Preface to the Series |
Preface to Volume 36 |
Contributors |
Contents of Previous Volumes |
Handbook on Toxicity of Inorganic Compounds |
Handbook on Metals in Clinical and Analytical Chemistry |
The Mechanism of "Fenton-Like" Reactions and Their Importance for Biological Systems. A Biologist's View / Stefan I. LiochevChapter 1: |
Introduction / 1.: |
The Fenton Reaction and Fenton-Like Reactions / 2.: |
Significance of the Fenton-Like Reactions in vivo / 3.: |
Conclusions / 4.: |
Acknowledgments |
Abbreviations |
References |
Reactions of Aliphatic Carbon-Centered and Aliphatic-Peroxyl Radicals with Transitionmetal Complexes as a Plausible Source for Biological Damage Induced by Radical Processes / Dan MeyersteinChapter 2: |
Sources of Radicals in Biological Systems |
Redox Properties of Alkyl and Alkyl-Peroxyl Radicals |
The Role of Transition Metal Complexes in Radical-Induced Biological Deleterious Processes |
The "Site-Specific" Mechanism / 5.: |
Reactions of Aliphatic Carbon-Centered Radicals with Transition Metal Complexes in Aqueous Solutions / 6.: |
Mechanisms of Decomposition of the Transient Complexes, L[subscript m]M[superscript n+1]-R / 7.: |
Reactions of Alkyl-Peroxyl Radicals with Transition Metal Complexes in Aqueous Solution / 8.: |
Mechanisms of Decomposition of the Transient Complexes, L[subscript m]M[superscript n+1]-OOR / 9.: |
Concluding Remarks / 10.: |
Free Radicals as a Result of Dioxygen Metabolism / Bruce P. BranchaudChapter 3: |
Redox Chemistry, Acid-Base Chemistry and Bond Energies of Dioxygen and Reactive Oxygen Species |
Major Radical Reactions of Dioxygen and Reactive Oxygen Species |
Lipid Peroxidation, an Especially Facile and Major Type of Radical Chain Autoxidation |
Lipid Hydroperoxides as a Major Source of Radicals |
Production of Reactive Oxygen Species by Respiratory Burst of Phagocytes |
Free Radicals as a Source of Uncommon Oxidation States of Transition Metals / George V. Buxton ; Quinto G. Mulazzani7: |
Properties of Free Radicals |
Generation of Free Radicals |
Measurement of Reaction Rates |
Interaction of Free Radicals with Simple Transition Metal Ions |
Interaction of Free Radicals with Complexed Transition Metal Ions |
Biological Chemistry of Copper-Zinc Superoxide Dismutase and Its Link to Amyotrophic Lateral Sclerosis / Thomas J. Lyons ; Edith Butler Gralla ; Joan Selverstone ValentineChapter 5: |
Biophysical Properties of Wild-Type Superoxide Dismutase |
Enzymatic Activity |
Evidence Concerning Biological Function |
Role of Mutant Human CuZn Superoxide Dismutase in Amyotrophic Lateral Sclerosis |
DNA Damage Mediated by Metal Ions with Special Reference to Copper and Iron / Jose-Luis SagripantiChapter 6: |
Binding of Metal Ions to DNA |
DNA Lesions |
Biological Implications of Metal-DNA Damage |
Conclusion |
Radical Migration Through the DNA Helix: Chemistry at a Distance / Shana O. Kelley ; Jacqueline K. BartonChapter 7: |
Charge Transport in DNA: Chemical and Biological History |
DNA as a Bridge for Long-Range Charge Transport |
DNA as a Reactant in Long-Range Charge Transfer Reactions |
Involvement of Metal Ions in Lipid Peroxidation: Biological Implications / Odile Sergent ; Isabelle Morel ; Josiane CillardChapter 8: |
Outline of the Mechanism of Lipid Peroxidation |
Involvement of Metal Ions in Various Stages of the Lipid Peroxidation Process |
Biological Examinations of the Effect of Metal Ions on Lipid Peroxidation |
Considerations on Tissue Damage |
Formation of Methemoglobin and Free Radicals in Erythrocytes / Hans Nohl ; Klaus StolzeChapter 9: |
ESR Detection of Free Radical Intermediates |
Chemiluminescence Detection of the Ferryl Hemoglobin Protein Radical |
Spin Labeling of the Erythrocyte Membrane |
Iron Liberation |
Reactions Involving Thiol Groups (R-SH) |
Electrophoresis of Membranes with SDS-PAGE |
Role of Free Radicals and Metal Ions in the Pathogenesis of Alzheimer's Disease / Craig S. Atwood ; Xudong Huang ; Robert D. Moir ; Rudolph E. Tanzi ; Ashley I. BushChapter 10: |
Normal Cerebral Transition Metal Ion Homeostasis and Oxidative Metabolism |
Altered Cerebral Metal Ion and Oxidative Metabolism in Alzheimer's Disease |
Cerebral Amyloid Deposition in Neurological Diseases and Aging |
Neurochemical Factors that Precipitate Alzheimer A[beta] Protein |
Sources of Neuronal Free Radicals |
