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1.

図書

図書
edited by Helmut Sies, Lester Packer ; editorial advisory board, Bob Buchanan ... [et al.]
出版情報: San Diego ; Tokyo : Academic Press, c2002  xxxvi, 511 p. ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 347 . Protein sensors and reactive oxygen species ; pt. A
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2.

図書

図書
edited by Helmut Sies, Lester Packer ; editorial advisory board, Bob Buchanan ... [et al.]
出版情報: San Diego ; Tokyo : Academic Press, c2002  xxxiv, 404 p. ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 348 . Protein sensors and reactive oxygen species ; pt. B
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3.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2011  xx, 583 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 3
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Amino Acids As Building Blocks
Alpha-Amino Acid Biosnythesis (Proteinogenic and Non-Proteinogenic)
Heterocycles from Amino Acids
Radical Synthetic Methods for Alpha-Amino Acids
Enzymatic or Microbial Beta-Lactam Synthesis
Amino Acid Coupling Chemistry
Solution Phase Peptide Synthesis
Solid Phase Peptide Synthesis: Historical Aspects
Solid Phase Peptide Synthesis: Linkers
Solid Phase Peptide Synthesis: The Fmoc Methodology 1
Solid Phase Peptide Synthesis: The Fmoc Methodology 2
Solid Phase Peptide Synthesis: SPPS Strategies
Coupling Reagents
Chemical Ligation
Automation of Peptide Synthesis
Peptide Purification
Difficult Peptides
Amino Acids As Building Blocks
Alpha-Amino Acid Biosnythesis (Proteinogenic and Non-Proteinogenic)
Heterocycles from Amino Acids
4.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2012  xviii, 490 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 5
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5.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2011  xx, 531 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 4
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Protection Reactions
General Considerations
Alpha-Amino Protection (Nalpha-Protection)
Carboxy Protection
Side Chain Protection
Photocleavable Protections
Conclusion
Experimental Section
The Huisgen Cycloaddition in Peptidomimetic Chemistry
Introduction
The Huisgen [2+3] Cycloaddition Between Azides and Acetylenes
Mechanistic Consideration for the Cu-Huisgen and Ru-Huisgen Cycloaddition
Building Blocks for the Synthesis of Triazole Modified Peptidomimetics
Cyclic Triazole Peptidomimetics
Acylic Triazole Peptidomimetics
Useful Experimental Procedures
Recent Advances in Beta-Strand Mimetics
Macrocyclic Peptidomimetics
Acyclic Compounds
Aliphatic and Aromatic Carbocycles
Ligands Containing One Ring or Multiple Rings with One Heteroatom (O, S)
Ligands Containing One Ring with Two Heteroatoms (N,N)
Ligands Containing One Ring with Two Heteroatoms (N,S) or Three Heteroatoms (N,N,S or N,N,N)
Ligands Containing Two Rings with One Heteroatom (N or O)
Ligands Containing Two Rings with Two or Three Heteroatoms (N,N or N,S or N,N,N)
Concluding Remarks
Medicinal Chemistry of Alpha-Amino Acids
Glutamic Acid
Conformational Restriction
Bioisosterism
Structure-Activity-Studies
Medicinal Chemistry of Alicyclic Beta-Amino Acids
Five-Membered Alicyclic Beta-Amino Acids
Six-Membered Alicyclic Beta-Amino Acids
medicinal Chemistry of Alpha-Hydroxy-Beta-Amino Acids
Alpha-Hydroxy-Beta-Amino Acids
Antibacterial Agents
Inhibitors of Aminopeptidases
Aspartyl Proteases Inhibitors
Paclitaxel and its Derivatives
Peptide Drugs
Lights and Shades of Peptide and Protein Drugs
Peptide Drugs Available on the Market
Approved Peptides in Oncology
Antimicrobial Peptides
Perspectives
Oral Bioavailability of Peptide and Peptidomimetic Drugs
Fundamental Considerations of Intestinal Absorption
Barriers Limiting Oral Peptide/Peptidomimetic Drugs Bioavailability
Strategies to Improve Peptide-Based Drugs Oral Bioavailability
Conclusions
Asymmetric Synthesis of Beta-Lactams Via the Staudinger Reaction
The Staudinger Reaction
Influence of the Geometry of the Imine on Stereoselectivity in the Reaction
Influence of the Polarity of the Solvent on Stereoselectivity of the Reaction
Influence of the Isomerization of the Imine Prior to its Nucleophilic Attack onto the Ketene Stereoselectivity in the Reaction
Influence of the Order of Addition of the Reactants to the Reaction
Influence of Chiral Substituents on the Stereoselectivity of the Reaction
Asymmetric Induction from the Imine Component
Asymmetric Induction from the Ketene Component
Double Asymmetric Cycloinduction
Influence of Catalysts on the Stereoselectivity of the Reaction
Advances in N- and O-Glycopeptide Synthesis - A Tool to Study Clycosylation and Develop New Therapeutics
O-Glycopeptide Synthesis
Synthesis of Mucin Type Glycopeptides
Synthesis of Tumor-Associated Glycopeptides and Glycopeptide Vaccines
Synthesis of Tn, T, sialyl Tn, sialyl T Glycosylated Amino Acid Building Blocks
Synthesis of Tn, T, sialyl Tn, sialyl T Glycopeptides and Vaccines
Synthesis of Glycopeptide Recognition Domain of P-Selectin Glycoprotein Ligand 1 (PSGL-1)
Synthesis of a Core 2 sLe AMino Acid Building Block Including a sLe Mimic
Synthesis of Unsulfated and Sulfated Core 2 sLe and Core 2 sLe Mimic PSGL-1 Glycopeptides
Chemoenzymatic Synthesis of Unsulphated and Sulphated Sialyl Lewis PSGL-1 Glycopeptide
Synthesis of Other Types of O-Glycopeptides
Synthesis of Fmoc-GlcNAc-Ser/Thr Amino Acids
Synthesis of Estrogene Receptor Peptides for Conformational Analysis
Synthesis of N-Glycopeptides
Synthesis of Ribonuclease C (RNase C) Glycoprotein
Synthesis of Erythropoietin N-Glycopeptide Fragment 1-28
Synthesis of Biantennary Dodecasaccharide
Synthesis of N-Glycopeptide Fragment 1-28
Chemoenzymatic Synthesis of a HIV GP120 V3 Domain N-Glycopeptide
Synthesis of the Oxazoline Tetrasaccharide Donor
Synthesis of Fmoc-GlcNAc-Asn Amino Acid Building Block
Synthesis of V3 Cyclic GlcNAc Peptide and Endo A Coupling with Man3GlcNAc Oxazoline Donor
Recent Developments in Neoglycopeptide Synthesis
Neoglycoside and Neoglycopeptide Synthesis
Protein Side-Chain Modifications
Cu-Catalyzed Azide-Alkyne "Click" Cycloaddition
Cross Metathesis
Application of Neoglycopeptides as Synthetic Vaccines
Enzymatic, Molecular and Cell Biological Techniques
Combinatorial/Library Peptide Synthesis
High Throughput Synthesis of Peptides
Peptide Libraries
Future of Peptide Libraries
Synthetic Protocols
Protection Reactions
General Considerations
Alpha-Amino Protection (Nalpha-Protection)
6.

図書

図書
Arthur M. Lesk
出版情報: Oxford : Oxford University Press, 2010  xix, 455 p. ; 27 cm
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Introduction: Proteins in their Biological Context / 1:
Fundamentals of Protein Structure / 2:
Protein Structure Determination / 3:
Structural Bioinformatics / 4:
Proteins as Catalysts: Enzyme Structure, Kinetics, and Mechanism / 5:
Protein Interactions and Assemblies / 6:
Evolution of Protein Structure and Function / 7:
Protein Folding, Engineering and Design / 8:
Proteomics and Systems Biology / 9:
Systems Biology of Proteins / 10:
Proteins in Disease / 11:
Introduction: Proteins in their Biological Context / 1:
Fundamentals of Protein Structure / 2:
Protein Structure Determination / 3:
7.

