Historical Development and Perspectives of the Series |
Preface to Volume 8 |
Contributors to Volume 8 |
Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series |
Contents of Volumes in the Metal Ions in Life Sciences Series |
Understanding Combined Effects for Metal Co-Exposure in Ecotoxicology / Rolf Altenburger1: |
Abstract |
Ecotoxicity from Mixture Exposure |
Combination Effect Analysis / 2: |
Interactions During Exposure / 3: |
Joint Action in Toxicodynamics / 4: |
Interaction with Organic Compounds / 5: |
Outlook / 6: |
Acknowledgments |
Abbreviations |
References |
Human Risk Assessment of Heavy Metals: Principles and Applications / Jean-Lou C. M. Dorne ; George E. N. Kass ; Luisa R. Bordajandi ; Billy Amzal ; Ulla Bertelsen ; Anna F. Castoldi ; Claudia Heppner ; Mari Eskola ; Stefan Fabiansson ; Pietro Ferrari ; Elena Scaravelli ; Eugenia Dogliotti ; Peter Fuerst ; Alan R. Boobis ; Philippe Verger |
Introduction |
Principles of Chemical Risk Assessment |
Toxicology of Heavy Metals |
Analytical Techniques and Exposure Assessment of Heavy Metals |
Applications to the Human Risk Assessment of Heavy Metals and Metalloids |
Conclusions and Future Perspectives |
Abbreviations and Definitions |
Mixtures and Their Risk Assessment in Toxicology / Moiz M. Mumtaz ; Hugh Hansen ; Hana R. Pohl |
Predictions of Toxicity Outcomes |
Weight-of-Evidence Evaluations |
Experimental Validations |
Conclusion |
Metal Ions Affecting the Pulmonary and Cardiovascular Systems / Massino Corradi ; Antonio Mutti |
Aluminum |
Arsenic |
Beryllium |
Copper |
Cadmium |
Chromium / 7: |
Cobalt / 8: |
Lead / 9: |
Manganese / 10: |
Nickel / 11: |
Zinc / 12: |
Concluding Remarks / 13: |
Metal Ions Affecting the Gastrointestinal System Including the Liver / Declan P. Naughton ; Tamás Nepusz ; Andrea Petroczi |
Exposure to Metal Ions in the Gastrointestinal Tract and Liver |
Estimation of Toxicity Associated with Metal Ions in the Gastrointestinal Tract and Liver |
Metal Ion-Molecular Interactions: Effects on Oxidative Damage |
Concluding Remarks and Future Directions |
Metal Ions Affecting the Kidney / Bruce A. Fowler |
Exposure to Metal Ions in Air, Food, and Water |
Transport of Metals/Metalloids in the Circulation |
Mechanisms of Metal and Metalloid Uptake by the Kidney |
Effects of Metals/Metalloids on the Kidney |
Mechanisms of Renal Cell Injury |
Renal Biomarkers |
Metal/Metalloid Interactions in the Kidney |
Metal Ions Affecting the Hematological System / Nickolette Roney ; Henry G. Abadin ; Bruce Fowler |
Exposure to Metals and Their Mixtures |
Metals Affecting the Hematological System |
Binary Interactions of Metals and Hematological Effects |
Interaction of Metals with other Chemicals |
Conclusions |
Metal Ions Affecting the Immune System / Irina Lehmann ; Ulrich Sack ; Jörg Lehmann |
Immunotoxicity and Immunomodulation |
Effect of Heavy Metals on Innate Immunity |
Effect of Heavy Metals on Adaptive Immunity |
Mechanisms of Heavy Metal-Induced Immunotoxic/Immunomodulatory Effects |
Influence of Heavy Metals on the Resistance Toward Infections |
Chronic Inflammation and Autoimmunity |
Metal Ions Affecting the Skin and Eyes / Alan B. G. Lansdown |
Metal Ions and Metal Ion Gradients in the Physiology and Homeostasis of Mammalian Skin |
Xenobiotic Metal Ions |
Carcinogenicity of Metal Ions in the Skin |
The Eye |
General Conclusions |
Metal Ions Affecting the Neurological System |
Metals Affecting the Neurological System |
Interaction of Metals and Neurological Effects |
Interactions of Metals with Other Chemicals |
Metal Ions Affecting Reproduction and Development / Pietro Apostoli ; Simona Catalani |
Time and Duration of Exposure |
Mechanisms of Action |
Reproductive Effects |
Abortions and Other Pregnancy Effects |
Prenatal Exposure and Developmental Effects |
Early Postnatal Exposure and Developmental Effects |
Concluding Remarks and Needs for Further Research |
Are Cadmium and Other Heavy Metal Compounds Acting as Endocrine Disrupters? / Andreas Kortenkamp |
A Model for Estrogen Receptor Activation by Cadmium |
Cadmium Exposure and Cancer Risks in Endocrine-Sensitive Tissues |
In Vivo Studies of Estrogenic Effects of Cadmium |
Cadmium and Other Heavy Metals in In Vitro Cell-Based Assays of Estrogenicity |
Weight of Evidence and Implications for Human Risk Assessment |
Genotoxicity of Metal Ions: Chemical Insights / Wojciech Bal ; Anna Maria Protas ; Kazimierz S. Kasprzak |
Overview of Chemical and Biochemical Processes Leading to Genotoxic Lesions |
Mechanisms of Metal Ion Genotoxicity |
Genotoxic Properties of Selected Metals |
Critical Overview of the Experimental Methods for Studying the Genotoxic Potential of Metals |
Metal Ions in Human Cancer Development / Erik J. Tokar ; Lamia Benbrahim-Tallaa ; Michael P. Waalkes14: |
Known Human Metallic Carcinogens |
Probable and Possible Metallic Carcinogens |
Potential Mechanisms of Metallic Carcinogens |
Periods of Particular Sensitivity to Inorganic Carcinogens |
Future Issues in Metal Carcinogenesis |
Subject Index |
Historical Development and Perspectives of the Series |
Preface to Volume 8 |
Contributors to Volume 8 |