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1.

図書

図書
Robert P. Lanza, Robert Langer, Joseph Vacanti原書編 ; 大野典也 [ほか] 監訳
出版情報: 東京 : エヌ・ティー・エス, 2002.1  7, viii, 14, 927, 23p ; 27cm
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2.

図書

図書
デイヴィッド・クーパー, ロバート・ランザ著 ; 山内一也訳
出版情報: 東京 : 岩波書店, 2001.9  xxii, 357, 15p ; 20cm
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3.

図書

図書
editors, Robert Lanza ... [et al.]
出版情報: London : Academic Press, 2009  xxix, 650 p. ; 29 cm
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Foreword
Why Stem Cell Research?
A New Path ?
Induced Pluripotent Stem Cells
Embryonic Stem Cells
Versus Adult Stem Cells
'Stemness': Definitions, Criteria and Standards
Introduction to Stem Cells / Part 1:
Present Perspective and Future Challenges / 1:
Embryonic Stem Cells in Perspective / 2:
The Development of Epithelial Stem Cell Concepts / 3:
The Advent of Direct Reprogramming / 4:
Clinical Translation of Stem Cells / 5:
Basic Biology Mechanisms / Part 2:
Molecular Basis of Pluripotency / 6:
Stem Cell Niches / 7:
Mechanisms of Stem Cell Self-Renewal / 8:
Cell Cycle Regulators in Stem Cells / 9:
Epigenetic Mechanisms of Cellular Memory / 10:
Cell Fusion and the Differentiated State / 11:
How Cells Change Their Phenotype / 12:
Tissue and Organ Development / Part 3:
Differentiation in Early Development / 13:
Primordial Germ Cells in Mouse and Human / 14:
Stem Cells in Extraembryonic Lineages / 15:
Amniotic Fluid Derived Pluripotent Cells / 16:
Cord Blood Stem Cells / 17:
Neurogenesis in the Vertebrate Embryo / 18:
The Nervous System / 19:
Neuronal Progenitors in the Adult Brain / 20:
Sensory Epithelium of the Eye and Ear / 21:
Epithelial Skin Stem Cells / 22:
The Ontogeny of the Hematopoietic System / 23:
Hematopoietic Stem Cells / 24:
Red Blood Cells / 25:
Cell Differentiation in the Skeleton / 26:
Vascular Progenitor Cells / 27:
Multipotent Adult Progenitor Cells / 28:
Mesenchymal Stem Cells / 29:
Skeletal Muscle Stem Cells / 30:
Stem Cells and the Regenerating Heart / 31:
Potential of ES Cell Differentiation Culture for Vascular Biology / 32:
Cell Lineages and Stem Cells in the Kidney / 33:
Adult Liver Stem Cells / 34:
Pancreatic Stem Cells / 35:
Stem Cells in the Gastrointestinal Tract / 36:
Stem Cells in the Lung / 37:
Methods / Part 4:
Generation of Induced Pluripotent Stem Cells / 38:
Characteristics and Characterization of Pluripotent Stem Cells / 39:
Isolation and Maintenance of Murine Embryonic Stem Cells / 40:
Isolation, Characterization, and Maintenance of Primate ES Cells / 41:
Approaches for Derivation and Maintenance of Human ES cells: Detailed Procedures and Alternatives / 42:
Derivation and Differentiation of Human EG Cells / 43:
Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells / 44:
Feeder-Free Culture / 45:
Genetic Manipulation of Human Embryonic Stem Cells / 46:
Homologous Recombination in Human Embryonic Stem Cells / 47:
Surface Antigen Markers / 48:
Lineage Marking / 49:
Genomic Reprogramming / 50:
Isolation and Characterization of Hematopoietic Stem Cells / 51:
Microarray Analysis of Stem Cells and Differentiation / 52:
Zebrafish and Stem Cell Research / 53:
Applications / Part 5:
Cancer Stem Cells / 54:
Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases / 55:
Spinal Cord Injury / 56:
Use of Embryonic Stem Cells to Treat Heart Disease / 57:
Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes / 58:
Burns and Skin Ulcers 978-0-12-370465-8 / 59:
Stem Cells and Heart Disease / 60:
Stem Cells for the Treatment of Muscular Dystropy / 61:
Skin Regeneration / 62:
Orthopaedic Applications of Stem Cells / 63:
Embryonic Stem Cells in Tissue Engineering / 64:
Adult Stem Cells in Tissue Engineering / 65:
Stem Cell Gene Therapy / 66:
Regulation and Ethics / Part 6:
Ethical Considerations / 67:
Religious Considerations / 68:
Regulatory Considerations / 69:
Ití s Not About Curiosity, Ití s About Cures / 70:
Epilogue: Concluding Statement
Foreword
Why Stem Cell Research?
