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1.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2011  xx, 583 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 3
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Amino Acids As Building Blocks
Alpha-Amino Acid Biosnythesis (Proteinogenic and Non-Proteinogenic)
Heterocycles from Amino Acids
Radical Synthetic Methods for Alpha-Amino Acids
Enzymatic or Microbial Beta-Lactam Synthesis
Amino Acid Coupling Chemistry
Solution Phase Peptide Synthesis
Solid Phase Peptide Synthesis: Historical Aspects
Solid Phase Peptide Synthesis: Linkers
Solid Phase Peptide Synthesis: The Fmoc Methodology 1
Solid Phase Peptide Synthesis: The Fmoc Methodology 2
Solid Phase Peptide Synthesis: SPPS Strategies
Coupling Reagents
Chemical Ligation
Automation of Peptide Synthesis
Peptide Purification
Difficult Peptides
Amino Acids As Building Blocks
Alpha-Amino Acid Biosnythesis (Proteinogenic and Non-Proteinogenic)
Heterocycles from Amino Acids
2.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2012  xviii, 490 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 5
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3.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2011  xx, 531 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 4
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Protection Reactions
General Considerations
Alpha-Amino Protection (Nalpha-Protection)
Carboxy Protection
Side Chain Protection
Photocleavable Protections
Conclusion
Experimental Section
The Huisgen Cycloaddition in Peptidomimetic Chemistry
Introduction
The Huisgen [2+3] Cycloaddition Between Azides and Acetylenes
Mechanistic Consideration for the Cu-Huisgen and Ru-Huisgen Cycloaddition
Building Blocks for the Synthesis of Triazole Modified Peptidomimetics
Cyclic Triazole Peptidomimetics
Acylic Triazole Peptidomimetics
Useful Experimental Procedures
Recent Advances in Beta-Strand Mimetics
Macrocyclic Peptidomimetics
Acyclic Compounds
Aliphatic and Aromatic Carbocycles
Ligands Containing One Ring or Multiple Rings with One Heteroatom (O, S)
Ligands Containing One Ring with Two Heteroatoms (N,N)
Ligands Containing One Ring with Two Heteroatoms (N,S) or Three Heteroatoms (N,N,S or N,N,N)
Ligands Containing Two Rings with One Heteroatom (N or O)
Ligands Containing Two Rings with Two or Three Heteroatoms (N,N or N,S or N,N,N)
Concluding Remarks
Medicinal Chemistry of Alpha-Amino Acids
Glutamic Acid
Conformational Restriction
Bioisosterism
Structure-Activity-Studies
Medicinal Chemistry of Alicyclic Beta-Amino Acids
Five-Membered Alicyclic Beta-Amino Acids
Six-Membered Alicyclic Beta-Amino Acids
medicinal Chemistry of Alpha-Hydroxy-Beta-Amino Acids
Alpha-Hydroxy-Beta-Amino Acids
Antibacterial Agents
Inhibitors of Aminopeptidases
Aspartyl Proteases Inhibitors
Paclitaxel and its Derivatives
Peptide Drugs
Lights and Shades of Peptide and Protein Drugs
Peptide Drugs Available on the Market
Approved Peptides in Oncology
Antimicrobial Peptides
Perspectives
Oral Bioavailability of Peptide and Peptidomimetic Drugs
Fundamental Considerations of Intestinal Absorption
Barriers Limiting Oral Peptide/Peptidomimetic Drugs Bioavailability
Strategies to Improve Peptide-Based Drugs Oral Bioavailability
Conclusions
Asymmetric Synthesis of Beta-Lactams Via the Staudinger Reaction
The Staudinger Reaction
Influence of the Geometry of the Imine on Stereoselectivity in the Reaction
Influence of the Polarity of the Solvent on Stereoselectivity of the Reaction
Influence of the Isomerization of the Imine Prior to its Nucleophilic Attack onto the Ketene Stereoselectivity in the Reaction
Influence of the Order of Addition of the Reactants to the Reaction
Influence of Chiral Substituents on the Stereoselectivity of the Reaction
Asymmetric Induction from the Imine Component
Asymmetric Induction from the Ketene Component
Double Asymmetric Cycloinduction
Influence of Catalysts on the Stereoselectivity of the Reaction
Advances in N- and O-Glycopeptide Synthesis - A Tool to Study Clycosylation and Develop New Therapeutics
O-Glycopeptide Synthesis
Synthesis of Mucin Type Glycopeptides