図書

図書
John R. Whitaker ... [et al.], editors
出版情報: Washington, DC : American Chemical Society, c1998  xi, 292 p. ; 24 cm
シリーズ名: ACS symposium series ; 708
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Preface
Fundamental Properties and Instrumental Methods
Molecular Bases of Surface Activity of Proteins / S. Damodaran ; L. Razumovsky1:
Computer-Aided Optimization of Site-Directed Mutagenesis of Bacillus stearothermophilus Neutral Protease for Improving Thermostability / S. Nakai ; S. Nakamura ; M. Ogawa2:
Computer Analysis of Protein Properties / A. Rojo-Dominguez ; A. J. Padilla-Zuniga3:
Evaluation of Viscous Food Properties Using a Helical Ribbon Impeller Plant Protein Functionalities / E. Brito-De La Fuente et al.4:
Production of High-Protein Flours as Milk Substitutes / S. H. Guzman-Maldonado ; O. Paredes-Lopez5:
Functional Properties of Soy Proteins / N. S. Hettiarachchy ; U. Kalapathy6:
Effect of Acylation on Flax Protein Functionality Animal Protein Functionalities / F. Shahidi ; P. K. J. P. D. Wanasundara7:
Structure-Function Relationships in Milk-Clotting Enzymes: Pepsin--a Model / R. Y. Yada ; T. Tanaka8:
Functional Properties of Whey Proteins in Forming Networks / E. A. Foegeding ; E. A. Gwartney ; A. D. Errington9:
Whey Proteins Interactions: Effects on Edible Film Properties / John M. Krochta10:
Thermal Denaturation and Gelatin Characteristics of Beta-Lactoglobulin Genetic Variants / Joyce I. Boye ; Ching-Y. Ma ; Ashraf A. Ismail11:
Limited Proteolysis of Alpha-Lactalbumin and Whey Protein Isolate: Effect on Their Functional Properties / Fakhrieh Vojdami ; John R. Whitaker12:
Emulsifying Properties of Cholesterol-Reduced Egg Yolk Low-Density Lipoprotein / Yoshinori Mine ; Marie Bergougnoux13:
Functional Properties of Goat Meat Proteins Fat and Oil Functionality; Physiological Functionality / A. Totosaus ; I. Guerrero ; P. Lara14:
Physicochemical Aspects of Triacylglycerides and Their Association to Functional Properties of Vegetable Oils / Jorge F. Toro-Vazquez ; Miriam Charo-Alonso15:
Low Calorie and Fats and Sugar Esters / Casimo C. Akoh16:
Intestinal Absorption and Physiologically Functional Food Substances / M. Shimizu ; K. Hashimoto17:
Indexes
Author Index
Subject Index
Preface
Fundamental Properties and Instrumental Methods
Molecular Bases of Surface Activity of Proteins / S. Damodaran ; L. Razumovsky1:
8.