A New Path ?
4.

図書

図書
edited by Robert P. Lanza, Robert Langer, Joseph Vacanti
出版情報: San Diego : Academic Press, c2000  xli, 995 p. ; 29 cm
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Contributors
Foreword
Preface to the Second Edition
Preface to the First Edition
Tissue Engineering in Perspective / Eugene Bell
Origins of Tissue Engineering
The Tissue Engineering Triad
What Parts of the Body Can Tissue Engineering Replace?
Acellular Prostheses
The Relevance of Developmental Biology
Can Nature Be Imitated?
The Need for Vascularization in Vitro and in Vivo
Stem Cells
Cell Signaling
Looking Forward
References
Introduction to Tissue Engineering
The History and Scope of Tissue Engineering / Joseph P. Vacanti ; Charles A. Vacanti1.:
Introduction
Scientific Challenges
General Scientific Issues
Social Challenges
The Challenge of Imitating Nature / Robert M. Nerem2.:
Cell Technology
Construct Technology
Integration into the Living System
Concluding Discussion
The Basis of Growth and Differentiation / Part I.:
Organization of Cells into Higher Ordered Structures / Carol A. Erickson3.:
Cellular Changes Involved in the EMT
Stimuli of the Transformation
Conclusion
Dynamics of Cell-ECM Interactions / Manuela Martins-Green4.:
Composition and Diversity of the ECM
Receptors for Extracellular Matrix Molecules
Cell-ECM Interactions
Signal Transduction Events during Cell-ECM Interactions
Relevance for Tissue Engineering
Matrix Molecules and Their Ligands / Bjorn Reino Olsen5.:
Fibrillar Collagens: Major Scaffold Proteins in the ECM
Elastic Fibers and Microfibrils
Fibronectin: A Multidomain, Multifunctional Adhesive ECM Glycoprotein
Laminins: Large, Adhesive Basement Membrane Molecules
Modulators of Cell-Matrix Interactions
Proteoglycans: Multifunctional ECM and Cell Surface Molecules
Summary
Inductive Phenomena / Matthias Hebrok ; Douglas A. Melton6.:
Epithelial to Mesenchymal Signaling in Endoderm Development
Lung Development and Instructive Signaling
Permissive Signaling during Pancreas Development
Morphogenesis and Tissue Engineering / A. H. Reddi7.:
Bone Morphogenetic Proteins
Cartilage-Derived Morphogenetic Proteins
Pleitropy and Thresholds
BMPs Bind to Extracellular Matrix
BMPs: Actions Beyond Bone
BMP Receptors
Responding Stem Cells
Morphogens and Gene Therapy
Biomimetic Biomaterials
Tissue Engineering of Bones and Joints
Future Challenges
Cell Determination and Differentiation / Leon W. Browder8.:
Roles of MRFs during Embryogenesis
Initiation of Skeletal Muscle Development
In Vitro Control of Tissue Development / Part II.:
Mechanical and Chemical Determinants of Tissue Development / Donald E. Ingber9.:
Extracellular Matrix Structure and Function
Pattern Formation through ECM Remodeling
Mechanochemical Switching between Growth and Differentiation
Animal Cell Culture / Gordon H. Sato ; David W. Barnes10.:
Regulation of Cell Behavior by Matricellular Proteins / Amy D. Bradshaw ; E. Helene Sage11.:
Matricellular Proteins
Conclusions
Growth Factors / Thomas F. Deuel ; Nan Zhang12.:
Wound Healing
Role of Basic Fibroblast Growth Factor and Angiogenesis
Other Roles of Growth Factors and Cytokines
Tissue Engineering Bioreactors / Lisa E. Freed ; Gordana Vunjak-Novakovic13.:
Cell-Polymer Constructs
Bioreactor Technologies
Bioreactor Modulation of Tissue Formation
Bioreactor Cultivation of Functional Tissues
Tissue Engineering Bioreactors: State of the Art
Summary and Research Needs
Tissue Assembly in Microgravity / Brian R. Unsworth ; Peter I. Lelkes14.:
Microgravity as a Novel Tissue Culture Venue
