Preface |
Vitamins C and E and LDL Oxidation / B. Frei ; J.F. Keaney, Jr ; K.L. Retsky ; K. Chen |
Antioxidant Vitamins and Human Immune Responses / A. Bendich |
Cytokine Regulation of Bone Cell Differentiation / M. Alsina ; T.A. Guise ; G.D. Roodman |
The Molecular Pharmacology of Ovarian Steroid Receptors / E. Vegeto ; B.L. Wagner ; M.O. Imhof ; D.P. McDonnell |
Signal Transduction Pathways Combining Peptide Hormones and Steroidogenesis / M.R. Waterman ; D.S. Keeney |
The Roles of 14-3-3 Proteins in Signal Transduction / G.W. Reuther ; A.M. Pendergast |
Physiological Roles for Parathyroid Hormone-Related Protein: Lessons from Gene Knockout Mice / A.C. Karaplis ; H.M. Kronenberg |
Index |
The Steroid/Nuclear Receptors: From Three Dimensional Structure to Complex Function / B.F. Luisi ; J.W.R. Schwabe ; L.P. Freedman |
Function/Activity of Specific Amino Acids in Glucocorticoid Receptors / S.S. Simons, Jr. |
Genetic Diseases of Steroid Metabolism / P.C. White |
Structure, Function and Regulation of Androgen-Binding Protein/Sex Hormone-Binding Globulin / D.R. Joseph |
Molecular Biology of Vitamin D Acation / T.K. Ross ; H.D. Darwish ; H.F. Deluca |
Nuclear Retinoid Receptors and Their Mechanism of Action / M. Pfahlr ; R. Apfel ; I. Bendik ; A. Fanjul ; G. Graupner ; M.-O. Lee ; N. La-Vista ; X.-P. Lu ; J. Piedrafita ; A. Ortiz-Caseda ; G. Salbert ; X.-K. Zhang |
Molecular Mechanisms of Androgen Action / J. Lindzey ; M.V. Kumar ; M. Grossman ; C. Young ; D.J. Tindall |
Role of Androgens in Prostatic Cancer / J.T. Isaacs |
Cumulative Index, Volumes 30-55 |
Subject Index |
Author Index |
Contributors |
Neuroendocrine and Behavioral Development During Puberty: A Tale of Two Axes / Russell D. Romeo1: |
Introduction / I: |
HPG Axis / II: |
HPA Axis / III: |
Conclusions and Future Directions / IV: |
References |
Regulation of Oxytocin Secretion / Gareth Leng ; Celine Caquineau ; Nancy Sabatier2: |
The Hypothalamo-Neurohypophysial Oxytocin System |
The Milk-Ejection Reflex |
Control of Oxytocin Secretion at Parturition |
Oxytocin Secretion and Stress |
Osmotic Regulation of Oxytocin Secretion / V: |
Oxytocin Secretion and Behavior / VI: |
Conclusions / VII: |
Gonadotropin-Releasing Hormone: Gene Evolution, Expression, and Regulation / Denise D. Belsham ; David A. Lovejoy3: |
The GnRH Genes |
Early Formation and Migration of GnRH Neurons |
Analysis of GnRH Gene Expression |
Regulation of GnRH Gene Expression |
Future Directions and Critical Studies |
Thyroid Hormones and Brain Development / Juan Bernal4: |
Morphological Aspects |
Control of Local Brain Thyroid Hormone Concentrations |
Role of Thyroid Hormone Receptors |
Regulation of Brain Gene Expression by Thyroid Hormone |
Estrogen Signaling in the Hypothalamus / Martin J. Kelly ; Jian Qui ; Oline K. Ronnekleiv5: |
Hypothalamus and Feedback of E[subscript 2] on the Hypothalamic-Pituitary Axis |
Transcriptional Signaling of Estrogen in Hypothalamic Neurons |
Membrane-Initiated Signaling by Estrogen in Hypothalamic Neurons |
Coupling of a Membrane Estrogen Receptor to Signaling Cascades |
Cross-Talk between E[subscript 2] Signaling with other Signaling Cascades |
Hormonal Influences on Cancer Progression and Prognosis / G. V. Sherbet6: |
Hormone-Mediated Induction of Invasive Behavior |
Estrogens and Progestins on Breast Cancer Progression and Prognosis |
Androgen Receptors in Prostate Cancer |
Vitamin D3 in Cell Proliferation, Apoptosis, and Differentiation |