図書

図書
edited by Robert K. Poole
出版情報: Amsterdam ; Tokyo : Elsevier Academic Press, c2008  2 v. ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 436-437
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Nitric Oxide: Chemical and Analytical Methods / Section I:
The Chemistry of Nitric Oxide and Related Species / Martin H. HughesChapter 1:
Delivery of nitric oxide for analysis of the function of cytochrome / c. Lindsay J. Cole ; Wilhelmina M. Huston ; James W.B. MoirChapter 2:
The preparation and purification of NO gas and the use of NO releasers / Chapter 3:
The application of NO donors and other agents of nitrosative stress in biological systems / Rubina G. Aga ; Martin N. Hughes
The Chemistry of Peroxynitrite Implications for Biological Activity / Sara Goldstein ; Gabor Mereacute;nyiChapter 4:
Nitric Oxide (NO) Selective Electrodes / Ian R. Davies ; Xueji ZhangChapter 5:
NO, N2O and O2 Reaction Kinetics: Scope and Limitations of the / Clark Electrode L.A.M. Pouvreau ; M. J. F. Strampraad ; S. Van Berloo ; J. H. Kattenberg ; S. de VriesChapter 6:
Chemiluminescence quantification of Nitric oxide and its derivatives in liquid samples / Jay R. Laver ; Tacirc;nia M. Stevanin ; Robert C. ReadChapter 7:
Bacterial and Archaeal Hemoglobins / Section II:
Interactions of nitric oxide with hemoglobin: from microbes to man / Michael Angelo ; Alfred Hausladen ; Jonathan S. StamlerChapter 8:
Expression and purification of / E. coli Hmp Robert K. PooleChapter 9:
Alberto Boffi / Chapter 10:
Liacute;gia M. Saraiva / Chapter 11:
Paul R. Gardner / Chapter 12:
Alessandra Bonamore / Chapter 13:
Assessment of Biotechnologically Relevant Characteristics of Heterologous Hemoglobins in Escherichia coli / Pauli T. Kallio ; Christian J. T. Bollinger ; Taija Koskenkorva ; Alexander D. FreyChapter 14:
Guo-Qiang CHEN / Chapter 15:
Robert K. Poole / Chapter 16:
Martino Bolognesi / Chapter 17:
Paolo Visca / Chapter 18:
Other Hemoglobins / Section III:
Kirsten Mees / Laurent Coger ; Christophe Lechauve ; Michael C. Marden ; Alexandra Pesce ; Martino Bolognesi ; Luc MoneesChapter 19:
Measurement of distal histidine coordination equilibrium and kinetics in hexacoordinate hemoglobins / Benoit J. Smagghe ; Puspita Halder ; Mark S. HargroveChapter 20:
Purification of Class 1 Plant Hemoglobins and Examination of their Functional Properties / Abir U. Igamberdiev ; Robert D. HillChapter 21:
Use of in silico (computer) methods to predict and analyze the tertiary structure of plant hemoglobins / Sabarinathan Kuttalingam Gopalasubramaniam ; Veroacute;nica Garrocho-Villegas ; Genoveva Bustos Rivera ; Nina Pastor ; Rauacute;l Arredondo-PeterChapter 22:
A Self-induction Method to Produce High Quantities of Recombinant Functional Flavo-Leghemoglobin Reductase / Estibaliz Urarte ; Intilde;igo Auzmendi ; Selene Rol ; Idoia Ariz ; Pedro Aparicio-Tejo ; Jose F. MoranChapter 23:
Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins / Alessandro Vergara ; Luigi VitaglianoChapter 24:
Contributors
Preface
Volumes in Series
Nitric Oxide-Metabolising and Detoxifying Enzymes
Structural Studies on Flavodiiron Proteins / Joao B. Vicente ; Maria Armenia Carrondo ; Miguel Teixeira ; Carlos Frazao1:
Introduction
Crystallization of Flavodiiron Proteins / 2:
Diffraction Data Collection, Structure Determination, and Refinement / 3:
Overall Description of Structures / 4:
Conclusion / 5:
References
Biochemical, Spectroscopic, and Thermodynamic Properties of Flavodiiron Proteins / Marta C. Justino ; Vera L. Goncalves ; Ligia M. Saraiva
Cloning of Genes Encoding Flavodiiron Proteins and Their Truncated Domains
Production and Purification of Recombinant Flavodiiron Proteins
Biochemical Characterization of Flavodiiron Proteins
Spectroscopic Properties
Redox Properties / 6:
Conclusions / 7:
Acknowledgments
Kinetic Characterization of the Escherichia coli Nitric Oxide Reductase Flavorubredoxin / Francesca M. Scandurra ; Elena Forte ; Maurizio Brunori ; Paolo Sarti ; Alessandro Giuffre
Amperometric Measurements
Spectroscopic Measurements
Escherichia coli Cytochrome c Nitrite Reductase NrfA / Thomas A. Clarke ; Paul C. Mills ; Susie R. Poock ; Julea N. Butt ; Myles R. Cheesman ; Jeffrey A. Cole ; Jay C. D. Hinton ; Andrew M. Hemmings ; Gemma Kemp ; Christopher A. G. Soderberg ; Stephen Spiro|cJessica Van Wonderen ; David J. Richardson
Measurement of Cytochrome c Nitrite Reductase-Dependent Consumption of Nitric Oxide in Whole Cells
Growth of E. coli Optimized for Cytochrome c Nitrite Reductase Production for Use in Enzyme Purification
Purification of Cytochrome c Nitrite Reductase
Assaying the Cytochrome c Nitrite Reductase
Crystallization of E. coli Cytochrome c Nitrite Reductase
Concluding Remarks
The Respiratory Nitric Oxide Reductase (NorBC) from Paracoccus denitrificans / Sarah J. Field ; Faye H. Thorndycroft ; Andrey D. Matorin ; Nicholas J. Watmough
Purification of Native NorBC from Paracoccus denitrificans
Purification of Recombinant NorBC
Amperometric Assays of NO Consumption
Pseudoazurin as an Electron Donor in Assays of NorBC
Preparation of NOR for Spectroscopic Investigation
Electron Paramagnetic Resonance Spectroscopy
Redox-Controlled Dinitrosyl Formation at the Diiron-Oxo Center of NorA / Rainer Cramm ; Katja Strube8:
Genetic Context and Expression of the NorA Gene in R. eutropha
Purification of NorA
Disulfide Bridges in NorA
Iron Analysis and Preparation of Apo-NorA
Interconversion of Redox Forms of NorA
Generation of NorA-DNIC In Vitro
Preparation of NorA-DNIC Formed In Vivo
Quantification of NO from NorA-DNIC / 9:
Outlook / 10:
Purification and Functional Analysis of Fungal Nitric Oxide Reductase Cytochrome P450nor / Li Zhang ; Hirofumi Shoun
Screening of P450nor Activity
Gas Analysis
Purification of P450nor
Nitric Oxide Reductase Activity Assay
Protein Sequencing
Isolation of cDNA
Subcellular Fractionation of T. cutaneum
Site-Directed Mutagenesis
Expression of Recombinant Proteins
Purification of Recombinant Proteins / 11:
Titration of NAD Analogs / 12:
Stopped-Flow Rapid Scan Analysis / 13:
Other Analysis / 14:
A Quantitative Approach to Nitric Oxide Inhibition of Terminal Oxidases of the Respiratory Chain / Maria G. Mason ; Rebecca S. Holladay ; Peter Nicholls ; Mark Shepherd ; Chris E. Cooper15:
Evaluation of Current Techniques for Measuring pNO, pO[subscript 2], and K[subscript M] (O[subscript 2])
Nitric Oxide Donor Compounds
Nitric Oxide Kinetics
Oxygen Kinetics
Optical Detection of Enzyme Intermediates in the Presence of Oxygen and NO
Appendices
Sensor Proteins
Cloning, Expression, and Purification of the N-terminal Heme-Binding Domain of Globin-Coupled Sensors / Jennifer A. Saito ; Tracey Allen K. Freitas ; Maqsudul Alam
Bioinformatic Search of Globin-Coupled Sensors
Functional Analysis of Globin-Coupled Sensors
Oxygen-Sensing Histidine-Protein Kinases: Assays of Ligand Binding and Turnover of Response-Regulator Substrates / Marie-Alda Gilles-Gonzalez ; Gonzalo Gonzalez ; Eduardo Henrique Silva Sousa ; Jason Tuckerman
Assays
Reactions of Nitric Oxide and Oxygen with the Regulator of Fumarate and Nitrate Reduction, a Global Transcriptional Regulator, during Anaerobic Growth of Escherichia coli / Jason C. Crack ; Nick E. Le Brun ; Andrew J. Thomson ; Jeffrey Green ; Adrian J. Jervis
Production of 4Fe-FNR Protein
Determination of Iron and Acid-Labile Sulfide Content of FNR
UV-Visible Absorbance Spectra of FNR
Cluster Reaction with Nitric Oxide and Oxygen
Purification of 2Fe-FNR
Detection of Other Reaction Products
Genome-Wide Identification of Binding Sites for the Nitric Oxide-Sensitive Transcriptional Regulator NsrR / Sam Efromovich ; David Grainger ; Diane Bodenmiller ; Stephen Spiro
Strain Construction
Reference and Control Samples
Culture Conditions
Immunoprecipitation of DNA Targets Associated with NsrR
DNA Labeling, Microarray Hybridization, and Processing
Visualization and Analysis of DNA Microarray Data
A New Statistical Methodology for Treatment of Chip-on-Chip Data
Characterization of the Nitric Oxide-Reactive Transcriptional Activator NorR / Benoit D'Autreaux ; Nick Tucker ; Ray Dixon
Measurement of NorR Activity In Vivo
Measurement of Transcriptional Activation by NorR In Vitro
Detection of the Ferrous-Nitrosyl Form of NorR by In Vivo Electron Paramagnetic Resonance (EPR)
In Vitro Reconstitution of the Iron Center in NorR
Measurement of NO Affinity
Standardization of the NO Electrode
Determination of NorRFe(NO) K[subscript d]
Acknowledgment
Advanced Spectroscopic Methods
Hemoglobins from Mycobacterium tuberculosis and Campylobacter jejuni: A Comparative Study with Resonance Raman Spectroscopy / Changyuan Lu ; Tsuyoshi Egawa ; Masahiro Mukai ; Robert K. Poole ; Syun-Ru Yeh
Hemoglobin Superfamily: An Overview
Microbial Hemoglobins
Resonance Raman Spectroscopy: Applications in Hemeproteins
Structures and Functions of Microbial Hemoglobins
Closing Remarks
The Power of Using Continuous-Wave and Pulsed Electron Paramagnetic Resonance Methods for the Structure Analysis of Ferric Forms and Nitric Oxide-Ligated Ferrous Forms of Globins / Sabine Van Doorslaer ; Filip Desmet
Electron Paramagnetic Resonance in a Nutshell
EPR Studies of NO-Ligated Globins
EPR Studies of Ferric globins
Spin-Labeling Heme Proteins
Future Challenges and Possibilities
Oxygen Binding to Heme Proteins in Solution, Encapsulated in Silica Gels, and in the Crystalline State / Luca Ronda ; Stefano Bruno ; Serena Faggiano ; Stefano Bettati ; Andrea Mozzarelli16:
Oxygen-Binding Curves to Heme Proteins
Determination of OBCs for Hemoglobin in Solution
Determination of K[subscript 1] for Hemoglobin in Solution in the Absence of Allosteric Effectors
Determination of OBCs for T State Hemoglobin Gels in the Absence and Presence of Allosteric Effectors
Determination of OBCs for T State Hemoglobin Crystals
Determination of OBCs for Hemocyanin in Solution and in Silica Gels
Characterization of Ligand Migration Mechanisms inside Hemoglobins from the Analysis of Geminate Rebinding Kinetics / Stefania Abbruzzetti ; Elena Grandi ; Cristiano Viappiani17:
Principles of Nanosecond Laser Flash Photolysis
Basic Experimental Layouts
Encapsulation of Hbs in Silica Gels
Enhancement of Geminate Rebinding and Advantages of Gel Encapsulation
Extraction of Kinetic Information
Ligand Dynamics in Heme Proteins Observed by Fourier Transform Infrared Spectroscopy at Cryogenic Temperatures / Karin Nienhaus ; G. Ulrich Nienhaus18:
Materials
Fourier Transform Infrared Cryospectroscopy
Low-Temperature FTIR Spectroscopy on NO-Ligated Heme Proteins
Time-Resolved X-Ray Crystallography of Heme Proteins / Vukica Srajer ; William E. Royer, Jr.19:
Experiment
Data Processing and Analysis
A Case Study: Scapharca Dimeric Hemoglobin
Structural Dynamics of Myoglobin / M. Brunori ; D. Bourgeois ; B. Vallone20:
Background
Crystallographic Studies of Myoglobin States
Experimental Approaches
Use of the Conjugate Peak Refinement Algorithm for Identification of Ligand-Binding Pathways in Globins / Stephen D. Golden ; Kenneth W. Olsen21:
Exploration of Oxygen-Binding Pathways in Myoglobin
Theoretical Models
Potential Energy Function
Transition Pathways
Methods
Results
Finding Gas Migration Pathways in Proteins Using Implicit Ligand Sampling / Jordi Cohen ; Klaus Schulten22:
Example Calculation: Truncated Hemoglobin (trHb) from Paramecium caudatum
Discussion
Identification of Ligand-Binding Pathways in Truncated Hemoglobins Using Locally Enhanced Sampling Molecular Dynamics / 23:
Molecular Dynamics
Locally Enhanced Sampling Molecular Dynamics
Nitric Oxide Reactivity with Globins as Investigated Through Computer Simulation / Marcelo A. Marti ; Luciana Capece ; Axel Bidon-Chanal ; Alejandro Crespo ; Victor Guallar ; F. Javier Luque ; Dario A. Estrin24:
Molecular Dynamics (MD) Methods
Quantum Mechanical-Molecular Mechanical Methods
Illustrative Examples
Ligand Migration Profiles from MSMD and PELE Simulations: Exploring Ligand Entry Pathways in M. tuberculosis trHbN
Microbial Responses to Nitric Oxide and Nitrosative Stress: Growth, "Omic," and Physiological Methods / Steven T. Pullan ; Claire E. Monk ; Lucy Lee25:
Nitric Oxide, NO-Releasing Agents, and Nitrosating Agents
Illustrative Results from Applications of These Methods
Analysis of Nitric Oxide-Dependent Antimicrobial Actions in Macrophages and Mice / Andres Vazquez-Torres ; Tania Stevanin ; Jessica Jones-Carson ; Margaret Castor ; Ferric C. Fang26:
NO.-Dependent Antimicrobial Actions of Murine Macrophages
NO.-Dependent Antimicrobial Actions of Human Macrophages
NO.-dependent Antimicrobial Actions in Laboratory Mice
Measuring Nitric Oxide Metabolism in the Pathogen Neisseria meningitidis / Melanie J. Thomson ; Tania M. Stevanin ; James W. B. Moir27:
Safety Aspects of Handling N. meningitidis in the Laboratory
Metabolism of Neisseria sp.
Experimental Approaches to Analyzing Nitrogen Metabolism Relevant to NO
Simultaneous Measurement of Oxygen and NO during Pure Culture of N. meningitidis
Measurement of NO Production/Disappearance in Tissue Culture Using Human Monocyte-Derived Macrophages
Localization of S-Nitrosothiols and Assay of Nitric Oxide Synthase and S-Nitrosoglutathione Reductase Activity in Plants / Francisco J. Corpas ; Alfonso Carreras ; Francisco J. Esteban ; Mounira Chaki ; Raquel Valderrama ; Luis A. Del Rio ; Juan B. Barroso28:
Determination of L-Arginine-Dependent NOS Activity by Ozone Chemiluminescence in Plant Tissues
Assay of GSNOR Activity
Localization of S-Nitrosothiols and S-Nitrosoglutathione in Plant Tissues by Confocal Laser-Scanning Microscopy (CLSM)
Methods for Nitric Oxide Detection during Plant-Pathogen Interactions / E. Vandelle ; M. Delledonne29:
Nitric Oxide Detection by Mass Spectrometry
Nitric Oxide Detection by Laser Photoacoustic Spectroscopy
Nitric Oxide Detection by Chemiluminescence
Nitric Oxide Detection by Hemoglobin Conversion
Nitric Oxide Detection by Electron Paramagnetic Resonance (EPR) Spin Trap
Nitric Oxide Detection Using Diaminofluoresceins
Bioimaging Techniques for Subcellular Localization of Plant Hemoglobins and Measurement of Hemoglobin-Dependent Nitric Oxide Scavenging In Planta / Kim H. Hebelstrup ; Erik Ostergaard-Jensen30:
Measuring Hemoglobin-Dependent NO Scavenging
Techniques for Determination of Subcellular Localization of Plant Hemoglobins
Imaging of Hemoglobin-Dependent NO Scavenging in Arabidopsis Plants
Engineering of GLB1-GFP/GLB2-GFP Constructs and Microscopic Analysis of A. thaliana Plants Expressing GFP-Tagged Hemoglobin
Use of Recombinant Iron-Superoxide Dismutase as A Marker of Nitrative Stress / Estibaliz Larrainzar ; Inigo Auzmendi ; Cesar Arrese-Igor ; Esther M. Gonzalez31:
Immunodetection of Nitrated Proteins: Metal-Mediated Tyrosine Nitration of BSA
Tyrosine Nitration of Purified Recombinant Vu_FeSOD Affects its Enzymatic Activity
Tyrosine Nitration in Vu_FeSOD can be Estimated Using Antibodies Against 3-Nitrotyrosine
SIN-1-Dependent Vu_FeSOD Nitration can be Detected by the Loss of Enzymatic Activity
Author Index
Subject Index
Nitric Oxide: Chemical and Analytical Methods / Section I:
The Chemistry of Nitric Oxide and Related Species / Martin H. HughesChapter 1:
Delivery of nitric oxide for analysis of the function of cytochrome / c. Lindsay J. Cole ; Wilhelmina M. Huston ; James W.B. MoirChapter 2:
9.