Vascularization: Overcoming Size Limitations of Tissue Assemblies
From Single Cells to Tissues in Space
In Vitro Embryology
Gravitational Sensing
Caveats
In Vivo Synthesis of Tissues and Organs / Part III.:
Scale of Functional Deficit: Macromolecule versus Organ / Ioannis V. Yannas15.:
Basic Parameters of the Living Environment during in Vivo Organ Synthesis
Fundamental Design Principles for Tissue and Organ Regeneration Templates
Examples of in Vivo Organ Synthesis
Models for Tissue Engineering / Part IV.:
Organotypic and Histiotypic Models of Engineered Tissues / 16.:
The Collagen Gel Model
Models of Cell Interactions in Collagen Lattices
Other Types of Epithelial-Mesenchymal Models
Vascular Models
Selection of Scaffolds Other Than Gels for Model Systems
Cell Signaling and the Enrichment of Scaffolds
Goals and Uses of Model Tissue and Organ Building
Quantitative Aspects of Tissue Engineering: Basic Issues in Kinetics, Transport, and Mechanics / Alan J. Grodzinsky ; Roger D. Kamm ; Douglas A. Lauffenburger17.:
Molecular Interactions with Cells
Molecular and Cell Transport through Tissue
Cell and Tissue Mechanics
Biomaterials in Tissue Engineering / Part V.:
Patterning of Cells and Their Environment / Shuichi Takayama ; Robert G. Chapman ; Ravi S. Kane ; George M. Whitesides18.:
Soft Lithography
Self-Assembled Monolayers
Microcontact Printing
Microfluidic Patterning
Laminar Flow Patterning
Conclusion and Future Prospects
Cell Interactions with Polymers / W. Mark Saltzman19.:
Methods for Characterizing Cell Interactions with Polymers
Cell Interaction with Polymer Surfaces
Cell Interactions with Polymers in Suspension
Cell Interactions with Three-Dimensional Polymer Scaffolds and Gels
Matrix Effects / Jeffrey A. Hubbell20.:
Extracellular Matrix Proteins and Their Receptors
Model Systems for Study of Matrix Interactions
Cell Pattern Formation by Substrate Patterning
Signal Transduction and Functional Regulation via the Extracellular Matrix
Translation to Working Biomaterial Systems
Polymer Scaffold Processing / Robert C. Thomson ; Albert K. Shung ; Michael J. Yaszemski ; Antonios G. Mikos21.:
Fiber Bonding
Solvent Casting and Particulate Leaching
Membrane Lamination
Melt Molding
Extrusion
Three-Dimensional Printing
Gas Foaming
Freeze Drying
Phase Separation
Polymer/Ceramic Composite Foams
In Situ Polymerization
Biodegradable Polymers / James M. Pachence ; Joachim Kohn22.:
Biodegradable Polymer Selection Criteria
Biologically Derived Bioresorbables
Experimental Biologically Derived Bioresorbables
Creating Materials for Tissue-Engineered Products
Transplantation of Engineered Cells and Tissues / Part VI.:
Approaches to Transplanting Engineered Cells and Tissues / Janet Hardin-Young ; Jeffrey Teumer ; Robert N. Ross ; Nancy L. Parenteau23.:
Developing Workable Strategies
Mode of Action--An Important Design Consideration
Role of the Host
Source of Cells
The Immunology of Nonautologous Cells
Safety Considerations
Cryopreservation / Jens O. M. Karlsson ; Mehmet Toner24.:
Applications of Cryopreservation Technology in Tissue Engineering
Challenges in Cryopreservation Protocol Development
Cryobiology of Cells
Cryobiology of Tissue
Summary and Future Directions
Immunomodulation / Denise Faustman25.:
Origin of the Designer Tissue Concept
Expansion of Research on Designer Tissues
Mechanisms of Graft Survival after Class I Donor Ablation or Antibody Masking
The Launching of Xenogeneic Human Clinical Trials in the United States Using Immunomodulation
Gene Addition
RNA Ablation
Comment