Synthesis of Tumor-Associated Glycopeptides and Glycopeptide Vaccines
Synthesis of Tn, T, sialyl Tn, sialyl T Glycosylated Amino Acid Building Blocks
Synthesis of Tn, T, sialyl Tn, sialyl T Glycopeptides and Vaccines
Synthesis of Glycopeptide Recognition Domain of P-Selectin Glycoprotein Ligand 1 (PSGL-1)
Synthesis of a Core 2 sLe AMino Acid Building Block Including a sLe Mimic
Synthesis of Unsulfated and Sulfated Core 2 sLe and Core 2 sLe Mimic PSGL-1 Glycopeptides
Chemoenzymatic Synthesis of Unsulphated and Sulphated Sialyl Lewis PSGL-1 Glycopeptide
Synthesis of Other Types of O-Glycopeptides
Synthesis of Fmoc-GlcNAc-Ser/Thr Amino Acids
Synthesis of Estrogene Receptor Peptides for Conformational Analysis
Synthesis of N-Glycopeptides
Synthesis of Ribonuclease C (RNase C) Glycoprotein
Synthesis of Erythropoietin N-Glycopeptide Fragment 1-28
Synthesis of Biantennary Dodecasaccharide
Synthesis of N-Glycopeptide Fragment 1-28
Chemoenzymatic Synthesis of a HIV GP120 V3 Domain N-Glycopeptide
Synthesis of the Oxazoline Tetrasaccharide Donor
Synthesis of Fmoc-GlcNAc-Asn Amino Acid Building Block
Synthesis of V3 Cyclic GlcNAc Peptide and Endo A Coupling with Man3GlcNAc Oxazoline Donor
Recent Developments in Neoglycopeptide Synthesis
Neoglycoside and Neoglycopeptide Synthesis
Protein Side-Chain Modifications
Cu-Catalyzed Azide-Alkyne "Click" Cycloaddition
Cross Metathesis
Application of Neoglycopeptides as Synthetic Vaccines
Enzymatic, Molecular and Cell Biological Techniques
Combinatorial/Library Peptide Synthesis
High Throughput Synthesis of Peptides
Peptide Libraries
Future of Peptide Libraries
Synthetic Protocols
Protection Reactions
General Considerations
Alpha-Amino Protection (Nalpha-Protection)
4.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2009  xix, 701 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 1
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目次情報: 続きを見る
Amino Acid Origins
Primitive Amino Acid Chemistry Extraterrestrial Amino Acids Terrestrial Amino Acids and Their Evolution
The Common alpha-Amino Acids; Proteinogenic Amino Acid Biosynthesis Uncommon alpha-Amino Acid;
Non-Proteinogenic Amino Acid Biosynthesis beta-Amino Acid Biosynthesis
Synthesis Of Amino Acids
Common or Proteinogenic alpha-Amino Acids Fermentation Production of alpha-Amino Acids Radical Synthetic
Methods for alpha-Amino Acids Uncommon or Non-Proteinogenic alpha-Amino Acids Synthesis of Non-Coding
Amino Acids Synthesis of N-Alkyl Amino Acids Synthesis of beta-Amino Acids Synthesis of Alicyclic beta-Amino Acids
Synthesis of alpha,beta-Diamino Acids Synthesis of Halogenated Amino Acids Synthesis of Isotopically Labelled Amino
Acids Synthesis of Unnatural/Non-proteinogenic alpha-Amino Acids Synthesis of gamma- and delta-Amino Acids Synthesis of GABA and Amino Acid-Based
GABA analogues Synthesis and Chemistry of alpha,beta-Dehydroamino Acids Synthesis and Chemistry of Hydrazino Acids Synthesis and Chemistry of Hydroxamic
Acids (N-Hydroxy Amino Acids) Chemistry of Aminoboronic Acids Chemistry of alpha-Aminophosphonic Acids and Phosphonopeptides
Chemistry of alpha-Silyl Amino Acids Use of Enzymes in Synthesis of Amino Acids
Amino Acid Origins
Primitive Amino Acid Chemistry Extraterrestrial Amino Acids Terrestrial Amino Acids and Their Evolution
The Common alpha-Amino Acids; Proteinogenic Amino Acid Biosynthesis Uncommon alpha-Amino Acid;
5.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2009  xxii, 683 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 2
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Amino Acid Organocatalysis
Catalysis of Reactions by Amino Acids
Catalysis of Reactions by Small Peptides
Enzymes
Enzymic Mechanisms of Catalysis
The Chemistry of Proteases
Semi-Synthetic Enzymes
Non-Enzymic Mechanisms of Catalysis
Substrate Recognition
Protein Recognition
Non-Ribosomal Peptide Synthesis
Amino Acid Organocatalysis
Catalysis of Reactions by Amino Acids
Catalysis of Reactions by Small Peptides
6.

図書

図書
Kurt Wüthrich
出版情報: Amsterdam : North-Holland Pub. Co. , New York : sole distributors for the U.S.A. and Canada, American Elsevier Pub. Co., 1976  xii, 379 p. ; 23 cm
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