図書

図書
edited by Jan Sedzik, Paolo Riccio
出版情報: New Jersey : World Scientific, c2009  xi, 352 p. ; 24 cm
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Preface
From Kuru to Nucleation, Aggregation, Polymerization and Crystallization in Biology and Medicine / D. Carleton Gajdusek1:
Gels Mimicking Antibodies in Their Selective Recognition of Proteins and Its Potential Use for Protein Crystallization / Jan Sedzik ; Nasim Ghasemzadeh ; Fred Nyberg ; Stellan Hjertén2:
Bioinformatics of Myelin Membrane Proteins / Gunnar von Heijne3:
Biomolecular Mass Spectrometry: Applications to Proteins and Peptides / Leopold L. Ilag ; Gianluca Maddalo4:
Myelin: A One-Dimensional Biological "Crystal" for X-Ray and Neutron Scattering / Hideyo Inouye ; Daniel A. Kirschner5:
Two-Dimensional Crystallization of Biological Macromolecules / Hans Hebert6:
Crystallization of Proteins: Principles and Methods / Lata Govada7:
The Role of Oil in Protein Crystallization / Naomi E. Chayen8:
Introduction to Crystallization of Fine Chemicals and Pharmaceuticals / Ã…ke C. Rasmuson9:
Myelin Basic Protein, A Saucy Molecule With High Responsiveness to the Environment or Just an Unusual Membrane Protein? / Paolo Riccio10:
The Use of a Magnetic Field and Magnetic Force as a Means to Improve the Quality of Protein Crystals / Mitsuo Ataka11:
Interactive Crystallomic / 12:
Virtual Molecule: P0 Myelin Glycoprotein. I. Homology Modeling and Prediction of the Secondary and Tertiary Structure / Jan Pawel Jastrzebski13:
In meso Approaches to Membrane Protein Crystallization / Valentin I. Gordeliy ; Ekaterina S. Moiseeva14:
Amyloid, The Amyloid ?-Peptide and Alzheimer's Disease: Structural Considerations / Lars O. Tjernberg15:
Recent Advances in Structural Basis for Molecular Mimicry in Inflammatory Autoimmune Demyelinating Polyneuropathy / Xin Yang16:
Fresh Water Pearls of Wisdom on Protein Crystallization / 17:
Glossary
Index
Preface
From Kuru to Nucleation, Aggregation, Polymerization and Crystallization in Biology and Medicine / D. Carleton Gajdusek1:
Gels Mimicking Antibodies in Their Selective Recognition of Proteins and Its Potential Use for Protein Crystallization / Jan Sedzik ; Nasim Ghasemzadeh ; Fred Nyberg ; Stellan Hjertén2:
10.