Neurochemical Environments Leading to Amyloid Deposition and Neuronal Death in Alzheimer's Disease |
Metal Binding and Radical Generation of Proteins in Human Neurological Diseases and Aging / Gerd Multhaup ; Colin L. MastersChapter 11: |
Introduction: Transition Metal Ions in Biological Systems |
Free Radicals and Human Diseases |
Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis: A Gain of Function |
Radical Generation of Amyloid Precursor Protein in Alzheimer's Disease |
Involvement of Oxygen Radicals in A[beta] Amyloid Formation |
Oxidative Stress and Antioxidants |
Thiyl Radicals in Biochemically Important Thiols in the Presence of Metal Ions / Hans-Jurgen Hartmann ; Christian Sievers ; Ulrich WeserChapter 12: |
Thiyl Radicals |
Thiyl Radicals in the Presence of Iron, Cobalt, Nickel, Manganese, Chromium, and Vanadium |
Copper(I)-Stabilized Thiyl Radicals |
Improved Stabilization of Copper(I)-Thiyl Radicals Embedded in Inorganic and Biological Matrices |
Methylmercury-Induced Generation of Free Radicals: Biological Implications / Theodore A. SarafianChapter 13: |
Introduction: The Toxicity and Pathology of Mercury |
Mercury Chemistry |
Mercurial-Induced Oxidative Stress in Biological Systems |
Protective Mechanisms Against Mercury Toxicity |
Biological Implications |
Role of Free Radicals in Metal-Induced Carcinogenesis / Joseph R. LandolphChapter 14: |
The Role of Free Radicals in Chromium Carcinogenesis |
The Role of Free Radicals in Nickel Carcinogenesis |
The Possible Role of Free Radicals in Arsenic Carcinogenesis |
Beryllium Pulmonary Fibrosis and Carcinogenesis: Is There a Role for Free Radicals? |
Iron and Free Radicals: Is There a Role in Carcinogenesis or Tumor Promotion? |
Copper and Free Radicals: Is There a Role in Carcinogenesis? |
pH-Dependent Organocobalt Sources for Active Radical Species: a New Type of Anticancer Agents / Mark E. Vol'pin ; Ilia Ya. Levitin ; Sergei P. OsinskyChapter 15: |
Introduction: Prerequisites for the Search for Potential Anticancer Drugs Among Organocobalt Complexes |
Alkylcobalt(III) Chelates with Tridentate Schiff Bases |
Biomedical Examinations |
Conclusion and Outlook |
Detection of Chromatin-Associated Hydroxyl Radicals Generated by DNA-Bound Metal Compounds and Antitumor Antibiotics / G. Mike MakrigiorgosChapter 16: |
Chromatin-Associated Hydroxyl Radicals |
Detection of Chromatin-Associated Hydroxyl Radicals |
Methods for Attaching SECCA to In Vitro Chromatin Models |
Metal Compounds and Antitumor Antibiotics that Generate Chromatin-Associated HO |
Nitric Oxide (No): Formation and Biological Roles in Mammalian Systems / Jon M. Fukuto ; David A. WinkChapter 17: |
Biologically Relevant Chemistry of Nitric Oxide |
Nitric Oxide Biosynthesis |
Physiology and Pathophysiology of Nitric Oxide: A Chemical Perspective |
Chemistry of Peroxynitrite and Its Relevance to Biological Systems / Willem H. KoppenolChapter 18: |
Introduction and Brief Historical Overview |
Is Peroxynitrite Formed in vivo? |
Syntheses |
Properties, Isomerization, and Decomposition |
Reactions that Are First Order in Peroxynitrous Acid |
Biomolecular Reactions |
Superoxide Dismutase and Peroxynitrite |
Peroxynitrite or Hydroxyl Radical? |
Note Added in Proof |
Novel Nitric Oxide-Liberating Heme Proteins from the Saliva of Bloodsucking Insects / F. Ann Walker ; Jose M. C. Ribeiro ; William R. MontfortChapter 19: |
Strategies Used by Bloodsucking Insects to Ensure that They Obtain a Sufficient Blood Meal |
Properties of Nitric Oxide |
Spectroscopy of the Nitrophorins of Rhodnius prolixus in Comparison to Other Heme Proteins |
Redox Chemistry of Nitric Oxide-Heme Systems and the Nitrophorins of Rhodnius prolixus |
X-Ray Crystallography |
Other Metal-Nitric Oxide Complexes of Importance in Inorganic Chemistry and Biochemistry |
Summary |
Nitrogen Monoxide-Related Disease and Nitrogen Monoxide Scavengers as Potential Drugs / Simon P. FrickerChapter 20: |
Nitric Oxide and Disease |
Therapeutic Strategies |
Organic Molecules as Nitric Oxide Scavengers |
Inorganic Molecules as Scavengers |
Ruthenium Complexes |
Therapeutics of Nitric Oxide Modulation / Ho-Leung Fung ; Brian P. Booth ; Mohammad Tabrizi-FardChapter 21: |
Diversity of Molecular Forms of Nitric Oxide |
Interactions Between Nitric Oxide and Calcitonin-Gene Related Peptide (CGRP) |
Therapeutics of Nitric Oxide Enhancement |
Therapeutics of Nitric Oxide Inhibition |
Subject Index |