Immunoisolation / Beth A. Zielinski ; Michael J. Lysaght26.:
Technology
Clinical
Future Directions
Engineering Challenges in Immunoisolation Device Development / Efstathios S. Avgoustiniatos ; Haiyan Wu ; Clark K. Colton27.:
Engineering Challenges
Oxygen-Supply Limitations
Theoretical Analysis of in Situ Oxygen Generation
Calculations
Concluding Remarks
Fetal Tissue Engineering / Part VII.:
General Characteristics of Fetal Cells / Dario O. Fauza28.:
The Fetus as a Transplantation Host
Ethical Considerations
Future Perspectives
Pluripotent Stem Cells / Michael J. Shamblott ; Brian E. Edwards ; John D. Gearhart29.:
Differentiation in Vitro
Examples of in Vitro Differentiation and Markers
In Vivo Applications
Summary and Future Prospects
Gene Therapy / Part VIII.:
Gene-Based Therapeutics / Lee G. Fradkin ; J. Dezz Ropp ; John F. Warner30.:
Gene Delivery
Persistent Gene Expression
Safety Considerations for Gene-Based Therapeutics
Large-Scale Production Issues
Breast / Part IX.:
Breast Reconstruction / Kuen Young Lee ; Craig R. Halberstadt ; Walter D. Holder ; David J. Mooney31.:
Cell Types for Soft Tissue Engineering
Materials
Animal Models
Strategies to Enhance the Vascularization of Engineered Tissue
Cardiovascular System / Part X.:
Blood Vessels / Lian Xue ; Howard P. Greisler32.:
Graft Healing
Strategies for the Development of Vascular Grafts
Small-Diameter Vascular Grafts / Susan J. Sullivan ; Kelvin G. M. Brockbank33.:
Synthetic Grafts
In Vitro Blood Vessel Tissue Engineering
In Vivo Tissue Engineering of Blood Vessels
Cardiac Prostheses / Jack W. Love34.:
A Short History of Tissue Heart Valves
The Status of Tissue Valves in 1999
The Issue of Whether to Use a Stent
The Issue of Repair versus Replacement
Speculation about the Future
Recent Developments
The Ideal Valve Repair or Replacement
Cornea / Part XI.:
Biology of the Cornea / Vickery Trinkaus-Randall35.:
Criteria for Keratoprostheses
Development of the Keratoprosthesis
Evaluation of Intact Devices
Other Devices Used to Change the Curvature of the Cornea
Endocrinology and Metabolism / Part XII.:
Bioartificial Pancreas / Taylor G. Wang ; Robert P. Lanza36.:
Theoretical Background
Experiment
Capsule Development
Discussion
Parathyroid / C. Hasse ; A. Zielke ; T. Bohrer ; U. Zimmermann ; M. Rothmund37.:
History of Parathyroid Allotransplantation
Hypoparathyroidism
Microencapsulation
Alginates
Experimental and Clinical Transplantation of Microencapsulated Parathyroid Tissue
Alternative Approaches and Perspectives
Gastrointestinal System / Part XIII.:
Alimentary Tract / Gregory M. Organ38.:
Enterocyte Isolation
Procedural Steps
Liver / Hugo O. Jauregui39.:
Anatomy and Function of the Liver
Liver Failure: Pathophysiological Classification
Mechanisms of HE in Liver Failure
Medical Need for Liver-Assist Devices
Biological Component of Liver-Assist Devices
Liver-Assist Device Configurations
HepatAssist Liver Support System / Claudy Mullon ; Barry A. Solomon40.:
HepatAssist System
Cell Preparation
Clinical Study
Lineage Biology and Liver / Arron S. L. Xu ; Thomas L. Luntz ; Jeffrey M. Macdonald ; Hiroshi Kubota ; Edward Hsu ; Robert E. London ; Lola M. Reid41.:
Liver Organization and Development
Identification, Isolation, and Sourcing of Cells for Tissue Engineering
Sourcing of Human Cells for Tissue Engineering
Microenvironment
Designing Bioreactors for Tissue Engineering
Technical Aspects of Tissue Engineering
Future Considerations
Hematopoietic System / Part XIV.:
Red Blood Cell Substitutes / Thomas Ming Swi Chang42.:
Why Do We Have to Modify Hemoglobin?