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図書
edited by Tom W. Muir, John N. Abelson
出版情報: Amsterdam ; Tokyo : Academic Press, 2009  xliii, 264 p., [8] p. of plates ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 462
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目次情報: 続きを見る
(Tentative)
Protein Engineering with the Traceless Staudinger Ligation / Ronald T. Raines ; Annie Tam1:
Mechanistic studies of RNR using unnatural amino acids and semisynthesis / Joann Stubbe2:
Using Expressed Protein Ligation to Probe the Substrate Specificity of Lantibiotic Synthetases / Wilfred van der Donk ; Xingang Zhang3:
Protein Phosphorylation by Semisynthesis: From Paper to Practice / Phlip A. Cole,Lawrence M. Szewczuk ; Mary Katherine Tarrant4:
Mechanistic studies of semisynthetic ion channels / Francis Valiyaveetil5:
Semi-synthesis of proteins using split inteins / Henning D. Mootz ; Christina Ludwig ; Joachim Zettler ; Daniel Garbe6:
Segmental Isotopic Labeling of Proteins for Nuclear Magnetic Resonance / David Cowburn ; Dongsheng Liu ; Rong Xu7:
Use of intein-mediated protein ligation strategies for the fabrication of functional protein arrays / Shao Q Yao ; Souvik Chattopadhaya ; Farhana B. Abu Bakar8:
Expressed Protein Ligation for Metalloprotein Design and Engineering / Yi Lu ; Kenneth Clark9:
(Tentative)
Protein Engineering with the Traceless Staudinger Ligation / Ronald T. Raines ; Annie Tam1:
Mechanistic studies of RNR using unnatural amino acids and semisynthesis / Joann Stubbe2:
11.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2009  xix, 701 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 1
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目次情報: 続きを見る
Amino Acid Origins
Primitive Amino Acid Chemistry Extraterrestrial Amino Acids Terrestrial Amino Acids and Their Evolution
The Common alpha-Amino Acids; Proteinogenic Amino Acid Biosynthesis Uncommon alpha-Amino Acid;
Non-Proteinogenic Amino Acid Biosynthesis beta-Amino Acid Biosynthesis
Synthesis Of Amino Acids
Common or Proteinogenic alpha-Amino Acids Fermentation Production of alpha-Amino Acids Radical Synthetic
Methods for alpha-Amino Acids Uncommon or Non-Proteinogenic alpha-Amino Acids Synthesis of Non-Coding
Amino Acids Synthesis of N-Alkyl Amino Acids Synthesis of beta-Amino Acids Synthesis of Alicyclic beta-Amino Acids
Synthesis of alpha,beta-Diamino Acids Synthesis of Halogenated Amino Acids Synthesis of Isotopically Labelled Amino
Acids Synthesis of Unnatural/Non-proteinogenic alpha-Amino Acids Synthesis of gamma- and delta-Amino Acids Synthesis of GABA and Amino Acid-Based
GABA analogues Synthesis and Chemistry of alpha,beta-Dehydroamino Acids Synthesis and Chemistry of Hydrazino Acids Synthesis and Chemistry of Hydroxamic
Acids (N-Hydroxy Amino Acids) Chemistry of Aminoboronic Acids Chemistry of alpha-Aminophosphonic Acids and Phosphonopeptides
Chemistry of alpha-Silyl Amino Acids Use of Enzymes in Synthesis of Amino Acids
Amino Acid Origins
Primitive Amino Acid Chemistry Extraterrestrial Amino Acids Terrestrial Amino Acids and Their Evolution
The Common alpha-Amino Acids; Proteinogenic Amino Acid Biosynthesis Uncommon alpha-Amino Acid;
12.

図書

図書
edited by Andrew B. Hughes
出版情報: Weinheim : Wiley-VCH, c2009  xxii, 683 p. ; 25 cm
シリーズ名: Amino acids, peptides and proteins in organic chemistry / edited by Andrew B. Hughes ; v. 2
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目次情報: 続きを見る
Amino Acid Organocatalysis
Catalysis of Reactions by Amino Acids
Catalysis of Reactions by Small Peptides
Enzymes
Enzymic Mechanisms of Catalysis
The Chemistry of Proteases
Semi-Synthetic Enzymes
Non-Enzymic Mechanisms of Catalysis
Substrate Recognition
Protein Recognition
Non-Ribosomal Peptide Synthesis
Amino Acid Organocatalysis
Catalysis of Reactions by Amino Acids
Catalysis of Reactions by Small Peptides
13.

図書

図書
edited by Richard H. Templar and Robin Leatherbarrow
出版情報: Cambridge : Royal Society of Chemistry, 2002  ix, 280 p ; 24 cm.
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Probing Biological Molecules: Theory and Experiment / I:
Flow Oriented Linear Dichroism to Probe Protein Orientation in Membrane Environments / A. Rodger ; J. Rajendra ; R. Mortimer ; T. Andrews ; J.D. Hirst ; A.T.B. Gilbert ; R. Marrington ; T.R. Dafforn ; D.J. Halsall ; M. Ardhammar ; B. Norden ; C.A. Woolhead ; C. Robinson ; T.J.T. Pinheiro ; J. Kazlauskaite ; M. Seymour ; N. Perez ; M.J. Hannon
Quantitative Protein Circular Dichroism Calculations / N.A. Besley
Probing Cellular Structure and Function by Atomic Force Microscopy / M.A. Horton ; P.P. Lehenkari ; G.T. Charras
Physical Characterization of Wild Type and mnn9 Mutant Cells of Saccharomyces cerevisiae by Atomic Force Microscopy (AFM) / A. Mendez-Vilas ; I. Corbacho ; M.L. Gonzalez-Martin ; M.J. Nuevo
Probing Supramolecular Organisation at Immune Synapses / F.E. McCann ; K. Suhling ; L.M. Carlin ; K. Eleme ; K. Yanagi ; P.M.W. French ; D. Phillips ; D.M. Davis
Probing the Structure of Viral Ion Channel Proteins: A Computational Approach / W.B. Fischer ; M.S.P. Sansom
The Impact of H[subscript 2]O[subscript 2] on the Structure of Catalases by Molecular Modelling Methods / S.G. Kalko ; J.Ll. Gelpi ; M. Orozco
Entropy in the Alignment and Dimerization of Class C G-Protein Coupled Receptors / M.K. Dean ; C. Higgs ; R.E. Smith ; P.D. Scott ; R.P. Bywater ; T.J. Howe ; C.A. Reynolds
Electrostatic Stability of Wild Type and Mutant Transthyretin Oligomers / S. Skoulakis ; J.M. Goodfellow
Simulations of Human Lysozyme: Conformations Triggering Amyloidosis in 156T Mutant / G. Moraitakis
Collective Excitation Dynamics in Molecular Aggregates: Exciton Relaxation, Self-Trapping and Polaron Formation / M. Dahlbom ; W. Beenken ; V. Sundstrom ; T. Pullerits
Surprising Electro-magnetic Properties of Close Packed Organized Organic Layers--Magnetization of Chiral Monolayers of Polypeptide / I. Carmeli ; V. Shakalova ; R. Naaman ; Z. Vager
Barrier Crossing by a Flexible Long Chain Molecule--The Kink Mechanism / K.L. Sebastian
Proteins, Lipids and Their Interactions / II:
Lipid Interaction with Cytidylyltransferase Regulates Membrane Synthesis / S. Jackowski ; I. Baburina
Models and Measurements on the Monolayer Bending Energy of Inverse Lyotropic Mesophases / A.M. Squires ; J.M. Seddon ; R.H. Templer
Hemolytic and Antibacterial Activities of LK Peptides of Various Topologies: A Monolayer and PM-IRRAS Approach / S. Castano ; B. Desbat ; H. Wroblewski ; J. Dufourcq
A Novel Approach for Probing Protein--Lipid Interactions of MscL, a Membrane-Tension-Gated Channel / P.C. Moe ; P. Blount
Folding of The [alpha]-Helical Membrane Proteins DsbB and NhaA / D.E. Otzen
FhuA, an Escherichia coli Transporter and Phage Receptor / P. Boulanger ; L. Plancon ; M. Bonhivers ; L. Letellier
Morpholgical Aspects of in cubo Protein Crystallisation / C. Sennoga ; B. Hankamer ; A. Heron ; J. Barber
Mobility of Proteins and Lipids in the Photosynthetic Membranes of Cyanobacteria / C.W. Mullineaux ; M. Sarcina
Partitioning and Thermodynamics of Chlordiazepoxide in n-Octanol/Buffer and Liposome System / C. Rodrigues ; P. Gameiro ; S. Reis ; J.L.F.C. Lima ; B. De Castro
Distribution of Vitamin E in Model Membranes / P.J. Quinn
Theory on Opening-up of Liposomal Membranes by Adsorption of Talin / Y. Suezaki
Differential Scanning Calorimetry and X-Ray Diffraction Studies of Glycolipid Membranes / O. Ces ; D.A. Mannock ; R.N. McElhaney
Subject Index
Probing Biological Molecules: Theory and Experiment / I:
Flow Oriented Linear Dichroism to Probe Protein Orientation in Membrane Environments / A. Rodger ; J. Rajendra ; R. Mortimer ; T. Andrews ; J.D. Hirst ; A.T.B. Gilbert ; R. Marrington ; T.R. Dafforn ; D.J. Halsall ; M. Ardhammar ; B. Norden ; C.A. Woolhead ; C. Robinson ; T.J.T. Pinheiro ; J. Kazlauskaite ; M. Seymour ; N. Perez ; M.J. Hannon
Quantitative Protein Circular Dichroism Calculations / N.A. Besley
14.

