Protection Reactions |
General Considerations |
Alpha-Amino Protection (Nalpha-Protection) |
Carboxy Protection |
Side Chain Protection |
Photocleavable Protections |
Conclusion |
Experimental Section |
The Huisgen Cycloaddition in Peptidomimetic Chemistry |
Introduction |
The Huisgen [2+3] Cycloaddition Between Azides and Acetylenes |
Mechanistic Consideration for the Cu-Huisgen and Ru-Huisgen Cycloaddition |
Building Blocks for the Synthesis of Triazole Modified Peptidomimetics |
Cyclic Triazole Peptidomimetics |
Acylic Triazole Peptidomimetics |
Useful Experimental Procedures |
Recent Advances in Beta-Strand Mimetics |
Macrocyclic Peptidomimetics |
Acyclic Compounds |
Aliphatic and Aromatic Carbocycles |
Ligands Containing One Ring or Multiple Rings with One Heteroatom (O, S) |
Ligands Containing One Ring with Two Heteroatoms (N,N) |
Ligands Containing One Ring with Two Heteroatoms (N,S) or Three Heteroatoms (N,N,S or N,N,N) |
Ligands Containing Two Rings with One Heteroatom (N or O) |
Ligands Containing Two Rings with Two or Three Heteroatoms (N,N or N,S or N,N,N) |
Concluding Remarks |
Medicinal Chemistry of Alpha-Amino Acids |
Glutamic Acid |
Conformational Restriction |
Bioisosterism |
Structure-Activity-Studies |
Medicinal Chemistry of Alicyclic Beta-Amino Acids |
Five-Membered Alicyclic Beta-Amino Acids |
Six-Membered Alicyclic Beta-Amino Acids |
medicinal Chemistry of Alpha-Hydroxy-Beta-Amino Acids |
Alpha-Hydroxy-Beta-Amino Acids |
Antibacterial Agents |
Inhibitors of Aminopeptidases |
Aspartyl Proteases Inhibitors |
Paclitaxel and its Derivatives |
Peptide Drugs |
Lights and Shades of Peptide and Protein Drugs |
Peptide Drugs Available on the Market |
Approved Peptides in Oncology |
Antimicrobial Peptides |
Perspectives |
Oral Bioavailability of Peptide and Peptidomimetic Drugs |
Fundamental Considerations of Intestinal Absorption |
Barriers Limiting Oral Peptide/Peptidomimetic Drugs Bioavailability |
Strategies to Improve Peptide-Based Drugs Oral Bioavailability |
Conclusions |
Asymmetric Synthesis of Beta-Lactams Via the Staudinger Reaction |
The Staudinger Reaction |
Influence of the Geometry of the Imine on Stereoselectivity in the Reaction |
Influence of the Polarity of the Solvent on Stereoselectivity of the Reaction |
Influence of the Isomerization of the Imine Prior to its Nucleophilic Attack onto the Ketene Stereoselectivity in the Reaction |
Influence of the Order of Addition of the Reactants to the Reaction |
Influence of Chiral Substituents on the Stereoselectivity of the Reaction |
Asymmetric Induction from the Imine Component |
Asymmetric Induction from the Ketene Component |
Double Asymmetric Cycloinduction |
Influence of Catalysts on the Stereoselectivity of the Reaction |
Advances in N- and O-Glycopeptide Synthesis - A Tool to Study Clycosylation and Develop New Therapeutics |
O-Glycopeptide Synthesis |
Synthesis of Mucin Type Glycopeptides |
Synthesis of Tumor-Associated Glycopeptides and Glycopeptide Vaccines |
Synthesis of Tn, T, sialyl Tn, sialyl T Glycosylated Amino Acid Building Blocks |
Synthesis of Tn, T, sialyl Tn, sialyl T Glycopeptides and Vaccines |
Synthesis of Glycopeptide Recognition Domain of P-Selectin Glycoprotein Ligand 1 (PSGL-1) |
Synthesis of a Core 2 sLe AMino Acid Building Block Including a sLe Mimic |
Synthesis of Unsulfated and Sulfated Core 2 sLe and Core 2 sLe Mimic PSGL-1 Glycopeptides |
Chemoenzymatic Synthesis of Unsulphated and Sulphated Sialyl Lewis PSGL-1 Glycopeptide |
Synthesis of Other Types of O-Glycopeptides |
Synthesis of Fmoc-GlcNAc-Ser/Thr Amino Acids |
Synthesis of Estrogene Receptor Peptides for Conformational Analysis |
Synthesis of N-Glycopeptides |
Synthesis of Ribonuclease C (RNase C) Glycoprotein |
Synthesis of Erythropoietin N-Glycopeptide Fragment 1-28 |
Synthesis of Biantennary Dodecasaccharide |
Synthesis of N-Glycopeptide Fragment 1-28 |
Chemoenzymatic Synthesis of a HIV GP120 V3 Domain N-Glycopeptide |
Synthesis of the Oxazoline Tetrasaccharide Donor |
Synthesis of Fmoc-GlcNAc-Asn Amino Acid Building Block |
Synthesis of V3 Cyclic GlcNAc Peptide and Endo A Coupling with Man3GlcNAc Oxazoline Donor |
Recent Developments in Neoglycopeptide Synthesis |
Neoglycoside and Neoglycopeptide Synthesis |
Protein Side-Chain Modifications |
Cu-Catalyzed Azide-Alkyne "Click" Cycloaddition |
Cross Metathesis |
Application of Neoglycopeptides as Synthetic Vaccines |
Enzymatic, Molecular and Cell Biological Techniques |
Combinatorial/Library Peptide Synthesis |
High Throughput Synthesis of Peptides |
Peptide Libraries |
Future of Peptide Libraries |
Synthetic Protocols |
Protection Reactions |
General Considerations |
Alpha-Amino Protection (Nalpha-Protection) |