RA and Its Receptors in Cell Differentiation, Proliferation, and Survival |
General Conclusions and Reflections on Cancer Progression |
Antiestrogens, Aromatase Inhibitors, and Apoptosis in Breast Cancer / Rebecca B. Riggins ; Amy H. Bouton ; Minetta C. Liu ; Robert Clarke7: |
Estrogen and ERs |
Antiestrogens |
Aromatase Inhibitors, Estrogen Independence, and Antiestrogens |
Antiestrogens versus Aromatase Inhibitors as Endocrine Therapies |
Apoptosis |
Antiestrogen Resistance and Defects in Apoptosis |
De Novo Antiestrogen Resistance / VIII: |
Summary and Future Directions / IX: |
Glucocorticoid Receptor and Heat Shock Factor 1: Novel Mechanism of Reciprocal Regulation / Dapei Li ; Edwin R. Sanchez8: |
GR and HSF1 are Chaperoned by Similar Hsp90/TPR Protein Complexes |
Stress Potentiation of Glucocorticoid Receptor-Mediated Gene Expression |
GR Regulation of HSF1 |
Speculations on GR and HSF1 Reciprocal Regulation |
C[subscript 19]-5-ene Steroids in Nature / Henry Lardy ; Ashok Marwah ; Padma Marwah9: |
Dehydroepiandrosterone |
Androstenediol (androst-5-ene-3[beta],17[beta]-diol; Adiol) |
7-Oxygenated Steroids |
16-Hydroxydhea |
The Androgen Receptor: Unlocking the Secrets of Its Unique Transactivation Domain / Howard C. Shen ; Gerhard A. Coetzee10: |
The Androgen Signaling Axis |
The Role of AR in Prostate Cancer |
Overview of AR Structure |
The AR LBD |
The AR DBD |
The AR NTD |
AR AF-1 and AF-5 |
Q and G Repeats |
AR NTD Signature Sequence |
FxxLF and WxxLF Motifs / X: |
Phosphorylation of the AR NTD / XI: |
Sumoylation at NRM1 and NRM2 / XII: |
AR NTD-Associated Cofactors / XIII: |
The Focus on AR NTD / XIV: |
Cytokine Recognition by Human Interleukin 5 Receptor / Tetsuya Ishino ; Noreen Robertson ; Irwin Chaiken11: |
Assembly and Activation Mechanism of IL-5 Receptor |
Relationship of Cytoplasmic Signaling by IL-5 to Receptor Organization |
Structure and Function of IL-5 |
Mapping of Binding Epitope on IL-5 Receptor [alpha] |
Peptide Approach to IL-5 Mimetics |
Conclusion-Future Study for Cytokine Recognition |
Leptin: Structure, Function and Biology / Faming Zhang ; Yanyun Chen ; Mark Heiman ; Richard DiMarchi12: |
Leptin |
Leptin Structure |
Leptin Receptor |
Leptin-Binding Protein |
Leptin-Receptor Binding Model |
Leptin Signal Transduction |
Therapeutic Application |
Conclusion |
Leptin Gene Polymorphisms and Their Phenotypic Associations / T. van der Lende ; M. F. W. te Pas ; R. F. Veerkamp ; S. C. Liefers13: |
Structural Organization of the Leptin Gene and Leptin Protein |
Polymorphisms in the Human Leptin Gene |
Polymorphisms in the Bovine Leptin Gene |
Polymorphisms in the Porcine Leptin Gene |
Concluding Remarks |
Ghrelin, the Same Peptide for Different Functions: Player or Bystander? / Francisca Lago ; Jose Ramon Gonzalez-Juanatey ; Felipe F. Casanueva ; Juan Gomez-Reino ; Carlos Dieguez ; Oreste Gualillo14: |
Ghrelin, the First Orexigenic Gastrointestinal Acylated Peptide: Isolation, Identification, and Structures |
Tissue Distribution and Regulation |
Mechanism of Action |
Biological Action |
Ghrelin and Ghrelin Receptor Knockout: Relevant or Redundant? |
Cholecystokinin and Adrenal-Cortex Secretion / Gastone G. Nussdorfer ; Raffaella Spinazzi ; Giuseppina Mazzocchi15: |
Biology of CCK and Adrenocortical Cells |
CCK and Its Receptors in the HPA Axis |
Effects of CCK on Adrenal-Cortex Secretion |
Preface |
Vitamins C and E and LDL Oxidation / B. Frei ; J.F. Keaney, Jr ; K.L. Retsky ; K. Chen |
Antioxidant Vitamins and Human Immune Responses / A. Bendich |