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図書
岡田芳男編著
出版情報: 東京 : 広川書店, 1991.7  viii, 237p ; 27cm
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15.

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図書
edited by Hans Bisswanger and Eva Schmincke-Ott
出版情報: New York : Wiley, c1980  x, 333 p. ; 24 cm
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16.

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図書
editor D.L. Lark ; associate editors S. Normark, B-E Uhlin, H. Wolf-Watz
出版情報: London ; Tokyo : Academic, 1986  xxix, 464 p. ; 24 cm
シリーズ名: FEMS symposium ; no. 31
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17.

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図書
Robert J. Fletterick, Trina Schroer, Raymond J. Matela
出版情報: Oxford : Blackwell Scientific Publications, 1985  xiv, 196 p. ; 24 cm
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18.

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図書
editors, Frances A. Jurnak and Alexander McPherson
出版情報: New York : Wiley, c1985  xii, 508 p. ; 24 cm
シリーズ名: Biological macromolecules and assemblies ; v. 2
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19.

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図書
edited by Felix Bronner and Arnost Kleinzeller
出版情報: New York : Academic Press, 1979  xiv, 437 p. ; 24 cm
シリーズ名: Current topics in membranes and transport ; v. 12
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20.

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図書
edited by Felix Bronner and Arnost Kleinzeller
出版情報: New York : Academic Press, 1980  xv, 477 p. ; 24 cm
シリーズ名: Current topics in membranes and transport ; v. 14
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21.

図書

図書
edited by Dixie W. Frederiksen, Leon W. Cunningham
出版情報: New York ; Tokyo : Academic Press, 1982-1986  v. ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 85, 134 . Structural and contractile proteins ; pt. B-C
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22.

図書

図書
edited by Thomas L. James, Norman J. Oppenheimer
出版情報: San Diego ; Tokyo : Academic Press, c1994  v. ; 24 cm
シリーズ名: Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan ; v. 239
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23.

図書

図書
Harold A. Scheraga
出版情報: New York : Academic Press, 1961  xiv, 305 p. ; 24 cm
シリーズ名: Molecular biology : an international series of monographs and textbooks ; v. 1
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24.

図書

図書
edited by Felix Bronner and Arnost Kleinzeller
出版情報: New York : Academic Press, 1978  ix, 367 p. ; 24 cm
シリーズ名: Current topics in membranes and transport ; v. 10
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25.

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図書
ed. by Sydney J. Leach
出版情報: New York ; London : Academic Press, 1969-73  3 v. ; 24 cm
シリーズ名: Molecular biology : an international series of monographs and textbooks
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26.

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図書
T. L. Blundell and L. N. Johnson
出版情報: London : Academic Press, 1976  xiv, 565 p. ; 24 cm
シリーズ名: Molecular biology : an international series of monographs and textbooks
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27.

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図書
edited by Hans Neurath
出版情報: New York ; London : Academic Press, 1963-1970  v. ; 24 cm
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28.

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図書
[by] Rudy H. Haschemeyer [and] Audrey E. V. Haschemeyer
出版情報: New York : Wiley, [1973]  ix, 445 p ; 23 cm
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29.

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図書
by Clyde Manwell and C. M. Ann Baker
出版情報: London : Sidgwick & Jackson, 1970  xix, 394 p. ; 23 cm
シリーズ名: Biology series
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30.

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図書
Robert Earl Feeney & Richard Gall Allison
出版情報: New York : Wiley-Interscience, c1969  viii, 290 p. ; 23 cm
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31.

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図書
Charis Ghélis, Jeannine Yon
出版情報: New York ; Tokyo : Academic Press, 1982  xiii, 562 p. ; 24 cm
シリーズ名: Molecular biology : an international series of monographs and textbooks
Molecular biology series
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32.

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図書
edited by Hans Neurath, Kenneth Bailey
出版情報: New York : Academic Press, 1953-1954  4 v. ; 24 cm
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33.

図書

図書
edited by Hans Neurath, Robert L. Hill ; assisted by Carol-Leigh Boeder
出版情報: New York : Academic Press, 1975-1982  5 v. ; 24 cm
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34.

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図書
Gary E. Means, Robert E. Feeney
出版情報: San Francisco : Holden-Day, c1971  x, 254 p. ; 23 cm
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35.

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図書
Nicholas Parris, editor, Robert Barford, editor
出版情報: Washington, DC : American Chemical Society, 1991  ix, 294 p. ; 24 cm
シリーズ名: ACS symposium series ; 454
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目次情報: 続きを見る
Relationship of Composition to Protein Functionality
Significance of Macromolecular Interaction and Stability in Functional
Properties of Food Proteins
Effect of Preheat Temperature on the Hydrophobic Properties of Milk Proteins
Quantitation of Hydrophobicity for Elucidating the Structure-Activity
Relationships of Food Proteins
Milk Protein Ingredients: Their Role in Food Systems
Significance of Lysozyme in Heat-Induced Aggregation of Egg White Protein
Formation and Interaction of Plant Protein Micelles in Food Systems
Diffusion and Energy Barrier Controlled Adsorption of Proteins at the Air-Water
Interface
Surface Activity of Bovine Whey Proteins at the Phospholipid-Water Interface
Interactions Between Milk Proteins and Lipids: A Mobility Study
Some Aspects of Casein Micelle Structure
Cross-Linkage Between Casein and Colloidal Calcium Phosphate in Bovine Casein
Micelles
Quaternary Structural Changes of Bovine Casein by Small-Angle X-ray Scattering:Effect of Genetic Variation
Genetic Engineering of Bovine k-Casein to Enhance Proteolysis by Chymosin
Rheology: A Tool for Understanding Thermally Induced Protein Gelation
Food Dough Constant Stress Rheometry
Factors Influencing Heat-Induced Gelation of Muscle Proteins
Gelation of Myofibrillar Protein
Interactions of Muscle and Nonmuscle Proteins Affecting Heat-Set Gel Rheology
Relationship of Composition to Protein Functionality
Significance of Macromolecular Interaction and Stability in Functional
Properties of Food Proteins
36.

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図書
Dennis Sherwood
出版情報: London : Longman, 1976  xxii, 702 p. ; 24 cm
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37.

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図書
organized and edited by Reinhold Benesch ...[and others]
出版情報: New York : Academic Press, 1959  xi, 469 p.: ill., diagrs., tables ; 24 cm
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38.

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図書
Jacinto Steinhardt, Jacqueline A. Reynolds
出版情報: New York : Academic Press, 1969  x, 391 p. ; 24 cm
シリーズ名: Molecular biology : an international series of monographs and textbooks / editors, Bernard Horecker ... [et al.]
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39.

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図書
Kurt Wüthrich
出版情報: Amsterdam : North-Holland Pub. Co. , New York : sole distributors for the U.S.A. and Canada, American Elsevier Pub. Co., 1976  xii, 379 p. ; 23 cm
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40.

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図書
[by] Herbert R. Wilson
出版情報: London : Edward Arnold, 1966  vi, 137 p ; 23 cm
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41.

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図書
edited by F. Korte and M. Goto ; contributions from K. Anno ... [et al.]
出版情報: New York ; London : Academic Press , Stuttgart : G. Thieme, 1976  viii, 231 p. ; 28 cm
シリーズ名: Methodicum chimicum ; v. 11 . Natural compounds ; pt. 1
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42.

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図書
by H.E. Schultze and J.F. Heremans
出版情報: Amsterdam ; New York : Elsevier, 1966  xii, 904 p. ; 25 cm
シリーズ名: Molecular biology of human proteins : with special reference to plasma proteins ; v. 1
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43.

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図書
by M. Joly
出版情報: London ; New York : Academic Press, 1965  ix, 350 p. ; 24 cm
シリーズ名: Molecular biology : an international series of monographs and textbooks ; v. 6
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44.

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図書
edited by H. Gutfreund
出版情報: London : Butterworths , Baltimore : University Park Press, c1974  411 p ; 24 cm
シリーズ名: MTP international review of science ; . Biochemistry, ser. 1 ; v. 1
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45.

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図書
Richard E. Dickerson and Irving Geis
出版情報: New York : Harper & Row, c1969  viii, 120 p. ; 26 cm
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46.

