions and Opportune Comparisons to Copolymer Micelles / 9.6： |
| Polymer-Based Nanostructures with an Intelligent Functionality / 4： |
| Polymer-based Nanoreactors for Medical Applications / An Ranquin ; Caroline De Vocht ; Patrick Van GelderChapter 10： |
| The Nanoreactor Toolbox / 10.1： |
| Polymers / 10.2.1： |
| Channels and Enzymes used in Nanoreactors / 10.2.2： |
| Preparation Methods / 10.2.3： |
| Functionalized Reactors / 10.3： |
| Targeting Nanoreactors to Different Tissues / 10.3.1： |
| Controlling the Activity of the Nanoreactor / 10.3.2： |
| Cancer Therapy / 10.4： |
| Diagnostic Tools / 10.4.2： |
| Brain Delivery / 10.4.3： |
| Enzyme Replacement Therapy / 10.4.4： |
| Biosensors / 10.4.5： |
| Production of Crystals / 10.4.6： |
| Open Questions / 10.5： |
| Toxicity / 10.5.1： |
| Polymer Chemistry / 10.5.2： |
| Vesicle Shape / 10.5.3： |
| Endocytotic Mechanisms / 10.5.4： |
| Nanoparticles for Cancer Diagnosis and Therapy / Yong-Eun Lee Koo ; Daniel A. Orringer ; Raoul KopelmanChapter 11： |
| Cancer Facts/Problems / 11.1： |
| Nanoparticle Advantages for Cancer Therapy and Imaging / 11.1.2： |
| Nanoparticles for Therapy / 11.2： |
| Chemotherapy / 11.2.1： |
| Radiotherapy / 11.2.2： |
| Photo-dynamic Therapy / 11.2.3： |
| Thermotherapy / 11.2.4： |
| Nanoparticles for Imaging / 11.3： |
| Magnetic Resonance Imaging / 11.3.1： |
| X-Ray Computed Tomography / 11.3.2： |
| Bimodal Imaging: MRI and Fluorescence Imaging / 11.3.4： |
| Multitasking Nanoparticles for Integrated Imaging and Therapy / 11.4： |
| Summary and Future Challenges / 11.5： |
| Acknowledgements / 11.6： |
| Subject Index |
| Basics / 1： |
| Polymer Materials for Biomedical Applications / Violeta Malinova ; Wolfgang MeierChapter 1： |
| Introduction / 1.1： |
図書
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