Contributors |
Preface |
Discovery of New Macrolides / Kazuro Shiomi ; Satoshi Omura1.: |
Introduction / I.: |
Macrolides from Actinomycetes / II.: |
Macrolides from Bacteria Including Myxobacteria / III.: |
Macrolides from Fungi / IV.: |
Macrolides from Plants and Lichens / V.: |
Macrolides from Insects / VI.: |
Other Macrolides / VII.: |
Concluding Remarks / VIII.: |
References |
Discovery of New Macrolides from Marine Organisms / Masami Ishibashi2.: |
Macrocyclic Lactones of Marine Organism Origin |
Chemical Modification of Macrolides / Toshiaki Sunazuka ; Sadafumi Omura ; Shigeo Iwasaki3.: |
Fourteen-Membered Macrolides |
Sixteen-Membered Macrolide Antibiotics and the Avermectin Family |
Total Synthesis of Macrolides / Tadashi Nakata4.: |
Synthetic Strategy for Macrolide Synthesis |
Total Synthesis of Selected Macrolides |
Biosynthesis, Regulation, and Genetics of Macrolide Production / Haruo Ikeda5.: |
Reaction Mechanism of Polyketide Biosynthesis |
Polyketide Synthase |
Genes Encoding Modular Polyketide Synthase |
Sugar Biosynthesis |
Genetic Manipulation of PKS Genes |
Pharmacokinetics and Metabolism of Macrolides / Yoshiro Kohno6.: |
Pharmacokinetics and Metabolism |
Drug Interaction |
Antimicrobial Macrolides in Clinical Practice / Salvador Alvarez-Elcoro ; Joseph D. C. Yao7.: |
Fourteen- and Fifteen-Membered Macrolides |
Sixteen-Membered Macrolides |
Ivermectin in Clinical Practice / Osamu Zaha ; Tetsuo Hirata ; Fukunori Kinjo ; Atsushi Saito8.: |
Novel Activity of Ivermectin in Clinical Practice |
Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice / Tadahiro Amaya ; Jun Hiroi ; Ira D. Lawrence9.: |
Tacrolimus, a Brief Developmental History |
Novel Activity of Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice |
Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides / Yoshinori Nakajima10.: |
Mode of Action of Macrolide Antibiotics |
Mechanisms of Resistance to Antimicrobial Macrolides |
Important Developments in Macrolide Antibiotics |
Addendum |
Mode of Action of Macrolides with Motilin Agonistic Activity--Motilides / Nobuhiro Inatomi ; Fumihiko Sato ; Zen Itoh11.: |
Mode of Action of Motilin |
Invention of Motilides |
Biological Activity of Motilides |
Clinical Trials of Motilides |
Novel Activity of Erythromycin and Its Derivatives / Shoji Kudoh ; Arata Azuma ; Jyun Tamaoki ; Hajime Takizawa ; Koh Nakata ; Hajime Goto12.: |
Erythromycin Treatment in Diffuse Panbronchiolitis |
Inhibition of Chloride Channel |
Effects of Macrolides on Cytokine/Chemokine Expression |
Modulation of Bacterial Function |
New Challenge for Novel Action |
Mode of Action of Avermectin / 13.: |
Target of Avermectin Action |
Cloning and Structure of Avermectin Binding Protein |
Mode of Action of FK506 and Rapamycin / Nobuhiro Takahashi14.: |
Initial Cellular Target for FK506 and Rapamycin; Peptidyl Prolyl cis-trans Isomerases (Rotamases, Immunophilins) |
Target of FK506-FKBP12 Complex: Calcineurin |
Target of Rapamycin-FKBP12 Complex: mTOR/FRAP/RFAT |
Intervention of Intracellular Signaling Pathways by FK506 and Rapamycin |
Index |
Contributors |
Preface |
Discovery of New Macrolides / Kazuro Shiomi ; Satoshi Omura1.: |
Introduction / I.: |
Macrolides from Actinomycetes / II.: |
Macrolides from Bacteria Including Myxobacteria / III.: |