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図書
Danton H. O'Day, Andrew Catalano, editors
出版情報: Dordrecht : Springer, c2013  vi, 371 p. ; 25 cm
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47.

図書

図書
volume editor, Stephan A. Sieber ; with contributions by R. Breinbauer ... [et al.]
出版情報: Heidelberg : Springer, c2012  xi, 165 p. ; 24 cm
シリーズ名: Topics in current chemistry = Fortschritte der chemischen Forschung ; 324
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48.

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図書
G.E. Schulz, R.H. Schirmer
出版情報: New York : Springer-Verlag, c1979  x, 314 p. ; 24 cm
シリーズ名: Springer advanced texts in chemistry / Charles R. Cantor, editor
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49.

図書

図書
David Whitford
出版情報: Chichester : Wiley, c2005  xiv, 528 p. ; 27 cm
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目次情報: 続きを見る
Preface
An introduction to protein structure and function / 1:
An Introduction to protein structure and function
Amino acids: the building blocks of proteins / 2:
A brief and very selective historical perspective
The three-dimensional structure of proteins / 3:
The biological diversity of proteins
The structure and function of fibrous proteins / 4:
Proteins and the sequencing of the human and other genomes
The structure and function of membrane proteins / 5:
Why study proteins?
The diversity of proteins / 6:
Enzyme kinetics, structure, function and catalysis / 7:
The 20 amino acids found in proteins / 8:
Protein synthesis, processing and turnover
The acid-base properties of amino acids / 9:
Protein expression, purification and characterization
Stereochemical representations of amino acids / 10:
Physical methods of determining the three-dimensional structure of proteins
Peptide bonds / 11:
Protein folding in vivo and in vitro
The chemical and physical properties of amino acids / 12:
Protein structure and a molecular approach to medicine
Epilogue
Detection, identification and quantification of amino acids and proteins
Glossary
Appendices
Stereoisomerism
Bibliography
References
Non-standard amino acids
Index
Summary
Problems
Primary structure or sequence
Secondary structure
Tertiary structure
Quaternary structure
The globin family and the role of quaternary structure in modulating activity
Immunoglobulins
Cyclic proteins
The amino acid composition and organization of fibrous proteins
Keratins
Fibroin
Collagen
The molecular organization of membranes
Membrane protein topology and function seen through organization of the erythrocyte membrane
Bacteriorhodopsin and the discovery of seven transmembrane helices
The structure of the bacterial reaction centre
Oxygenic photosynthesis
Photosystem I
Membrane proteins based on transmembrane [beta] barrels
Respiratory complexes
Complex III, the ubiquinol-cytochrome c oxidoreductase
Complex IV or cytochrome oxidase
The structure of ATP synthetase
ATPase family
Prebiotic synthesis and the origins of proteins
Evolutionary divergence of organisms and its relationship to protein structure and function
Protein sequence analysis
Protein databases
Gene fusion and duplication
Secondary structure prediction
Genomics and proteomics
Enzyme kinetics, structure, function, and catalysis
Enzyme nomenclature
Enzyme co-factors
Chemical kinetics
The transition state and the action of enzymes
The kinetics of enzyme action
Catalytic mechanisms
Enzyme structure
Lysozyme
The serine protease
Triose phosphate isomerase
Tyrosyl tRNA synthetase
EcoRI restriction endonuclease
Enzyme inhibition and regulation
Irreversible inhibition of enzyme activity
Allosteric regulation
Covalent modification
Isoenzymes or isozymes
Cell cycle
The structure of Cdk and its role in the cell cycle
Cdk-cyclin complex regulation
DNA replication
Transcription
Eukaryotic transcription factors: variation on a 'basic' theme
The spliceosome and its role in transcription
Translation
Transfer RNA (tRNA)
The composition of prokaryotic and eukaryotic ribosomes
A structural basis for protein synthesis
An outline of protein synthesis
Antibiotics provide insight into protein synthesis
Affinity labelling and RNA 'footprinting'
Structural studies of the ribosome
Post-translational modification of proteins
Protein sorting or targeting
The nuclear pore assembly
Protein turnover
Apoptosis
The isolation and characterization of proteins
Recombinant DNA technology and protein expression
Purification of proteins
Centrifugation
Solubility and 'salting out' and 'salting in'
Chromatography
Dialysis and ultrafiltration
Polyacrylamide gel electrophoresis
Mass spectrometry
How to purify a protein?
Introduction
The use of electromagnetic radiation
X-ray crystallography
Nuclear magnetic resonance spectroscopy
Cryoelectron microscopy
Neutron diffraction
Optical spectroscopic techniques
Vibrational spectroscopy
Raman spectroscopy
ESR and ENDOR
Factors determining the protein fold
Factors governing protein stability
Folding problem and Levinthal's paradox
Models of protein folding
Amide exchange and measurement of protein folding
Kinetic barriers to refolding
In vivo protein folding
Membrane protein folding
Protein misfolding and the disease state
Sickle cell anaemia
Viruses and their impact on health as seen through structure and function
HIV and AIDS
The influenza virus
p53 and its role in cancer
Emphysema and [alpha subscript 1]-antitrypsin
Preface
An introduction to protein structure and function / 1:
An Introduction to protein structure and function
50.

雑誌

雑誌
出版情報: New York : Academic Press, 1944-2007  v. ; 24 cm
巻次年月次: Vol. 1 (1944)-v. 74 (2007)
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51.