Sources of Hemoglobin
Circulating Time of Modified Hemoglobin
Safety of Modified Hemoglobin Blood Substitute
Efficacy of Modified Hemoglobin Blood Substitute
Present Status and Future Research and Development
Lymphoid Cells / Una Chen43.:
Lymphocyte Engineering: Reality and Potential
Concluding Remarks and Prospects for Lymphocyte Engineering
Hematopoietic Stem Cells / Anne Kessinger ; Graham Sharp44.:
Overview of Hematopoiesis: Properties and Regulation of Hematopoietic Stem Cells Relevant to Tissue Engineering
Organization of the Stem Cell Compartment
Stromal Microenvironments
Kidney and Genitourinary System / Part XV.:
Renal Replacement Devices / H. David Humes45.:
Basics of Kidney Function
Tissue Engineering Approach to Renal Function Replacement
Genitourinary System / Byung-Soo Kim ; Anthony Atala46.:
Tissue Engineering Strategies in the Genitourinary System
Engineering Genitourinary Tissues
Musculoskeletal System / Part XVI.:
Structural Tissue Engineering / Lawrence J. Bonassar47.:
Materials Development
Structural Tissues
Biomechanics
Bone Regeneration through Cellular Engineering / Scott P. Bruder ; Arnold I. Caplan48.:
Marrow: The Source of Mesenchymal Progenitor Cells
Delivery of Osteoprogenitor Cells
Bone Regeneration by MSCs
MSCs and Gene Therapy
Prevention of Age-Related Bone Loss
Articular Cartilage Injury / John M. McPherson ; Ross Tubo49.:
Autologous Chondrocyte Transplantation
Commercialization of Autologous Chondrocyte Implantation
Alternative Strategies for the Delivery of Cell-Based Therapies for Cartilage Repair
Tendons and Ligaments / Francine Goulet ; Denis Rancourt ; Rejean Cloutier ; Lucie Germain ; A. Robin Poole ; Francois A. Auger50.:
The Need for Bioengineered Tendon and Ligament Substitutes
Histologic Description of Tendons and Ligaments
Production of Bioengineered Tendons and Ligaments
A New Living Bioengineered Ligament Model
Technical Steps to Produce and Analyze Our bACL
Perspectives in Tendon and Ligament Bioengineering
Mechanosensory Mechanisms in Bone / Stephen C. Cowin ; Melvin L. Moss51.:
The Connected Cellular Network
Mechanosensation on the CCN
Questions for Future Research; Socratic Questions
Myoblast Therapy / Joanne C. Cousins ; Jennifer E. Morgan ; Terence A. Partridge52.:
Myoblast-Mediated Gene Transfer
Therapeutic Myoblast Transplantation for Myopathies
Nervous System / Part XVII.:
Protection and Repair of Hearing / Richard A. Altschuler ; Yehoash Raphael ; Jochen Schacht ; David J. Anderson ; Josef M. Miller53.:
Basis for Interventions
Methods of Intervention
Vision Enhancement Systems / Gislin Dagnelie ; Mark S. Humayun ; Robert W. Massof54.:
Visual System: Architecture and (Dys) Function
Possible Approaches to Vision Restoration
Current Approaches
Applications of Engineered Cells and Tissues: Challenges and Tentative Solutions
Toward "2020" Vision
Brain Implants / Lars U. Wahlberg55.:
Naked Cell Implants
Encapsulated Cell Implants
Controlled-Release Implants
Axonal Guidance Implants
Disease Targets
Surgical Considerations
Nerve Regeneration / Eric G. Fine ; Robert F. Valentini ; Patrick Aebischer56.:
Nerve Regeneration and Neural Tissue Engineering
Overview of Neural Regeneration
Experimental Use of Guidance Channels
Biomaterial-Based Approaches to Nerve Repair
Tissue Engineering Approaches to Nerve Repair
Specificity of Nerve Reconnections
Transplantation Strategies for Treatment of Spinal Cord Dysfunction and Injury / Jacqueline Sagen ; Mary Bartlett Bunge ; Naomi Kleitman57.:
Spinal Implants as Axon Bridges
Spinal Implants for Replacement of Specific Cell Populations
Spinal Implants for Provision of Neurotransmitters
Neural Stem Cells / Martin P. Vacanti58.:
Background
Neural Stem Cell Applications in Tissue Engineering
Periodontal and Dental Applications / Part XVIII.:
Periodontal Applications / Neal A. Miller ; Marie C. Bene ; Jacques Penaud ; Pascal Ambrosini ; Gilbert C. Faure59.:
Guided Tissue Regeneration
Bone Substitutes
Dental Implants
Growth Factors and Plasma Proteins
Cell Culture Techniques
Regeneration of Dentin / R. Bruce Rutherford60.:
Dentin
Induction Potential of Dentin
Recombinant Human BMPs Induce Dentin Formation
Delivery Systems
Clinical Considerations
Additional Considerations
Potential Applications of BMP-Induced Dentinogenesis
Skin / Part XIX.:
Wound Repair: Basic Biology to Tissue Engineering / Richard A. F. Clark ; Adam J. Singer61.:
Inflammation
Epithelialization
Granulation Tissue
Wound Contraction and Extracellular Matrix Reorganization
Skin Structure and Function / 62.:
Engineering Skin Tissue
Epidermal Regeneration
Dermal Replacement
Composite Skin Grafts
Dermal Equivalents / Gail K. Naughton63.:
Cell Testing and Establishment of Manufacturing Cell Banks
Manufacturing a Dermal Replacement
Clinical Results of Wound Healing
Contributors
Foreword
Preface to the Second Edition
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