図書

図書
Arthur M. Lesk
出版情報: Oxford : Oxford University Press, 2016  xxii, 466 p. ; 27 cm
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目次情報: 続きを見る
Preface to the first edition
Preface to the second edition
Preface to the third edition
Introduction / 1:
Proteins in their biological context
The amino acids
Dogmas-central and peripheral
The relationship between ammo acid sequence and protein stricture is robust
Disorder in proteins
Regulation
The genetic code
With life so dependent on proteins, there is ample opportunity for things to go wrong
Genome sequences
Gene sequence determines amino acid sequence
Protein synthesis: the ribosome is the point of contact between genes and proteins-it is the fulcrum of genomics
Ribosomes were implicated in protein synthesis very early on
Structural studies of ribosomes by X-ray crystallography and electron microscopy
Protein stability, denaturation, aggregation, and turnover
Protein turnover
Description of protein structures
Primary structure
Secondary structure: helices and sheets are favourable conformations of the chain that recur in many proteins
Tertiary and quaternary structure
Folding patterns in native proteins-themes and variations
Modular proteins, and 'mixing and matching' as a mechanism of evolution
How do proteins develop new functions?
The study of proteins: in the laboratory, in the cell, in the computer
Spectroscopic methods of characterizing proteins in solution
Absorbance and fluorescence of proteins
Fluorescence is sensitive to the environment and dynamics of the chromophore
Fluorescence resonance energy transfer (FRET)
Circular dichroism
Protein expression patterns in space and time: Proteomics
Subcellular localization
The transcriptome
DNA microaaays
Mass spectrometry
Computing in protein science
Computer-instrument partnerships in the laboratory
Simulations, including molecular dynamics
Bioinformatics
Introduction to databanks for protein science
Information-retrieval tools
Web access to the scientific literature
Useful websites
Recommended reading
Exercises and Problems
Protein structure / 2:
Structures of the amino acids
Protein conformation
Conformational angles and the Sasisekharan-Ramakrishnan-Ramachandran plot
Sidechain conformation
Rotamer libraries
Stabilization of the naïve state
Conformational change
Protein folding patterns
Supersecondary structures
An album of small structures
Comparison of the folding patterns of acylphosphatase and a fungal toxin
Classification of protein structures
Databanks of protein structure classifications
SCOP
SCOP2
CATH
The DALI Database
A survey of protein structures and functions
Fibrous proteins
Enzymes-proteins that catalyse chemical reactions
Antibodies
Inhibitors
Carrier proteins
Membrane proteins
Receptors
Regulatory proteins
Motor proteins
Control of protein activity
Regulation of tyrosine hydroxylase illustrates several control mechanisms common to many proteins
Control cascades
Protein structure determination / 3:
X-ray crystallography
X-ray structure determination
X-ray crystallography of proteins
Interpretation of the electron density: model building and improvement
The endgame-refinement
How accurate are the structures?
X-ray crystallography-the theoretical background
Nuclear magnetic resonance spectroscopy in structural biology
NMR spectra of proteins
Measurement of NMR spectra
Protein structure determination by NMR
Assignment of the spectrum
Transverse relaxation optimized spectroscopy
From the data to the structure
Solid-state NMR: magic angle spinning
Near atomic-resolution low-temperature electron microscopy (cryo-EM)
Octameric pyruvate-ferredoxin oxidoreductase from Desulfovibrio vulgaris Hildenborough
Conformational change in activation of human integrin αVβ3
Trajectories of conformational change
The elastic network model accounts for conformational change in Mycobacterium tuberculosis thioredoxin reductase
The relationship between structure determinations of Isolated proteins, and protein structure and function in vivo
Protein structure prediction and modeling
A priori methods of protein structure prediction
Empirical, or 'knowledge-based', methods of protein structure prediction
Secondary structure prediction
Homology modelling
Fold recognition
Antibody modeling
Prediction of special categories of structures
Conformational energy calculations and molecular dynamics
ROSETTA
Protein structure prediction from contact maps derived from correlated mutations in multiple sequence alignments
Critical Assessment of Structure Prediction (CASP)
CAPRI
Bioinformatics of protein sequence and structure / 4:
Databases and information retrieval
Amino acid sequence databases
Protein databases at the U.S. National Center for Biotechnology Information
Specialized, or 'boutique', databases
Nucleic acid sequence databases
Genome databases and genome browsers
Ensembl
Expression and proteomics databases
Debases of macromolecular structure
Organization of wwPDB entries
Retrieval of sequences and structures
Retrieval of amino acid sequences by keyword
The Protein Information Resource (PIR) and associated databases
Retrieval of structures by keyword
Probing databanks with sequence information
Sequence alignment
The dotplot
Dotplots and alignments
BLAST and PSI-BLAST
Significance of alignments
Multiple sequence alignment
A multiple sequence alignment of thioredoxins shows the importance of conservation patterns
Analysis of structures
Superposition of structures
Structural alignment
Multiple structure alignment
Database searching for structures or fragments
Databases of protein families
Classifications of protein structures
Classification and assignment of protein function
The Enzyme Commission
The Gene Ontology™ Consortium protein function classification
The ENZYME database and PROSITE
Databases of metabolic networks
Proteins as catalysts: enzyme structure, kinetics, and mechanism / 5:
What are the crucial features of enzymes?
Reaction rates and transition states
The activated complex
Measurement of reaction rates
Slow the reaction down
Fast methods of data collection
Active sites
Cofactors
Protein-ligand binding equilibria
The Scatchard plot
Catalysis by enzymes
Enzyme kinetics
Derivation of KM and Vmax from rate data
Measures of effectiveness of enzymes
Irreversible inhibitor binding
Multisubstrate reactions
Enzyme mechanisms
The mechanism of action of thymidylate synthase
Computational approaches to enzyme mechanisms
The mechanism of action of chymotrypsin
The evidence from kinetics
The evidence from crystallography
Blood coagulation
Thrombosis
Serpins: serine proteinase inhibitors-conformational disease
Several conformational states of serpins are known
Mechanism of proteinase inhibition by serpins
Evolutionary divergence of enzymes
The mechanism of action of malate and lactate dehydrogenases
Enolase, mandelate racemase, and muconate lactonizing enzyme catalyse different reactions but have related mechanisms
The structure and mechanism of E. coli topoisomerase III
The sliding filament mechanism of muscle contraction
ATP synthase
Membrane transport
Specificity of the potassium channel from Streptomyces lividans-room to swing a cation?
Allosteric regulation of protein activity
The allosteric structural change of haemoglobin
Proteins with partners / 6:
General properties of protein-protein interfaces
Burial of protein surface
The composition of the interface
Complementarity
Specific interactions at protein-protein interfaces
Phage M13 gene III protein and E. coli TolA
Multisubunit proteins
Diseases of protein aggregation
Amyloidoses
Alzheimer's disease
Prion diseases-spongiform encephalopathies
The immune system
Antibody structure
Antibody maturation
Catalytic antibodies-'abzymes'
Proteins of the major histocompatibility complex
T-cell receptors
Virus structures
Tomato bushy stunt virus
Bacteriophage HK97: protein chain-mail
Photosynthetic reaction centres
Protein-DNA interactions
Structural themes in protein-DNA binding and sequence recognition
Bacteriophage T7 DNA polymerase
Some protein-DNA complexes that regulate gene transcription
Evolution of protein structure and function / 7:
Protein structure classification
A case study: superpositions and alignments of pairs of proteins with increasingly more-distant relationships
Structural relationships among homologous domains
Changes in proteins during evolution give clues to the roles of residues at different positions
To what constraint are pathways of protein evolution subject?
Closed β-barrel structures
The TIM barrel
Evolution of the globins
Mammalian globins
What determines the globin folding pattern?
Truncated globins
Expansion of the globin family
Classification of the globins
Globin functions
Phycocyanins and the globins
Evolution of NAD-binding domains of dehydrogenases
Comparison of NAD-binding domains of dehydrogenases
The sequence motif G*G**G
Structure and evolution of serine proteinases of the chymotrypsin family
Structures of individual domains
The domain/domain interface
The specificity pocket
The β-barrels in serine proteinase domains and the packing of residues in their interiors
Evolution of visual pigments and related molecules
Selection has tuned vertebrate opsins so that the absorption maximum varies with the light environment
How do proteins evolve new functions?
Pathways and limits in the divergence of sequence, structure and function
Evolution of functional change in the enolase superfamily
Protein evolution at the level of domain assembly
Domain swapping is a general mechanism for forming an oligomer from a multidomain protein
Directed evolution
Directed evolution of subtilisin E
Enhancement of thermal stability
Activity in organic solvents
Affinity selectivity by phage display
Protein folding and design / 8:
Why is protein folding so fast?
Thermodynamics-key concepts
Entropy
Spontaneity and equilibrium
Kinetics
Thermodynamics, protein folding
Thermodynamics of mutated proteins
Experimental character nation of events in protein folding
The molten globule
Folding funnels
The effect of denaturants on rates of folding and unfolding: chevron plots
The kinetics of folding of mutated proteins gives clues to the structure of the transition state for folding
Comparison of folding pathways of a natural protein and a circular permutant
Relationship between native structure and folding
The hierarchical model of protein folding
How fast could a protein fold?
Protein misfolding and the GroEL-GroES chaperone protein
The GroEL-GroES conformational change
Protein design
ab initio design of a hyperstable variant of Streptococcal protein G, β1 domain
Expanding and contracting the genetic code
Expansion of the genetic code
Contraction of the genetic code
Understanding the contents and layout of the common genetic code
Proteomics and systems biology / 9:
Separation and analysis of proteins
Polyacrylamide gel electrophoresis
Two-dimensional polyacrylamide gel electrophoresis
Difference gel electrophoresis
Identification of components of a complex mixture
Protein sequencing by mass spectrometry
Quantitative analysis of relative abundance
Measuring deuterium exchange in proteins
'Ome, 'ome, on the range-environmental genomics and proteomics
Metagenomics
Metaproteomics
Dynamic proteomics of the response to cadmium challenge
Microarrays
Microarray data are semiquantitative
Applications of DNA microarrays
Analysis of microarray data
Expression patterns in different physiological states
Expression pattern changes in development: the life cycle of Drosophila melanogaster
RNAseq
RNAseq v. microarrays
Systems biology
Two parallel networks: physical and logical
Networks and graphs
Robustness and redundancy
Connectivity in networks
Dynamics, stability, and robustness
Protein complexes and aggregates
Protein interaction networks
Regulatory networks
Structures of regulatory networks
Structural biology of regulatory networks
Gene regulation
The transcriptional regulatory network of E. coli
Regulation of the lactose operon in E. coli
The genetic regulatory network of Saccharomyces cerevisiae
Adaptability of the yeast regulatory network
Epilogue
List of Abbreviations
Glossary
Index
Preface to the first edition
Preface to the second edition
Preface to the third edition
52.

図書

図書
[edited by] R. D. B. Fraser and T. P. MacRae
出版情報: New York : Academic Press, 1973  xviii, 628 p ; 24 cm
シリーズ名: Molecular biology : an international series of monographs and textbooks
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